LOCUS       NM_001105573            5927 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens F-box protein 45 (FBXO45), mRNA.
ACCESSION   NM_001105573 XM_931557 XM_946180
VERSION     NM_001105573.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5927)
  AUTHORS   Lin,X., Tao,T., He,X., Mao,L., Pan,L. and Chen,L.
  TITLE     LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation
            through miR-485-3p/FBXO45 axis
  JOURNAL   Acta Neurol Belg 124 (2), 549-557 (2024)
   PUBMED   37814093
  REMARK    GeneRIF: LncRNA MEG8 ameliorates Parkinson's disease
            neuro-inflammation through miR-485-3p/FBXO45 axis.
REFERENCE   2  (bases 1 to 5927)
  AUTHORS   Zhang,F., Wang,Y., He,Y. and Dong,B.
  TITLE     Correlation of FBXO45 Expression Levels with Cancer Severity by
            ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer
  JOURNAL   J Environ Pathol Toxicol Oncol 43 (4), 13-23 (2024)
   PUBMED   39016138
  REMARK    GeneRIF: Correlation of FBXO45 Expression Levels with Cancer
            Severity by ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer.
REFERENCE   3  (bases 1 to 5927)
  AUTHORS   Wang,Q., Xu,C., Cai,R., An,W., Yuan,H. and Xu,M.
  TITLE     Fbxo45-mediated NP-STEP46 degradation via K6-linked ubiquitination
            sustains ERK activity in lung cancer
  JOURNAL   Mol Oncol 16 (16), 3017-3033 (2022)
   PUBMED   35838331
  REMARK    GeneRIF: Fbxo45-mediated NP-STEP46 degradation via K6-linked
            ubiquitination sustains ERK activity in lung cancer.
REFERENCE   4  (bases 1 to 5927)
  AUTHORS   Zeng,F., You,S. and Dai,X.
  TITLE     MiR-30a-5p hampers proliferation of lung squamous cell carcinoma
            through targeting FBXO45
  JOURNAL   Histol Histopathol 37 (5), 483-492 (2022)
   PUBMED   35098525
  REMARK    GeneRIF: MiR-30a-5p hampers proliferation of lung squamous cell
            carcinoma through targeting FBXO45.
REFERENCE   5  (bases 1 to 5927)
  AUTHORS   Wu,L., Yu,K., Chen,K., Zhu,X., Yang,Z., Wang,Q., Gao,J., Wang,Y.,
            Cao,T., Xu,H., Pan,X., Wang,L., Xia,J., Li,Y., Wang,Z.P. and Ma,J.
  TITLE     Fbxo45 facilitates pancreatic carcinoma progression by targeting
            USP49 for ubiquitination and degradation
  JOURNAL   Cell Death Dis 13 (3), 231 (2022)
   PUBMED   35279684
  REMARK    GeneRIF: Fbxo45 facilitates pancreatic carcinoma progression by
            targeting USP49 for ubiquitination and degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5927)
  AUTHORS   Chen,X., Sahasrabuddhe,A.A., Szankasi,P., Chung,F., Basrur,V.,
            Rangnekar,V.M., Pagano,M., Lim,M.S. and Elenitoba-Johnson,K.S.
  TITLE     Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates
            cancer cell survival
  JOURNAL   Cell Death Differ 21 (10), 1535-1545 (2014)
   PUBMED   24992930
  REMARK    GeneRIF: Fbxo45 is the substrate-receptor subunit of a functional
            E3 ligase for Par-4 that has a critical role in cancer cell
            survival.
REFERENCE   7  (bases 1 to 5927)
  AUTHORS   Wang,C., Koide,T., Kimura,H., Kunimoto,S., Yoshimi,A., Nakamura,Y.,
            Kushima,I., Banno,M., Kawano,N., Takasaki,Y., Xing,J., Noda,Y.,
            Mouri,A., Aleksic,B., Ikeda,M., Okada,T., Iidaka,T., Inada,T.,
            Iwata,N. and Ozaki,N.
  TITLE     Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia
  JOURNAL   Schizophr Res 157 (1-3), 149-156 (2014)
   PUBMED   24878430
  REMARK    GeneRIF: Study found that the R108C mutation in FBXO45 is a rare
            variant with a modest effect on schizophrenia risk that may disrupt
            the structure and function of the FBXO45 protein
REFERENCE   8  (bases 1 to 5927)
  AUTHORS   Peschiaroli,A., Scialpi,F., Bernassola,F., Pagano,M. and Melino,G.
