LOCUS       NM_012179               2060 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens F-box protein 7 (FBXO7), transcript variant 1, mRNA.
ACCESSION   NM_012179
VERSION     NM_012179.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Luo,L., Wu,X., Fan,J., Dong,L., Wang,M., Zeng,Y., Li,S., Yang,W.,
            Jiang,J. and Wang,K.
  TITLE     FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor
            growth in hepatocellular carcinoma
  JOURNAL   Nat Commun 15 (1), 4790 (2024)
   PUBMED   38839752
  REMARK    GeneRIF: FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and
            tumor growth in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Li,S., Chen,Y., Xie,Y., Zhan,H., Zeng,Y., Zeng,K., Wang,L.,
            Zhan,Z., Li,C., Zhao,L., Chen,X., Tan,Y., Wang,Z., Bu,J., Song,Y.,
            Deng,F. and Zhou,A.
  TITLE     FBXO7 Confers Mesenchymal Properties and Chemoresistance in
            Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing
  JOURNAL   Adv Sci (Weinh) 10 (33), e2303561 (2023)
   PUBMED   37822160
  REMARK    GeneRIF: FBXO7 Confers Mesenchymal Properties and Chemoresistance
            in Glioblastoma by Controlling Rbfox2-Mediated Alternative
            Splicing.
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Lee,S.H. and Chung,K.C.
  TITLE     USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell
            death through deubiquitination and stabilization of FBXO7
  JOURNAL   PLoS One 18 (10), e0290371 (2023)
   PUBMED   37874827
  REMARK    GeneRIF: USP7 attenuates endoplasmic reticulum stress-induced
            apoptotic cell death through deubiquitination and stabilization of
            FBXO7.
            Erratum:[PLoS One. 2024 Jan 24;19(1):e0297970. doi:
            10.1371/journal.pone.0297970.. PMID: 38265984]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2060)
  AUTHORS   Zhang,H., Zhao,Y., Wang,J., Li,J., Xia,J., Lin,Y., Zhong,Y.,
            Cao,X., Jin,J., Li,X., Yang,W., Ye,M. and Jin,X.
  TITLE     FBXO7, a tumor suppressor in endometrial carcinoma, suppresses
            INF2-associated mitochondrial division
  JOURNAL   Cell Death Dis 14 (6), 368 (2023)
   PUBMED   37344480
  REMARK    GeneRIF: FBXO7, a tumor suppressor in endometrial carcinoma,
            suppresses INF2-associated mitochondrial division.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2060)
  AUTHORS   Lee,S.H., Lee,Y.J., Jung,S. and Chung,K.C.
  TITLE     E3 ligase adaptor FBXO7 contributes to ubiquitination and
            proteasomal degradation of SIRT7 and promotes cell death in
            response to hydrogen peroxide
  JOURNAL   J Biol Chem 299 (3), 102909 (2023)
   PUBMED   36646384
REFERENCE   6  (bases 1 to 2060)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   7  (bases 1 to 2060)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 2060)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   9  (bases 1 to 2060)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 2060)
  AUTHORS   Cook Shukla,L., Schulze,J., Farlow,J., Pankratz,N.D., Wojcieszek,J.
            and Foroud,T.
  TITLE     Parkinson Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX362053.2 and AL050254.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012179.3.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class and it may play a role in regulation of
            hematopoiesis. Alternatively spliced transcript variants of this
            gene have been identified with the full-length natures of only some
            variants being determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008361.1, AK226087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266087.12/ ENSP00000266087.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               BX362053.2         63-671
            610-2060            AL050254.1         623-2073
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2060
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /note="F-box protein 7"
                     /db_xref="GeneID:25793"
                     /db_xref="HGNC:HGNC:13586"
                     /db_xref="MIM:605648"
     exon            1..314
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1761
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 7"
                     /codon_start=1
                     /product="F-box only protein 7 isoform 1"
