LOCUS       NM_001029860            3260 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens F-box protein 43 (FBXO43), transcript variant 2, mRNA.
ACCESSION   NM_001029860 XM_209918
VERSION     NM_001029860.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3260)
  AUTHORS   Zheng,L., Shen,J., Chen,Y., Lin,J., Li,P., Zhao,X., Ren,H., Sun,Y.
            and Wang,Z.
  TITLE     FBXO43 promotes cell cycle progression in cancer cells through
            stabilizing SKP2
  JOURNAL   Cancer Lett 591, 216848 (2024)
   PUBMED   38604312
  REMARK    GeneRIF: FBXO43 promotes cell cycle progression in cancer cells
            through stabilizing SKP2.
REFERENCE   2  (bases 1 to 3260)
  AUTHORS   Ma,R., Liu,W., Sun,T., Dang,C. and Li,K.
  TITLE     Clinical significance of FBXO43 in hepatocellular carcinoma and its
            impact on tumor cell proliferation, migration and invasion
  JOURNAL   PeerJ 11, e15373 (2023)
   PUBMED   37250703
  REMARK    GeneRIF: Clinical significance of FBXO43 in hepatocellular
            carcinoma and its impact on tumor cell proliferation, migration and
            invasion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3260)
  AUTHORS   Wu,S., Qin,L., Yang,J., Wang,J. and Shen,Y.
  TITLE     Association between F-box-only protein 43 overexpression and
            hepatocellular carcinoma pathogenesis and prognosis
  JOURNAL   Cancer Med 12 (8), 10062-10076 (2023)
   PUBMED   36710413
  REMARK    GeneRIF: Association between F-box-only protein 43 overexpression
            and hepatocellular carcinoma pathogenesis and prognosis.
REFERENCE   4  (bases 1 to 3260)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
  REMARK    GeneRIF: A homozygous loss-of-function mutation in FBXO43 causes
            human non-obstructive azoospermia.
REFERENCE   5  (bases 1 to 3260)
  AUTHORS   Ma,R., Zhu,K., Yuan,D., Gong,M., Li,Y., Li,K. and Meng,L.
  TITLE     Downregulation of the FBXO43 gene inhibits tumor growth in human
            breast cancer by limiting its interaction with PCNA
  JOURNAL   J Transl Med 19 (1), 425 (2021)
   PUBMED   34645483
  REMARK    GeneRIF: Downregulation of the FBXO43 gene inhibits tumor growth in
            human breast cancer by limiting its interaction with PCNA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3260)
  AUTHORS   Tang,W., Wu,J.Q., Guo,Y., Hansen,D.V., Perry,J.A., Freel,C.D.,
            Nutt,L., Jackson,P.K. and Kornbluth,S.
  TITLE     Cdc2 and Mos regulate Emi2 stability to promote the meiosis
            I-meiosis II transition
  JOURNAL   Mol Biol Cell 19 (8), 3536-3543 (2008)
   PUBMED   18550795
  REMARK    GeneRIF: Cdc2 and Mos regulate Emi2 stability to promote the
            meiosis I-meiosis II transition
REFERENCE   7  (bases 1 to 3260)
  AUTHORS   Shoji,S., Yoshida,N., Amanai,M., Ohgishi,M., Fukui,T., Fujimoto,S.,
            Nakano,Y., Kajikawa,E. and Perry,A.C.
  TITLE     Mammalian Emi2 mediates cytostatic arrest and transduces the signal
            for meiotic exit via Cdc20
  JOURNAL   EMBO J 25 (4), 834-845 (2006)
   PUBMED   16456547
REFERENCE   8  (bases 1 to 3260)
  AUTHORS   Hansen,D.V., Tung,J.J. and Jackson,P.K.
  TITLE     CaMKII and polo-like kinase 1 sequentially phosphorylate the
            cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic
            exit
  JOURNAL   Proc Natl Acad Sci U S A 103 (3), 608-613 (2006)
   PUBMED   16407128
REFERENCE   9  (bases 1 to 3260)
  AUTHORS   Tung,J.J., Hansen,D.V., Ban,K.H., Loktev,A.V., Summers,M.K.,
            Adler,J.R. 3rd and Jackson,P.K.
  TITLE     A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a
            homolog of early mitotic inhibitor 1, in cytostatic factor arrest
            of Xenopus eggs
  JOURNAL   Proc Natl Acad Sci U S A 102 (12), 4318-4323 (2005)
   PUBMED   15753281
REFERENCE   10 (bases 1 to 3260)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA996924.1, DB088246.1, AK310518.1, BC028709.1, AI198884.1,
            BG391951.1 and AC021590.10.
            
            On Nov 23, 2018 this sequence version replaced NM_001029860.3.
