LOCUS       NM_033480               4743 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box protein 9 (FBXO9), transcript variant 2, mRNA.
ACCESSION   NM_033480
VERSION     NM_033480.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4743)
  AUTHORS   Hussain,S., Dong,J., Ma,X., Li,J., Chen,S., Clement,A. and Liu,H.
  TITLE     F-box only protein 9 and its role in cancer
  JOURNAL   Mol Biol Rep 49 (2), 1537-1544 (2022)
   PUBMED   35025031
  REMARK    GeneRIF: F-box only protein 9 and its role in cancer.
            Review article
REFERENCE   2  (bases 1 to 4743)
  AUTHORS   Lai,Y., Li,X., Li,T., Nyunoya,T., Chen,K., Kitsios,G.D.,
            Nouraie,S.M., Zhang,Y., McVerry,B.J., Lee,J.S., Mallampalli,R.K.
            and Zou,C.
  TITLE     Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4)
            protein triggering death of lung epithelia
  JOURNAL   Cell Death Dis 12 (9), 828 (2021)
   PUBMED   34480022
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4743)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4743)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4743)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 4743)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   7  (bases 1 to 4743)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 4743)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   9  (bases 1 to 4743)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 4743)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031178.1 and AL137520.1.
            
            On Jun 2, 2019 this sequence version replaced NM_033480.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. Alternative splicing of this gene
            generates at least 3 transcript variants diverging at the 5'
            terminus. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains a different segment
            for the 5' UTR and 5' coding region, compared to variant 1. It uses
            a different translation start codon and the encoded protein
            (isoform 2) has a shorter and distinct N-terminus when it is
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL137520.1, AY858798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323557.12/ ENSP00000326968.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL031178.1         42234-42288
            56-1786             AL137520.1         1-1731
            1787-4743           AL031178.1         74747-77703
FEATURES             Location/Qualifiers
     source          1..4743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..4743
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /note="F-box protein 9"
                     /db_xref="GeneID:26268"
                     /db_xref="HGNC:HGNC:13588"
                     /db_xref="MIM:609091"
     exon            1..389
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1700
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     protein Fbx9; F-box only protein 9; cross-immune reaction
                     antigen 1; renal carcinoma antigen NY-REN-57"
                     /codon_start=1
                     /product="F-box only protein 9 isoform 2"
                     /protein_id="NP_258441.1"
                     /db_xref="CCDS:CCDS55022.1"
                     /db_xref="GeneID:26268"
                     /db_xref="HGNC:HGNC:13588"
                     /db_xref="MIM:609091"
                     /translation="MAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFEL
                     APGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYE
                     AIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQ
                     ESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICAR
