LOCUS       NM_012177               2054 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens F-box protein 5 (FBXO5), transcript variant 1, mRNA.
ACCESSION   NM_012177
VERSION     NM_012177.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Campos Gudino,R., Neudorf,N.M., Andromidas,D., Lichtensztejn,Z. and
            McManus,K.J.
  TITLE     Loss of EMI1 compromises chromosome stability and is associated
            with cellular transformation in colonic epithelial cell contexts
  JOURNAL   Br J Cancer 131 (9), 1516-1528 (2024)
   PUBMED   39358461
  REMARK    GeneRIF: Loss of EMI1 compromises chromosome stability and is
            associated with cellular transformation in colonic epithelial cell
            contexts.
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Kuang,Y., Huang,S., Tang,S., Zhuo,Z. and Linghu,K.
  TITLE     Effect of Emi1 gene silencing on the proliferation and invasion of
            human breast cancer cells
  JOURNAL   BMC Mol Cell Biol 24 (1), 34 (2023)
   PUBMED   38041032
  REMARK    GeneRIF: Effect of Emi1 gene silencing on the proliferation and
            invasion of human breast cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Zhang,J., Zhang,G., Wang,K., Cui,F., Yang,H. and Jiao,Z.
  TITLE     Exploring the role of FBXO5 in gastric cancer
  JOURNAL   Mol Cell Probes 69, 101915 (2023)
   PUBMED   37121410
  REMARK    GeneRIF: Exploring the role of FBXO5 in gastric cancer.
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Li,H., Yang,C., Chen,K. and Sun,M.
  TITLE     Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal
            squamous cell carcinoma
  JOURNAL   Pathol Oncol Res 29, 1611081 (2023)
   PUBMED   37168048
  REMARK    GeneRIF: Expression significance of Emi1, UBCH10 and CyclinB1 in
            esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Reimann,J.D. and Jackson,P.K.
  TITLE     Emi1 is required for cytostatic factor arrest in vertebrate eggs
  JOURNAL   Nature 416 (6883), 850-854 (2002)
   PUBMED   11976684
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Reimann,J.D., Freed,E., Hsu,J.Y., Kramer,E.R., Peters,J.M. and
            Jackson,P.K.
  TITLE     Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits
            the anaphase promoting complex
  JOURNAL   Cell 105 (5), 645-655 (2001)
   PUBMED   11389834
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Chiaur,D.S., Murthy,S., Cenciarelli,C., Parks,W., Loda,M.,
            Inghirami,G., Demetrick,D. and Pagano,M.
  TITLE     Five human genes encoding F-box proteins: chromosome mapping and
            analysis in human tumors
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 255-258 (2000)
   PUBMED   10828603
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA819893.1, BC018905.1,
            AJ420499.1 and AF129535.2.
            
            On Nov 23, 2018 this sequence version replaced NM_012177.4.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. This protein is similar to xenopus early
            mitotic inhibitor-1 (Emi1), which is a mitotic regulator that
            interacts with Cdc20 and inhibits the anaphase promoting complex.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.181552.1,
                                           SRR1660803.149738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267754, SAMN03267767
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229758.8/ ENSP00000229758.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA819893.1         42-85
            45-400              BC018905.1         14-369
            401-2049            AJ420499.1         448-2096
            2050-2054           AF129535.2         2030-2034
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.2"
     gene            1..2054
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /note="F-box protein 5"
                     /db_xref="GeneID:26271"
                     /db_xref="HGNC:HGNC:13584"
                     /db_xref="MIM:606013"
     exon            1..185
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1426
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /note="isoform a is encoded by transcript variant 1; F-box
