LOCUS       NM_024735               5953 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens F-box protein 31 (FBXO31), transcript variant 1, mRNA.
ACCESSION   NM_024735
VERSION     NM_024735.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5953)
  AUTHORS   Zhao,F., Yan,L., Zhao,X., Wu,J., Fang,Y., Xin,Z., Wang,H. and
            Yang,X.
  TITLE     Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian
            Insufficiency
  JOURNAL   Aging Dis 15 (2), 804-823 (2024)
   PUBMED   37611899
  REMARK    GeneRIF: Aberrantly High FBXO31 Impairs Oocyte Quality in Premature
            Ovarian Insufficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5953)
  AUTHORS   Chen,K., Wang,Y., Dai,X., Luo,J., Hu,S., Zhou,Z., Shi,J., Pan,X.,
            Cao,T., Xia,J., Li,Y., Wang,Z. and Ma,J.
  TITLE     FBXO31 is upregulated by METTL3 to promote pancreatic cancer
            progression via regulating SIRT2 ubiquitination and degradation
  JOURNAL   Cell Death Dis 15 (1), 37 (2024)
   PUBMED   38216561
  REMARK    GeneRIF: FBXO31 is upregulated by METTL3 to promote pancreatic
            cancer progression via regulating SIRT2 ubiquitination and
            degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5953)
  AUTHORS   Ma,Y., Sun,W.L., Ma,S.S., Zhao,G., Liu,Z., Lu,Z. and Zhang,D.
  TITLE     LincRNA ZNF529-AS1 inhibits hepatocellular carcinoma via FBXO31 and
            predicts the prognosis of hepatocellular carcinoma patients
  JOURNAL   BMC Bioinformatics 24 (1), 54 (2023)
   PUBMED   36803542
  REMARK    GeneRIF: LincRNA ZNF529-AS1 inhibits hepatocellular carcinoma via
            FBXO31 and predicts the prognosis of hepatocellular carcinoma
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5953)
  AUTHORS   Vadhvani,M., Schwedhelm-Domeyer,N., Mukherjee,C. and Stegmuller,J.
  TITLE     The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal
            morphogenesis and migration
  JOURNAL   PLoS One 8 (2), e57530 (2013)
   PUBMED   23469015
  REMARK    GeneRIF: ascribe a role for FBXO31 in dendrite growth and neuronal
            migration in the developing cerebellar cortex. Taken together, we
            uncovered the centrosomal E3 ligase FBXO31-SCF as a novel regulator
            of neuronal development
REFERENCE   5  (bases 1 to 5953)
  AUTHORS   Huang,H.L., Zheng,W.L., Zhao,R., Zhang,B. and Ma,W.L.
  TITLE     FBXO31 is down-regulated and may function as a tumor suppressor in
            hepatocellular carcinoma
  JOURNAL   Oncol Rep 24 (3), 715-720 (2010)
   PUBMED   20664978
REFERENCE   6  (bases 1 to 5953)
  AUTHORS   Santra,M.K., Wajapeyee,N. and Green,M.R.
  TITLE     F-box protein FBXO31 mediates cyclin D1 degradation to induce G1
            arrest after DNA damage
  JOURNAL   Nature 459 (7247), 722-725 (2009)
   PUBMED   19412162
  REMARK    GeneRIF: ectopic expression of FBXO31 acts through a
            proteasome-directed pathway to mediate the degradation of cyclin
            D1, an important regulator of progression from G1 to S phase,
            resulting in arrest in G1
REFERENCE   7  (bases 1 to 5953)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 5953)
  AUTHORS   Kumar,R., Neilsen,P.M., Crawford,J., McKirdy,R., Lee,J.,
            Powell,J.A., Saif,Z., Martin,J.M., Lombaerts,M., Cornelisse,C.J.,
            Cleton-Jansen,A.M. and Callen,D.F.
  TITLE     FBXO31 is the chromosome 16q24.3 senescence gene, a candidate
            breast tumor suppressor, and a component of an SCF complex
  JOURNAL   Cancer Res 65 (24), 11304-11313 (2005)
   PUBMED   16357137
  REMARK    GeneRIF: Loss of FBXO31 is associated with breast cancer
REFERENCE   9  (bases 1 to 5953)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 5953)
  AUTHORS   Powell,J.A., Gardner,A.E., Bais,A.J., Hinze,S.J., Baker,E.,
            Whitmore,S., Crawford,J., Kochetkova,M., Spendlove,H.E.,
            Doggett,N.A., Sutherland,G.R., Callen,D.F. and Kremmidiotis,G.