  TITLE     The F-box protein FBXO45 promotes the proteasome-dependent
            degradation of p73
  JOURNAL   Oncogene 28 (35), 3157-3166 (2009)
   PUBMED   19581926
  REMARK    GeneRIF: FBXO45 promotes the proteasome-dependent degradation of
            p73.
REFERENCE   9  (bases 1 to 5927)
  AUTHORS   Yoshida,K.
  TITLE     Characterization of estrogen-induced F-box protein FBXO45
  JOURNAL   Oncol Rep 14 (2), 531-535 (2005)
   PUBMED   16012741
  REMARK    GeneRIF: FBXO45 gene consisting of 3 exons, and the vicinity of the
            transcriptional start site had several estrogen receptor binding
            consensus sequences.
REFERENCE   10 (bases 1 to 5927)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092933.21, DB636510.1, BE778263.1, CA445163.1 and BE047625.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001105573.1.
            
            Summary: Members of the F-box protein family, such as FBXO45, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (summary by Jin et al., 2004 [PubMed
            15520277]).[supplied by OMIM, Jan 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.155239.1,
                                           SRR1163657.577130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311630.7/ ENSP00000310332.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC092933.21        79496-79689
            195-545             DB636510.1         4-354
            546-1154            BE778263.1         1-609
            1155-1754           CA445163.1         7-606               c
            1755-5546           AC092933.21        95723-99514
            5547-5927           BE047625.1         22-402
FEATURES             Location/Qualifiers
     source          1..5927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..5927
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /note="F-box protein 45"
                     /db_xref="GeneID:200933"
                     /db_xref="HGNC:HGNC:29148"
                     /db_xref="MIM:609112"
     exon            1..643
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1186
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /note="hFbxo45; F-box only protein 45"
                     /codon_start=1
                     /product="F-box/SPRY domain-containing protein 1"
                     /protein_id="NP_001099043.1"
                     /db_xref="CCDS:CCDS46985.1"
                     /db_xref="GeneID:200933"
                     /db_xref="HGNC:HGNC:29148"
                     /db_xref="MIM:609112"
                     /translation="MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVL
                     ELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPS
                     YKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVW
                     WEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQC
                     NNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVT
                     LVYLGKPLDG"
     exon            644..1000
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..5927
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4133..4138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /note="hexamer: ATTAAA"
     polyA_site      4155
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /note="major polyA site"
     regulatory      5908..5913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
                     /note="hexamer: AATAAA"
     polyA_site      5927
                     /gene="FBXO45"
                     /gene_synonym="Fbx45"
ORIGIN      
        1 gcccttgctt cgtgccctca acccgcatgg cggagccgct ggcgcgccgc ggagaggccg
       61 ggcgagtcgg gcggtttcgg cgcccgcgct gagccgcgga ggaggggcgg aggacgcccc
