LOCUS       NM_203301               3771 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens F-box protein 33 (FBXO33), mRNA.
ACCESSION   NM_203301
VERSION     NM_203301.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3771)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3771)
  AUTHORS   Kulminski,A.M., Loika,Y., Nazarian,A. and Culminskaya,I.
  TITLE     Quantitative and Qualitative Role of Antagonistic Heterogeneity in
            Genetics of Blood Lipids
  JOURNAL   J Gerontol A Biol Sci Med Sci 75 (10), 1811-1819 (2020)
   PUBMED   31566214
  REMARK    GeneRIF: Quantitative and Qualitative Role of Antagonistic
            Heterogeneity in Genetics of Blood Lipids.
REFERENCE   3  (bases 1 to 3771)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   4  (bases 1 to 3771)
  AUTHORS   Sanchez-Mora,C., Ramos-Quiroga,J.A., Bosch,R., Corrales,M.,
            Garcia-Martinez,I., Nogueira,M., Pagerols,M., Palomar,G.,
            Richarte,V., Vidal,R., Arias-Vasquez,A., Bustamante,M., Forns,J.,
            Gross-Lesch,S., Guxens,M., Hinney,A., Hoogman,M., Jacob,C.,
            Jacobsen,K.K., Kan,C.C., Kiemeney,L., Kittel-Schneider,S.,
            Klein,M., Onnink,M., Rivero,O., Zayats,T., Buitelaar,J.,
            Faraone,S.V., Franke,B., Haavik,J., Johansson,S., Lesch,K.P.,
            Reif,A., Sunyer,J., Bayes,M., Casas,M., Cormand,B. and Ribases,M.
  TITLE     Case-control genome-wide association study of persistent
            attention-deficit hyperactivity disorder identifies FBXO33 as a
            novel susceptibility gene for the disorder
  JOURNAL   Neuropsychopharmacology 40 (4), 915-926 (2015)
   PUBMED   25284319
  REMARK    GeneRIF: This study findings show tentative evidence for the
            involvement of FBXO33 in the susceptibility to adult
            attention-deficit hyperactivity disorder.
REFERENCE   5  (bases 1 to 3771)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   6  (bases 1 to 3771)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   7  (bases 1 to 3771)
  AUTHORS   Lutz,M., Wempe,F., Bahr,I., Zopf,D. and von Melchner,H.
  TITLE     Proteasomal degradation of the multifunctional regulator YB-1 is
            mediated by an F-Box protein induced during programmed cell death
  JOURNAL   FEBS Lett 580 (16), 3921-3930 (2006)
   PUBMED   16797541
REFERENCE   8  (bases 1 to 3771)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049875.2 and AL157791.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 21, 2021 this sequence version replaced NM_203301.3.
            
            Summary: This locus represents an member of the F-box gene family.
