LOCUS       NM_058229               6744 bp    mRNA    linear   PRI 01-FEB-2025
DEFINITION  Homo sapiens F-box protein 32 (FBXO32), transcript variant 1, mRNA.
ACCESSION   NM_058229
VERSION     NM_058229.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6744)
  AUTHORS   Su,D., Wang,R., Chen,G., Ding,C., Liu,Y., Tao,J., Wang,Y., Qiu,J.,
            Luo,W., Weng,G., Yang,G. and Zhang,T.
  TITLE     FBXO32 Stimulates Protein Synthesis to Drive Pancreatic Cancer
            Progression and Metastasis
  JOURNAL   Cancer Res 84 (16), 2607-2625 (2024)
   PUBMED   38775804
  REMARK    GeneRIF: FBXO32 Stimulates Protein Synthesis to Drive Pancreatic
            Cancer Progression and Metastasis.
REFERENCE   2  (bases 1 to 6744)
  AUTHORS   Wu,J., Wen,T., Marzio,A., Song,D., Chen,S., Yang,C., Zhao,F.,
            Zhang,B., Zhao,G., Ferri,A., Cheng,H., Ma,J., Ren,H., Chen,Q.Y.,
            Yang,Y. and Qin,S.
  TITLE     FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma
            progression
  JOURNAL   Cell Death Dis 15 (4), 282 (2024)
   PUBMED   38643215
  REMARK    GeneRIF: FBXO32-mediated degradation of PTEN promotes lung
            adenocarcinoma progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6744)
  AUTHORS   Liao,X., Li,Z., Zheng,H., Qian,W., Zhang,S., Chen,S., Li,X.,
            Tang,M., Xu,Y., Yu,R., Li,M., Song,L. and Li,J.
  TITLE     Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas
            via Epigenetic Activation of the FBXO32/NF-kappaB/MGMT Axis
  JOURNAL   Mol Cancer Res 21 (7), 648-663 (2023)
   PUBMED   36961398
  REMARK    GeneRIF: Downregulation of BASP1 Promotes Temozolomide Resistance
            in Gliomas via Epigenetic Activation of the FBXO32/NF-kappaB/MGMT
            Axis.
REFERENCE   4  (bases 1 to 6744)
  AUTHORS   Lu,Y., Huang,P., Li,Y., Liu,W., Li,J., Zhao,R., Feng,H., Shi,C. and
            Cao,G.
  TITLE     The FBXO32/ATR/ATM axis acts as a molecular switch to control the
            sensitivity of osteosarcoma cells to irradiation through its
            regulation of EXO1 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 842-852 (2023)
   PUBMED   37227155
  REMARK    GeneRIF: The FBXO32/ATR/ATM axis acts as a molecular switch to
            control the sensitivity of osteosarcoma cells to irradiation
            through its regulation of EXO1 expression.
REFERENCE   5  (bases 1 to 6744)
  AUTHORS   Xu,K., Liu,Q., Huang,W., Chu,Y., Fan,W., Liu,J., He,Y. and Huang,F.
  TITLE     Promotive Effect of FBXO32 on the Odontoblastic Differentiation of
            Human Dental Pulp Stem Cells
  JOURNAL   Int J Mol Sci 24 (9), 7708 (2023)
   PUBMED   37175415
  REMARK    GeneRIF: Promotive Effect of FBXO32 on the Odontoblastic
            Differentiation of Human Dental Pulp Stem Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6744)
  AUTHORS   Doucet,M., Russell,A.P., Leger,B., Debigare,R., Joanisse,D.R.,
            Caron,M.A., LeBlanc,P. and Maltais,F.
  TITLE     Muscle atrophy and hypertrophy signaling in patients with chronic
            obstructive pulmonary disease
  JOURNAL   Am J Respir Crit Care Med 176 (3), 261-269 (2007)
   PUBMED   17478621
  REMARK    GeneRIF: Atrogin-1 mRNA expression was significantly increased in
            quadriceps of patients with COPD; transcriptional regulation of
            atrogin-1 and MuRF1 may occur via FoxO-1, but independently of AKT
REFERENCE   7  (bases 1 to 6744)
  AUTHORS   Ogawa,T., Furochi,H., Mameoka,M., Hirasaka,K., Onishi,Y., Suzue,N.,
            Oarada,M., Akamatsu,M., Akima,H., Fukunaga,T., Kishi,K., Yasui,N.,
            Ishidoh,K., Fukuoka,H. and Nikawa,T.