  TITLE     Sequencing, transcript identification, and quantitative gene
            expression profiling in the breast cancer loss of heterozygosity
            region 16q24.3 reveal three potential tumor-suppressor genes
  JOURNAL   Genomics 80 (3), 303-310 (2002)
   PUBMED   12213200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI596608.1, BC012748.1,
            AF318348.1, BM151642.1, BI914636.1, DA493744.1, BX329100.2,
            AL576585.3, BX106211.1 and BE465371.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024735.4.
            
            Summary: This gene is a member of the F-box family. Members are
            classified into three classes according to the substrate
            interaction domain, FBW for WD40 repeats, FBL for leucing-rich
            repeats, and FBXO for other domains. This protein, classified into
            the last category because of the lack of a recognizable substrate
            binding domain, has been proposed to be a component of the SCF
            ubiquitination complex. It is thought to bind and recruit substrate
            for ubiquitination and degradation. This protein may have a role in
            regulating the cell cycle as well as dendrite growth and neuronal
            migration. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.13165.1,
                                           SRR11853564.11287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311635.12/ ENSP00000310841.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BI596608.1         20-38
            20-1895             BC012748.1         11-1886
            1896-2570           AF318348.1         2112-2786
            2571-3604           BC012748.1         2562-3595
            3605-3954           BM151642.1         1-350               c
            3955-4259           BI914636.1         409-713
            4260-4489           DA493744.1         288-517
            4490-5088           BX329100.2         21-619              c
            5089-5466           AL576585.3         460-837             c
            5467-5476           BX106211.1         377-386
            5477-5798           AL576585.3         128-449             c
            5799-5953           BE465371.1         21-175              c
FEATURES             Location/Qualifiers
     source          1..5953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..5953
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="F-box protein 31"
                     /db_xref="GeneID:79791"
                     /db_xref="HGNC:HGNC:16510"
                     /db_xref="MIM:609102"
     exon            1..372
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1652
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative breast cancer tumor-suppressor; F-box only
                     protein 31; SCF ubiquitin ligase specificity factor"
                     /codon_start=1
                     /product="F-box only protein 31 isoform 1"
                     /protein_id="NP_079011.3"
                     /db_xref="CCDS:CCDS32501.1"
                     /db_xref="GeneID:79791"
                     /db_xref="HGNC:HGNC:16510"
                     /db_xref="MIM:609102"
                     /translation="MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERI
                     EASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRILH
                     TDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLL
                     NVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHI
                     QIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIY
                     TSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGD
                     PNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGR
                     GRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVLPV
                     GVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSL
                     YSRVQATFRNADAPSPQAFDEMLKNIQSLTS"
     exon            373..444
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            445..521
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            522..689
