LOCUS       NM_033182               2928 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box protein 44 (FBXO44), transcript variant 1, mRNA.
ACCESSION   NM_033182
VERSION     NM_033182.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Shen,J.Z., Qiu,Z., Wu,Q., Finlay,D., Garcia,G., Sun,D., Rantala,J.,
            Barshop,W., Hope,J.L., Gimple,R.C., Sangfelt,O., Bradley,L.M.,
            Wohlschlegel,J., Rich,J.N. and Spruck,C.
  TITLE     FBXO44 promotes DNA replication-coupled repetitive element
            silencing in cancer cells
  JOURNAL   Cell 184 (2), 352-369 (2021)
   PUBMED   33357448
  REMARK    GeneRIF: FBXO44 promotes DNA replication-coupled repetitive element
            silencing in cancer cells.
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   McNabb,H.J., Gonzalez,S., Muli,C.S. and Sjogren,B.
  TITLE     N-Terminal Targeting of Regulator of G Protein Signaling Protein 2
            for F-Box Only Protein 44-Mediated Proteasomal Degradation
  JOURNAL   Mol Pharmacol 98 (6), 677-685 (2020)
   PUBMED   33008920
  REMARK    GeneRIF: N-Terminal Targeting of Regulator of G Protein Signaling
            Protein 2 for F-Box Only Protein 44-Mediated Proteasomal
            Degradation.
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   Glenn,K.A., Nelson,R.F., Wen,H.M., Mallinger,A.J. and Paulson,H.L.
  TITLE     Diversity in tissue expression, substrate binding, and SCF complex
            formation for a lectin family of ubiquitin ligases
  JOURNAL   J Biol Chem 283 (19), 12717-12729 (2008)
   PUBMED   18203720
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031731.44.
            
            On Aug 31, 2019 this sequence version replaced NM_033182.6.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. It is also a member of the NFB42 (neural
            F Box 42 kDa) family, similar to F-box only protein 2 and F-box
            only protein 6. Several alternatively spliced transcript variants
            encoding two distinct isoforms have been found for this gene.
            [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 4, and 6 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY040878.1, AK301418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251547.10/ ENSP00000251547.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AL031731.44        29037-29112
            77-371              AL031731.44        29966-30260
            372-498             AL031731.44        32427-32553
            499-594             AL031731.44        32693-32788
            595-730             AL031731.44        32896-33031
            731-2928            AL031731.44        35290-37487
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..2928
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /note="F-box protein 44"
                     /db_xref="GeneID:93611"
                     /db_xref="HGNC:HGNC:24847"
                     /db_xref="MIM:609111"
     exon            1..76
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            77..371
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..874
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein FBX30; F-box gene 3; F-box only protein 44;
                     F-box/G-domain protein 3"
                     /codon_start=1
                     /product="F-box only protein 44 isoform 1"
                     /protein_id="NP_149438.2"
                     /db_xref="CCDS:CCDS132.1"
                     /db_xref="GeneID:93611"
                     /db_xref="HGNC:HGNC:24847"
                     /db_xref="MIM:609111"
                     /translation="MAVGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLV
                     TLWKRKCLREGFITEDWDQPVADWKIFYFLRSLHRNLLHNPCAEEGFEFWSLDVNGGD
                     EWKVEDLSRDQRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEV
                     KDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPP
                     GVRYIWFQHGGVDTHYWAGWYGPRVTNSSITIGPPLP"
     exon            372..498
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            499..594
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            595..730