            The encoded protein contains an F-box motif and a domain that might
            form a structure similar to a leucine-rich repeat found in
            placental RNAse inhibitor. This locus may be associated with copy
            number variation of UGT2B17 (GeneID 7367), which has been
            associated with susceptibility to osteoporosis.[provided by RefSeq,
            Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053537.1, DRR138524.1223515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298097.8/ ENSP00000298097.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-870               AL049875.2         3055-3924           c
            871-981             AL157791.4         29277-29387
            982-1667            AL157791.4         29927-30612
            1668-3771           AL157791.4         32001-34104
FEATURES             Location/Qualifiers
     source          1..3771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..3771
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /note="F-box protein 33"
                     /db_xref="GeneID:254170"
                     /db_xref="HGNC:HGNC:19833"
                     /db_xref="MIM:609103"
     exon            1..870
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1939
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /codon_start=1
                     /product="F-box only protein 33"
                     /protein_id="NP_976046.1"
                     /db_xref="CCDS:CCDS9677.1"
                     /db_xref="GeneID:254170"
                     /db_xref="HGNC:HGNC:19833"
                     /db_xref="MIM:609103"
                     /translation="MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRV
                     LRGRPGAGSRRRGRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECL
                     FYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGA
                     DTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQG
                     SLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAV
                     ANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPL
                     QRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSI
                     PLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLV
                     LLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVD
                     PVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI"
     exon            871..981
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1667
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..3771
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /note="hexamer: AATAAA"
     polyA_site      3700
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /note="major polyA site"
     regulatory      3751..3756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /note="hexamer: AATAAA"
     polyA_site      3771
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
ORIGIN      
        1 accacttctc tgtctctgcc gaccggcgca gggagggctg ccttttcctt acagtacgcc
       61 ttgaggcttc cgggccgctg aagtttacga gcgagggcag tgcagttact cagtgtgccg
      121 gcctcggacg cacgtgagta gagtttgaga agacagaggc tggctcccgg caggccacgc
      181 ccgcagaggc ctttccccct ctccacaact tgtgttctac ttggttccgc cgagacccac
      241 gacggttccg cccccttctt cctagtcatt gatgttgttg ttcttgtcag tgccgcagcc
      301 ccgaccgccg ggagctcgaa cccgagccgg ggccgcccgg gtggcgcggt ggcggcggct
      361 gcggctgcag cagctgcgac ggctgcgggg gctgctccgg gtactgcggg ggcggccggg
      421 agccggcagc cggcggcggg gccggatggc tctgtgcggg caggcggcgg gcgctgcgtc
      481 gctgcccagc gagctgatcg tgcacatctt ctcttttctg ccggcgcccg accggctgcg
      541 ggcctcggcc tcctgctcgc actggcgtga gtgcctcttc tatccggccc tgtggcccca
      601 gctccgcatc tgcctccgcg tctcgcccgc ggagcagcct cggctggaat tcctcatgcg
      661 caagtgcggc tggttcgtgc gagagctgcg tgttgaattc gccgccgaga actatctgag