                     /protein_id="NP_036311.3"
                     /db_xref="CCDS:CCDS13907.1"
                     /db_xref="GeneID:25793"
                     /db_xref="HGNC:HGNC:13586"
                     /db_xref="MIM:605648"
                     /translation="MRLRVRLLKRTWPLEVPETEPTLGHLRSHLRQSLLCTWGYSSNT
                     RFTITLNYKDPLTGDEETLASYGIVSGDLICLILQDDIPAPNIPSSTDSEHSSLQNNE
                     QPSLATSSNQTSMQDEQPSDSFQGQAAQSGVWNDDSMLGPSQNFEAESIQDNAHMAEG
                     TGFYPSEPMLCSESVEGQVPHSLETLYQSADCSDANDALIVLIHLLMLESGYIPQGTE
                     AKALSMPEKWKLSGVYKLQYMHPLCEGSSATLTCVPLGNLIVVNATLKINNEIRSVKR
                     LQLLPESFICKEKLGENVANIYKDLQKLSRLFKDQLVYPLLAFTRQALNLPDVFGLVV
                     LPLELKLRIFRLLDVRSVLSLSAVCRDLFTASNDPLLWRFLYLRDFRDNTVRVQDTDW
                     KELYRKRHIQRKESPKGRFVMLLPSSTHTIPFYPNPLHPRPFPSSRLPPGIIGGEYDQ
                     RPTLPYVGDPISSLIPGPGETPSQFPPLRPRFDPVGPLPGPNPILPGRGGPNDRFPFR
                     PSRGRPTDGRLSFM"
     exon            315..609
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            610..837
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            838..979
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1063
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1159
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1336
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1374
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2060
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /note="hexamer: ATTAAA"
     polyA_site      2060
                     /gene="FBXO7"
                     /gene_synonym="FBX; FBX07; FBX7; PARK15; PKPS"
                     /note="major polyA site"
ORIGIN      
        1 gctctattcc agagaccgag tggcagggcg gccactgtgg cggggctctt tccccgtttc
       61 gcctcagcta cccctcagct ccggtagtcg ccagtccggg gtcgtcgccg tttggggcgg
      121 gagctgctcg gccccgccgc cgtccccgtc gccgcttccg ggtccaggcc cctcgggccg
      181 cctgccgccg tcatgaggct gcgggtgcgg cttctgaagc ggacctggcc gctggaggtg
      241 cccgagacgg agccgacgct ggggcatttg cgctcgcacc tgaggcagtc cctgctgtgc
      301 acctgggggt acagttctaa tacccgattt acaattacat tgaactacaa ggatcccctc
      361 actggagatg aagagacctt ggcttcatat gggattgttt ctggggactt gatatgtttg
      421 attcttcaag atgacattcc agcgcctaat ataccttcat ccacagattc agagcattct
      481 tcactccaga ataatgagca accctctttg gccaccagct ccaatcagac tagcatgcag
      541 gatgaacaac caagtgattc attccaagga caggcagccc agtctggtgt ttggaatgac
      601 gacagtatgt tagggcctag tcaaaatttt gaagctgagt caattcaaga taatgcgcat
      661 atggcagagg gcacaggttt ctatccctca gaacccatgc tctgtagtga atcggtggaa
      721 gggcaagtgc cacattcatt agagaccttg tatcaatcag ctgactgttc tgatgccaat
      781 gatgccttga tagtgttgat acatcttctc atgttggagt caggttacat acctcagggc
      841 accgaagcca aagcactgtc catgccggag aagtggaagt tgagcggggt gtataagctg
      901 cagtacatgc atcctctctg cgagggcagc tccgctactc tcacctgtgt gcctttggga
      961 aacctgattg ttgtaaatgc tacactaaaa atcaacaatg agattagaag tgtgaaaaga
     1021 ttgcagctgc taccagaatc ttttatttgc aaagagaaac taggggaaaa tgtagccaac
     1081 atatacaaag atcttcagaa actctctcgc ctctttaaag accagctggt gtatcctctt
     1141 ctggctttta cccgacaagc actgaaccta ccagatgtat ttgggttggt cgtcctccca
     1201 ttggaactga aactacggat cttccgactt ctggatgttc gttccgtctt gtctttgtct
     1261 gcggtttgtc gtgacctctt tactgcttca aatgacccac tcctgtggag gtttttatat
     1321 ctgcgtgatt ttcgagacaa tactgtcaga gttcaagaca cagattggaa agaactgtac
     1381 aggaagaggc acatacaaag aaaagaatcc ccgaaagggc ggtttgtgat gctcctgcca
     1441 tcgtcaactc acaccattcc attctatccc aaccccttgc accctaggcc atttcctagc
     1501 tcccgccttc ctccaggaat tatcgggggt gaatatgacc aaagaccaac acttccctat
     1561 gttggagacc caatcagttc actcattcct ggtcctgggg agacgcccag ccagtttcct
     1621 ccactgagac cacgctttga tccagttggc ccacttccag gacctaaccc catcttgcca
     1681 gggcgaggcg gccccaatga cagatttccc tttagaccca gcaggggtcg gccaactgat
     1741 ggccggctgt cattcatgtg attgatttgt aatttcattt ctggagctcc atttgttttt
     1801 gtttctaaac tacagatgtc aactccttgg ggtgctgatc tcgagtgtta ttttctgatt
     1861 gtggtgttga gagttgcact cccagaaacc ttttaagaga tacatttata gccctagggg
     1921 tggtatgacc caaaggttcc tctgtgacaa ggttggcctt gggaatagtt ggctgccaat
     1981 ctccctgctc ttggttctcc tctagattga agtttgtttt ctgatgctgt tcttaccaga
     2041 ttaaaaaaaa gtgtaaatta
//
