LOCUS       NM_001080469            2993 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box protein 46 (FBXO46), mRNA.
ACCESSION   NM_001080469 NM_012066 XM_371179
VERSION     NM_001080469.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Choppara,S., Ganga,S., Manne,R., Dutta,P., Singh,S. and Santra,M.K.
  TITLE     The SCFFBXO46 ubiquitin ligase complex mediates degradation of the
            tumor suppressor FBXO31 and thereby prevents premature cellular
            senescence
  JOURNAL   J Biol Chem 293 (42), 16291-16306 (2018)
   PUBMED   30171069
  REMARK    GeneRIF: reveal that FBXO46 is a crucial proteasomal regulator of
            FBXO31 and thereby prevents senescence in normal growth conditions
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007774.1 and AC007191.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001080469.1.
            
            Summary: Members of the F-box protein family, such as FBXO46, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.434298.1,
                                           SRR1163657.261446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317683.4/ ENSP00000410007.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC007774.1         13148-13150         c
            4-48                AC007774.1         13103-13147         c
            49-2993             AC007191.1         30558-33502         c
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2993
                     /gene="FBXO46"
                     /gene_synonym="20D7-FC4; Fbx46; FBXO34L"
                     /note="F-box protein 46"
                     /db_xref="GeneID:23403"
                     /db_xref="HGNC:HGNC:25069"
                     /db_xref="MIM:609117"
     exon            1..48
                     /gene="FBXO46"
                     /gene_synonym="20D7-FC4; Fbx46; FBXO34L"
                     /inference="alignment:Splign:2.1.0"
     exon            49..2993
                     /gene="FBXO46"
                     /gene_synonym="20D7-FC4; Fbx46; FBXO34L"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1938
                     /gene="FBXO46"
                     /gene_synonym="20D7-FC4; Fbx46; FBXO34L"
                     /codon_start=1
                     /product="F-box only protein 46"
                     /protein_id="NP_001073938.1"
                     /db_xref="CCDS:CCDS46116.1"
                     /db_xref="GeneID:23403"
                     /db_xref="HGNC:HGNC:25069"
                     /db_xref="MIM:609117"
                     /translation="MDRGSLLPFQLWCPRPFGTYSQNQPRPPSAALKPSACPEPGGGA
                     EPDHGPAHSENTPPALATEVPASQPAPLLSAAAAGDEGRVLLDTWYVIKPGNTKEKVA
                     FFVAHQCGGGSRASSMKVKGHWGSDSSKAKRRRRCLDPTKAPPDPGGREGPPAAEEGP
                     ASAGEDVDLLSVAEMVALVEQRAALALQSYPRPTTPAPVVFVSAEQGGPAKGVGSERR
                     SGGGDCSRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRIAFRISNGREPRAPDS
                     GLPSGGGGRPGCAYPGSPGPGARAKDKITCDLYQLISPSRDALPSNVEFLLARADEAS
                     EGDSPAPARPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDECIFFGKDGTKNVKEET
                     VCLTVSPEEPPPPGQLFFLQNRGPDGPPEPPPADSPATAPGPDDAEGTADTSLCRLYR
                     HVSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIE
                     AFGVRATDSRWSRDPLYRDDPCKQCRKRYEKGDVSLCRWHPKPYHHDLPYGRSYWMCC
                     RRADRETPGCRLGLHDNNWVLPCNGPGGGRAGREEGR"
     regulatory      2974..2979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO46"
                     /gene_synonym="20D7-FC4; Fbx46; FBXO34L"
                     /note="hexamer: TATAAA"
     polyA_site      2993
                     /gene="FBXO46"
                     /gene_synonym="20D7-FC4; Fbx46; FBXO34L"
                     /note="major polyA site"
ORIGIN      
