LOCUS       NM_205836               4401 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens F-box protein 38 (FBXO38), transcript variant 2, mRNA.
ACCESSION   NM_205836 XM_005268513
VERSION     NM_205836.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4401)
  AUTHORS   Pegat,A., Chanson,J.B., Lozeron,P., Joubert,B., Bani-Sadr,A.,
            Quadrio,I., Vidoni,L. and Latour,P.
  TITLE     Identification of rare variants in the FBXO38 gene of patients with
            chronic inflammatory demyelinating polyradiculoneuropathy
  JOURNAL   J Neuroimmunol 392, 578381 (2024)
   PUBMED   38823119
  REMARK    GeneRIF: Identification of rare variants in the FBXO38 gene of
            patients with chronic inflammatory demyelinating
            polyradiculoneuropathy.
REFERENCE   2  (bases 1 to 4401)
  AUTHORS   Wu,Y., Lin,Y., Shen,F., Huang,R., Zhang,Z., Zhou,M., Fang,Y.,
            Shen,J. and Fan,X.
  TITLE     FBXO38 deficiency promotes lysosome-dependent STING degradation and
            inhibits cGAS-STING pathway activation
  JOURNAL   Neoplasia 49, 100973 (2024)
   PUBMED   38277817
  REMARK    GeneRIF: FBXO38 deficiency promotes lysosome-dependent STING
            degradation and inhibits cGAS-STING pathway activation.
REFERENCE   3  (bases 1 to 4401)
  AUTHORS   Zheng,X., Jiang,Q., Han,M., Ye,F., Wang,M., Qiu,Y., Wang,J.,
            Gao,M., Hou,F. and Wang,H.
  TITLE     FBXO38 regulates macrophage polarization to control the development
            of cancer and colitis
  JOURNAL   Cell Mol Immunol 20 (11), 1367-1378 (2023)
   PUBMED   37821621
  REMARK    GeneRIF: FBXO38 regulates macrophage polarization to control the
            development of cancer and colitis.
REFERENCE   4  (bases 1 to 4401)
  AUTHORS   Saferali,A., Yun,J.H., Parker,M.M., Sakornsakolpat,P., Chase,R.P.,
            Lamb,A., Hobbs,B.D., Boezen,M.H., Dai,X., de Jong,K., Beaty,T.H.,
            Wei,W., Zhou,X., Silverman,E.K., Cho,M.H., Castaldi,P.J. and
            Hersh,C.P.
  CONSRTM   COPDGene Investigators; International COPD Genetics Consortium
            Investigators
  TITLE     Analysis of genetically driven alternative splicing identifies
            FBXO38 as a novel COPD susceptibility gene
  JOURNAL   PLoS Genet 15 (7), e1008229 (2019)
   PUBMED   31269066
  REMARK    GeneRIF: Study found that a COPD associated alternative splicing
            variant of previously unknown function may contribute to the
            inclusion of a new exon in the FBXO38 gene.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4401)
  AUTHORS   Georges,A., Coyaud,E., Marcon,E., Greenblatt,J., Raught,B. and
            Frappier,L.
  TITLE     USP7 Regulates Cytokinesis through FBXO38 and KIF20B
  JOURNAL   Sci Rep 9 (1), 2724 (2019)
   PUBMED   30804394
  REMARK    GeneRIF: USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4401)
  AUTHORS   Shang,D., Dong,L., Zeng,L., Yang,R., Xu,J., Wu,Y., Xu,R., Tao,H.
            and Zhang,N.
  TITLE     Two-stage comprehensive evaluation of genetic susceptibility of
            common variants in FBXO38, AP3B2 and WHAMM to severe chronic
            periodontitis
  JOURNAL   Sci Rep 5, 17882 (2015)
   PUBMED   26643602
  REMARK    GeneRIF: Our findings provide direct evidence for the association
            of FBXO38 and AP3B2 with severe chronic periodontitis in the Han
            Chinese population.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4401)
  AUTHORS   Sumner,C.J., d'Ydewalle,C., Wooley,J., Fawcett,K.A., Hernandez,D.,
            Gardiner,A.R., Kalmar,B., Baloh,R.H., Gonzalez,M., Zuchner,S.,
            Stanescu,H.C., Kleta,R., Mankodi,A., Cornblath,D.R., Boylan,K.B.,
            Reilly,M.M., Greensmith,L., Singleton,A.B., Harms,M.B., Rossor,A.M.
            and Houlden,H.
