LOCUS       NM_001008777            2303 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 47 (FBXO47), mRNA.
ACCESSION   NM_001008777
VERSION     NM_001008777.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2303)
  AUTHORS   Hua,R., Wei,H., Liu,C., Zhang,Y., Liu,S., Guo,Y., Cui,Y., Zhang,X.,
            Guo,X., Li,W. and Liu,M.
  TITLE     FBXO47 regulates telomere-inner nuclear envelope integration by
            stabilizing TRF2 during meiosis
  JOURNAL   Nucleic Acids Res 47 (22), 11755-11770 (2019)
   PUBMED   31724724
  REMARK    GeneRIF: A novel mechanism of FBXO47 in telomeric shelterin subunit
            stabilization during meiosis.
REFERENCE   2  (bases 1 to 2303)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 2303)
  AUTHORS   Simon-Kayser,B., Scoul,C., Renaudin,K., Jezequel,P., Bouchot,O.,
            Rigaud,J. and Bezieau,S.
  TITLE     Molecular cloning and characterization of FBXO47, a novel gene
            containing an F-box domain, located in the 17q12 band deleted in
            papillary renal cell carcinoma
  JOURNAL   Genes Chromosomes Cancer 43 (1), 83-94 (2005)
   PUBMED   15723337
  REMARK    GeneRIF: FBXO47 is preferentially expressed in normal tissue
            relative to the corresponding tumor tissue, particularly in the
            kidney, liver, and pancreas.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006441.13, BC140879.1, AY700575.1 and DB340247.1.
            
            On May 17, 2019 this sequence version replaced NM_001008777.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY700575.1, BC140880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378079.3/ ENSP00000367319.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC006441.13        57886-57916
            32-826              BC140879.1         1-795
            827-827             AC006441.13        80162-80162
            828-2270            AY700575.1         827-2269
            2271-2303           DB340247.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..2303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2303
                     /gene="FBXO47"
                     /note="F-box protein 47"
                     /db_xref="GeneID:494188"
                     /db_xref="HGNC:HGNC:31969"
                     /db_xref="MIM:609498"
     exon            1..175
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            176..382
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1560
                     /gene="FBXO47"
                     /codon_start=1
                     /product="F-box only protein 47"
                     /protein_id="NP_001008777.2"
                     /db_xref="CCDS:CCDS32639.1"
                     /db_xref="GeneID:494188"
                     /db_xref="HGNC:HGNC:31969"
                     /db_xref="MIM:609498"
                     /translation="MASRINTNFTLIPNQKLRRSNRQTSCYSKTLGSGFQPISTFGNF
                     KALPLEIFQIILKYLSVKDISMLSMVSKTVSQHIINYISTSSGSKRLLLQDFHNLELP
                     DRRQDSAILEHYRSLGLLFKRCTLLLPTKERLKYIHKILTEVSCFKFNGCAAPMQCLG
                     LTCYGMFLQTLTAGWDELECHRVYNFLCELTNLCRKIQMAVCSKPGSAQKLELRIRLF
                     CRNVLLDHWTHRSDSAFWLTRILKPWPMVNQARLLYIIFGPISPQDGQVVWQEMIEEP
                     TDEFSLKGLADAIKLLYDASTKEWTADDVISLVDELSVVPREWLLENNARLLMLSGNN
                     ICFSFMASKAVNGRTIELARLVVFLALVCEKELYCMDWTVKMMQKVCKVFSTPVERKN
                     FLQNVANAFACVIMEMLQSIMSGDRDEDDRSFLNLFHLVHAQANFHKEVLYLTMNTPL
                     ST"
     exon            383..553