            
            Summary: Members of the F-box protein family, such as FBXO43, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) represents the shorter
            transcript but encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028709.1, SRR14038193.2131433.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428847.3/ ENSP00000403293.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               DA996924.1         55-237
            184-376             DB088246.1         184-376
            377-2140            AK310518.1         1-1764
            2141-2659           BC028709.1         1779-2297
            2660-3055           AI198884.1         16-411              c
            3056-3240           BG391951.1         361-545
            3241-3251           BC028709.1         2880-2890
            3252-3260           AC021590.10        155597-155605       c
FEATURES             Location/Qualifiers
     source          1..3260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..3260
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /note="F-box protein 43"
                     /db_xref="GeneID:286151"
                     /db_xref="HGNC:HGNC:28521"
                     /db_xref="MIM:609110"
     exon            1..767
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /inference="alignment:Splign:2.1.0"
     CDS             683..2809
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /note="early mitotic inhibitor 2; endogenous meiotic
                     inhibitor 2"
                     /codon_start=1
                     /product="F-box only protein 43"
                     /protein_id="NP_001025031.2"
                     /db_xref="CCDS:CCDS47904.1"
                     /db_xref="GeneID:286151"
                     /db_xref="HGNC:HGNC:28521"
                     /db_xref="MIM:609110"
                     /translation="MSFKDKDERISCLEAYVTLTSKSSRFTDETEILKMSQRHSGQAG
                     TEAGNGADSPPIVNSKYSTFRDFCSTSSFQDSGYNELKSCSFDNIDKEYLGKKEKGPT
                     LLYEHPETSGLGLTHPLESPTQKKKCILPRKEKDKTPELCETPKISGKKCLPRRRLNV
                     SFALLKGDFESQNSSLESSISQVINLEKNIPSSASGFSRANNFSPLVTSTLKTEEVTS
                     CSQKLRLNFSQQKTSTIDDSKDDCSLFEVECISPIQGNNFKDSITHDFSDSSLCINDE
                     NACPELLGSSVSGTTCGTDEDIFVTPISNLVANIRFNASQILSPSPEVRGSISTPEDS
                     GFNSLSLEKSEDSLSDQEGSFQELLQKHKGTPKVGDTIRKTRHLGRSRRLSTLREQSS
                     QSETEEEKQIVHPDSEKRAAAASAISEGQLSSDESGDLTFSLKNLSKTPALQLVHELF
                     MKSKRKRLQENSGHEFLEQGDGEKIAVLQCILAGLIGKKMGIEKLDILTELKYRNLKH
                     ILAMVLESLTAESLCSVWKVSRNWREIVVQDKNANRRRKFYITQLKTDSEGAVLNVED
                     AATRLQLLNRSALRSVQAQARIPGSQREQGSTLSPWGEVLTPLASSSVTHLSSKQEEY
                     VKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSRTACGFDFCVLCLCAYHGSEECS
                     RGAAKPRNRKDALPGSAQSKRNLKRL"
     exon            768..2253
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2356
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2560
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..3260
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /note="hexamer: AATAAA"
     polyA_site      3055
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /note="major polyA site"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
                     /note="hexamer: AATAAA"
     polyA_site      3260
                     /gene="FBXO43"
                     /gene_synonym="EMI2; ERP1; FBX43; OOMD12; OZEMA12; SPGF64"
ORIGIN      
        1 aaacctaagg aggtaaaggc agcggcccca cgcgaagctg gcgtgggggt tgccatagcc
       61 cgcatcccag ggggcgaggc cgaggcttct ccccggccca tccagcggct gctgcccggc
      121 tcctctccca cctgtccgct tcggcgcctc gcccggcccc gcggcctcca ggcaggcggc
      181 gggaccccag gcgagtgccc gttagcgggt ctcccggcgg cccggccccg cgtcgccctg