      121 tgcagccggt gcgtctgccc tcagtgaggc ggggcgcgcg gcggacgccc ccgggcaggg
      181 gcgggagtgg tggaggcgcc ggcggttggc actgacaggg gcggtgagcg agccgctccg
      241 gtctccgggc gaggcttggc cttccgagca gagacggcgg gaagcggcgg cggcagcggc
      301 ggccctaggg ccggctggtg aggcgatggc ggcgccggcc ccgggggctg gggcagcctc
      361 gggcggcgct ggctgtagcg gcggcggcgc gggcgcgggc gcgggctcgg gctctggggc
      421 cgcgggggcc gggggccggc tgcccagccg ggtgctggag ttggtgttct cttacctgga
      481 gctgtccgag ctgcggagct gcgccctggt gtgcaagcac tggtaccgct gcctgcacgg
      541 cgatgagaac agcgaggtgt ggcggagcct gtgcgcccgc agcctggcag aagaggctct
      601 gcgcacggac atcctgtgca acctgcccag ctacaaggcc aagatacgtg cttttcaaca
      661 tgccttcagc actaatgact gctccaggaa tgtctacatt aagaagaatg gctttacttt
      721 acatcgaaac cccattgctc agagcactga tggtgcaagg accaagattg gtttcagtga
      781 gggccgccat gcatgggaag tgtggtggga gggccctctg ggcactgtgg cagtgattgg
      841 aattgccaca aaacgggccc ccatgcagtg ccaaggttat gtggcattgc tgggcagtga
      901 tgaccagagc tggggctgga atctggtgga caataatcta ctacataatg gagaagtcaa
      961 tggcagtttt ccacagtgca acaacgcacc aaaatatcag ataggagaaa gaattcgagt
     1021 catcttggac atggaagata agactttagc ttttgaacgt ggatatgagt tcctgggggt
     1081 tgcttttaga ggacttccaa aggtctgctt atacccagca gtttctgctg tatatggcaa
     1141 cacagaagtg actttggttt accttggaaa acctttggac ggatgacagt ggctttcttg
     1201 tgatgacaga cagaatggag gagagatctg cttatgggaa gtagaaccat gaagtgactg
     1261 tcacacatgc atgtccaaga aacatcctga aaacacatga agtcgtaaac tggagaagca
     1321 gctctacagc agagattatc ttcgtgtttc ctctttctac tgggccagaa aaatcctcag
     1381 ggttgcagtt ggttgagtgg gcagttgaca tatgcatgtt gcacccgatg ttgtctctaa
     1441 gttagcaatg tgttatttcc agctttaaag gtgagattgt agagatgctg tcaaagggat
     1501 aaggaaatag caagattttt aagtagtgtg tttgtgaaga ctgatcccat tttacaactg
     1561 cctgttcttt ctccagtcct tttttttcca gccagcttga ctattagaaa agtatgaaac
     1621 tggttgggtt ttatttaata tttttaatat attgagaagc atggtctgcc tggactgcac
     1681 ttctctaaaa gtgagatata aaattgtgca gctattttaa aagttgtata taatatgtgt
     1741 gtaaaaaaaa aaaactgtaa aaaagaaagg acaaacaggt tgttttgttc tagttctaat
     1801 ttcttaaaaa ccactacatg gttacaaaat tggaataaca tttggggaca actgggttaa
     1861 ctacaaagaa gaggatttta agaggagatg tgttgtattg actcattttg tattattttt
     1921 ggcttacagt tcccatagct gttagagtct ggtttgtttt tgtttttact ctcaaaatca
     1981 tagtaaagat ctctcagtct cctggctaaa gattgaagga aggcaaatct atttctaatt
     2041 atacatatat cagtaaggat gatctcaaca taatagtaat gtgtatcttt tggtatccag
     2101 ttttattttt ggccttctaa gaaagtgtct cataacacag aacattgcca tttgctcttg
     2161 taggcctcaa atatgaaagc tattagtcat agagcctagg aaaaaaagaa ttgattaatg
     2221 gtccttttat tttgtaacct tataaatgct gtagatatta tcaaaaaaat tttaatttca
     2281 tattgtttac atcatgcaac taatctaagc ctcaaactcg ttattggggc tataaagaaa
     2341 acgtttactt acccagctga aacaggttaa gaatattctt aatctcatta tagataattg
     2401 cccccatggg acttgaaata caacaccttg tgctgaaaac ttcaggttgg caatatttga
     2461 aggtttcgtt gtagaagagt ttaacattaa ctcctatttt gacttacaaa tcttgtttct
     2521 catcactaaa atgcttttga attaataatc caacccacat gagctgagag tttttctttt
     2581 gttagaaaag aaacagacat ctttctgtat gaaagtataa attgtatggt tttagataca
     2641 taagaattga caaaagcgag cgaaatcttt gtacttctga gttcttgctg tatgtatgtt
     2701 ttgttttaaa tctgattagg gacacccagc agctggccgg gattcttgga ttgctccttg
     2761 ggagttaaga ttgtcaatac tcctgtgaag caagggattt cagccataga acaaagattt
     2821 attgttgcca cctgaaaagt ttacaagtat ttattgtgta tttgatacat tgcttgaaaa
     2881 gatgaaatct gttaaagatt cttttcgatg tccaggttaa gaagaaacct ccttgtattg
     2941 agtgaaatta tatgttaaat gtattagaga atgtaggtgg tatagaaatt gatttttctt
