LOCUS       NM_001282683            5732 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens F-box protein 31 (FBXO31), transcript variant 2, mRNA.
ACCESSION   NM_001282683 NR_024568
VERSION     NM_001282683.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5732)
  AUTHORS   Zhao,F., Yan,L., Zhao,X., Wu,J., Fang,Y., Xin,Z., Wang,H. and
            Yang,X.
  TITLE     Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian
            Insufficiency
  JOURNAL   Aging Dis 15 (2), 804-823 (2024)
   PUBMED   37611899
  REMARK    GeneRIF: Aberrantly High FBXO31 Impairs Oocyte Quality in Premature
            Ovarian Insufficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5732)
  AUTHORS   Chen,K., Wang,Y., Dai,X., Luo,J., Hu,S., Zhou,Z., Shi,J., Pan,X.,
            Cao,T., Xia,J., Li,Y., Wang,Z. and Ma,J.
  TITLE     FBXO31 is upregulated by METTL3 to promote pancreatic cancer
            progression via regulating SIRT2 ubiquitination and degradation
  JOURNAL   Cell Death Dis 15 (1), 37 (2024)
   PUBMED   38216561
  REMARK    GeneRIF: FBXO31 is upregulated by METTL3 to promote pancreatic
            cancer progression via regulating SIRT2 ubiquitination and
            degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5732)
  AUTHORS   Ma,Y., Sun,W.L., Ma,S.S., Zhao,G., Liu,Z., Lu,Z. and Zhang,D.
  TITLE     LincRNA ZNF529-AS1 inhibits hepatocellular carcinoma via FBXO31 and
            predicts the prognosis of hepatocellular carcinoma patients
  JOURNAL   BMC Bioinformatics 24 (1), 54 (2023)
   PUBMED   36803542
  REMARK    GeneRIF: LincRNA ZNF529-AS1 inhibits hepatocellular carcinoma via
            FBXO31 and predicts the prognosis of hepatocellular carcinoma
            patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5732)
  AUTHORS   Vadhvani,M., Schwedhelm-Domeyer,N., Mukherjee,C. and Stegmuller,J.
  TITLE     The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal
            morphogenesis and migration
  JOURNAL   PLoS One 8 (2), e57530 (2013)
   PUBMED   23469015
  REMARK    GeneRIF: ascribe a role for FBXO31 in dendrite growth and neuronal
            migration in the developing cerebellar cortex. Taken together, we
            uncovered the centrosomal E3 ligase FBXO31-SCF as a novel regulator
            of neuronal development
REFERENCE   5  (bases 1 to 5732)
  AUTHORS   Huang,H.L., Zheng,W.L., Zhao,R., Zhang,B. and Ma,W.L.
  TITLE     FBXO31 is down-regulated and may function as a tumor suppressor in
            hepatocellular carcinoma
  JOURNAL   Oncol Rep 24 (3), 715-720 (2010)
   PUBMED   20664978
REFERENCE   6  (bases 1 to 5732)
  AUTHORS   Santra,M.K., Wajapeyee,N. and Green,M.R.
  TITLE     F-box protein FBXO31 mediates cyclin D1 degradation to induce G1
            arrest after DNA damage
  JOURNAL   Nature 459 (7247), 722-725 (2009)
   PUBMED   19412162
  REMARK    GeneRIF: ectopic expression of FBXO31 acts through a
            proteasome-directed pathway to mediate the degradation of cyclin
            D1, an important regulator of progression from G1 to S phase,
            resulting in arrest in G1
REFERENCE   7  (bases 1 to 5732)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 5732)
  AUTHORS   Kumar,R., Neilsen,P.M., Crawford,J., McKirdy,R., Lee,J.,
            Powell,J.A., Saif,Z., Martin,J.M., Lombaerts,M., Cornelisse,C.J.,
            Cleton-Jansen,A.M. and Callen,D.F.
  TITLE     FBXO31 is the chromosome 16q24.3 senescence gene, a candidate
            breast tumor suppressor, and a component of an SCF complex
  JOURNAL   Cancer Res 65 (24), 11304-11313 (2005)
   PUBMED   16357137
  REMARK    GeneRIF: Loss of FBXO31 is associated with breast cancer
REFERENCE   9  (bases 1 to 5732)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 5732)
  AUTHORS   Powell,J.A., Gardner,A.E., Bais,A.J., Hinze,S.J., Baker,E.,
            Whitmore,S., Crawford,J., Kochetkova,M., Spendlove,H.E.,
            Doggett,N.A., Sutherland,G.R., Callen,D.F. and Kremmidiotis,G.
