LOCUS       NM_012180               1980 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 8 (FBXO8), mRNA.
ACCESSION   NM_012180
VERSION     NM_012180.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Khan,A.J., Man,S., Abbas,M., Liu,S. and Zhang,F.
  TITLE     FBXO8 is a novel prognostic biomarker in different molecular
            subtypes of breast cancer and suppresses breast cancer progression
            by targeting c-MYC
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (4), 130577 (2024)
   PUBMED   38301858
  REMARK    GeneRIF: FBXO8 is a novel prognostic biomarker in different
            molecular subtypes of breast cancer and suppresses breast cancer
            progression by targeting c-MYC.
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Zhu,X., Wang,F., Wu,X., Li,Z., Wang,Z., Ren,X., Zhou,Y., Song,F.,
            Liang,Y., Zeng,Z., Liao,W., Ding,Y., Liao,W. and Liang,L.
  TITLE     FBX8 promotes metastatic dormancy of colorectal cancer in liver
  JOURNAL   Cell Death Dis 11 (8), 622 (2020)
   PUBMED   32796813
  REMARK    GeneRIF: FBX8 promotes metastatic dormancy of colorectal cancer in
            liver.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   FeiFei,W., HongHai,X., YongRong,Y., PingXiang,W., JianHua,W.,
            XiaoHui,Z., JiaoYing,L., JingBo,S., Kun,Z., XiaoLi,R., Lu,Q.,
            XiaoLiang,L., ZhiQiang,C., Na,T., WenTing,L., YanQing,D. and Li,L.
  TITLE     FBX8 degrades GSTP1 through ubiquitination to suppress colorectal
            cancer progression
  JOURNAL   Cell Death Dis 10 (5), 351 (2019)
   PUBMED   31024008
  REMARK    GeneRIF: FBX8 directly targets GSTP1 for ubiquitin-mediated
            proteasome degradation in colorectal carcinoma. The inactivation of
            FBX8 negatively correlated with increased levels and stability of
            GSTP1 in clinical CRC tissues and FBX8 knockout transgenic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Wang,F.F., Zhang,X.J., Yan,Y.R., Zhu,X.H., Yu,J., Ding,Y., Hu,J.L.,
            Zhou,W.J., Zeng,Z.C., Liao,W.T., Ding,Y.Q. and Liang,L.
  TITLE     FBX8 is a metastasis suppressor downstream of miR-223 and targeting
            mTOR for degradation in colorectal carcinoma
  JOURNAL   Cancer Lett 388, 85-95 (2017)
   PUBMED   27916606
  REMARK    GeneRIF: FBX8 as a metastasis suppressor that functions through
            mTOR signaling pathway and has significant prognostic power.
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Cronin,S., Tomik,B., Bradley,D.G., Slowik,A. and Hardiman,O.
  TITLE     Screening for replication of genome-wide SNP associations in
            sporadic ALS
  JOURNAL   Eur J Hum Genet 17 (2), 213-218 (2009)
   PUBMED   18987618
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1980)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1980)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   9  (bases 1 to 1980)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 1980)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097653.2.
            
            On Jul 15, 2019 this sequence version replaced NM_012180.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. It contains a C-terminal amino acid
            sequence that bears a significant similarity with a portion of
            yeast Sec7p, a critical regulator of vesicular protein transport.
