LOCUS       NM_018438               1444 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens F-box protein 6 (FBXO6), mRNA.
ACCESSION   NM_018438
VERSION     NM_018438.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1444)
  AUTHORS   Satoh,T., Yagi-Utsumi,M., Ishii,N., Mizushima,T., Yagi,H., Kato,R.,
            Tachida,Y., Tateno,H., Matsuo,I., Kato,K., Suzuki,T. and Yoshida,Y.
  TITLE     Structural basis of sugar recognition by SCFFBS2 ubiquitin ligase
            involved in NGLY1 deficiency
  JOURNAL   FEBS Lett 598 (18), 2259-2268 (2024)
   PUBMED   39171510
  REMARK    GeneRIF: Structural basis of sugar recognition by SCF[FBS2]
            ubiquitin ligase involved in NGLY1 deficiency.
REFERENCE   2  (bases 1 to 1444)
  AUTHORS   Li,G., Shi,W., Xu,Y., Li,K., Chen,Z., Lv,M., Lv,J., Qiu,T.,
            Qian,Q., Ji,J., Liu,W., Liu,B. and Zhao,Y.
  TITLE     The USP18-FBXO6 axis maintains the malignancy of ovarian cancer
  JOURNAL   Biochem Biophys Res Commun 593, 101-107 (2022)
   PUBMED   35063764
  REMARK    GeneRIF: The USP18-FBXO6 axis maintains the malignancy of ovarian
            cancer.
REFERENCE   3  (bases 1 to 1444)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1444)
  AUTHORS   Ji,M., Zhao,Z., Li,Y., Xu,P., Shi,J., Li,Z., Wang,K., Huang,X. and
            Liu,B.
  TITLE     FBXO6-mediated RNASET2 ubiquitination and degradation governs the
            development of ovarian cancer
  JOURNAL   Cell Death Dis 12 (4), 317 (2021)
   PUBMED   33767133
  REMARK    GeneRIF: FBXO6-mediated RNASET2 ubiquitination and degradation
            governs the development of ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1444)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1444)
  AUTHORS   Yoshida,Y., Tokunaga,F., Chiba,T., Iwai,K., Tanaka,K. and Tai,T.
  TITLE     Fbs2 is a new member of the E3 ubiquitin ligase family that
            recognizes sugar chains
  JOURNAL   J Biol Chem 278 (44), 43877-43884 (2003)
   PUBMED   12939278
  REMARK    GeneRIF: Fbs2 is a novel member of F-box protein family that
            recognizes N-glycans and plays a role in ERAD
REFERENCE   7  (bases 1 to 1444)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
REFERENCE   8  (bases 1 to 1444)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   9  (bases 1 to 1444)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 1444)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314989.1, BC020880.1 and
            AF129536.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018438.5.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class, and its C-terminal region is highly
            similar to that of rat NFB42 (neural F Box 42 kDa) which may be
            involved in the control of the cell cycle. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF129536.1, BC020880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376753.9/ ENSP00000365944.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-941               AK314989.1         108-1048
            942-1438            BC020880.1         991-1487
            1439-1444           AF129536.1         1516-1521
FEATURES             Location/Qualifiers
     source          1..1444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..1444
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="F-box protein 6"
                     /db_xref="GeneID:26270"
                     /db_xref="HGNC:HGNC:13585"
                     /db_xref="MIM:605647"
     exon            1..56
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /inference="alignment:Splign:2.1.0"
     exon            57..345
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..941
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="F-box protein Fbx6; F-box protein FBG2;
                     F-box/G-domain protein 2; F-box protein that recognizes
                     sugar chains 2"
                     /codon_start=1
                     /product="F-box only protein 6"
                     /protein_id="NP_060908.1"
                     /db_xref="CCDS:CCDS133.1"
                     /db_xref="GeneID:26270"
                     /db_xref="HGNC:HGNC:13585"
                     /db_xref="MIM:605647"
                     /translation="MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLW
                     RDLIDLMTLWKRKCLREGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQ
                     IDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMCLKSQLVDLVAEGYWEELLDT
                     FRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEPPPVTIQQWNNATWTEVSY
                     TFSDYPRGVRYILFQHGGRDTQYWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKH
                     GQEEAAQSPYRAVVQIF"
     exon            346..472
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /inference="alignment:Splign:2.1.0"
     exon            473..568
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /inference="alignment:Splign:2.1.0"
     exon            569..704
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1444
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="major polyA site"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="hexamer: AATAAA"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="hexamer: AATAAA"
     polyA_site      1426
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
     polyA_site      1444
                     /gene="FBXO6"
                     /gene_synonym="FBG2; FBS2; FBX6; Fbx6b"
                     /note="major polyA site"
ORIGIN      
        1 gagacagctt caggacacgc aggccgcagc gagggcccgg gccctgggga tcccaggcca
       61 tggatgctcc ccactccaaa gcagccctgg acagcattaa cgagctgccc gagaacatcc
      121 tgctggagct gttcacgcac gtgcccgccc gccagctgct gctgaactgc cgcctggtct
      181 gcagcctctg gcgggacctc atcgacctca tgaccctctg gaaacgcaag tgcctgcgag
      241 agggcttcat caccaaggac tgggaccagc ccgtggccga ctggaaaatc ttctacttcc
      301 tacggagcct gcataggaac ctcctgcgca acccgtgtgc tgaagaggat atgtttgcat
      361 ggcaaattga tttcaatggt ggggaccgct ggaaggtgga gagcctccct ggagcccacg
      421 ggacagattt tcctgacccc aaagtcaaga agtattttgt cacatcctac gaaatgtgcc
      481 tcaagtccca gctggtggac cttgtagccg agggctactg ggaggagcta ctagacacat
      541 tccggccgga catcgtggtt aaggactggt ttgctgccag agccgactgt ggctgcacct
      601 accaactcaa agtgcagctg gcctcggctg actacttcgt gttggcctcc ttcgagcccc
      661 cacctgtgac catccaacag tggaacaatg ccacatggac agaggtctcc tacaccttct
      721 cagactaccc ccggggtgtc cgctacatcc tcttccagca tgggggcagg gacacccagt
      781 actgggcagg ctggtatggg ccccgagtca ccaacagcag cattgtcgtc agccccaaga
      841 tgaccaggaa ccaggcctcc tccgaggctc agcctgggca gaagcatgga caggaggagg
      901 ctgcccaatc gccctaccga gctgttgtcc agattttctg acagctgtcc atcctgtgtc
      961 tgggtcagcc agaggttcct ccaggcagga gctgagcatg gggtgggcag tgaggtccct
     1021 gtaccagcga ctcctgcccc ggttcaaccc taccagcttg tggtaactta ctgtcacata
     1081 gctctgacgt tttgttgtaa taaatgtttt caggccgggc actgtggctc acgcctgtaa
     1141 tcccagcact ttgggagacc gaggcaggtg gatcacgagg tcaggagata gagaccatcc
     1201 tggccaacac ggtgaaaccc tgtctctact aaaaatacaa aaaattagcc gggcgtggtg
     1261 gcgggcgcct gtagtcccag ctactcggga ggctgatgca gaagaatggc gtgaacccgg
     1321 aaggcagagc ttgcagtgag ccgagatcac gccactgcac tccagcctgg gtgacagagc
     1381 gagactctgg ctcataaaat aataataata ataaataaat aaaaaataaa tgttttcagt
     1441 aaaa
//