  TITLE     Sequencing, transcript identification, and quantitative gene
            expression profiling in the breast cancer loss of heterozygosity
            region 16q24.3 reveal three potential tumor-suppressor genes
  JOURNAL   Genomics 80 (3), 303-310 (2002)
   PUBMED   12213200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010531.8, DB444853.1,
            BG718342.1, BC012748.1, AL117444.1, BM151642.1, BI914636.1,
            DA493744.1, BX329100.2, AL576585.3, BX106211.1 and BE465371.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001282683.1.
            
            Summary: This gene is a member of the F-box family. Members are
            classified into three classes according to the substrate
            interaction domain, FBW for WD40 repeats, FBL for leucing-rich
            repeats, and FBXO for other domains. This protein, classified into
            the last category because of the lack of a recognizable substrate
            binding domain, has been proposed to be a component of the SCF
            ubiquitination complex. It is thought to bind and recruit substrate
            for ubiquitination and degradation. This protein may have a role in
            regulating the cell cycle as well as dendrite growth and neuronal
            migration. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and thus differs in the 5' UTR and 5' coding region
            compared to variant 1. These differences cause translation
            initiation at a downstream AUG and result in an isoform (2) with a
            shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038194.1649083.1, SRR1803615.99649.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC010531.8         151714-151727       c
            15-25               DB444853.1         2-12
            26-140              BG718342.1         10-124
            141-458             BG718342.1         126-443
            459-763             BC012748.1         671-975
            764-3383            AL117444.1         510-3129
            3384-3733           BM151642.1         1-350               c
            3734-4038           BI914636.1         409-713
            4039-4268           DA493744.1         288-517
            4269-4867           BX329100.2         21-619              c
            4868-5245           AL576585.3         460-837             c
            5246-5255           BX106211.1         377-386
            5256-5577           AL576585.3         128-449             c
            5578-5732           BE465371.1         21-175              c
FEATURES             Location/Qualifiers
     source          1..5732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..5732
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="F-box protein 31"
                     /db_xref="GeneID:79791"
                     /db_xref="HGNC:HGNC:16510"
                     /db_xref="MIM:609102"
     exon            1..39
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            40..151
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            152..223
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            224..300
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            301..468
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1431
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="isoform 2 is encoded by transcript variant 2;
                     putative breast cancer tumor-suppressor; F-box only
                     protein 31; SCF ubiquitin ligase specificity factor"
                     /codon_start=1
                     /product="F-box only protein 31 isoform 2"
                     /protein_id="NP_001269612.1"
                     /db_xref="CCDS:CCDS73922.1"
                     /db_xref="GeneID:79791"
                     /db_xref="HGNC:HGNC:16510"
                     /db_xref="MIM:609102"
                     /translation="MYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHG
                     HIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKF
                     IYTSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKIT
                     GDPNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGE
