LOCUS       NM_012176               1655 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box protein 4 (FBXO4), transcript variant 1, mRNA.
ACCESSION   NM_012176
VERSION     NM_012176.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1655)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1655)
  AUTHORS   Liu,J., Yang,H., Cheung,P.Y., Tsao,S.W., Lv,L. and Cheung,A.L.M.
  TITLE     FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage in
            immortalized esophageal epithelial cells
  JOURNAL   Biochem Biophys Res Commun 554, 76-82 (2021)
   PUBMED   33784509
  REMARK    GeneRIF: FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage
            in immortalized esophageal epithelial cells.
REFERENCE   3  (bases 1 to 1655)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1655)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1655)
  AUTHORS   Qie,S., Majumder,M., Mackiewicz,K., Howley,B.V., Peterson,Y.K.,
            Howe,P.H., Palanisamy,V. and Diehl,J.A.
  TITLE     Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head
            and neck squamous cell carcinoma
  JOURNAL   Nat Commun 8 (1), 1534 (2017)
   PUBMED   29142209
  REMARK    GeneRIF: in head and neck squamous cell carcinoma, fragile X mental
            retardation syndrome related protein 1 (Fxr1) overexpression
            correlates with reduced F-box protein 4 (Fbxo4) levels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1655)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   7  (bases 1 to 1655)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 1655)
  AUTHORS   Chiaur,D.S., Murthy,S., Cenciarelli,C., Parks,W., Loda,M.,
            Inghirami,G., Demetrick,D. and Pagano,M.
  TITLE     Five human genes encoding F-box proteins: chromosome mapping and
            analysis in human tumors
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 255-258 (2000)
   PUBMED   10828603
REFERENCE   9  (bases 1 to 1655)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 1655)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024075.1, BC040011.1,
            BC048098.1 and AC034222.5.
            
            On Nov 22, 2018 this sequence version replaced NM_012176.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.123476.1, AK024075.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281623.8/ ENSP00000281623.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1074              AK024075.1         28-1101
            1075-1479           BC040011.1         1063-1467
            1480-1482           BC048098.1         1475-1477
            1483-1655           AC034222.5         140683-140855
FEATURES             Location/Qualifiers
     source          1..1655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..1655
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /note="F-box protein 4"
                     /db_xref="GeneID:26272"
                     /db_xref="HGNC:HGNC:13583"
                     /db_xref="MIM:609090"
     exon            1..218
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1193
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein Fbx4; F-box only protein 4"
                     /codon_start=1
                     /product="F-box only protein 4 isoform 1"
                     /protein_id="NP_036308.1"
                     /db_xref="CCDS:CCDS3938.1"
                     /db_xref="GeneID:26272"
                     /db_xref="HGNC:HGNC:13583"
                     /db_xref="MIM:609090"
                     /translation="MAGSEPRSGTNSPPPPFSDWGRLEAAILSGWKTFWQSVSKERVA
                     RTTSREEVDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYF
                     LLRDLPSWSSVDWKSLPDLEILKKPISEVTDGAFFDYMAVYRMCCPYTRRASKSSRPM
                     YGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPTAGLPQRQIDGIG
                     SGVNFQLNNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSRHNEGDDQQGSRYSVI
                     PQIQKVCEVVDGFIYVANAEAHKRHEWQDEFSHIMAMTDPAFGSSGRPLLVLSCISQG
                     DVKRMPCFYLAHELHLNLLNHPWLVQDTEAETLTGFLNGIEWILEEVESKRAR"
     exon            219..454
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            455..675
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..751
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            752..927
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1103
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1655
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1462..1467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /note="hexamer: ATTAAA"
     polyA_site      1482
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /note="major polyA site"
     regulatory      1631..1636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
                     /note="hexamer: AATACA"
     polyA_site      1655
                     /gene="FBXO4"
                     /gene_synonym="FBX4"
ORIGIN      
        1 agacgcgtca cccacgctgc gggcaagcca tggcgggaag cgagccgcgc agcggaacaa
       61 actcgccgcc gccgcccttc agcgactggg gccgcctgga ggcggccatc ctcagcggct
      121 ggaagacctt ctggcagtca gtgagcaagg agagggtggc gcgtacgacc tcacgggagg
      181 aggtggatga ggcggccagc accctgacgc ggctgccgat tgatgtacag ctatatattt
      241 tgtcctttct ttcacctcat gatctgtgtc agttgggaag tacaaatcat tattggaatg
      301 aaactgtaag agatccaatt ctgtggagat actttttgtt gagggatctt ccttcttggt
      361 cttctgttga ctggaagtct cttccagatc tagaaatctt aaaaaagcct atatctgagg
      421 tcactgatgg tgcatttttt gactacatgg cagtctatag aatgtgctgt ccatacacaa
      481 gaagagcttc aaaatccagc cgtcctatgt atggagctgt cacttctttt ttacactccc
      541 tgatcattca gaatgaacca cgatttgcta tgtttggacc aggtttggaa gaattgaata
      601 cctctttggt gttgagcttg atgtcttcag aggaactttg cccaacagct ggtttgcctc
      661 agaggcagat tgatggtatt ggatcaggag tcaattttca gttgaacaac caacataaat
      721 tcaacattct aatcttatat tcaactacca gaaaggaaag agatagagca agggaagagc
      781 atacaagtgc agttaacaag atgttcagtc gacacaatga aggtgatgat caacaaggaa
      841 gccggtacag tgtgattcca cagattcaaa aagtgtgtga agttgtagat gggttcatct
      901 atgttgcaaa tgctgaagct cataaaagac atgaatggca agatgaattt tctcatatta
      961 tggcaatgac agatccagcc tttgggtctt cgggaagacc attgttggtt ttatcttgta
     1021 tttctcaagg ggatgtaaaa agaatgccct gtttttattt ggctcatgag ctgcatctga
     1081 atcttctaaa tcacccatgg ctggtccagg atacagaggc tgaaactctg actggttttt
     1141 tgaatggcat tgagtggatt cttgaagaag tggaatctaa gcgtgcaaga tgattctctt
     1201 ttcagatctt gggaactgaa accatttgaa atttattact aaggtcgtga tgtgaatatt
     1261 tgctcagtca gcccaccttg tcctgccttt ttgcagatag gctttcattt ggacagctat
     1321 aactgctgtg ttttttatat tatttttact ctttaccata aatcaattac aagaaaagag
     1381 tttcagtcct agtatttagc cccaaaatga acctttaaac atttttttgg taatttttat
     1441 attttctgtc tttttaaaaa tattaaattc tggaaaaaac aagtttgtgc ctctcattcc
     1501 ctgagtttct attcttttgg gtataaagat tgccttagtg agaaatagca aatttgctaa
     1561 actttctatt cagtcttttc aagggttcat aagtggttat cagaaaagaa atttttatct
     1621 attcttaata aatacactgc ttaaagactg aaaaa
//