                     protein Fbx5; F-box only protein 5; early mitotic
                     inhibitor 1; early fission inhibitory protein 1"
                     /codon_start=1
                     /product="F-box only protein 5 isoform a"
                     /protein_id="NP_036309.1"
                     /db_xref="CCDS:CCDS5242.1"
                     /db_xref="GeneID:26271"
                     /db_xref="HGNC:HGNC:13584"
                     /db_xref="MIM:606013"
                     /translation="MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLS
                     VKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVS
                     PRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHE
                     EGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDRE
                     MLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSK
                     VSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQ
                     TSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQ
                     RATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL"
     exon            186..900
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /inference="alignment:Splign:2.1.0"
     exon            901..991
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1174
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..2054
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /note="hexamer: AATAAA"
     polyA_site      2054
                     /gene="FBXO5"
                     /gene_synonym="EMI1; FBX5; Fbxo31"
                     /note="major polyA site"
ORIGIN      
        1 atacaggtct gtgaagcagg caggttgctc agctgccccc ggagcggttc ctccacctga
       61 ggcagactcc acgtcggctg gcatgagccg gcgcccctgc agctgcgccc tacggccacc
      121 ccgctgctcc tgcagcgcca gccccagcgc agtgacagcc gccgggcgcc ctcgaccctc
      181 ggatagttgt aaagaagaaa gttctaccct ttctgtcaaa atgaagtgtg attttaattg
      241 taaccatgtt cattccggac ttaaactggt aaaacctgat gacattggaa gactagtttc
      301 ctacacccct gcatatttgg aaggttcctg taaagactgc attaaagact atgaaaggct
      361 gtcatgtatt gggtcaccga ttgtgagccc taggattgta caacttgaaa ctgaaagcaa
      421 gcgcttgcat aacaaggaaa atcaacatgt gcaacagaca cttaatagta caaatgaaat
      481 agaagcacta gagaccagta gactttatga agacagtggc tattcctcat tttctctaca
      541 aagtggcctc agtgaacatg aagaaggtag cctcctggag gagaatttcg gtgacagtct
      601 acaatcctgc ctgctacaaa tacaaagccc agaccaatat cccaacaaaa acttgctgcc
      661 agttcttcat tttgaaaaag tggtttgttc aacattaaaa aagaatgcaa aacgaaatcc
      721 taaagtagat cgggagatgc tgaaggaaat tatagccaga ggaaatttta gactgcagaa
      781 tataattggc agaaaaatgg gcctagaatg tgtagatatt ctcagcgaac tctttcgaag
      841 gggactcaga catgtcttag caactatttt agcacaactc agtgacatgg acttaatcaa
      901 tgtgtctaaa gtgagcacaa cttggaagaa gatcctagaa gatgataagg gggcattcca
      961 gttgtacagt aaagcaatac aaagagttac cgaaaacaac aataaatttt cacctcatgc
     1021 ttcaaccaga gaatatgtta tgttcagaac cccactggct tctgttcaga aatcagcagc
     1081 ccagacttct ctcaaaaaag atgctcaaac caagttatcc aatcaaggtg atcagaaagg
     1141 ttctacttat agtcgacaca atgaattctc tgaggttgcc aagacattga aaaagaacga
     1201 aagcctcaaa gcctgtattc gctgtaattc acctgcaaaa tatgattgct atttacaacg
     1261 ggcaacctgc aaacgagaag gctgtggatt tgattattgt acgaagtgtc tctgtaatta
     1321 tcatactact aaagactgtt cagatggcaa gctcctcaaa gccagttgta aaataggtcc
     1381 cctgcctggt acaaagaaaa gcaaaaagaa tttacgaaga ttgtgatctc ttattaaatc
     1441 aattgttact gatcatgaat gttagttaga aaatgttagg ttttaactta aaaaaaattg
     1501 tattgtgatt ttcaatttta tgttgaaatc ggtgtagtat cctgaggttt ttttcccccc
     1561 agaagataaa gaggatagac aacctcttaa aatattttta caatttaatg agaaaaagtt
     1621 taaaattctc aatacaaatc aaacaattta aatattttaa gaaaaaagga aaagtagata
     1681 gtgatactga gggtaaaaaa aaattgattc aattttatgg taaaggaaac ccatgcaatt
     1741 ttacctagac agtcttaaat atgtctggtt ttccatctgt tagcatttca gacattttat
     1801 gttcctctta ctcaattgat accaacagaa atatcaactt ctggagtcta ttaaatgtgt
     1861 tgtcaccttt ctaaagcttt ttttcattgt gtgtatttcc caagaaagta tcctttgtaa
     1921 aaacttgctt gttttcctta tttctgaaat ctgttttaat atttttgtat acatgtaaat
     1981 atttctgtat tttttatatg tcaaagaata tgtctcttgt atgtacatat aaaaataaat
     2041 tttgctcaat aaaa
//