  TITLE     Ubiquitin ligase gene expression in healthy volunteers with 20-day
            bedrest
  JOURNAL   Muscle Nerve 34 (4), 463-469 (2006)
   PUBMED   16868939
  REMARK    GeneRIF: results suggest that Cbl-b- or atrogin-1-mediated
            ubiquitination plays an important role in unloading-induced muscle
            atrophy, and that unloading stress may preferentially inhibit
            transcriptional responses in skeletal muscle
REFERENCE   8  (bases 1 to 6744)
  AUTHORS   Leger,B., Vergani,L., Soraru,G., Hespel,P., Derave,W., Gobelet,C.,
            D'Ascenzio,C., Angelini,C. and Russell,A.P.
  TITLE     Human skeletal muscle atrophy in amyotrophic lateral sclerosis
            reveals a reduction in Akt and an increase in atrogin-1
  JOURNAL   FASEB J 20 (3), 583-585 (2006)
   PUBMED   16507768
  REMARK    GeneRIF: Human skeletal muscle atrophy in the amyotrophic lateral
            sclerosis shows an increase in atrogin-1 & a decrease in Akt. The
            transcriptional regulation of human atrogin-1 may be controlled by
            an Akt-mediated transcription factor other than FKHR.
REFERENCE   9  (bases 1 to 6744)
  AUTHORS   Gomes,M.D., Lecker,S.H., Jagoe,R.T., Navon,A. and Goldberg,A.L.
  TITLE     Atrogin-1, a muscle-specific F-box protein highly expressed during
            muscle atrophy
  JOURNAL   Proc Natl Acad Sci U S A 98 (25), 14440-14445 (2001)
   PUBMED   11717410
REFERENCE   10 (bases 1 to 6744)
  AUTHORS   Bodine,S.C., Latres,E., Baumhueter,S., Lai,V.K., Nunez,L.,
            Clarke,B.A., Poueymirou,W.T., Panaro,F.J., Na,E., Dharmarajan,K.,
            Pan,Z.Q., Valenzuela,D.M., DeChiara,T.M., Stitt,T.N.,
            Yancopoulos,G.D. and Glass,D.J.
  TITLE     Identification of ubiquitin ligases required for skeletal muscle
            atrophy
  JOURNAL   Science 294 (5547), 1704-1708 (2001)
   PUBMED   11679633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056986.1, AC090193.7,
            AK125888.1 and AI077844.1.
            
            On Nov 23, 2018 this sequence version replaced NM_058229.3.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class and contains an F-box domain. This
            protein is highly expressed during muscle atrophy, whereas mice
            deficient in this gene were found to be resistant to atrophy. This
            protein is thus a potential drug target for the treatment of muscle
            atrophy. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (1) has a longer and alternate 5'
            terminal sequence containing an in-frame translation start codon,
            as compared to variant 2. It encodes a longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056986.1, SRR1803613.255344.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517956.5/ ENSP00000428205.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1271              AK056986.1         1-1271
            1272-3292           AC090193.7         133652-135672
            3293-5421           AK125888.1         1489-3617
            5422-5422           AC090193.7         137802-137802
            5423-6743           AK125888.1         3619-4939
            6744-6744           AI077844.1         10-10               c
FEATURES             Location/Qualifiers
     source          1..6744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..6744
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /note="F-box protein 32"
                     /db_xref="GeneID:114907"
                     /db_xref="HGNC:HGNC:16731"