  TITLE     A dominant mutation in FBXO38 causes distal spinal muscular atrophy
            with calf predominance
  JOURNAL   Am J Hum Genet 93 (5), 976-983 (2013)
   PUBMED   24207122
REFERENCE   8  (bases 1 to 4401)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J Dent Res 91 (7 Suppl), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   9  (bases 1 to 4401)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 4401)
  AUTHORS   Smaldone,S., Laub,F., Else,C., Dragomir,C. and Ramirez,F.
  TITLE     Identification of MoKA, a novel F-box protein that modulates
            Kruppel-like transcription factor 7 activity
  JOURNAL   Mol Cell Biol 24 (3), 1058-1069 (2004)
   PUBMED   14729953
  REMARK    GeneRIF: This publication identifies the F-box protein 38 mouse
            ortholog and characterizes its interaction with KLF7 during
            regulation of cell cycle progression.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091948.3 and AC114939.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_205836.2.
            
            Summary: This gene encodes a large protein that contains an F-box
            domain and may participate in protein ubiquitination. The encoded
            protein is a transcriptional co-activator of Krueppel-like factor 7
            (Klf7). A heterozygous mutation in this gene was found in
            individuals with autosomal dominant distal hereditary motor
            neuronopathy type IID. There is a pseudogene for this gene on
            chromosome 4. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.46644.1,
                                           SRR1660807.18548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340253.10/ ENSP00000342023.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC091948.3         133768-133849
            83-273              AC091948.3         144524-144714
            274-407             AC091948.3         148809-148942
            408-571             AC091948.3         151792-151955
            572-737             AC091948.3         152158-152323
            738-875             AC091948.3         154495-154632
            876-1013            AC091948.3         156067-156204
            1014-1107           AC091948.3         158934-159027
            1108-1238           AC091948.3         160445-160575
            1239-1409           AC091948.3         163946-164116
            1410-1552           AC091948.3         165738-165880
            1553-1763           AC091948.3         166804-167014
            1764-1883           AC114939.2         29880-29999
            1884-2063           AC114939.2         31404-31583
            2064-2798           AC114939.2         33095-33829
            2799-2899           AC114939.2         39306-39406
            2900-3002           AC114939.2         39517-39619
            3003-3169           AC114939.2         44214-44380
            3170-3315           AC114939.2         45529-45674
            3316-3419           AC114939.2         46306-46409
            3420-3533           AC114939.2         47006-47119
            3534-4401           AC114939.2         47851-48718
FEATURES             Location/Qualifiers
     source          1..4401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4401
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /note="F-box protein 38"
                     /db_xref="GeneID:81545"
                     /db_xref="HGNC:HGNC:28844"
                     /db_xref="MIM:608533"
     exon            1..82
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            83..273
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3712
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /note="isoform b is encoded by transcript variant 2; F-box
                     only protein 38; modulator of KLF7 activity homolog"
                     /codon_start=1
                     /product="F-box only protein 38 isoform b"
                     /protein_id="NP_995308.1"
                     /db_xref="CCDS:CCDS4290.1"
                     /db_xref="GeneID:81545"
                     /db_xref="HGNC:HGNC:28844"
                     /db_xref="MIM:608533"
                     /translation="MGPRKKSVKTCIMNNEIPEEMTADETKDYMNQLSHEVLCHIFRY
                     LPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDASFLTLLKKMP
                     DVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMP
                     HVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWV
                     RLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLG
                     GLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKD
                     GVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGM
                     KAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIE
                     LLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDDNNAQNNNANI
                     HDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHS
                     QAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSE
                     REEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIK
                     ADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHNTASQSPDFVRTVNSGGSSEPS
                     PTEVDVSRQCACSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPS
                     TSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCD
                     VQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIED
                     DHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNR
                     FDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICII
                     HEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIY
                     TLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADIC
                     METIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI"
     exon            274..407
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            408..571
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            572..737
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            738..875
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1013
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1107
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1238
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1409
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1552
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1763
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1883
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2063
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2798
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2899
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3002
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3169
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3315
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3419
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3533
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..4401
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4107..4112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /note="hexamer: AGTAAA"
     polyA_site      4126
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /note="major polyA site"
     regulatory      4379..4384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
                     /note="hexamer: AATAAA"
     polyA_site      4401
                     /gene="FBXO38"
                     /gene_synonym="Fbx38; HMN2D; HMND6; MOKA; SP329"
ORIGIN      
        1 agtgcctcag cggtaggggc cggggaagtg tctgtagcgt ccctccctct caaccacaat
       61 aacaggcgga gggtcggcgt aggtactttg aactcaagta aacaaaaggg aagattttct
      121 cgttgatact ggagactgca caacaatggg gccacgaaag aaaagtgtga aaacatgtat
      181 catgaataat gaaattccag aagaaatgac agcagatgaa acaaaggact atatgaatca
      241 actttcacat gaagtacttt gccatatttt taggtacctc cctctgcagg atatcatgtg
      301 tatggaatgt ctttcccgga agctaaagga agcagtgacc ctatatctgc gagttgtgag
      361 agttgtagat ctctgtgcag ggcggtggtg ggaatacatg ccaagtggct ttacagatgc
      421 cagttttcta acactattaa agaagatgcc agatgttgaa cagctatatg gccttcaccc
      481 tcgatacctt gagaggcgaa gagtaagggg ccatgaggct tttagcattc caggagtcct
      541 agaagctttg caggcatgcc caaacttagt gggtgtggaa acttctcatt tggagttggt
      601 agaatccatt tggacatata tgccccatgt tcatattttg gggaaatttc gtaatcgtaa
      661 tggagctttt ccaattcctc ctgaaaataa actgaaaatt cctataggag ccaaaattca
      721 aactttacat ttagttgggg tgaatgttcc tgaaattcct tgtatcccaa tgctaaggca
      781 cctttatatg aagtgggtaa gactcactaa accacagcca tttaaagact tcctttgtat
      841 cagcttaaga actttcgtca tgaggaactg tgcaggaccc acaaattcct tgaaatatgt
      901 ccctttagta acaggcttag cctctgcccg aaacttggaa cacttagaaa tggttcgagt