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            690..764
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            765..874
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1028
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1429
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..5953
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3582..3587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="hexamer: ATTAAA"
     polyA_site      3604
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="major polyA site"
     regulatory      5932..5937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="hexamer: AGTAAA"
     polyA_site      5953
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
ORIGIN      
        1 acaggcggca gcagtggccg tcactgggcg gcatggcggt gtgtgctcgc ctttgcggcg
       61 tgggcccgtc gcgcggatgt cggcgccgcc agcagcgccg gggcccggcc gagacggcgg
      121 cggccgacag cgagccggac acagaccccg aggaggagcg catcgaggct agcgccgggg
      181 tcgggggcgg cttgtgcgcg ggcccctcgc cgccgccccc gcgctgctcg ctgctggagc
      241 tgccgcccga gctgctggtg gagatcttcg cgtcgctgcc gggcacggac ctacccagct
      301 tggcccaggt ctgcacgaag ttccggcgca tcctccacac cgacaccatc tggaggaggc
      361 gttgccgtga ggagtatggt gtttgcgaaa acttgcggaa gctggagatc acaggcgtgt
      421 cttgtcggga cgtctatgcg aagctgcttc accgatatag acacattttg ggattgtggc
      481 agccagatat cgggccatac ggaggactgc tgaacgtggt ggtggacggc ctgttcatca
      541 tcgggtggat gtacctgcct ccccatgacc cccacgtcga tgaccctatg agattcaagc
      601 ctctgttcag gatccacctg atggagagga aggctgccac agtggagtgc atgtacggcc
      661 acaaagggcc ccaccacggc cacatccaga ttgtgaagaa ggatgagttc tccaccaagt
      721 gcaaccagac ggaccaccac aggatgtccg gcgggaggca ggaggagttt cggacgtggc
      781 tgagggagga atgggggcgc acgctggagg acatcttcca cgagcacatg caggagctca
      841 tcctgatgaa gttcatctac accagtcagt acgacaactg cctgacctac cgccgcatct
      901 acctgccgcc cagccgcccc gacgacctca tcaagcctgg cctcttcaaa ggtacctatg
      961 gcagccacgg cctggagatt gtgatgctca gcttccacgg ccggcgtgcc aggggcacca
     1021 agatcacggg cgaccccaac atccccgctg ggcagcagac agtggagatc gacctgaggc
     1081 atcggatcca gctgcccgac ctcgagaacc agcgcaactt caatgagctc tcccgcatcg
     1141 tcctggaggt gcgcgagagg gtgcgccagg agcagcagga aggcgggcac gaggcgggcg
     1201 agggtcgtgg ccggcagggc ccccgggagt cccagccaag ccctgcccag cccagggcag
     1261 aggcgcccag caagggccca gatgggacac ctggtgagga tggtggcgag cctggggatg
     1321 ccgtagctgc ggccgagcag cctgcccagt gtgggcaggg gcagccgttc gtgctgcccg
     1381 tgggcgtgag ctccaggaat gaggactacc cccgaacctg caggatgtgt ttttatggca
     1441 caggcctcat cgcgggccac ggcttcacca gccctgaacg cacccccggg gtcttcatcc
     1501 tcttcgatga ggaccgcttc gggttcgtct ggctggagct gaaatccttc agcctgtaca
     1561 gccgggtcca ggccaccttc cggaacgcag atgcgccgtc cccacaggcc ttcgatgaga
     1621 tgctcaagaa cattcagtcc ctcacctcct gaccggccac atccttgccg ccacatcccg
     1681 ggtggctctg gggctctgaa ctctgacctg tgaatagaag cagcatgcac tttggaaatc
     1741 cggccttttg accagaacgc acacctcgtc ggggggccca gtccagccac cccccagcac
     1801 tttatgtaga gagtgtgaca tagacctgca tatttgtcag tgccatgatg gaagaagctg
     1861 agcatgtctt accaaaaaca gagagaacga gcctgaatac agcagatgta ggggacagcc
     1921 gtgggaccgc gtgagaattg aagcggtggg gttcccgcac cctgggctgg ctggtggttt
     1981 tctcgggaag caggaccctc ctgactggtg ctcttcctgt gagcggatag agtgatagac
     2041 tgggtcgtgt gtgagacgca tgtgctccac cccactcctt ttgggggaag ccaggcaaca
     2101 gtggcctctg ggagggggtc aggaagaggc gaacagctca ggcagcgcag gtgtgatggg
     2161 cacagtacgc agagcaagct cgggaagttg gtaggatctc aggcttgggg ccgggactct
     2221 ggagtgaatc cccatttctc taccggcttg cttggagttt ggacagaagc atttcacctc
     2281 tgatctcagc ttccccacct gtggagtggg tttagtgacc tgagtcacta gggaatgtca
     2341 cctgaatgca cagcccagcc catgcacctg ccccagcccc tccagctttg gagccaaggc
     2401 catcgttcca gccacttgac tgtcctcgac ggcctgttcc agacagggcg tttgttttgt
     2461 ccatgccttc ctccctgcac gcacacggcg tcaaaaccaa gctgccggcc actgtctcca
     2521 gaacgcaagg ctccaggccc gtgtgtctga agcagtgagt ggtccacaca ggtgccagga
     2581 gtgcccatat gagatgacga ggaaacccct ttgcaggtga ggggacagct ttctagaaaa
     2641 gccacacctg catctgggga cacactttgg aaagtgggac cctccagcct ggagacccca