                     /db_xref="MIM:606604"
     exon            1..308
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1260
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 32; muscle atrophy F-box protein; atrogin 1"
                     /codon_start=1
                     /product="F-box only protein 32 isoform 1"
                     /protein_id="NP_478136.1"
                     /db_xref="CCDS:CCDS6345.1"
                     /db_xref="GeneID:114907"
                     /db_xref="HGNC:HGNC:16731"
                     /db_xref="MIM:606604"
                     /translation="MPFLGQDWRSPGQNWVKTADGWKRFLDEKSGSFVSDLSSYCNKE
                     VYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGE
                     AFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQ
                     QNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRP
                     AFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKKLCQYHFSE
                     RQIRKRLILSDKGQLDWKKMYFKLVRCYPRKEQYGDTLQLCKHCHILSWKGTDHPCTA
                     NNPESCSVSLSPQDFINLFKF"
     exon            309..421
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            422..471
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            565..658
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            659..843
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1026
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1170
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..6744
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /note="hexamer: AATAAA"
     polyA_site      1515
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /note="major polyA site"
     regulatory      6723..6728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /note="hexamer: AATAAA"
     polyA_site      6744
                     /gene="FBXO32"
                     /gene_synonym="Fbx32; MAFbx"
                     /note="major polyA site"
ORIGIN      
        1 agcactcccg gagcctgcaa cgcttgagat cctctccgcg cccgccaccc cgcagggtgc
       61 cccgcgccgt tcccgccgcc ccgccgcccc cgtcgcgggc ccctgcaccc cgagcatccg
      121 ccccgggtgg cacgtccccg agcccaccag gccggccccg tctccccatc cgtctagtcc
      181 gctcgcggtg ccatgccatt cctcgggcag gactggcggt cccccgggca gaactgggtg
      241 aagacggccg acggctggaa gcgcttcctg gatgagaaga gcggcagttt cgtgagcgac
      301 ctcagcagtt actgcaacaa ggaggtatac aataaggaga atcttttcaa cagcctgaac
      361 tatgatgttg cagccaagaa gagaaagaag gacatgctga atagcaaaac caaaactcag
      421 tatttccacc aagaaaaatg gatctatgtt cacaaaggaa gtactaaaga gcgccatgga
      481 tattgcaccc tgggggaagc tttcaacaga ctggacttct caactgccat tctggattcc
      541 agaagattta actacgtggt ccggctgttg gagctgatag caaagtcaca gctcacatcc
      601 ctgagtggca tcgcccaaaa gaacttcatg aatattttgg aaaaagtggt actgaaagtc
      661 cttgaagacc agcaaaacat tagactaata agggaactac tccagaccct ctacacatcc
      721 ttatgtacac tggtccaaag agtcggcaag tctgtgctgg tcgggaacat taacatgtgg
      781 gtgtatcgga tggagacgat tctccactgg cagcagcagc tgaacaacat tcagatcacc
      841 aggcctgcct tcaaaggcct caccttcact gacctgcctt tgtgcctaca actgaacatc
      901 atgcagaggc tgagcgacgg gcgggacctg gtcagcctgg gccaggctgc ccccgacctg
      961 cacgtgctca gcgaagaccg gctgctgtgg aagaaactct gccagtacca cttctccgag
     1021 cggcagatcc gcaaacgatt aattctgtca gacaaagggc agctggattg gaagaagatg
     1081 tatttcaaac ttgtccgatg ttacccaagg aaagagcagt atggagatac ccttcagctc
     1141 tgcaaacact gtcacatcct ttcctggaag ggcactgacc atccgtgcac tgccaataac
