LOCUS       NM_016298               5669 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 40 (FBXO40), mRNA.
ACCESSION   NM_016298
VERSION     NM_016298.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5669)
  AUTHORS   Le Clerc,S., Taing,L., Ezzedine,K., Latreille,J., Delaneau,O.,
            Labib,T., Coulonges,C., Bernard,A., Melak,S., Carpentier,W.,
            Malvy,D., Jdid,R., Galan,P., Hercberg,S., Morizot,F., Guinot,C.,
            Tschachler,E. and Zagury,J.F.
  TITLE     A genome-wide association study in Caucasian women points out a
            putative role of the STXBP5L gene in facial photoaging
  JOURNAL   J Invest Dermatol 133 (4), 929-935 (2013)
   PUBMED   23223146
REFERENCE   2  (bases 1 to 5669)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   3  (bases 1 to 5669)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   4  (bases 1 to 5669)
  AUTHORS   Ye,J., Zhang,Y., Xu,J., Zhang,Q. and Zhu,D.
  TITLE     FBXO40, a gene encoding a novel muscle-specific F-box protein, is
            upregulated in denervation-related muscle atrophy
  JOURNAL   Gene 404 (1-2), 53-60 (2007)
   PUBMED   17928169
  REMARK    GeneRIF: FBXO40 may function as a regulator involved in the
            postnatal myogenesis.
REFERENCE   5  (bases 1 to 5669)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB081227.1, BC109275.1, AC063920.19 and AB033021.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016298.3.
            
            Summary: Members of the F-box protein family, such as FBXO40, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033021.1, SRR1803613.5063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338040.6/ ENSP00000337510.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               DB081227.1         57-442
            387-3150            BC109275.1         254-3017
            3151-3810           AC063920.19        31617-32276
            3811-5666           AB033021.1         4072-5927
            5667-5669           AC063920.19        34133-34135
FEATURES             Location/Qualifiers
     source          1..5669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..5669
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /note="F-box protein 40"
                     /db_xref="GeneID:51725"
                     /db_xref="HGNC:HGNC:29816"
                     /db_xref="MIM:609107"
     exon            1..124
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /inference="alignment:Splign:2.1.0"
     exon            125..157
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2284
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /note="muscle disease-related protein"
                     /codon_start=1
                     /product="F-box only protein 40"
                     /protein_id="NP_057382.2"
                     /db_xref="CCDS:CCDS33835.1"
                     /db_xref="GeneID:51725"
                     /db_xref="HGNC:HGNC:29816"
                     /db_xref="MIM:609107"
                     /translation="MGKARRSPPGHHRHCEGCFNRHCHIPVEPNTSCLVISCHLLCGA
                     TFHMCKEAEHQLLCPLEQVPCLNSEYGCPLSMSRHKLAKHLQVCPASVVCCSMEWNRW
                     PNVDSETTLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETREATEEEPTM
                     NGETSVEEMGGAVGGVDIGLVPHGLSATNGEMAELSQEEREVLAKTKEGMDLVKFGQW
                     ENIFSKEHAASALTNSSASCESKNKNDSEKEQISSGHNMVEGEGAPKKKEPQENQKQQ
                     DVRTAMETTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDF
                     VYGKLEAQEVKTVYTFKVPVSYCGKRARLGDAMLSCKPSEHKAVDTSDLGITVEDLPK
                     SDLIKTTLQCALERELKGHVISESRSIDGLFMDFATQTYNFEPEQFSSGTVLADLTAA
                     TPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSCLNGWFQ
                     HRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEGRKNNHLLGHG
                     GKSQNSLTSLPLEILKYIAGFLDSVSLAQLSQVSVLMRNICATLLQERGMVLLQWKKK