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     exon            731..2928
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /note="hexamer: AATAAA"
     polyA_site      1892
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /note="major polyA site"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
                     /note="hexamer: ATTAAA"
     polyA_site      2928
                     /gene="FBXO44"
                     /gene_synonym="FBG3; FBX30; Fbx44; FBX6A; Fbxo6a"
ORIGIN      
        1 gctttccagg caagcgcagg tccaggcggt gcagcttggg cggcccaacg gatcgtgccg
       61 cggcggccga gcgcagctac aggagggtgt ccagaagcca caagccatgg ctgtggggaa
      121 catcaacgag ctgcccgaga acatcctgct ggagctgttc acgcacgtgc ccgcccgcca
      181 gctgctgctg aactgccgcc tggtctgcag cctctggcgg gacctcatcg acctcgtgac
      241 cctctggaaa cgcaagtgcc tgcgagaggg cttcatcact gaggactggg accagcccgt
      301 ggccgactgg aagatcttct acttcttacg gagcctgcac aggaacctcc tgcacaaccc
      361 gtgcgctgaa gaggggttcg agttctggag cctggatgtg aatggaggcg atgagtggaa
      421 ggtggaggat ctctctcgag accagaggaa ggaattcccc aatgaccagg tcaagaaata
      481 cttcgttact tcatattaca cctgcctcaa gtcccaggtg gtggacctca aggccgaagg
      541 gtattgggag gagctgatgg ataccacacg gccggacatc gaggtcaagg actggttcgc
      601 agccaggcca gattgcgggt ccaagtacca gctgtgcgtt cagctcctgt cgtccgcgca
      661 cgcgcctctg gggaccttcc agccagaccc ggcgaccatc cagcagaaga gcgatgccaa
      721 gtggagggag gtctcccaca cattctccaa ctacccgccc ggcgtccgct acatctggtt
      781 tcagcacggc ggcgtggaca ctcattactg ggccggctgg tacggcccga gggtcaccaa
      841 cagcagcatc accatcgggc ccccgctgcc ctgacacccc ctgagccccc atctgctgaa
      901 ccctgactgg taaacaactg ctgtcagaaa agggctgggc ttgggaaggg gaggtggagg
      961 ccaggtgtcc ccagacctct aacccttgcc cctagcagcc tcttctttgt ggagcctctc
     1021 agtgtgggca gccctcgcat gctggggtcg ggccagctct ccccgaaagg tcttgacctg
     1081 aatgatggcc ggggaagcct gcgtgtgccc ctttcagaga cggagcacct gagatgtggg
     1141 aggtgcagca tgttcccctg ggcccctcag aaagtcgagc ttggaggcca gcctggatct
     1201 gtctctccct tcccctcctg ggaccattct acctgtgttc tttgaccctc ggagcaggga
     1261 caggcaagac aactggcaag cttgcagctg ccctgatggt gcaggtgcag ggaggtgacc
     1321 atgtaactct gaccaatctg ggaagtggag ggtgggctca tgggccgtgc tctgcccctg
     1381 tctgctgctc ccagtctctc gctctgcctg cctgctcaga agaggtggct ttggcccaga
     1441 ggctcaggcc gggactgaga tggacagacc cagggtgggg tggggtccag gtcgggtgtg
     1501 gactgtcctc actgtcagtg gagccccaga agctagatgg gtaccaggtg gggttaggtt
     1561 cccagaggac tgagggaatc ctgtacagga tgtcccaggg tagatgggga gcaggattgg
     1621 gacctgctct gacagctgga cacatgagcc ctggatgagt atggtagggg gtttgaagaa
     1681 tcccctgtcc acctcccaaa tccaggcccg gccccctctg gcttggagag cattccaagc
     1741 ccccacccca cccctagaac tgccattccc aagacctctg tctcccagcc aaccaccctt
     1801 ggaacttgcc tcttgtcctg ctggaaagat agcagtgttc tcctgacttc gccctactgc
     1861 atgcagccaa ataaaaggtg tgcccagtct aacctgtgcc ctgtggtttc tggaaggaaa
     1921 ggcagacttt aggtggtcct gcctggacct gcagatggta caatggcatg gcttctgtct
     1981 aaggtacaga ggggttggca tttcaggaac caggccatca cagaaacagg ttcatgggca
     2041 gacccctcag tgagctgcag gtatctcacc tggcagccgt ccagtactgc tggcttcctc
     2101 tggaggccca gccacaggct ggggttgggg tgtgtggaca tctctgggca gctcttgagt
     2161 ccaccttgtg ccagatcagc agtgccaccc aggctctgcc tcctggtgtt actctttgcc
     2221 aacagcttta cggacattgg atgaagccga agcatttaga atggtgcctg gcacacagtt
     2281 ggtgcgtgat atggttaagc tttgtgtccc cacccacatc tcatcttgaa tggtaatcct
     2341 gggtgtttag ggagagacct ggtgggaagt gattggatta tgggagcggt tttcccccat
     2401 gctgttctca tgatagtgag tgagttctca cgagatctga tggttttaca agtgacggtt
     2461 tccccggctc cctcctgccg ccatgtgaag aaggtcgttg cttccccttc accttccacc
     2521 accatgattg taagttcctt ttttcttttc ttttcttttt tttttttttt tttttgagat
     2581 ggagtctcgc tctgtcgccc aggctggagt gcagtggcgc aatctcagct cactgcaagc
     2641 tctgcctccc aggttcgcgc cattcacctg cctcagcctc tggagtagct gagactacag
     2701 gcgcccacca ccatgcccgg ctaattttgt ttgtattttt agtagagatg gagtttcacc
     2761 atgttggcca gggtggtctc aatctcctga cctcgtgatc cacccacctc gacctcccaa
     2821 agtgctgaga ttacaggcgt gagccaccgc gcccagcgat tgtttcttga ggcttcccca
     2881 gccatatgga actataagtc aattaaacct ctttcctttt ataaatca
//