     1201 ccagagagct gctccgtttc actttcaccc caggacttta tcaacttgtt caagttctga
     1261 atcccagcac atgacaacac ttcagaaggg tccccctgct gactggagag ctgggaatat
     1321 ggcatttgga cacttcattt gtaaatagtg tacattttaa acattggctc gaaacttcag
     1381 agataagtca tggagaggac attggagggg agaaatgcag ttgctgactg ggaatttaag
     1441 aatgtgaact tctcactaga attggtatgg aaaagcaaaa tactgtaaat aaactttttt
     1501 tctaacaatt tgccagcaag actataaggg caataattct atttcagcgg tgaaaatgga
     1561 gtcctcttaa tggtcacaga aactctctta tagttcccta ggaagaaaaa ggcaaaactc
     1621 aaatacaaaa taggacgctt tgtttacaat gtgaaaattt gtttagaaaa gaaaaaatga
     1681 agaaggaaaa ctatatagga gaaattcctg ggctttgggg tttgatctgg tgtttgtttt
     1741 gagaaggcga aggaagcgcc acccatccta aacctgcatg ggcacagagc cttaccctac
     1801 agagatacca cacaatggtc tacctctaaa agcgtagagt gccctctctg acaacgcatg
     1861 tgatccagta ggcagtgtct gtttttctcg taagtgtttt catcactata aaaagtgatt
     1921 taaaatggaa agggatattg gaggcaatcc tctggtttca cacttccttt tcaggcaaac
     1981 agggccctcc ttagagttat ctgttcacca gaacaaccca aaagcacatg ttcctttttt
     2041 cctgtcatgt tgtagctcat ttgggggaaa agaaggccaa cttaaaacag tcccagggga
     2101 ggattgcttg agcccaggag tctgaggttt gcagtgagct atgattgtgc cactgcactc
     2161 cagcctgtct ccaaaacaaa acaaaacaaa acaaaagccg tcccagagga agtcctgctg
     2221 cagaaaagat gatagaattg gtcacccaat caatagctgt gaagacttcc ttattcctgc
     2281 tgaacttcct tccttggata tcttcatgga taagcctgtg tctgtggaca gagtggggcc
     2341 caagtgctga ggctcgaaag acaggtttta caatcagcca attaaacatc ttaccagttg
     2401 ctgtacccct tgccaagggg atgagctgag gagcttcttt tctttaggtc caacatcaaa
     2461 atgagtccat ctgagctagg gctttttgca aaggtgatta aaaatcaagg ctggagttcc
     2521 agccaaatag ggaggagagg taccacaagt tcatcttaaa cttgcttccg ggctgggtag
     2581 ttaaaacagg aagatcccaa ggggatctta cgaggcaaat atcagcaggt aactgtggaa
     2641 gaaaggaaat ctcaggacct aatgagttcg ttgtaaaata ttcctgggaa tagatggggg
     2701 atctactccc agttttttac tttttacaga atattgttgc tttcctacaa caatgtacat
     2761 atatttgcag ttgtatatgc tttttttttt tccaaataaa cttgtcaccc tgcatgccct
     2821 tggcaaataa gtgaagcaga aataggaaca cagtccacat tcaagttgag gaacagtgta
     2881 tctttaagag ctgagctttg ggtgacctgg aaagggggaa agatggctaa gcatggagag
     2941 aaacgaggca agagacaagc tatgatacaa caccgcttca gcccctgccc tcaatagcac
     3001 acaacccaca tatcagcttt ctgaagagaa ggaacctact gtttagtgct cctcactttg
     3061 caatgtttgt gctacgccag aatttctcca gtttttttca ttatcatccc cctgagaaaa
     3121 aaattacatt gaatttaaat tttccctaat aagagaaatt aaatatgaaa gaataggatt
     3181 ttgttgggta agattgagct ttggaaggtc acgaaccatt attctatcta aggtgtgtgt
     3241 tttgttttgt ttttttttgt tttttttttg caatccctct ccccctgaac caatttcaca
     3301 ttgggaatgc aggacctaga ctgctgaata aaaagctact tcttctataa ttgtcaggtt
     3361 ctctccaatt tctcagcttc ctcaaagaca tggggtggag ttgggtgtgc catcactgag
     3421 agagctctgg aacttttgac tcttagtgac atttttagat ttaggggttc atggccttcc
     3481 acatgttgcc accaactggt gatctctgcc ccttcatgct gatcaagaaa gtagaaactc
     3541 ctcgtcgcct tcaggtttgc agtcgcagaa acattgcctg ctgtggactg tcagcacaaa
     3601 actgggacac tggtgtcatt tagactgtca gcagtgcaca tgattgtacg atagactcca
     3661 ggcaaccatg tgcatctgtg caagatgacc tctgccccaa gagaagggtt acggtctaat
     3721 taaatgttta ccaagatggt accagtgggc tctccccgtg tcctttggtg ttattggagc
     3781 tggtgtatga cagactcaag gaaatttttt aaggaaaatg aagaagaaat caacctttat
     3841 ggttctcttt cattggaaga ggagaataag gaaagaaatg gcaggtagag agggaggggg
     3901 aaaggaatag aaatggcatg tctttgatgc tgtggcttgt gtggggacaa tgggaagagc