      961 tcctttcctt ggaggtctta tccaacatgt tgttgaagac agttggagat caggtggttt
     1021 tagaaatttg cacactattg ttctgggagc ttgcaaaaat gctcttgaag tagatcttgg
     1081 ttacctcatc attactgctg cccgtaggtt acatgaagtt cggatccagc cttccctaac
     1141 caaagatggt gtcttttctg ccctaaagat ggcagagttg gagtttcccc agtttgaaac
     1201 ccttcatcta ggatatgtag atgagttttt gctacagagc agaatggcta atgcggatct
     1261 ggtgaagtat ggtttggctg atgtggtaga aaatcctggt atcatcactg atatagggat
     1321 gaaagcagtc aatgaagttt tttcctgtat caaatatctg gcaatttaca attgccctca
     1381 tctacacaac ccatacaatt ggatctcaga ccactcaaga tggactcgat tggttgatat
     1441 caacctagta cggtgccatg ctttgaagct ggactctttt ggccagttta ttgaattatt
     1501 acccagccta gagtttattt cactggatca gatgtttcgt gaaccaccca agggttgtgc
     1561 tcgagttggt ctgagtgcag gcacaggaat tggtgtttca tcagctcttg ttagcaacca
     1621 gaactccaac aatgacgata ataatgccca gaataacaat gccaacatcc acgacaacaa
     1681 tcaccatcat ccagatgact cagacgagga gaatgacttt cggcaagatc tgcagccagg
     1741 agagcagcag tttgcagctg acgcattaaa tgagatggaa gacatcgtcc aagaagatgg
     1801 agaggtggtg gccgagagtg gaaataatac tccagctcac agccaggcaa ttattcctgt
     1861 ggatgttgat gaggaacaag caggacccag tggtcttcag cgtgtagtaa aaccaacctc
     1921 aattactgtt catgattcag agagtgatga tgaagaagat agtctagaac tccaagaagt
     1981 ctggattcct aagaacggta ctcggcgtta ctctgaacgt gaagaaaaaa ctggagagtc
     2041 agtgcagtcc agagaattgt cagtaagtgg aaaaggcaag actccacttc gaaagaggta
     2101 caactcccat cagatgggcc agtcgaagca gtttcccctc gaggaaagca gctgtgagaa
     2161 aggctgtcag gtcaccagtg agcagatcaa agccgatatg aaagcagcta gggatattcc
     2221 tgaaaagaaa aaaaacaagg atgtttatcc cagctgcagc agcaccaccg ccagcacagt
     2281 gggaaactcc agctcacaca acactgcttc tcaaagcccc gactttgtaa ggacggtgaa
     2341 cagcggcggc tcttccgagc ctagccctac agaagtggat gtgtccaggc agtgtgcctg
     2401 ctcccccggt gggtcagagg actctgaggc catggaggag ggagatgcag agagttctgt
     2461 ctgccccaga tgctgctgtc acaggcccca ggaatcccaa aggagaacta gcaggtgttc
     2521 tgatgaggaa cgtccttcaa ccagccgagc ctgtgttgtg aatggcccgg atggtacgag
     2581 atccgccttt tcctttagga ctctgccaca aggggggtct tcaggcccag cacatgatga
     2641 gaggactaat gggagtggct ctggggctac aggtgaggac aggaggggga gctcccagcc
     2701 tgagagttgt gacgtgcagt ctaatgaaga ctaccctcgg aggcccctaa ccagggccag
     2761 gagcagactg tcccatgtac tgctggtatc tgagtcagaa gtagccaaaa caaagccacg
     2821 tcacgccatg aaacggaagc ggacagcaga taaatccact agtacaagtg atcctgtgat
     2881 cgaggatgac catgtgcagg ttcttgtatt aaaatccaag aatcttgttg gagtcactat
     2941 gaccaattgt ggaatcacag atctagtgct aaaagactgt ccaaagatga tgttcatcca
     3001 tgctaccagg tgcagggtac taaaacattt aaaggtagaa aatgcaccaa ttgtaaaccg
     3061 atttgactat gcacagtgca agaaactgaa catggatcag gtactagacc agatactaag
     3121 aatgccaccc gagagaaacc gcatcatata cctacgccca atgcagcagg tggacactct
     3181 aactttggag cagaagctat ttagtggtcc ctacccctat cacatctgta ttatccatga
     3241 attcagtaac cctcccaatg tccggaataa ggtgcgcatt cgcagctgga tggacactat
     3301 agcaaacatc aatcaagagc tcattaaata tgaattcttc cctgaagcca ctcgaagtga
     3361 agaagactta aagaaatacc ccaagtaccc ctgggggaga gaaatctata ctttagaagg
     3421 tgttgtggat ggagctccat attccatgat ttctgacttc ccttggctga ggtcattacg
     3481 agctgcagag cccaacagct tcgctcgata cgactttgaa gacgatgaag aaagcactat
     3541 ctatgctcct agaaggaaag gacagctgtc tgcagacatc tgtatggaaa caataggaga
     3601 ggaaatttca gagatgcgtc agatgaagaa gggtgtattt cagcgagtag tggcaatttt
     3661 tatccactat tgtgatgtca atggagagcc agttgaagat gactacattt aattggtccc
     3721 tcctcctttc cagctatttt gtcagaaagc aagtagggcc atccagctgc cagagtgctc
     3781 cacagggact tgaggcatgc agttgggagg tcctggctcg gtttgctata tagggaatat
     3841 ataaggaaca tcgaaattgt atacaaagat ttgtacataa aaaatataca aagacgcttc
     3901 ctaaagtacc aactttatat catatgttta tacaatttaa tttaaaaatt cattttaagg
     3961 aagacagata atttgaaaga cttttgtttt tcttgactta attcatgaag tatcattttt
     4021 tgactgagtc tccatttact tcattcttaa tgattattgt catcccttta aatctgtgcc
     4081 tttttcttct tgagcgaagc tgtttgagta aacctgttga agagtgtttg tgtcttttgt
     4141 gcttttttgt tgttattaaa acaccaacta aaccttatag tcaagacaag gctctatgtt
     4201 tctgtacaaa gctgtagttc tttcttagta ttatagttgc catgtttctt aaaatcaagt
     4261 aaaaagactt atgagcttaa aaaaaagtga gtttgagagg gaaatggaaa agtttccaga
     4321 gtatttctag taatttattt ccacattgaa ttgtgtatat gctttatctt gaatataaaa
     4381 taaaagttta ttaaaaactt t
//