     2701 tggactgatg cctccactgc tgtgtgcccc atgttgtgtt aacacctgcg tgtggggacc
     2761 ccatctgagg tcttggctga ggttggcatc tcctgaagaa cagagagcac ggtgtccaga
     2821 gctggccctt cccccagccc acagccagct ccgtgcccga gtgggcgtcc ccagcgagcc
     2881 ttccctctct gccgcttgtc cttgtgtctg ggctgctcca agtccttgtg ctgggcaccc
     2941 tggacacgtc ctgctggtga gggacctcgg gaaggtgaca gtctgtgtgc cttggtgtgg
     3001 agaccaacct gaggatgtcc tgggaaatgt tttcctgatg aatttctcct tgactggcct
     3061 ttaaagaaca taagaattcc cattgcccag cctcagtgca tttggcaaat gcttactttg
     3121 cttcccagag tcagagaatt ggcaaaggtt cctaaatggt aatctggccg gcctgggaga
     3181 aagactcacg agaaaagcca gtggagaaag cgcccttcca gggcggcagc agcgggagcc
     3241 acgcagaccc cgaggcgcac ctgctggctc ttgtgtgtgg ccccagtttc tagcggcttt
     3301 tgcagcatta gcctacaagc tttgtcactc cctgccctct gtggtggtca ctgtttttct
     3361 ctcttgccaa atgaggcagt ctctgagtga cggtgactgt ggccttgaag cctggaggac
     3421 tgttgggcat gtagactggc accttgaaga ttcaccattg tttaaataaa atcaagcaaa
     3481 tgctttttta ccaagagccc gagcctcgct ctaagggacg cagtcctaga ggcgtgccct
     3541 ttggggcttg aagagcacac tgtgggacgc acgtgcttct gattaaagga atctcagatc
     3601 tcaattacgc ttccagtgtt tgggtataga aatagcttcc acccatcatg tctcagccat
     3661 gggctgttgg tcagttcatg tggctcctgg ttctggtgtg tatgttgggg gcgggggtct
     3721 ctccatggtg gtgacctgca gtgatgccag gcagggccag agccacacag ccaggaaagg
     3781 gaggcctttt tggccgcaca gccagtccct tcagtcgtga ctacaggtct tgttttttcc
     3841 gctccgatgt gtccttagcc agttcttggc tccggttctg tagggacagg cactgaatct
     3901 gcgcgcctca aaacagcagc ttcccttccg ggggagggca tccaccctct caggggatcc
     3961 tgcaggtggc ccatttcctg caggtgagaa ctcggaaggg ctgatgtcgt catcagaggc
     4021 ctaagggcag ctgagagttg gataaaaccg tttccaagga ggaggctgag taacccagtt
     4081 caggacagcc aagcgcatta ggcttgattg gggaaggtgg caggtggagt tgggaggttg
     4141 ggactctcca tcttttgcac cacggatgcc tttctgtcgc tgtctcactc tggggcagga
     4201 tcaagtctgc tctctggagt ggggctgcct gcagtgcagc tctgcacacc tgaacgtgtt
     4261 ctttgtcact tgtttggaaa tgatgtgatt gaagatttca gagaggtcat tggaggcttt
     4321 tctgtgccgg cactgaatgt tcatttgcat gaggaagttg caaacgactt ctgcaggctg
     4381 agattcaagg caggtggtat tggggtccct cagcccacct gggccgtgac ctcaagtgtc
     4441 cactgctgag tgtgagtggc tttgcaggcc tggtggtggg agagcctcag gctccctcct
     4501 tcttcgttcc tgaccatgcc ctgggcccct tcagtctgcc tgcggctctg tggcatccct
     4561 gccctgacac tgggcacctg tgcccctagc aagcccacct ggcacacgag gagggagggg
     4621 tgggtggcca tgtccttcct ctagccacat gccctgctgg ccgctccatt ctgagctttg
     4681 tgcagaaccg ggtctgagct ggagattttt ctctgagaac ctgcagttgt gctgcagccg
     4741 cacgcaaggg cccttcagcc gctggctctg gcttccctga ctcctcaggg cgtgttcacc
     4801 cccaggcttt ctcacctgca cacggttagg ccattttcag tgctcgtggg cagtcacgga
     4861 cagcagcaga aactcctcag cccctttgtt acttcagaac gcctgcccac atgcatcttc
     4921 tgagctcgtg ttgtcctcat ggccgtgggg tcttgggtgc gaacaggaga tgctgagctg
     4981 tggtccaccg tccaaggtgc tgcagaaagc agctaggctc ttttaggatg tttctattct
     5041 ggttgctgcc ttcgtggtgt aacttttaag aacacttacg ggaatgtgct catagaacca
     5101 tcacctgtcc tgagaataaa actcctggaa tcatgatcaa gtccagtgtt aacgtggccc
     5161 aacctgtctg tacttctggg gagagaccag gaacatcact ggactcctca tccccgtaat
     5221 tatttagaga agatgcaagc agcagatagt ctccatgcgg ctggtacttt ttttgttgtt
     5281 ttttgagaca gggtcttgct ctgtcacctg ggctggagtg cagagcggcg atcatggctc
     5341 cctgaggcct caacctacta ggctcaagct gtctgcccgc cttagcctcc caagtagctg
     5401 ggaccacagg cacccaccac caccatgctt ggctaacttg tttttgtaga gatggagttt
     5461 tgccatgttg ctcaggttgg tctcgaactc ccgatctcag gtgatccacc cgcctcggcc
     5521 tcccaaagtg ctgggattac aggcgtgagc ccctgcgccc cagccttggg gcctgtcttt
     5581 gaatgggaat gagactgtgc aaaccgtgga ctaccctgtg tcacccacag ctcagtggcc
     5641 tgcctgccgg ccctcagggg ctgctgaccg ggagaccagc cagagcacga gggggtcagg
     5701 gctgtgtggg ttttggcctg attctgcatt tggttgtttc tgggggccat gtagcctgcc
     5761 tgcattagga aagcgctgtg ccatctgatc atgagcacct ctgcaccccc tggtaaggtg
     5821 accttgcagc aggagctgtg ccctgcctgg gtaggcaccc actaggtagg accggagcaa
     5881 tcctggcagc cgccacctgc acccgtgcac ttgtttctcc tcacagtttc aagtaaatcc
     5941 gtttttgaag gct
//
