LOCUS       NM_174899               2813 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 36 (FBXO36), mRNA.
ACCESSION   NM_174899
VERSION     NM_174899.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2813)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017869.1, BC033935.1, AK123085.1, AC009973.10 and BM997950.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174899.4.
            
            Summary: Members of the F-box protein family, such as FBXO36, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.52603.1,
                                           SRR1660809.214853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283946.8/ ENSP00000283946.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               BC017869.1         13-228
            217-268             BC033935.1         222-273
            269-1309            AK123085.1         586-1626
            1310-2737           AC009973.10        197621-199048
            2738-2803           BM997950.1         18-83               c
            2804-2813           AC009973.10        199115-199124
FEATURES             Location/Qualifiers
     source          1..2813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..2813
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /note="F-box protein 36"
                     /db_xref="GeneID:130888"
                     /db_xref="HGNC:HGNC:27020"
                     /db_xref="MIM:609105"
     exon            1..107
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..578
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /codon_start=1
                     /product="F-box only protein 36"
                     /protein_id="NP_777559.3"
                     /db_xref="CCDS:CCDS2472.1"
                     /db_xref="GeneID:130888"
                     /db_xref="HGNC:HGNC:27020"
                     /db_xref="MIM:609105"
                     /translation="MASWLPETLFETVGQGPPPSKDYYQLLVTRSQVIFRWWKISLRS
                     EYRSTKPGEAKETHEDFLENSHLQGQTALIFGARILDYVINLCKGKFDFLERLSDDLL
                     LTIISYLDLEDIARLCQTSHRFAKLCMSDKLWEQIVQSTCDTITPDVRALAEDTGWRQ
                     LFFTNKLQLQRQLRKRKQKYGNLREKQP"
     exon            108..216
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /inference="alignment:Splign:2.1.0"
     exon            217..389
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /inference="alignment:Splign:2.1.0"
     exon            390..2813
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /note="hexamer: ATTAAA"
     polyA_site      2813
                     /gene="FBXO36"
                     /gene_synonym="Fbx36"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcccaa gatggcgtcg tggctgccgg agactctctt tgaaactgta ggacaaggcc
       61 cgccgcctag caaagactat taccagttac tggtcacccg gtctcaggta atctttagat
      121 ggtggaagat ctctctaagg agtgagtatc gatcaacaaa acctggagaa gcaaaagaaa
      181 cccatgaaga cttcctagag aattcacatc ttcaaggtca aactgcctta atatttggtg
      241 caagaatatt agactatgtc atcaatttgt gcaaaggtaa atttgacttc cttgaacggc
      301 tctcagacga tttgctcctg actatcattt cttatctgga tcttgaagat attgccaggc
      361 tttgtcaaac atcacacaga tttgcaaagc tgtgcatgtc tgataaactg tgggaacaga
      421 tagtccagtc gacctgcgac accatcactc ctgacgtgag ggccctggcg gaggacacag
      481 gctggagaca gctgttcttc accaacaagc tccagctcca gcggcagctc cgcaagagga
      541 aacaaaaata tggaaacctg agagaaaagc aaccttaggc acacattttc ctaccagcag
      601 ggagctcagg catggctgtg tttctcttca gtgtccaaat ctcttctgtc tccttttctt
      661 aagaactaag aggttttgtt gatgcgtgga gccatttgaa actcgtaggg gatttgcaca
      721 caaatgcagc agagtctggc tccccagtgc cttgctagag tcaccgtcat tctgaggtca
      781 aatcatggcc cgaggacaag ggctgtaaga cagggagccc cataggccat catcatcctt
      841 atcccacacc cattataaaa gaggtttcta ttgtatataa acaaacaata aatgattatt
      901 agcaggtttt tattagacat ctattttatc taggcattag aaagggtaat ggggcttttg
      961 aattttttcc tggcattgtg tcgtctgcgt ccagccatga agctggtggc tgagtgtccc
     1021 caccaggaac tgtgaagggc acgtaccacg ggaggcactc agggtgggtg cagctgcctt
     1081 cccaactttg ttctgctaag tccatattca gggccctatc cttgtgagcc caggatgcca
     1141 gggtccatcc ccgcatgtag acagcttccg acctggtgct ggagcatgac tggagaagtg
     1201 caggcatcct gcttgcggac cttgctcaaa gtacaacttc ccaggactac ttcacattgt
     1261 taaataaacc tataaacatt tcttttcttt tctttttttt tttttttttg tattttcttt
     1321 ttagtagagg tggagtttcg ccatgtaggc caggctggtc ttgaactcct gacctcaagt
     1381 gatctacctg ctctggcttc caaagtgctg ggattacagg catgagccac tatgtctggc
     1441 taaaacctat aaacatttct tagagaaatg ctgttcccca aaggaatgtg aacagctacc
     1501 acttttaaca aggatattta agaaaacaga ctatgagtta actaagtaaa aatgtaaata
     1561 tggtttgcat gctgttaaca tggcagaggg gtaaaaagaa tacagtcctg gggagaaagg
     1621 tcacttcact gagaaggctt acttaaaaat gtttttctcc ctgcactttc atgattatta
     1681 agtaccccta gaaaatgaac tcatagcagc aaataatcta atgactcctt ttaggttaca
     1741 gagcaaagta gctttctact tccacatcac attataatat agccttataa tttcttcttt
     1801 cctgcaacct tcactttcct acctaggaaa actcacctcc ggtgccagag aaacttccca
     1861 ggatgcacta gggccctgtg aacaatacag aagttgtgga ctctggctct ttgtcccacc
     1921 taagtccttc cagaagggct ctacagcatg gcttagtgac attaaaaaaa aaaactgaac
     1981 ccatgttaat atcaaacaag attttaatct tcattcacac acccttaaaa cccagtcacg
     2041 gggctccccg gtgccagttt gagaccgtca acctagccct ctctgcttct cattgctgga
     2101 ggtacacaca gtcaaaagtt ttccgtgact gtgaaatcca gtgcaatctg cttcccagca
     2161 gatgaggagc ctgacgtggt tatgtctgga tttagtccaa gaacagagca aagctttaat
     2221 tgtcaagaga cccaggcctc attctccact taggagagtt tgctagggca ggtacaggta
     2281 aaggtaacca gcaggcagct gagagcaaga aggcacgtgc tctgcagagc tctagctgcc
     2341 ttggctctcc ctgagctccc agacttcact catggcctaa ttttcaatga cagaacgtag
     2401 gttttatcgt gaggatgcag acacaaccac aattacgtat gtcaacataa cttcataaat
     2461 atgtaactgt aacttattgg taacatcagt gcaagatgat taaagcttca tgtgtagtat
     2521 tttatcaaca aacagattct gaaagcttat ggacatgcgc aatagttgat tcagcttcaa
     2581 tcaataagaa cataaatatg gcaatttgaa aacactatgt atatacctac tcacatatat
     2641 attatactta cgatatatac ttatatgtag tatataataa tattacatat aaaaatgtta
     2701 taaaaataaa tgctaaagta aataaaaaaa gagccattaa tatgttaact attgttaaat
     2761 aatagctaaa ataatacaga ttattaaatt attttaatac ttacttgcca taa
//