        1 gagtggggga aacccgcgta gccgagggag atgcagcgcg cggcgatggt ggcatgtgga
       61 gcctcccacc accacctagg tcctgagatg cgctgaagcc cagcctgtct gccatcatcc
      121 cccagcatgg accgtgggag cctcctgccc ttccagctat ggtgcccccg gccctttggc
      181 acctactcac agaaccagcc acgcccgcct tctgcggccc tcaagccatc agcctgccct
      241 gagcctggtg gcggggccga gccagaccat gggcctgccc actcagagaa cacaccaccc
      301 gccttggcca ctgaggtccc tgcctcccag ccggctccgc tcctctcagc agcagctgct
      361 ggtgatgagg gtcgagtcct cctggacacg tggtatgtca tcaagcccgg gaatacaaag
      421 gagaaggtgg ccttctttgt ggcccaccag tgtggtgggg gcagccgggc cagctccatg
      481 aaggtcaagg ggcactgggg cagcgatagc tccaaggcca agcggcggag gcgctgtctt
      541 gaccccacca aggctcctcc tgacccaggg ggccgggagg gcccccctgc tgctgaggag
      601 ggccccgcct cagccggtga ggacgtggac ctgctctctg tggccgagat ggtggccctg
      661 gtggaacagc gggcagccct ggccctgcag agctacccac gaccgaccac cccagcgcct
      721 gtagtctttg tgtccgccga gcaaggtgga ccggccaagg gggtgggatc tgaacggcgg
      781 tccggtggtg gggactgcag ccgtgtagcc gaggccgtgg cccactttga agcgcagagg
      841 gacagccctc ccaccaaggg cctccgcaag gaagagcggc ccgggccagg ccctggggag
      901 gtgcgcatcg ccttccgcat ctccaacggc cgggagcccc gtgcaccaga cagcggcctg
      961 cccagtgggg gcgggggcag gcctggttgt gcctaccctg gcagcccagg tcctggggcc
     1021 cgagccaagg acaagatcac atgtgactta taccagctca tcagcccctc gcgggatgcc
     1081 ctccccagca acgtggagtt cctgctggcc agggcggatg aggccagtga gggtgacagc
     1141 ccggcacccg ccaggcctga ggacactccc ccggcgcccc ctccgccccc tgcccgggac
     1201 tgcggagcgt caggcttcca cgtggacgtg gtggtgacgg gcgtggtaga tgagtgcatc
     1261 ttctttggca aggacggcac caagaacgtg aaggaggaga ctgtgtgcct gacggtcagc
     1321 ccggaggaac cgccgcctcc gggccagctc ttctttctcc agaaccgcgg gccggacggg
     1381 cccccggagc cacccccggc cgactccccg gccactgcgc ccggcccaga cgatgccgag
     1441 ggcacggcgg acacctccct gtgccgcttg taccggcacg tgtcgcacga cttcctagag
     1501 atccgcttca agattcagcg gctgctggag ccgcgacagt acatgctgct gctgcccgag
     1561 cacgtgctgg tcaagatctt cagcttcctg cccacgcgcg cgctggccgc cctcaagtgc
     1621 acctgccacc acttcaaggg catcatcgag gcgtttggcg tgcgggccac agactcgcgc
     1681 tggagccgag acccgctcta ccgcgatgat ccgtgcaaac agtgccgcaa gagatacgag
     1741 aagggcgacg tgtcgctctg ccgctggcac cccaagccct accaccatga cctgccttac
     1801 ggacgttcct actggatgtg ctgccgtcga gccgaccgcg agactcccgg ctgccgcctg
     1861 ggcctccacg ataacaactg ggtgctgccc tgcaatgggc caggcggggg ccgggccggc
     1921 cgggaggagg ggaggtgaag ccgggggagg ggaggggaga gcccaccacg cccacccctc
     1981 ccctctcccc ccgggagccg agggtccgga ctgggccgcc tgcccattcc cctactccag
     2041 gcagcattga tccctcaccg gaactgagct ggggttcagc aggggtgacc caggaaagcc
     2101 ctctgcttga tcctgttgat tttctactct tcagaaccag ggccgtggac cctctgagaa
     2161 gggtgttttt ttttttttta tcagcatctc actttcttct ccattcagcc ccaaccccct
     2221 ccctgccatg ctttccaccc caaggaccca ccagcaggga gcagacggca gctaattttg
     2281 gtaccactta agggtccccc cattctggcc cccatcctct ccctcacccc aattctttct
     2341 cgctggagct gttatttccc aagaagccgc atcgcccaag gttggcacct ctcctaacct
     2401 gccacacgac agctctcacc tctctaggaa ttgggggctg tcaggtcaca ggtgggatct
     2461 ggcatttttt tatgacagtc catttctaga tggtttgcct attaaagaag tgggggggaa
     2521 atactgtttt ctccttaacc tcaagctacc agtctctcct cttccgcgta gaggaagagg
     2581 ggggcagaca aaaaaaaagc tgaagtataa aaaccctcct cctcccgtta ttatttaagc
     2641 tactgccatc aaccccaccc ccataaagct gtgaagccct ttgcctcgct tttgacagcg
     2701 tgggggggcc ccgtgggcag ggacttcgga tttgcatttc tgggttgttt ttccttccac
     2761 tctggggtct cgttcaggca ttggggtctc ctcaccccag ccacatgttt ctttaagaat
     2821 cctttggtca accaggacct tgatttttca ggcattttgg tctggggtat ttttgtttgt
     2881 tctctctgtt ttttgttttc ttttttttct ttccatcgtg gttctggaag cttctagcgt
     2941 gtggcatctg accaattttg aattggtcct ttctataaaa tcaatattta taa
//
