LOCUS       NM_153230               1685 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 39 (FBXO39), mRNA.
ACCESSION   NM_153230
VERSION     NM_153230.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Wu,J., Yao,F., Li,Y., Zhao,Z., Liu,J., Xu,T., Chai,J., Yang,Y.,
            Song,J., Tian,C., Jia,Q., Li,M. and Li,L.
  TITLE     The cancer-testis antigen FBXO39 predicts poor prognosis and is
            associated with stemness and aggressiveness in glioma
  JOURNAL   Pathol Res Pract 239, 154168 (2022)
   PUBMED   36244247
  REMARK    GeneRIF: The cancer-testis antigen FBXO39 predicts poor prognosis
            and is associated with stemness and aggressiveness in glioma.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Ramadan,R.A., Morsy,H., Samir,M., Shamseya,M., Shalaby,M. and
            El-Attar,E.A.
  TITLE     Significance of cancer testis-associated antigens (SPAG9 and
            FBXO39) in colon cancer
  JOURNAL   Indian J Cancer 59 (3), 394-401 (2022)
   PUBMED   34380828
  REMARK    GeneRIF: Significance of cancer testis-associated antigens (SPAG9
            and FBXO39) in colon cancer.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Liu,Y.C., Yan,S., Liu,D.M., Pei,D.X. and Li,Y.W.
  TITLE     Aberrant Expression of Cancer-Testis Antigen FBXO39 in Breast
            Cancer and its Clinical Significance
  JOURNAL   Clin Lab 66 (9) (2020)
   PUBMED   32902238
  REMARK    GeneRIF: Aberrant Expression of Cancer-Testis Antigen FBXO39 in
            Breast Cancer and its Clinical Significance.
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Motalebzadeh,J., Shabani,S., Rezayati,S., Shakournia,N.,
            Mirzaei,R., Mahjoubi,B., Hoseini,K. and Mahjoubi,F.
  TITLE     Prognostic Value of FBXO39 and ETS-1 but not BMI-1 in Iranian
            Colorectal Cancer Patients
  JOURNAL   Asian Pac J Cancer Prev 19 (5), 1357-1362 (2018)
   PUBMED   29802700
  REMARK    GeneRIF: High FBXO39 expression is associated with Colorectal
            Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Seifi-Alan,M., Shamsi,R., Ghafouri-Fard,S., Mirfakhraie,R.,
            Zare-Abdollahi,D., Movafagh,A., Modarressi,M.H., Kazemi,G.,
            Geranpayeh,L. and Najafi-Ashtiani,M.
  TITLE     Expression analysis of two cancer-testis genes, FBXO39 and TDRD4,
            in breast cancer tissues and cell lines
  JOURNAL   Asian Pac J Cancer Prev 14 (11), 6625-6629 (2014)
   PUBMED   24377578
  REMARK    GeneRIF: FBXO39 showed significant up-regulation in invasive ductal
            breast carcinoma.
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Song,M.H., Ha,J.C., Lee,S.M., Park,Y.M. and Lee,S.Y.
  TITLE     Identification of BCP-20 (FBXO39) as a cancer/testis antigen from
            colon cancer patients by SEREX
  JOURNAL   Biochem Biophys Res Commun 408 (2), 195-201 (2011)
   PUBMED   21338577
  REMARK    GeneRIF: These data suggest that the BCP-20 (FBXO39) gene is a new
            Cancer/Testis antigen and may be useful for diagnosis and
            immunotherapy.
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC034305.6, BM554273.1, BC034782.1, DB524242.1 and AI125619.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153230.2.
