LOCUS       NM_017943               3348 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens F-box protein 34 (FBXO34), transcript variant 1, mRNA.
ACCESSION   NM_017943
VERSION     NM_017943.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Yang,X., Zhao,X., Zhu,Y., Xun,J., Wen,Q., Pan,H., Yang,J., Wang,J.,
            Liang,Z., Shen,X., Liang,Y., Lin,Q., Liang,H., Li,M., Chen,J.,
            Jiang,S., Xu,J., Lu,H. and Zhu,H.
  TITLE     FBXO34 promotes latent HIV-1 activation by post-transcriptional
            modulation
  JOURNAL   Emerg Microbes Infect 11 (1), 2785-2799 (2022)
   PUBMED   36285453
  REMARK    GeneRIF: FBXO34 promotes latent HIV-1 activation by
            post-transcriptional modulation.
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC109120.1 and AI911690.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017943.3.
            
            Summary: Members of the F-box protein family, such as FBXO34, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring and longer transcript. Variants 1 and 2 both encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.163937.1,
                                           SRR1660803.223150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313833.5/ ENSP00000313159.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2914              BC109120.1         51-2964
            2915-3348           AI911690.1         3-436               c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..3348
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /note="F-box protein 34"
                     /db_xref="GeneID:55030"
                     /db_xref="HGNC:HGNC:20201"
                     /db_xref="MIM:609104"
     exon            1..117
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /inference="alignment:Splign:2.1.0"
     exon            118..3348
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2263
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /note="protein CGI-301"
                     /codon_start=1
                     /product="F-box only protein 34"
                     /protein_id="NP_060413.2"
                     /db_xref="CCDS:CCDS32086.1"
                     /db_xref="GeneID:55030"
                     /db_xref="HGNC:HGNC:20201"
                     /db_xref="MIM:609104"
                     /translation="MHLKPYWKLQKKEHPPEVSRETQRTPMNHQKAVNDETCKASHIT
                     SSVFPSASLGKASSRKPFGILSPNVLCSMSGKSPVESSLNVKTKKNAPSATIHQGEEE
                     GPLDIWAVVKPGNTKEKIAFFASHQCSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKA
                     KVQVERMREVNSRCYQPEPFACGIEHCSVHYVSDSGDGVYAGRPLSVIQMVAFLEQRA
                     SALLASCSKNCTNSPAIVRFSGQSRGVPAVSESYSAPGACEEPTERGNLEVGEPQSEP
                     VRVLDMVAKLESECLKRQGQREPGSLSRNNSFRRNVGRVLLANSTQADEGKTKKGVLE
                     APDTQVNPVGSVSVDCGPSRADRCSPKEDQAWDGASQDCPPLPAGVSFHIDSAELEPG
                     SQTAVKNSNRYDVEMTDELVGLPFSSHTYSQASELPTDAVDCMSRELVSLTSRNPDQR
                     KESLCISITVSKVDKDQPSILNSCEDPVPGMLFFLPPGQHLSDYSQLNESTTKESSEA
                     SQLEDAAGGDSASEEKSGSAEPFVLPASSVESTLPVLEASSWKKQVSHDFLETRFKIQ
                     QLLEPQQYMAFLPHHIMVKIFRLLPTKSLVALKCTCCYFKFIIEYYNIRPADSRWVRD
                     PRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHRSQKGFPGCKLGL
                     HDNHWVPACHSFNRAIHKKAKGTEAEEEY"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /note="hexamer: AATAAA"
     polyA_site      3348
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /note="major polyA site"
ORIGIN      
        1 gctcggtccg actcagcggt ggggagtgag ccaggcctcc cgccaccgct gctgccgcca
       61 ccactgcgtc gggctggtgc agccccgggc caggccgcgg ccggggcagg agcgcagggg
      121 ctttgttatg cacctaaagc catattggaa gctccagaag aaagagcacc ccccggaagt
      181 cagcagggaa acgcagagaa ctcctatgaa ccaccaaaag gctgtaaatg atgaaacatg
      241 caaagctagc cacataacat caagtgtctt tccttcagcc tctctcggta aagcatcatc