      721 cggcggtggc ccaggggacg gaggtggcgc ggacaccggg actggagggg aggaagtcga
      781 ggccctgcag ctctcagctc gttggctgga agtgctgcgc acctacttgg agctggtgct
      841 ttgcgtgctg gtcagcatcc ggaacaacag gaaccttcag aagtttagtc tttttggaga
      901 cataagtgtt ctacaacagc aaggaagttt gtcaaataca tacctcagca aggtggaccc
      961 tgatggcaaa aaaattaaac aaattcagca actgtttgaa gaaatcctga gtaatagtag
     1021 gcaactgaaa tggctgtcct gtgggtttat gctggaaata gtaaccccaa catcactgtc
     1081 atctctctct aatgctgttg ccaacaccat ggagcacctc agtttactgg acaataatat
     1141 tcctggtaac agcactctta ttactgcagt tgaactggag cgatttgtga atctgcactc
     1201 acttgccttg gatttttgtg actttacagc tgagatggca agagtcttaa ctgatagcaa
     1261 ccatgtgcct ttgcaacgac tgtctcttct ggttcacaat gtttctgtaa tgcacaagtc
     1321 tctggacaac atgccaaatg atgagcattg gaaagccctg tcacgaaaga gcaccagctt
     1381 tcgggtctat ataatggctt ttgatatcaa gagtgaagat atgttaaaga ttctgaaacc
     1441 cagtatacca ctagagagga ttcattttga tagctatatc acttgtgttt caggggctat
     1501 tgttgatctt atatccaggc aatatgacaa gttcctcact cattttattt taatgaatga
     1561 tgtgattgac acatctggtt ttccagatct tagtgacaac cgaaatgaag atccgttggt
     1621 tttattagca tggaggtgca caaagctctc tcttctggca attcatggtt acacggtgtg
     1681 ggcacacaac ctcattgcca ttgctcgtct tcggggctct gatctgaaag tgcttgaagt
     1741 caccgaagaa agcattgatt ttgaccaagg tgaactggcc gaccaggatg tagatccagt
     1801 gcataacctt attgagcagg tatccctggg cctgggtcaa ccttggcatg cagtcatgga
     1861 catcgaatca ctcagtgtct tcactgaacc aaatcgtcat ttttacagag agatgcaaag
     1921 cttcagtgaa gacatttagc ttttttttaa tgtagaattc ctgtggttac atatgcaagt
     1981 agggtcctat tatgtttttt tttcagtagt gtgaattaat ccttttgtgc tgtgtttaat
     2041 cagtattagc tttatagaat tatatatgta tattctactt cttgatcaaa gaacgtagtc
     2101 gggtattggt ttagaagttc aaagtgacaa tgtatagggc tttcacggtt aatggacttg
     2161 ttaccaaacc ttaaggatat acagccgaag attgtctgag gttgctggct aactttattt
     2221 ttcactgagt tactctgcct ttttgacgtt tttattcttt gtgtgtcaga gttcagagct
     2281 caggagccaa aatattttta tacatatata gatatatatc catagcctgg tagatttata
     2341 tgcaatgcac tgcatccatg cattctgata gcatttcatt aattttgatt tcaaatggaa
     2401 gataaataat atcccaaatg aattatctgt aacagaaaag ccaagacttt aactttcatt
     2461 acatatctaa tagttgatat caccagttac cattttgaat tttgtatagt actaggttag
     2521 aacattgctt aatcctttta aaaaaaatgc atttacgtaa acacgaatac tgaaattgtt
     2581 ggatttttta actatatctg acataatttt attcatcaat tacattacac attcatttag
     2641 cccagatttc aaatagtggg ggaagaaaga aactgtattt cagagtaaaa tctcctaaag
     2701 gaaataaaaa cacagagttg taaatacaca tgcttgcaaa aacattagtc gtgaaatccc
     2761 tagcaacaag tcactggatt tttctctgtc agcacgcgtg tcagctgcca aagaatagac
     2821 ttaatgaaga agtgcccaca tgctggcagg ggccggccca ctctggccag ccagatactg
     2881 ctagattgta atatttaagg tcgaatttcg acctgtggta cacagctgtg ctgtggctca
     2941 gtcagcaacc tcagaactct gaaaaaacaa aacaaaaaaa aaaaaaaaag aaaaaaaaaa
     3001 catgcacctg tttcactgtg aatagtgaat gtaaaggaaa gaaaggaaaa actgaaagct
     3061 tgttctatca caggtatgag ctgctatgat acatgaagaa cattccatga agtatgtttt
     3121 aaaaccttgt tatatctgag aggctttaaa agcctattaa ctgtttcagg gcaaccgcgg
     3181 tacagacgtg gtctctgtga gacttccacc tgaccccagt tttaagtggt acgaatgttg
     3241 tgcatttaat gttaaaggac agtctgcaat aataaagtaa gtagccaacc tgggtgccca
     3301 gcagtgctga gacctggctg ctctattgta agctttggaa acacaattta tgcaacagat
     3361 gtccagatat gattctattt atggaaaaaa gtttatatgt gttttacaaa tggttttacc
     3421 atcttatatt aaaatgacct tttgacaggt gtgcactgtt ttgtctccag tgagcacata
     3481 ccatgcggat tttatatgta catcagtagt gtgaatccac tggcacagtg tgtgtaaatg
     3541 ccagatgtgg tgagatttta tcttataaat gtgatcagat aaaataactc ctgacagaaa
     3601 ctgtaaggaa accagctgaa tgtttgacct gatgactgat gttgtatggt ttatgttaaa
     3661 tgtatattct tttaatcaat gaataaagca ttaaaaatga tcattgtaat atattttatt
     3721 gtatatgaag catgactact tttagtgtta aataaactgc aataatcctt a
//