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            554..630
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            631..708
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            709..817
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            818..994
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1141
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1284
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1444
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..2303
                     /gene="FBXO47"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtagggct gcagctccgg agcctacggg agtgtgaccc tctcgcctcc tggcgggaag
       61 ctcttgagga gatattttct tttctaaaca ctaagaaatt tgaggatggt ggggcaaaac
      121 gactaactcc cactttcctg tgactctgta gccggaaaaa ctgtcaaaat ctgtggataa
      181 atttgtgaga caagaagaag aatggcatcc agaataaata caaatttcac tttgattccc
      241 aaccagaaac ttagacgtag taatcgtcaa accagctgtt attccaagac ccttggctca
      301 ggctttcaac ccatatcaac atttggaaat tttaaagcct taccattgga aatattccag
      361 ataattttaa aatatttgtc agtgaaggat atcagcatgc taagcatggt gtccaaaaca
      421 gtcagccaac acattattaa ttatatctca acctcatcag gaagcaaaag acttttacta
      481 caggactttc ataaccttga gctgcctgac aggagacaag actctgctat actggagcac
      541 tacagatctc taggtctact gtttaaaaga tgcacattgc tgctacccac caaggaaagg
      601 ctaaaataca ttcacaagat actcacagaa gtttcctgct ttaaattcaa tggctgtgca
      661 gctcctatgc agtgtttagg attaacatgt tatggcatgt ttttacagac cttaacagca
      721 ggttgggatg aacttgagtg ccatcgcgtt tataatttct tatgcgaact gactaatctc
      781 tgccgcaaga tacaaatggc tgtctgcagc aaaccaggaa gtgcccaaaa actggagtta
      841 agaatcagac tcttctgtag gaatgtcctc cttgatcatt ggacacatcg aagtgattct
      901 gctttttggt tgacgcgaat attaaaacca tggccaatgg tgaatcaggc aagattactg
      961 tatatcatct ttgggccaat atctcctcaa gatggacagg tggtttggca ggaaatgata
     1021 gaagaaccta cagatgaatt cagtctgaaa ggtttggctg atgccattaa gttactatat
     1081 gacgctagca ctaaagagtg gacagcagat gatgttatca gtcttgtaga tgaactatca
     1141 gtggttcccc gtgagtggct tctagagaat aatgcacgtc tcctaatgct aagtggaaac
     1201 aacatctgtt tcagtttcat ggctagtaaa gctgtgaatg gacgcaccat tgaactggca
     1261 aggctcgtag tctttttggc tttggtgtgt gagaaagaac tgtactgcat ggattggaca
     1321 gttaaaatga tgcaaaaagt ctgcaaagtc tttagcactc cagtggaaag aaagaacttc
     1381 ctgcagaatg tggcaaatgc atttgcatgt gttataatgg aaatgctgca atcaattatg
     1441 tctggagacc gtgatgaaga tgacagaagc tttttgaatt tgttccatct tgtacatgct
     1501 caggctaact tccataagga ggtcctgtat ttgaccatga atactcctct gtctacctaa
     1561 atcctcagaa agccttgcct ttagagaacg tcactgaacg aatgattaga ggagtgctac
     1621 tttttcactc aaaaaatagc atccatggga ctttttatca tctaagtaac ctaagaattc
     1681 aaaagctgga tagaatttta gaagcaacta cgtacatcat tattaatata aaaataacag
     1741 gcagcctcaa gaatgtgctg agatttctct ggaaaacaag ctctgcctct ccgggtttta
     1801 gtcaacctaa caccaaacca aaatagaatg ttagctgttc aagaatctgg gaccagccaa
     1861 cctgtatgta tgcatttttg aagcaagaga aaattccatt ttatagttag acccaaattc
     1921 actaaatagt gtgtatgttc actttgttta agttgtatag acatagccca gaatgttttg
     1981 tgaagatttg caatatggtg ttttggaatg tgtagaatac aaatcacagt ttttactacc
     2041 ttcttggcat atgcttacaa agaacattat attttgttca tgttttacat gaactaatgg
     2101 ataaaaaaca aagtatacat atatgtctat atatatatat agacacacac acacagacat
     2161 atatttcctt ctttaaggta atcatacaaa aggtctatac atacaggaag gtatatattg
     2221 tctcaatgca atcaaatcat cttttactgg ggattcaaat aaaatgtagc aaataagaga
     2281 aaaataaaat gaaagaaaat agc
//