     3961 acagcaggca caacatatct gtgttagtgc cacgtggtat ctgttaagta tggccagagc
     4021 ctcacatata agtgaagaga gttaagacaa ttcttgctct ttgaacaata atagtctata
     4081 gaatttctat tggcaaacca tcccagacaa cctgacctat caaacaaaag caaataatcc
     4141 ctgtctcaga actgctggtc taaaagctag aaggggcatg ataatggaaa ttgctagaaa
     4201 agagagaatg ctctactctc tttcctgtgc ctacctaccc ccatcctaaa ccctgtaaaa
     4261 cagaatttca aaatagatgt caaatatgaa gtaattcaga cttccaaaga aggaaagagt
     4321 tctgcccagg gcagtatgag caaatccaca gggatgttaa gatttggtcc aactcaaagg
     4381 tttatgggca gtgagcctag agtctcttga gagtaaaccc ttgcatttgg gacaaggaga
     4441 atatgtgaag ttcaggagtg ctcacactag agcaagatcc agaaaaaaaa aaatccaatg
     4501 gcattttaaa ctagattgca ttatcactca atgctgttac tttgagcaga caaatcagtt
     4561 gaatgggagg gcaaatggca gaaatgaaca aaagctatta ggtgaaagca tccccaatgt
     4621 atcagttgtg agatgatttt tgtttaatga tgatcaggtt tacattgaag tggcttggaa
     4681 gacgtatttc agagggactg ggtttgtact gcaaaactct gaacactaga gcaggttcta
     4741 ctagcacttg ggcagtaagg tagcgggtgt gtattatgct attgccatag ttctcgtctt
     4801 tgtggattca catacccttt cccatgagga gcttgctact aacagcctcc tgtttctgtt
     4861 gtttttatat gggagaagag aaagagcttg gaatttcaat tgtctaaaca attggtatga
     4921 tttacaagaa ggcaaaccat tcaggagatg ttcaacagtg tatcattctt agcattcaat
     4981 acaatgttta ttataaaata tacacctgag tttatgtttt tctgccaggc tgaagggcaa
     5041 taatgtcttg ctatgcaaac actctatttt atgtgtgaat ttttttaact gtaattttat
     5101 gtgtgaattt ttttaactaa actctatcat cattttctat gttgacatct tttttttttt
     5161 tttaatctgt ttccaactct gagtctgtga actatctctt ctgactggat gctggcctaa
     5221 aatcctatta gtgcttaaac agacctcaaa acactctgaa cctgtaggcc aatacagaga
     5281 tgttgttctt tgatatatct tgggtccttg atggcttcaa caaacaaggt cataatttgt
     5341 ttaaattcag tgttttctgt agataccttc ttctcagttt cattaagaag agtaaccatc
     5401 tttggttttc caaagaatgg aaactcctac cctagacttt agacttagag cgtctgcctt
     5461 tcacgatgag taagagatcc agaatgttta ggggatgtgc gtcagcccac ctggtacagt
     5521 ggcaaagctg aatgcgaact tgaggcctcc tgaggcctga ccttctatgc ccccagccct
     5581 ccaccccaag caccttttgg tgtggctgga aacacatgac attggatgtg atttttctca
     5641 agcccttcac tgtggaaggc atgggagact gcccagcatt gggcatgtgg ctgttaacgt
     5701 ttccatttca agtccctgat tcttactgga gaagttaagg agccacttaa tgttttcaca
     5761 gacctctgat tctgttgtga atgtggcatt ccagtgagta caacctgctt gctataaaga
     5821 aagcagcata ttttgacaat tttatttctt ccttgggtac ttacattttt attacaaaaa
     5881 tggccgttat aaaaaaagac agaagggctg ggcagtggct tgctccctag aaactgagat
     5941 tccgaagcag gtgtttcctc tcccctagac tcagaggtac atttaatcca tcttctccat
     6001 ttcctccttc aggaccagct atgagattca gtgcatttct agcccagcgg atgttcattc
     6061 tccactaaac ttcatctttt actaagcaaa gggggattat tccatgaggc agccaggagc
     6121 aaggggccat gatattcatg actttgtctg ctgggcattt ttcaaagtgt ccttgaattc
     6181 actcagcaaa caaagctttc tggagaatct ctcaaaactt aggccctgct ccatttggcc
     6241 aaaaatgatg gctgctccaa aactctgaac ttcttaaaac tccatctgct acattatttc
     6301 tggagtttaa acatgacttt ttctgtcttt gagtatagat gtgtttgttt aattaacgaa
     6361 gcacaagtct gttaagcaga aggctccaag ctgtattcta tacttgggaa tccttggtgc
     6421 catctttatt ctaccaagtg ccaatcacca tggctaaagt gggcgtatat tacagcctgt
     6481 gtcctaagct tagaagcttt aatgtacttt tttaaatgaa aagtattaga gggggttgaa
     6541 cattgtaact aaagcataaa gttagaccaa ttacatgcag agatgtttat ttaatattgt
     6601 gtgagctgag tccttctgta taaattattt gcacactttt cttgcatgat gaactgattt
     6661 tttatagttg tttgtaccag acggtggcat atttttgtaa aaaacttttg acactgaatt
     6721 gcaataaatg tttttccaac aaca
//
