LOCUS       NP_976046                555 aa            linear   PRI 30-APR-2025
DEFINITION  F-box only protein 33 [Homo sapiens].
ACCESSION   NP_976046
VERSION     NP_976046.1
DBSOURCE    REFSEQ: accession NM_203301.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 555)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 555)
  AUTHORS   Kulminski,A.M., Loika,Y., Nazarian,A. and Culminskaya,I.
  TITLE     Quantitative and Qualitative Role of Antagonistic Heterogeneity in
            Genetics of Blood Lipids
  JOURNAL   J Gerontol A Biol Sci Med Sci 75 (10), 1811-1819 (2020)
   PUBMED   31566214
  REMARK    GeneRIF: Quantitative and Qualitative Role of Antagonistic
            Heterogeneity in Genetics of Blood Lipids.
REFERENCE   3  (residues 1 to 555)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   4  (residues 1 to 555)
  AUTHORS   Sanchez-Mora,C., Ramos-Quiroga,J.A., Bosch,R., Corrales,M.,
            Garcia-Martinez,I., Nogueira,M., Pagerols,M., Palomar,G.,
            Richarte,V., Vidal,R., Arias-Vasquez,A., Bustamante,M., Forns,J.,
            Gross-Lesch,S., Guxens,M., Hinney,A., Hoogman,M., Jacob,C.,
            Jacobsen,K.K., Kan,C.C., Kiemeney,L., Kittel-Schneider,S.,
            Klein,M., Onnink,M., Rivero,O., Zayats,T., Buitelaar,J.,
            Faraone,S.V., Franke,B., Haavik,J., Johansson,S., Lesch,K.P.,
            Reif,A., Sunyer,J., Bayes,M., Casas,M., Cormand,B. and Ribases,M.
  TITLE     Case-control genome-wide association study of persistent
            attention-deficit hyperactivity disorder identifies FBXO33 as a
            novel susceptibility gene for the disorder
  JOURNAL   Neuropsychopharmacology 40 (4), 915-926 (2015)
   PUBMED   25284319
  REMARK    GeneRIF: This study findings show tentative evidence for the
            involvement of FBXO33 in the susceptibility to adult
            attention-deficit hyperactivity disorder.
REFERENCE   5  (residues 1 to 555)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   6  (residues 1 to 555)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   7  (residues 1 to 555)
  AUTHORS   Lutz,M., Wempe,F., Bahr,I., Zopf,D. and von Melchner,H.
  TITLE     Proteasomal degradation of the multifunctional regulator YB-1 is
            mediated by an F-Box protein induced during programmed cell death
  JOURNAL   FEBS Lett 580 (16), 3921-3930 (2006)
   PUBMED   16797541
REFERENCE   8  (residues 1 to 555)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049875.2 and AL157791.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This locus represents an member of the F-box gene family.
            The encoded protein contains an F-box motif and a domain that might
            form a structure similar to a leucine-rich repeat found in
            placental RNAse inhibitor. This locus may be associated with copy
            number variation of UGT2B17 (GeneID 7367), which has been
            associated with susceptibility to osteoporosis.[provided by RefSeq,
            Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053537.1, DRR138524.1223515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298097.8/ ENSP00000298097.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     Protein         1..555
                     /product="F-box only protein 33"
                     /calculated_mol_wt=62499
     Region          68..115
                     /region_name="F-box_FBXO33"
                     /note="F-box domain found in F-box only protein 33
                     (FBXO33) and similar proteins; cd22104"
                     /db_xref="CDD:438876"
     Site            order(71,75,78..79,82..83,87,89..90,94..96,98)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438876"
     Region          <265..527
                     /region_name="FBXL3_LRR-like"
                     /note="Leucine-rich repeat domain of FBXL3 and related
                     proteins; cl45928"
                     /db_xref="CDD:480268"
     CDS             1..555
                     /gene="FBXO33"
                     /gene_synonym="BMND12; c14_5247; Fbx33"
                     /coded_by="NM_203301.4:272..1939"
                     /db_xref="CCDS:CCDS9677.1"
                     /db_xref="GeneID:254170"
                     /db_xref="HGNC:HGNC:19833"
                     /db_xref="MIM:609103"
ORIGIN      
        1 mllflsvpqp rppgartrag aarvarwrrl rlqqlrrlrg llrvlrgrpg agsrrrgrma
       61 lcgqaagaas lpselivhif sflpapdrlr asascshwre clfypalwpq lriclrvspa
      121 eqprleflmr kcgwfvrelr vefaaenyls gggpgdggga dtgtggeeve alqlsarwle
      181 vlrtylelvl cvlvsirnnr nlqkfslfgd isvlqqqgsl sntylskvdp dgkkikqiqq
      241 lfeeilsnsr qlkwlscgfm leivtptsls slsnavantm ehlslldnni pgnstlitav
      301 elerfvnlhs laldfcdfta emarvltdsn hvplqrlsll vhnvsvmhks ldnmpndehw
      361 kalsrkstsf rvyimafdik sedmlkilkp siplerihfd syitcvsgai vdlisrqydk
      421 flthfilmnd vidtsgfpdl sdnrnedplv llawrctkls llaihgytvw ahnliaiarl
      481 rgsdlkvlev teesidfdqg eladqdvdpv hnlieqvslg lgqpwhavmd ieslsvftep
      541 nrhfyremqs fsedi
//