            
            Summary: Members of the F-box protein family, such as FBXO39, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.378380.1,
                                           SRR5189667.241396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321535.5/ ENSP00000321386.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC034305.6         28294-28311
            19-38               BM554273.1         1-20
            39-1223             BC034782.1         1-1185
            1224-1433           DB524242.1         22-231
            1434-1685           AI125619.1         7-258               c
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1685
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /note="F-box protein 39"
                     /db_xref="GeneID:162517"
                     /db_xref="HGNC:HGNC:28565"
                     /db_xref="MIM:609106"
     exon            1..58
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /inference="alignment:Splign:2.1.0"
     exon            59..1161
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1467
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /codon_start=1
                     /product="F-box only protein 39"
                     /protein_id="NP_694962.1"
                     /db_xref="CCDS:CCDS11082.1"
                     /db_xref="GeneID:162517"
                     /db_xref="HGNC:HGNC:28565"
                     /db_xref="MIM:609106"
                     /translation="MDEESELIQPQDQSCWAFLPDLCLCRVFWWLGDRDRSRAALVCR
                     KWNQMMYSAELWRYRTITFSGRPSRVHASEVESAVWYVKKFGRYLEHLEVKFMNPYNA
                     VLTKKFQVTMRGLLSCLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKM
                     GKRLDYLNLKGARLTVEQGCQILDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKK
                     TMSTFHNLVSLNLNYNCISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKL
                     ARQATNLKVNFFFERIMKYERLARILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLLP
                     TFRHTLQKLTCEFNNNHESLDEELHLLIISCRKLFYFKIWAFLDVSFVERILKSQKER
                     QCALRVFKARIYTNRYETNEEDKTLQEIYRKYRKLIESELSYFVIVYSVM"
     exon            1162..1338
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1685
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1685
                     /gene="FBXO39"
                     /gene_synonym="CT144; FBOX39; Fbx39"
                     /note="major polyA site"
ORIGIN      
        1 gcagacccgg ggcgcccatg gagttggcgt cggagcaaca gctgcgcggg cggagcagaa
       61 agcaagtgat tgctttcctt tcctcatttt tggaagccct gcctaacaca cagctgcact
      121 gtacatccca gttcctggat ggacgaagaa agtgaactga tccagcccca agaccagagc
      181 tgctgggcct ttctgcccga tttgtgtctg tgccgtgttt tctggtggct aggagacagg
      241 gacaggtcca gggctgctct tgtctgcaga aagtggaacc agatgatgta ttctgctgag
      301 ctctggcggt acagaaccat caccttcagc gggagacctt ccagggtaca tgcatctgaa
      361 gttgagtcag ctgtttggta tgttaagaag tttggtcgtt atctggagca cctggaggtc
      421 aaattcatga atccttacaa tgctgtcttg accaagaagt tccaggtcac catgcggggc
      481 ctcctgtctt gtctgagtaa gagcaacaac cgtctgaaat ctctttccat ccaatacctg
      541 gagctggacc gcctggtatg gaggaacagc atcaggagct cattcatcag cagcttgagc
      601 ttcttcttaa agaagatggg caaacgcctg gattatctca acctaaaagg ggccaggctg
      661 accgtggagc aaggctgcca aattctcgac tccctcagct acatgaggaa tgagaatgtg
      721 atctcagagc tcaacatcga ggactatttc agccatcacc ttgctgtcta caacagcccc
      781 cagttcaaaa agaccatgtc cacattccac aatcttgtgt ccctgaacct caactacaac
      841 tgtatctccg acgagctgct tgagaacttg tgtgagaatg ccagcaccct ccggaccatc
      901 aacatcaaat gccacgttca tgacccccac ggacaggtca tctggggtat gtcctgggcc
      961 aagctggcca ggcaggccac caatctgaag gtgaacttct tctttgaacg gatcatgaag
     1021 tacgaacgct tggcccgaat cctcttgcag gagatcccga tcaggagcat cagtctgaga
     1081 agctgctatt tcagtgaccc agactgttca atgagaccca ctctgataga tctcctgccc
     1141 accttccggc acactctgca gaaattaact tgtgaattca acaacaacca tgagtcactc
     1201 gacgaggagc tgcacctcct catcatatcc tgcaggaagt tgttttactt caaaatctgg
     1261 gctttccttg atgttagttt tgtggagcgg atcctgaaga gtcagaaaga acggcagtgt
     1321 gccctgcgtg tattcaaggc gagaatttat acaaacagat atgagacgaa tgaagaggac
     1381 aagaccctgc aggaaattta caggaagtac agaaagctga tcgaatcaga gcttagctat
     1441 tttgtcatcg tttactctgt gatgtaatga gcactctaca gatgaagaaa gctgggagca
     1501 ctttgaactt gaaaatcatt tctcttagaa ctacacttgg gcactgccgg cccttttgct
     1561 cctctctctc ccctccactt tttttttttg tcagctccat gacaacatga ccagctcagc
     1621 aaaggctgag actgcccatg acctgaaggc tccaggtggc tttaaagcgc tatgtttacc
     1681 aacta
//