                     RYSHGGTSWRVHREIWQFSSLFSKIKSWEFNEVTSMSEHLKSCPFNIVEHKTDPILLT
                     SMCQPREQARESLVSTFRIRPRGRYVS"
     exon            158..2068
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..5669
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5644..5649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /note="hexamer: AATAAA"
     polyA_site      5669
                     /gene="FBXO40"
                     /gene_synonym="FBX40"
                     /note="major polyA site"
ORIGIN      
        1 gccttcccaa cagaacgctg tcctctactg cagctgatgc aacccagcca cctcccggca
       61 atccgcttac ttgcaatcaa gggttcaggt gcaagcagat gctgactcag cctgttccat
      121 taagagctaa gaagcaagaa gaaattgggg cgccatgggg aaagcccgca gatccccgcc
      181 agggcaccac aggcattgtg agggatgctt caaccgccac tgccacattc ctgtggaacc
      241 caacacctcc tgcctggtaa taagctgcca cctgctctgt ggtgccacct tccacatgtg
      301 caaagaggca gagcaccagc tcctctgccc tttagagcag gttccgtgcc tcaactccga
      361 atatggctgc cctctgtcca tgtcccgcca caaactggcc aagcacctgc aggtgtgccc
      421 cgccagcgtg gtctgctgct ccatggagtg gaaccgctgg ccaaatgtgg actctgaaac
      481 cacccttcat gaaaacatca tgaaagagac ccccagtgag gagtgtttgg acacagccct
      541 ggccctgcag gatcagaagg tcctcttcag atccttgaaa atggtggaac ttttcccaga
      601 aactagagag gctactgagg aggaaccaac tatgaatggt gaaaccagtg tggaggaaat
      661 gggaggagca gtgggtggag tggatatcgg tttggtacca catggtctgt cagcaactaa
      721 tggggagatg gcagagctaa gtcaagaaga acgggaggtg ctagccaaaa ccaaagaagg
      781 gatggacctg gtcaagtttg gccagtggga aaatattttc agcaaagagc acgcagcctc
      841 tgctttaaca aattcatcag cgagctgtga gagcaagaac aagaatgact ccgagaaaga
      901 acagatttcc agtggccata acatggtaga aggagagggc gctcccaaaa agaaagaacc
      961 acaggaaaat cagaagcagc aggacgttcg tacagccatg gaaaccacag ggcttgcccc
     1021 ttggcaggat ggtgttctgg aaagactgaa aacagctgtg gatgcaaagg actataacat
     1081 gtatctagtg cacaatgggc ggatgctgat acactttggt cagatgcctg cttgtacacc
     1141 caaggagaga gactttgttt atggcaagct ggaggctcag gaagttaaga ctgtttacac
     1201 cttcaaagtt cctgtgagct actgtggaaa gcgagctcga cttggagatg ccatgttgag
     1261 ttgtaagcca agtgaacaca aggcagtgga tacttcagat ttggggatca ctgtggagga
     1321 cctgcccaaa tcagatctca tcaagaccac cctccagtgt gctttggaaa gagaactcaa
     1381 aggccacgtc atctctgaat ccagaagcat tgatggactg ttcatggatt ttgccacaca
     1441 aacatacaac tttgagccag aacagttttc ctctgggaca gtgctggctg acctaaccgc
     1501 tgccacccca gggggactcc acgtggagct ccacagcgag tgtgtgacca ggagacacaa
     1561 caaaagcagc tctgccttca ctttcacttg caacaaattc ttcaggaggg atgagttccc
     1621 cctgcacttc aagaatgtcc acacagacat tcagtcatgt ctcaatggct ggttccagca
     1681 tcgatgcccc ctcgcctact tgggatgtac atttgttcaa aaccatttcc gtcccccagg
     1741 gcaaaaggca aaagtaatct atagccagga gctcaagacc tttgccatta agccggaggt
     1801 tgctccagag ctgagcgagg gaaggaagaa caaccatctt ttgggtcatg gaggaaaaag
     1861 ccagaattct ttaaccagcc tgcccctgga gattttgaag tacattgctg ggttcttgga
     1921 cagcgtcagc ctggcccagc tctcccaggt gtctgtgctg atgaggaata tctgtgccac
     1981 tttgttacaa gagagaggaa tggtcctttt gcaatggaag aaaaagaggt attcccatgg
     2041 aggcacctcc tggagagtcc acagagagat ctggcagttc agcagcctct tctccaaaat
     2101 caagagctgg gagtttaatg aagtcacctc catgtctgag cacctgaagt cctgtccttt
     2161 caacattgta gagcacaaaa ctgacccgat tcttttgact agcatgtgtc agccccgtga
     2221 gcaggcccga gagagcttag tctccacctt tagaatcaga ccacgaggaa gatacgtctc
     2281 ctaaaaattc agatgccact cgatgcaccc ttcttggatt tcttctcgga gttcctgaag
     2341 taggacagag tgtgtggttt tgaggactcc cttctgtaaa ctgcctattt gcttatcggg
     2401 gtgtattgga acacgcaatg tccttcgaaa cctcaacacg aggcctaaga atttcctaag
     2461 ccatgtcttg taccatagtg ccacattgat gacttgtttc cttttttctt ttcttttctt
     2521 ttcttttttc tttctttcta aaatagattg gtctgagaag aaaataagta atttgaggcc
     2581 atttggaaga tgggcccaat ttcttaagtg atgagagagc acgaaattcc ataaccagta