                     DPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDG
                     FYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQD
                     TDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIW
                     IHHSCHITYKSTGETAVSAFEIDKMYTPLFFARVRSYTAFSERPL"
     exon            390..476
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..635
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..693
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..793
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..924
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1039
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1158
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1249
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1345
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1439
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1591
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..4743
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2221..2226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /note="hexamer: AATAAA"
     polyA_site      2243
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /note="major polyA site"
     regulatory      4722..4727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
                     /note="hexamer: AATAAA"
     polyA_site      4743
                     /gene="FBXO9"
                     /gene_synonym="dJ341E18.2; FBX9; NY-REN-57; VCIA1"
ORIGIN      
        1 atgctcggcg cgtcggcgca ggtttccgca gctgaggggg cagctccgcg gcggcgtccg
       61 gggtctccag tagggctgac gctccggtgc tcgcacaatc ccccgcctcg gctggcaacg
      121 ggcgtccctc cactccccga gtccccggca gccgccgcca ccccagcgcg ccccgatctg
      181 gccccctgcc ccgcgaagat ggctgccgta cgccgggccc gcagttattg ccgctgcctg
      241 gtgcgcttct ccgaccgaga actctgctaa gctccgctgc agagacaggc aggagtagac
      301 acccggacac ccagcacccc tcctccgggg ggcggtgcag agggggcacg gagagcccct
      361 cgagcgcagc aggccgcccc gccagcatgg cagaagctga ggaagattgt cattctgata
      421 ctgtcagagc agatgatgat gaagaaaatg aaagtcctgc tgaaacagat ctgcaggcac
      481 aactccagat gttccgagct cagtggatgt ttgaacttgc tccaggtgta agctctagca
      541 atttagaaaa tcgaccttgc agagcagcaa gaggctctct ccagaaaaca tcggcagata
      601 ccaaaggaaa acaagaacag gcaaaagaag aaaaggctcg agaactcttc ctaaaagcag
      661 tagaagaaga acaaaatgga gctctctatg aagccatcaa gttttatcgt agggctatgc
      721 aacttgtacc tgatatagag ttcaagatta cttatacccg gtctccagat ggtgatggcg
      781 ttggaaacag ctacattgaa gataatgatg atgacagcaa aatggcagat ctcttgtcct
      841 acttccagca gcaactcaca tttcaggagt ctgtgcttaa actgtgtcag cctgagcttg
      901 agagcagtca gattcacata tcagtgctgc caatggaggt cctgatgtac atcttccgat
      961 gggtggtgtc tagtgacttg gacctcagat cattggagca gttgtcgctg gtgtgcagag
     1021 gattctacat ctgtgccaga gaccctgaaa tatggcgtct ggcctgcttg aaagtttggg
     1081 gcagaagctg tattaaactt gttccgtaca cgtcctggag agagatgttt ttagaacggc
     1141 ctcgtgttcg gtttgatggc gtgtatatca gtaaaaccac atatattcgt caaggggaac
     1201 agtctcttga tggtttctat agagcctggc accaagtgga atattacagg tacataagat
     1261 tctttcctga tggccatgtg atgatgttga caacccctga agagcctcag tccattgttc
     1321 cacgtttaag aactaggaat accaggactg atgcaattct actgggtcac tatcgcttgt
     1381 cacaagacac agacaatcag accaaagtat ttgctgtaat aactaagaaa aaagaagaaa
     1441 aaccacttga ctataaatac agatattttc gtcgtgtccc tgtacaagaa gcagatcaga
     1501 gttttcatgt ggggctacag ctatgttcca gtggtcacca gaggttcaac aaactcatct
     1561 ggatacatca ttcttgtcac attacttaca aatcaactgg tgagactgca gtcagtgctt
     1621 ttgagattga caagatgtac acccccttgt tcttcgccag agtaaggagc tacacagctt
     1681 tctcagaaag gcctctgtag agcctcaagt ccagtcctct atcacttttg catgaattaa
     1741 agtatatagc gcaaaagagc acctaagtta taaatgtgtg tgtgtgcgtg tgtgtgtata