                     GRGRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVL
                     PVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSF
                     SLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS"
     exon            469..543
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            544..653
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            654..807
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1208
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..5732
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3361..3366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="hexamer: ATTAAA"
     polyA_site      3383
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="major polyA site"
     regulatory      5711..5716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
                     /note="hexamer: AGTAAA"
     polyA_site      5732
                     /gene="FBXO31"
                     /gene_synonym="FBX14; Fbx31; FBXO14; MRT45; pp2386"
ORIGIN      
        1 agccccgccc agcaccgctg ggcgcctgag gcccctgaga ttccgaaatt tttaacctct
       61 gaagctgtgc cttcacatga tctaggacag cgttcagaag atggctacag tctgttggtt
      121 tgtattctgt gaaaatagaa aaaaaaatcc gagtatggtg tttgcgaaaa cttgcggaag
      181 ctggagatca caggcgtgtc ttgtcgggac gtctatgcga agctgcttca ccgatataga
      241 cacattttgg gattgtggca gccagatatc gggccatacg gaggactgct gaacgtggtg
      301 gtggacggcc tgttcatcat cgggtggatg tacctgcctc cccatgaccc ccacgtcgat
      361 gaccctatga gattcaagcc tctgttcagg atccacctga tggagaggaa ggctgccaca
      421 gtggagtgca tgtacggcca caaagggccc caccacggcc acatccagat tgtgaagaag
      481 gatgagttct ccaccaagtg caaccagacg gaccaccaca ggatgtccgg cgggaggcag
      541 gaggagtttc ggacgtggct gagggaggaa tgggggcgca cgctggagga catcttccac
      601 gagcacatgc aggagctcat cctgatgaag ttcatctaca ccagtcagta cgacaactgc
      661 ctgacctacc gccgcatcta cctgccgccc agccgccccg acgacctcat caagcctggc
      721 ctcttcaaag gtacctatgg cagccacggc ctggagattg tgatgctcag cttccacggc
      781 cggcgtgcca ggggcaccaa gatcacgggc gaccccaaca tccccgctgg gcagcagaca
      841 gtggagatcg acctgaggca tcggatccag ctgcccgacc tcgagaacca gcgcaacttc
      901 aatgagctct cccgcatcgt cctggaggtg cgcgagaggg tgcgccagga gcagcaggaa
      961 ggcgggcacg aggcgggcga gggtcgtggc cggcagggcc cccgggagtc ccagccaagc
     1021 cctgcccagc ccagggcaga ggcgcccagc aagggcccag atgggacacc tggtgaggat
     1081 ggtggcgagc ctggggatgc cgtagctgcg gccgagcagc ctgcccagtg tgggcagggg
     1141 cagccgttcg tgctgcccgt gggcgtgagc tccaggaatg aggactaccc ccgaacctgc
     1201 aggatgtgtt tttatggcac aggcctcatc gcgggccacg gcttcaccag ccctgaacgc
     1261 acccccgggg tcttcatcct cttcgatgag gaccgcttcg ggttcgtctg gctggagctg
     1321 aaatccttca gcctgtacag ccgggtccag gccaccttcc ggaacgcaga tgcgccgtcc
     1381 ccacaggcct tcgatgagat gctcaagaac attcagtccc tcacctcctg accggccaca
     1441 tccttgccgc cacatcccgg gtggctctgg ggctctgaac tctgacctgt gaatagaagc
     1501 agcatgcact ttggaaatcc ggccttttga ccagaacgca cacctcgtcg gggggcccag
     1561 tccagccacc ccccagcact ttatgtagag agtgtgacat agacctgcat atttgtcagt
     1621 gccatgatgg aagaagctga gcatgtctta ccaaaaacag agagaacgag cctgaataca
     1681 gcagatgtag gggacagccg tgggaccgcg tgagaattga agcggtgggg ttcccgcacc
     1741 ctgggctggc tggtggtttt ctcgggaagc aggaccctcc tgactggtgc tcttcctgtg
     1801 agcggataga gtgatagact gggtcgtgtg tgagacgcat gtgctccacc ccactccttt
     1861 tgggggaagc caggcaacag tggcctctgg gagggggtca ggaagaggcg aacagctcag
     1921 gcagcgcagg tgtgatgggc acagtacgca gagcaagctc gggaagttgg taggatctca
     1981 ggcttggggc cgggactctg gagtgaatcc ccatttctct accggcttgc ttggagtttg
     2041 gacagaagca tttcacctct gatctcagct tccccacctg tggagtgggt ttagtgacct
     2101 gagtcactag ggaatgtcac ctgaatgcac agcccagccc atgcacctgc cccagcccct
     2161 ccagctttgg agccaaggcc atcgttccag ccacttgact gtcctcgacg gcctgttcca
     2221 gacagggcgt ttgttttgtc catgccttcc tccctgcacg cacacggcgt caaaaccaag
     2281 ctgccggcca ctgtctccag aacgcaaggc tccaggcccg tgtgtctgaa gcagtgagtg
     2341 gtccacacag gtgccaggag tgcccatatg agatgacgag gaaacccctt tgcaggtgag
     2401 gggacagctt tctagaaaag ccacacctgc atctggggac acactttgga aagtgggacc