     2641 caggcctgtg cttttacatg ggctttttag ttcacaaagc actttcaaat ttatgggaca
     2701 ggaaatgcag gatgggactc cccagggaac gcagggtgaa gggaacaaag ctggaggctc
     2761 tggagctggg tctgttttga cggtcaagtc cagggctcat tttggttatt ctactgcctc
     2821 taggccaggg tagtcctaac acagcctgac ataggagagc ccctggctga gcatggcagc
     2881 cttgaagaca ccacaggcca aaacatgagg ggcagaaatg ggatcacaga gtctgttgct
     2941 agaatcttgg caacatacag caggaaagcc ttgataaatc gggagtccaa aggagacacc
     3001 atatttatgg agaacattag gacaaaaagt caccaactta ctttgtaaca ttttaataat
     3061 gacttaaggg tcaagatttt tttcttctga aaattatgtt ctgagttagg cagaacatag
     3121 ccatggccct gggccaccct gtgctatctg aaatgacctc aatacactaa tgccaacctc
     3181 agcgtcatgc cagaatgcac agggcagccc agggagatca cacctttggc aaagtccaga
     3241 caaggcccac tgcagttcct atggcgccag tcaccagctc ctagacagca cttgggtacc
     3301 ccattggggt cttggagagg aagacatgtg aacataacgg ctccctgaaa ttgctcctac
     3361 ccatccatat ttctggtcat gctttcagtc tgacaaaaat ggatgatact gctgtttttg
     3421 gtaacaaaca gtgaatattc ataagaacaa aagtaaaaga aaaaaagaca cagtagaaac
     3481 tggcatcccc taaagcaggg cttcttagcc ttggaactat tgacattttt aaatggataa
     3541 ttcttttttt ttttttctag gtggggaggg gatggagttc actcttgttg cccaggctgg
     3601 agcgcaatga catgatctcg gctcaccgca acctccgcct cctgggttca agcgattctc
     3661 ctgcctcagc ctcccgagta gctgggatta ctcgcctggc taattttgta tttttagtag
     3721 agacgggctt tctccatgtt gttcaggctg gtctcaaact cccgacctca ggtgactcgc
     3781 ccgccttggc cttccaaagt gctgggttta caggtgtgag ccactgcgcc ctgcctgaac
     3841 tggataattc tttgttgcaa gggactgttc tgtgtactac aggatacttg gcagcatcct
     3901 tggcctatcc attaaatgtc agtagcaccc ccacagtggc aacaatcaaa aatgtcacca
     3961 gacattgcta aatattgggg agcaaaatgg ctccccgttg aaaatcccta aaggatgtca
     4021 tactagtgac aataagttag gatatgctta ttttttagta cagcaaaatc ttatcgcaca
     4081 tagctatcca caatagttat gatttaatgc agctctttat ttatgaaata ggttttagac
     4141 atgtggtgat tttaagttgg gaaccagaag gaaatgattc gtttggtatg gcttcatgtc
     4201 cttcagccac ccccaagaat gtatcctttc agctctcttt ggttatacct gaagccagga
     4261 gcgttgagtt attagccttg tgtttatatt cctctcactg taattggtgt cattttccca
     4321 gcagtcctag cagtcctcaa gcaagtggga aatcggaaaa gaaaaggaca ggcattgtag
     4381 ggaagcagag gataaagaat ttagccaaca aaagaaacaa tctagtcaat ctgggtgctt
     4441 ttatttcctg ggttctctct aaacatggct cagagctggt gtagatgaag taggtgaaac
     4501 ctctgaaaag agtctagaag gcagtagagc aagtcccaga ccagaaacat gctcatcttt
     4561 tcatcgtaat gtgccactcg gtactatttg gtaatgtcac tctatttttc ctaatcccat
     4621 cctttggttt gtatttcata tttgtatata aggcaccatt ttctaaaaat atgactaggg
     4681 tgtgacctaa ggttttattc tgtgaagatg agtaactgga aagaagctaa cactgcagtg
     4741 ggaaggaagg aagagagttg tccaggtggt agttcgacgt gttttgaatc tagtccttcc
     4801 tacatggagg ataaaagctc ctaaagtcca ctctgggttt gtgattttaa tagaaataga
     4861 aagggaaact atagaccaat ggagatgaaa atcaggggct atcgacagat ggaggagaaa
     4921 taaggtgcta catagagaaa ggaagagggc agaaggcttt cccttcccaa actgggtgag
     4981 ctggggaagc cttggttcag gagagtggca ctgcccacaa ctgctttgtg ggttgtgcac
     5041 ttccagccgc actctccccc tccagttgct gccttcagag ccgtactgaa gcacgagctt
     5101 caataagaca agcacacttc atagtgagag ggcagcggta ccaaagcctt tcagagagac
     5161 tatggattag acagaaatga tttgtgagag gaagctggag tgaacagcat gaacagcgag
     5221 tgttacctga cagaggcaag acagctagaa gtggcttcag atttagaaac agctgagggg
     5281 agcaaagacg gactgtgtac acagggaggg aggatgtcta tgggcagagc ccttggtgag
     5341 tatcatcacc aagaaaggca gtccagagta gagatcagcc gaatatggag gctgaggtct
     5401 gtagaactgg gccagagagg accttactgc cttagtagca taagggtctg gaaaagaagt
     5461 ttctatctca caacaaagga aaaagtgaaa agcaaggtgg aacttgaaga tacgtcacga
     5521 aaatcactat aaaagtctga tttatgtgtg atgtcaaatc aaactgaaat gaagaatgag
     5581 attgagtata tctgtggtga ctgacctctg tatactagaa acctcaacat ctctagaaga
     5641 ggaaataaaa gctgctttgc actctgaaa
//