     1801 tatatatata tatatatata tatatatata tatatatata tatatggaat tggaacttat
     1861 tttaaattgt tggagttctt ttaagaagaa tataaattga ttattttttt tatttaaagg
     1921 gatagttgat tcctggggtg ttttgaaatt aagttggaat taagttgctt aagcatattt
     1981 atgttgtgag aaaccttaat atgaggttta tcatgccctt tttcaagcag atttatgagc
     2041 agatttctgt cacataagtc gtcttctgct tgagtatcct aatatttcaa tgcatcaggg
     2101 gagcgctcca ctggataagc attttatttc ccgcatggca taatgttttt gcactaaagg
     2161 ctcaaagtgt gagaacctgt tctggatttg tttgaaatta tttcaccaat aaagatcata
     2221 aataaatgtt tctttcaaga aaatatattt ggatggcctt tttaaagtaa caggatattt
     2281 aataagagtc ctagatagcc agcggagact ttaagaatca ttgcctctag ctgggtgtgg
     2341 tggcatgcac ctgtagtccc agctatttgg gaggctgatg caggagaata gcttaagccc
     2401 aggaatttga gtctgggagt ttgagtccag catgggcaac ataacaagac cccatccctt
     2461 attaaaagaa aaaaaaataa ttcctcattt catcattggt ctttatatgt agccacaaac
     2521 actgacctca tgtaggcacc ttaccaatat atgacattaa gtgagagtga atcccttagg
     2581 actggaacac ttcaagctca accaactgac tcagttgtca ttcttcacaa aagaatagta
     2641 gaggatcatg taaacctgag cctaactctt gttccagtat gaaagttggg ggagagcacc
     2701 agccacctag gaaaactgta tgttaccttt ttactcaaag gagtcccccc tgcccagtaa
     2761 cagtcctatt agtgtttaat ttcagagttt gtgtctggta gacctctacc tgattcagat
     2821 ttggttttgt tgtttcaacc atagttagag acaaattctc atgtactttc agaaatcaat
     2881 atctgcagcc actgttactt ttaattgaca ttaagagaca cttcataggt tcccacaatt
     2941 cagtatggga taggcttttt aaaaagcaca tacagaccag gcgtggtggc tcatgcctat
     3001 aatcccagca ctttgggagg ctaagacagg cagatcacct gagctcagga gtccaagacc
     3061 agcctgggca acatggcaaa acaccgtctc tacaaaaaaa aaaaaaaaaa aaattagcca
     3121 agtacagtgg ggcacaccta tagtcgcagc tacttgggag gctggggcag gagaattgcc
     3181 tgagcctggg aagtggaagt tgcagtgagc caagatcgtg ccattccact ccagcctgag
     3241 caacacagtg agaccctatc tcaaaaaaat aatgatgata gtacacgtta tgttaaaggt
     3301 gaaatgtgca tacagaagga agagagttgg ccaggtgtgg tgactcacac ctataatccc
     3361 aatactttgg gaggccaagg caggaggatt gcttgaggtc aggagtttta gaccagcctg
     3421 gacaacatag caagacctca tctcttctaa aaattaaaaa aaaaaaaaat aggcatggtg
     3481 gtacacacct gtggtcccag ctagttggga ggctaaggca ggaggatcac ttagccagga
     3541 ggctgaggct acagtgagcc aagattgcac cactgtgctc cagcctgggt gagaaagcga
     3601 gaccctgtct caaaaaagaa aaaaaagaga ggttggcctt ttgtagcaat ctgagaagtg
     3661 tgtttttcaa gttggaaagg aaggagaaaa gcaacttgcc taagataagg tagctcttca
     3721 tgatatgact gttatttctg atatacaaat aaatagaaca tgattaggac atagtcaaat
     3781 atagctagaa aaatatattc ctaaggaaag tgagatttga ggagtccctg ttgttctgca
     3841 acatccctag attgaatgat ctgttgcaga tggtggatac caagttcaaa tttaaagatt
     3901 tctttgtaag cagtaaagtg actttcactt atttaactta gaactggaaa aagtaacttt
     3961 tttccagatt acattttctg tatatttgta aaatgcaaaa gcaatatata tttgttgtga
     4021 gaaaattaga atatacagat aaaataaaat ttaaaaaaac acccaaagat aaccagaaga
     4081 aaatttttgc tatgtaacct ttttcttctg gtctttgcaa atcctgccgt agaaactttt
     4141 taacttcagg agtgtccttc ctttgctcta ttaggacatt acagaaacca atactatgaa
     4201 aagctgacag cagtatctgg attaactttt taaaaacaat gaaagcattt tacagaaatt
     4261 acatttcaga tcgtgctgga actgtgttca gaagatatcc tcagagggaa tctggcctga
     4321 gcaccatcat gtttaattgc ctcctcctgt cttgcatttt cctcccagcc cccttcctac
     4381 cccttagcag agggccaggt gagggtgctt ggggcccatg ggggctggga gtgtagactt
     4441 cagttacacc cccagccccc aggggaaagc attagccttg aatcctcaat cccaggccct
     4501 ctactaacca ctctcaacct atggtattta tcttttgatt attctgtgca tctataaaaa
     4561 tgggattata ttgtacagaa tgctttgtaa gctttctctc cccacataag aatgccctgt
     4621 aagcattttg ttaaatattt ttaatgactt tagagtccaa ctttatactc ctctttacgc
     4681 attttggttt tctaatttaa tggtagtgta aacgtttttg gaataaacat tcctgtggct
     4741 aaa
//