            This human protein may interact with ADP-ribosylation
            factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange
            factor) activity. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201932.1, AF115514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393674.7/ ENSP00000377280.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC097653.2         98065-98322         c
            259-595             AC097653.2         77419-77755         c
            596-722             AC097653.2         74354-74480         c
            723-841             AC097653.2         55755-55873         c
            842-1038            AC097653.2         53649-53845         c
            1039-1980           AC097653.2         51313-52254         c
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..1980
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /note="F-box protein 8"
                     /db_xref="GeneID:26269"
                     /db_xref="HGNC:HGNC:13587"
                     /db_xref="MIM:605649"
     exon            1..258
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /inference="alignment:Splign:2.1.0"
     exon            259..595
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1226
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /note="F-box protein Fbx8; F-box/SEC7 protein FBS"
                     /codon_start=1
                     /product="F-box only protein 8"
                     /protein_id="NP_036312.2"
                     /db_xref="CCDS:CCDS3820.1"
                     /db_xref="GeneID:26269"
                     /db_xref="HGNC:HGNC:13587"
                     /db_xref="MIM:605649"
                     /translation="MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHR
                     KQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLA
                     NDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSK
                     GILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFF
                     RHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTS
                     PHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA"
     exon            596..722
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /inference="alignment:Splign:2.1.0"
     exon            723..841
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1038
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1980
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1644..1649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /note="hexamer: ACTAAA"
     polyA_site      1669
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /note="major polyA site"
     regulatory      1953..1958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="FBXO8"
                     /gene_synonym="DC10; FBS; FBX8"
ORIGIN      
        1 aacaatagga aacgtcaaaa ttgggatagt cggcagttct ggcccctgca gctggaggta
       61 ccctgagttc tgagggtcgt agtgctgttt ctggtattct catcgcggtc acctctaccg
      121 gtgtggacaa gtaaagtttg aatcagcttc tccatggcct gggcaccagt tcccggctga
      181 gccattttcc ttttggctaa aagtccccgc ccagaggcca attcgtcgcg gcggcggtgg
      241 agatcgcagg tcgctcaggc ttgcagatgg gtcaagggtt gtggagagtg gtcagaaacc
      301 agcagctgca acaagaaggc tacagtgagc aaggctacct caccagagag cagagcagga
      361 gaatggctgc gagcaacatt tctaacacca atcatcgtaa acaagtccaa ggaggcattg
      421 acatatatca tcttttgaag gcaaggaaat cgaaagaaca ggaaggattc attaatttgg
      481 aaatgttgcc tcctgagcta agctttacca tcttgtccta cctgaatgca actgaccttt
      541 gcttggcttc atgtgtttgg caggaccttg cgaatgatga acttctctgg caagggttgt
      601 gcaaatccac ttggggtcac tgttccatat acaataagaa cccaccttta ggattttctt
      661 ttagaaaatt gtatatgcag ctggatgaag gcagcctcac ctttaatgcc aacccagatg
      721 agggagtgaa ctactttatg tccaagggta tcctggatga ttcgccaaag gaaatagcaa
      781 agtttatctt ctgtacaaga acactaaatt ggaaaaaact gagaatctat cttgatgaaa
      841 ggagagatgt cttggatgac cttgtaacat tgcataattt tagaaatcag ttcttgccaa
      901 atgcactgag agaatttttt cgtcatatcc atgcccctga agagcgtgga gagtatcttg
      961 aaactcttat aacaaagttc tcacatagat tctgtgcttg caaccctgat ttaatgcgag
     1021 aacttggcct tagtcctgat gctgtctatg tactgtgcta ctctttgatt ctactttcca
     1081 ttgacctcac tagccctcat gtgaagaata aaatgtcaaa aagggaattt attcgaaata
     1141 cccgtcgcgc tgctcaaaat attagtgaag attttgtagg gcatctttat gacaatatct
     1201 accttattgg ccatgtggct gcataaaaag cacaattgct aggacttcag tttttacttc
     1261 agactaaagc tacccaagga cttagcagat atgggggtta catcagtgct ggtcattgta
     1321 gcctgagtat acaatcaagc ttcagtgtgc aacctttttt tcttttgcca ttttctattt
     1381 tagtaatttc cttggggaac taaataattt tgcagaattt ttcctaattt tgtttatcac
     1441 gttttgcaca aagcagagcc actgtctaac acagctgtta acgaatgata aactgacatt
     1501 atactctaaa agatggtgta tttgtgcatt agatttgcct gaaaaacttt atccatttcc
     1561 attctttata caaataccat gtaatgtgta catatttaac taaagagatt tatagtcata
     1621 attattttat tgtaaagatt ttaactaaag tttttccttt tctctcaaac tgagttctga
     1681 aatttatttg attctgatct gaaactattg tcttcgtaaa agttagatct gacttcagac
     1741 agaaaccaat accagcttcc ttttccttta aactttgaag agtgttgatt tgttactata
     1801 ttactatgca aaactggcag ttatttttat aatataaatt tataatttga ttttttattt
     1861 taaaaactgg gttaatcaag tctcggtaag tcctttaaac catttaggat ttttaaaaca
     1921 tcaaaattta tgatttacat tcataggaat aaaataaaat attattagaa ctctggtaaa
//