     2461 ctccagcctg gagaccccat ggactgatgc ctccactgct gtgtgcccca tgttgtgtta
     2521 acacctgcgt gtggggaccc catctgaggt cttggctgag gttggcatct cctgaagaac
     2581 agagagcacg gtgtccagag ctggcccttc ccccagccca cagccagctc cgtgcccgag
     2641 tgggcgtccc cagcgagcct tccctctctg ccgcttgtcc ttgtgtctgg gctgctccaa
     2701 gtccttgtgc tgggcaccct ggacacgtcc tgctggtgag ggacctcggg aaggtgacag
     2761 tctgtgtgcc ttggtgtgga gaccaacctg aggatgtcct gggaaatgtt ttcctgatga
     2821 atttctcctt gactggcctt taaagaacat aagaattccc attgcccagc ctcagtgcat
     2881 ttggcaaatg cttactttgc ttcccagagt cagagaattg gcaaaggttc ctaaatggta
     2941 atctggccgg cctgggagaa agactcacga gaaaagccag tggagaaagc gcccttccag
     3001 ggcggcagca gcgggagcca cgcagacccc gaggcgcacc tgctggctct tgtgtgtggc
     3061 cccagtttct agcggctttt gcagcattag cctacaagct ttgtcactcc ctgccctctg
     3121 tggtggtcac tgtttttctc tcttgccaaa tgaggcagtc tctgagtgac ggtgactgtg
     3181 gccttgaagc ctggaggact gttgggcatg tagactggca ccttgaagat tcaccattgt
     3241 ttaaataaaa tcaagcaaat gcttttttac caagagcccg agcctcgctc taagggacgc
     3301 agtcctagag gcgtgccctt tggggcttga agagcacact gtgggacgca cgtgcttctg
     3361 attaaaggaa tctcagatct caattacgct tccagtgttt gggtatagaa atagcttcca
     3421 cccatcatgt ctcagccatg ggctgttggt cagttcatgt ggctcctggt tctggtgtgt
     3481 atgttggggg cgggggtctc tccatggtgg tgacctgcag tgatgccagg cagggccaga
     3541 gccacacagc caggaaaggg aggccttttt ggccgcacag ccagtccctt cagtcgtgac
     3601 tacaggtctt gttttttccg ctccgatgtg tccttagcca gttcttggct ccggttctgt
     3661 agggacaggc actgaatctg cgcgcctcaa aacagcagct tcccttccgg gggagggcat
     3721 ccaccctctc aggggatcct gcaggtggcc catttcctgc aggtgagaac tcggaagggc
     3781 tgatgtcgtc atcagaggcc taagggcagc tgagagttgg ataaaaccgt ttccaaggag
     3841 gaggctgagt aacccagttc aggacagcca agcgcattag gcttgattgg ggaaggtggc
     3901 aggtggagtt gggaggttgg gactctccat cttttgcacc acggatgcct ttctgtcgct
     3961 gtctcactct ggggcaggat caagtctgct ctctggagtg gggctgcctg cagtgcagct
     4021 ctgcacacct gaacgtgttc tttgtcactt gtttggaaat gatgtgattg aagatttcag
     4081 agaggtcatt ggaggctttt ctgtgccggc actgaatgtt catttgcatg aggaagttgc
     4141 aaacgacttc tgcaggctga gattcaaggc aggtggtatt ggggtccctc agcccacctg
     4201 ggccgtgacc tcaagtgtcc actgctgagt gtgagtggct ttgcaggcct ggtggtggga
     4261 gagcctcagg ctccctcctt cttcgttcct gaccatgccc tgggcccctt cagtctgcct
     4321 gcggctctgt ggcatccctg ccctgacact gggcacctgt gcccctagca agcccacctg
     4381 gcacacgagg agggaggggt gggtggccat gtccttcctc tagccacatg ccctgctggc
     4441 cgctccattc tgagctttgt gcagaaccgg gtctgagctg gagatttttc tctgagaacc
     4501 tgcagttgtg ctgcagccgc acgcaagggc ccttcagccg ctggctctgg cttccctgac
     4561 tcctcagggc gtgttcaccc ccaggctttc tcacctgcac acggttaggc cattttcagt
     4621 gctcgtgggc agtcacggac agcagcagaa actcctcagc ccctttgtta cttcagaacg
     4681 cctgcccaca tgcatcttct gagctcgtgt tgtcctcatg gccgtggggt cttgggtgcg
     4741 aacaggagat gctgagctgt ggtccaccgt ccaaggtgct gcagaaagca gctaggctct
     4801 tttaggatgt ttctattctg gttgctgcct tcgtggtgta acttttaaga acacttacgg
     4861 gaatgtgctc atagaaccat cacctgtcct gagaataaaa ctcctggaat catgatcaag
     4921 tccagtgtta acgtggccca acctgtctgt acttctgggg agagaccagg aacatcactg
     4981 gactcctcat ccccgtaatt atttagagaa gatgcaagca gcagatagtc tccatgcggc
     5041 tggtactttt tttgttgttt tttgagacag ggtcttgctc tgtcacctgg gctggagtgc
     5101 agagcggcga tcatggctcc ctgaggcctc aacctactag gctcaagctg tctgcccgcc
     5161 ttagcctccc aagtagctgg gaccacaggc acccaccacc accatgcttg gctaacttgt
     5221 ttttgtagag atggagtttt gccatgttgc tcaggttggt ctcgaactcc cgatctcagg
     5281 tgatccaccc gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc cctgcgcccc
     5341 agccttgggg cctgtctttg aatgggaatg agactgtgca aaccgtggac taccctgtgt
     5401 cacccacagc tcagtggcct gcctgccggc cctcaggggc tgctgaccgg gagaccagcc
     5461 agagcacgag ggggtcaggg ctgtgtgggt tttggcctga ttctgcattt ggttgtttct
     5521 gggggccatg tagcctgcct gcattaggaa agcgctgtgc catctgatca tgagcacctc
     5581 tgcaccccct ggtaaggtga ccttgcagca ggagctgtgc cctgcctggg taggcaccca
     5641 ctaggtagga ccggagcaat cctggcagcc gccacctgca cccgtgcact tgtttctcct
     5701 cacagtttca agtaaatccg tttttgaagg ct
//