     3001 ggtgtagaac aactcagttc ggcaaagttt aaaatttgat taaacaagag aagtggttca
     3061 ggttgaagat ggacttgtta ggaagtgatc aagtccttta agtacttgtt tctttttcag
     3121 gttgtgatgt ggccattccg aattttgttg agagtttggt ttataattgt ctcttttgtc
     3181 ttgttagtaa acattcattt gcaacagttt tgaaggtgct gagtggaaaa ccgaaacaca
     3241 tggttattgc gtattggacc tagaatgaaa taattgcctc aatatttaac aacaagccat
     3301 tcttatctca aagatttaaa ttcccgaatg tcccattcgc aaatcatatg caattgaagt
     3361 gagcagcatg agcatctggg tcatgagggc cttcatttac gtaaatttgt cactaaaacc
     3421 cagtagtagc tctacaaaat cttaaactgc tgcagtgctc aaggagatgg aatatctttg
     3481 tcattggtgc tgaggagagc atttcggtag aagacagttg cgcctgaaga ttgagtgtaa
     3541 atcattcaaa ccagtggttc tcagtgttgg ctgtatacac tttgtagtca ctttggaatg
     3601 ttggaagaca catcgatgct tgggttccgt atgccaagat tctgatgttg gtctggaata
     3661 tgagctggtc ataaggattt ttaaaaactt tctggtcatt tcaatatgct gccaaggttg
     3721 agaaccactg ttgtaaaatt caccttgagt tttctcatct gcaaaataga aaaaaaaaaa
     3781 tccttgctcc ctcccttcac tacctcacaa ggatattgag ggtaaaggag aaaataatgg
     3841 gaaagtgctt gtgccgtgga tgaaaagtgc tattaaaagt caaaggagtg ttctgtttca
     3901 attcatagta tgatcaggga aagtgtaact gagtatactt tgttgacttg ggaaacctgg
     3961 agcactttct ttggttggtt aacgaagcat gcagatgtgg aagcagacgt tactattatc
     4021 cctactatgg tcttctgtca tactgagaca ggctgtttta attacctggt tttacatagg
     4081 aaagaagaaa tattaaggct taaagtttgt aatgatcaat ggctcataat tcattaaatc
     4141 ttttcataca aggaatttgt ggttaatgtc atttcatagt tgccattatt ttctcattat
     4201 ttgacttaaa tgttaagcca tttatttcat ctccctcatt cacataaagt gtagatatgg
     4261 attcaataag acaccaaaag aaagtaagat ttacccagtt aatatttaaa atcattgttc
     4321 agtgattagg cattttctgc cttttagaat tatttgactg gagaaagagt ttcaaaaata
     4381 gcagagccct aaaccataaa gaaactacta ctgtataatg aacttttgtt tgtttttgga
     4441 gacagggttt cactctactg cctaggcagg tcttgaactc ctgggctcaa gcagtcttcc
     4501 tgcctcagcc tcccaagtag ctgggattac aggtgtatgc cactataccc agctttaact
     4561 tttaaatccc caaactatgt agattgtcat attaatatta attttttttt gttattttga
     4621 agaagtgagt aatttgaaga gatagaaact tagggagtgg tgtgtgtgtt tcttttttgg
     4681 agacagagtc acgcaggctg gagtgcacga tcttgactca ctgcaacctt tgccacccag
     4741 gttcaagcaa ttctcgtgcc tcagcctccc gagtagcatg tgccaccaca cctggctaat
     4801 ttttttcttt tttcttttag acggagtctt gctctgttgc ccaggctgga gtgcggtggt
     4861 gtgatctcag ttcactgcaa cctttgcctc ccgggttcaa gtgattctcc tgcctcagtc
     4921 tcccgagtag ctgggattac aggcacctgc caccatgcct ggctaatttt tgtattttta
     4981 atagagacgg ggtttcacca tgttggccag gctggtctcg aactcctgac cttgtgatcc
     5041 acccacctca gcctcccaaa gtgctgggat tacaggcatg agccactgtt cccgggccta
     5101 atctttgtat ttttagtaga gggggtttat gccatgttgg ccaggctggt cttgaactcc
     5161 tggccaacac cacccacctc gcctcccaaa gtgctggggt tacaggcgcg agccaccgtg
     5221 ccaggccaga aatttaagga gttttaaagg ttagcattga aaagattact ttccagaaat
     5281 tgagaccacc acagttccac aattgggact gtggtagata atcaggacca cttggaagcc
     5341 tttattagga acagcccaca cccagcccaa atgctgtcct caaaaacatt cctcagtttc
     5401 tctagctgaa tgtaatctct ccttgaaatt tccctagttt tatatatcta tagttgactc
     5461 atgctgtatt tatttatacc ttgtttaaaa ttatttattg attatttatt ggtgtcatat
     5521 cgcccctaaa ctgggacagg atctctaacg gactcatctt tgtgccacaa catgtaagcc
     5581 caataggcag gtgctcacat atttgctgaa ggaacagaga aagaactgcg gagaaagaca
     5641 aaagctcctc tgaagtttta gactatagaa gcaaaaatta tagtagcaaa agatgaatga
     5701 gaaattctgt tctagtccca gtgaagcagg aaggaaaggg ttgcaaactt gaggctggta
     5761 aggaagaaat aattactgtg aatgcattta gccactcccc tctactcaaa aatactggta
     5821 aactctgatt tttatatttg tttagaattt aaattagaat tctgtatctt tattttttgg
     5881 aattctgttg ttttgcctta gtttcttaat aaaaagttaa acattaa
//