      301 tcgaaagcca tttgggatcc tttctccaaa tgttctgtgc agtatgagtg ggaagagtcc
      361 tgtagagagc agcttgaatg ttaaaaccaa aaagaatgca ccatctgcaa cgatccacca
      421 gggcgaagaa gaaggaccac ttgatatctg ggctgttgtg aaacctggaa ataccaagga
      481 aaaaattgca ttctttgcat cccaccagtg tagtaacagg ataggatcta tgaaaataaa
      541 aagttcctgg gatattgatg ggagagctac taagagaagg aaaaaatcag gggatcttaa
      601 aaaagccaag gtacaggtgg aaaggatgag ggaggttaac agcaggtgct accaacctga
      661 gccttttgca tgtggcattg agcactgttc tgtgcactat gtgagtgaca gtggggatgg
      721 agtctatgct gggaggcctc tgtcagttat acagatggtt gccttcttgg agcaaagagc
      781 cagtgctctg ctagctagct gttcaaaaaa ctgcacaaac tcacctgcaa ttgtgaggtt
      841 ttctggccaa tccagaggtg tgcctgcagt gtctgagtcc tattctgccc caggagcttg
      901 tgaagaaccc acagaaaggg gaaatcttga ggttggtgaa ccacagagcg aaccagtccg
      961 tgtccttgac atggtagcca agttggagtc tgagtgcctg aagcggcagg gccagcgtga
     1021 gcctgggagc ctctcaagga ataacagctt ccgtcgaaat gtgggcagag tattgcttgc
     1081 aaatagcact caggctgatg aaggcaaaac aaagaaaggc gtcttggagg cacctgacac
     1141 tcaggtgaat cctgtggggt ctgtatctgt ggattgtggc ccttcaagag ctgatcgttg
     1201 ttctcctaag gaggaccagg cctgggacgg tgcttctcag gactgccccc cattgccagc
     1261 aggagtgagt ttccacatag acagtgcaga gttagagccg ggttcgcaaa ctgccgtgaa
     1321 aaacagcaac agatatgatg tggaaatgac agatgaactc gttgggttac ctttttcctc
     1381 tcatacctat tcccaagcct ctgaattgcc cacagatgct gttgattgta tgagcagaga
     1441 gcttgtgtcc cttactagcc gaaatcctga tcaaagaaaa gaatctttgt gcattagtat
     1501 cactgtgtcc aaggtagaca aagaccagcc ttccatttta aactcctgtg aagacccagt
     1561 tccagggatg ttgttttttt tgccacctgg tcagcacttg tcagactatt cccagttgaa
     1621 tgaaagcaca acaaaagagt cttcagaggc cagccagctt gaagatgctg ctgggggtga
     1681 cagtgcatct gaggaaaaaa gtgggtctgc tgagccattt gtactgccag cctcttctgt
     1741 ggaaagtaca ttaccagtgc ttgaggcatc cagttggaag aagcaggtgt cgcatgactt
     1801 cctggagacc aggtttaaaa tccagcagct tttggagcct cagcagtaca tggcttttct
     1861 gccccaccac attatggtaa aaatcttcag gttacttccc accaagagtt tagtggccct
     1921 taaatgtacc tgctgctatt tcaagtttat cattgagtac tacaatatca ggccagcaga
     1981 ttctcgctgg gttcgagatc cacgctatag agaggatcct tgcaaacagt gcaagaaaaa
     2041 gtatgtgaaa ggggatgtgt ccctgtgccg atggcacccc aagccctatt gccaggcatt
     2101 gccctatggg ccagggtatt ggatgtgctg ccaccggtct cagaaaggat tccctggctg
     2161 taagctgggg cttcatgaca atcactgggt tcctgcctgc cacagcttta atcgggcaat
     2221 ccataagaaa gcaaaaggga ctgaagctga agaggaatac taaagtccat gtgagaggca
     2281 acaaaaggac cggtttctaa agctgcaaaa cacctagata caccgttcaa atgagcgtag
     2341 ccccctgagt catcactcta gaagaatctg tacatcatca ggactgcatt gctcaggcat
     2401 tttctaaact ctaaatttac gagctgtaca aaaaaattgg tcttgttgtt tatagtggca
     2461 tctcatgttt gaacccgggt ggtatcccac agttggattc agttggctgt gaataactgc
     2521 ctgttttcct aaatcaaacc catcctcaaa ggatgaagac tcaccaccat ccaggacatt
     2581 cagaagagtt cactgcagat gctgcaggta gtcctcaaaa atgggttcca gaaatgtttt
     2641 gagcactggc aacatatttg aaataagtga atattgtcct gtgaaaagaa tagcaggact
     2701 tttagatgaa aagtattctt aaaaagaaaa gtcaggcacc ccaccttaga cctcgtatgc
     2761 ttgatcctgt gagattgatg tttgtggctg gaggtggatt tcatgccctg tggtgtttac
     2821 agtgtatata atggttgtgt tttcatgggg ctatgaaagt gcacgttaaa cctgagcgcc
     2881 tttaccttta gatgagtgct ttggcccctc tgtgaatagc acgattaaaa tccagttgta
     2941 tataatggac agctaacgga acaatataat caccacaatg cagctaggat agtgttgcgg
     3001 ctataatttt gtgttttttt tttttaattg tctagtctta aatttgtaca tcttgtataa
     3061 aatatgaatg tttcccaaat aaactatgaa tgtttcctgt ataatatatg aatgtttctg
     3121 agaagaaact ctaaatagtt gaaaggctaa cctgctcaaa ggataccaaa taatggttta
     3181 actggacaac ctgaaaatta gcatagaaaa caatcctttg ttatatttta gtgatccaca
     3241 agattgagaa aatattatat agttagataa taacattctt gtctacttta tcctgtctgg
     3301 ttacaaaatt ttttaaaact taaataaaaa catgcatctt aaatggaa
//