      241 tgtcttccag gtgctgggcc tagggaggcg cgcggcagcc ctcactcctc cgctcctggt
      301 gacgccagcc catcccctgc tgcccttggc tttctgggcc tagcggatct ttgacgccct
      361 ggtgagaccg ttacccaccc gcccgccata gctcctcggg ggagtcagtg ccaggctgca
      421 gcacacgctg ccttttcagg aacccgaatt tgggaagttt actcatgtct aagtccagct
      481 ggagaaaaca aggatattaa gataactatt ttctggaggg ctgaaggaaa ttcaaaatga
      541 tttagacctt ctcaagtgtt aggaataatc cctgcggcat gcaccctgtg tacccttcga
      601 ctttgagcaa tcatgatgct gctgcacctt tcaattaatt gtgcaaacta aagttttcct
      661 ctttaagtgg cattattttg gcatgagttt taaagacaaa gatgagagaa tttcttgttt
      721 ggaagcctac gtaactttga catctaagag ctcaagattt actgatgaaa cagagatttt
      781 gaagatgtcg caaaggcact caggtcaagc tggcactgaa gcaggaaatg gggcggactc
      841 tcctccaatt gtcaactcca agtactccac cttcagagat ttttgttcca catcttcatt
      901 tcaagatagt ggctacaatg agttaaaatc ttgtagcttt gataatatag ataaagaata
      961 tcttggaaag aaagaaaaag gcccaacatt actctatgag caccctgaaa cttcaggcct
     1021 gggcttaaca catcctttag aatctcccac tcaaaaaaag aaatgtatct tgcctagaaa
     1081 ggaaaaggat aaaaccccag aactttgtga aacacctaaa atcagtggga aaaaatgttt
     1141 acctcgcaga aggttgaatg tatctttcgc tcttctaaaa ggggactttg aatcacaaaa
     1201 tagttcttta gaaagtagta taagccaagt tatcaactta gaaaaaaata ttccaagcag
     1261 tgcttcaggt ttttccaggg caaataattt tagcccttta gttactagca ctttaaaaac
     1321 agaagaagtg acttcatgca gtcaaaaatt gaggcttaat ttttctcagc aaaagacttc
     1381 cacaattgat gattccaaag atgattgtag cctatttgaa gttgaatgta tatctccaat
     1441 tcagggcaat aattttaaag actctatcac acatgacttt agtgatagca gtttatgcat
     1501 taatgatgag aatgcatgtc cagagctcct gggctcctct gttagtggaa caacttgtgg
     1561 aacagatgag gacatatttg tgactccgat aagtaatctt gtggcaaaca ttagatttaa
     1621 cgcaagtcaa atactttctc cttcacctga agtgagaggc agtatttcaa cgcctgaaga
     1681 cagtggtttt aactcactta gcttggagaa atcagaagat tccctgtctg accaggaggg
     1741 ttcttttcaa gaactactgc agaaacataa ggggactccc aaagttgggg acaccataag
     1801 aaagacaaga catcttggaa ggtcgagaag actgtccacc cttcgggaac aaagctcgca
     1861 gtcagagaca gaagaggaaa agcagattgt ccaccctgac tctgaaaaaa gagcagcagc
     1921 tgcttctgcc atctcagagg gtcagctgag tagtgatgag agtggggatt tgacctttag
     1981 cttaaagaat ttatcaaaga ccccagcctt gcaattggta catgagctgt tcatgaaaag
     2041 caagaggaaa agattacagg aaaatagtgg acatgaattc ttagagcaag gggatgggga
     2101 gaaaatagct gtactgcagt gtatacttgc aggactgatc ggcaagaaaa tgggtataga
     2161 aaaactggac atcttaacag aattaaaata tagaaattta aagcatattc ttgctatggt
     2221 tttagagtcc ttgaccgcag agagcctatg cagtgtttgg aaagtaagca gaaattggcg
     2281 tgaaattgtt gttcaagata aaaatgcaaa tcggaggagg aaattttata tcacacaact
     2341 gaaaacagat tctgaggggg ctgtattaaa tgtcgaggat gctgccactc ggctccagct
     2401 tttaaatcgc tcagctttaa gatctgtgca ggcacaggct aggatacctg gttctcagag
     2461 agagcaaggg tcaacattat ctccctgggg agaagttttg acacctctag caagctcttc
     2521 tgttactcac ttaagtagta aacaggaaga atatgttaag gttgccaaaa cactttttac
     2581 tgatgaagca ttaaaacctt gcccaaggtg ccagtcccct gctaagtacc agccatataa
     2641 gaaaagggga ctgtgtagcc gaacagcctg tggttttgac ttttgtgtgt tatgtctgtg
     2701 tgcttatcat gggtctgaag aatgtagtag aggagcagca aagccaagaa atagaaaaga
     2761 tgctctccca ggaagtgccc agagtaagcg gaatttaaaa cgcctctgaa gagactaaat
     2821 atagaactcc cccatgcagt gttctattta tctgacttaa aattatgaat attttgaata
     2881 catgcaaatc ttcccattaa tgacaggtga tgattaattt cctattttgt atatattata
     2941 atcgatgtca ttgtatgttt tctttaaagt tgttttgaaa aaattttatt ttactatgtc
     3001 attttaccca ttttaataac ttggtatttt aaataaagaa ttttcattgt tgttatatgt
     3061 atgtacttta ttgttttatg taacatttta aatttgtgca tttcatcact cttgacatgt
     3121 tcttcaatca ttttttaaaa aatagttttt cagataatat taaagatttt gaactctaga
     3181 cagatggcct tatagatttg gaaaatgagt acttgactga aatgaaatat aaataaaata
     3241 ttttcagaag ttctattgaa
//
