LOCUS       NM_032145               9051 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens F-box protein 30 (FBXO30), transcript variant 1, mRNA.
ACCESSION   NM_032145
VERSION     NM_032145.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9051)
  AUTHORS   Yuan,Y., Liu,Z., Li,B., Gong,Z., Piao,C., Liu,Z., Zhang,Z. and
            Dong,X.
  TITLE     FBXO30 functions as a tumor suppressor and an E3 ubiquitin ligase
            for hZIP1-mediated HIF-1alpha degradation in renal cell carcinoma
  JOURNAL   Int J Oncol 62 (3) (2023)
   PUBMED   36799168
  REMARK    GeneRIF: FBXO30 functions as a tumor suppressor and an E3 ubiquitin
            ligase for hZIP1mediated HIF1alpha degradation in renal cell
            carcinoma.
REFERENCE   2  (bases 1 to 9051)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9051)
  AUTHORS   Cheng,X., Pei,P., Yu,J., Zhang,Q., Li,D., Xie,X., Wu,J., Wang,S.
            and Zhang,T.
  TITLE     F-box protein FBXO30 mediates retinoic acid receptor gamma
            ubiquitination and regulates BMP signaling in neural tube defects
  JOURNAL   Cell Death Dis 10 (8), 551 (2019)
   PUBMED   31320612
  REMARK    GeneRIF: Retinoic acid receptor gamma levels are controlled by
            FBXO30-mediated ubiquitination and that FBXO30 is a key regulator
            of BMP signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9051)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 9051)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   6  (bases 1 to 9051)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 9051)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (bases 1 to 9051)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 9051)
  AUTHORS   Xiong,W., Zeng,Z.Y., Shen,S.R., Li,X.L., Li,W.F., Wang,R.,
            Xiong,F., Peng,C., Zhang,Q.H., Zhou,M., Yang,Y.X., Zhou,H.D.,
            Huang,H. and Li,G.Y.
  TITLE     [Studies on the relationship between D6S1581, a high frequency
            allele imbalance locus, and genetic susceptibility to
            nasopharyngeal carcinoma]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20 (4), 311-314 (2003)
   PUBMED   12903040
  REMARK    GeneRIF: Results suggest that D6S1581 is highly associated with
            nasopharyngeal carcinoma, and there may be one or more NPC
            associated genes near D6S1581, including FBXO30.
REFERENCE   10 (bases 1 to 9051)
  AUTHORS   Li,Z.H., Zhang,X.H. and Li,G.Y.
  TITLE     [Study on the fusion expression of FBXO30: a novel member of F-box
            protein family]
  JOURNAL   Hunan Yi Ke Da Xue Xue Bao 26 (6), 495-498 (2001)
   PUBMED   12536519
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356599.19, BG718454.1,
            BC024326.1, AF248640.2 and AL023806.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032145.4.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class and it is upregulated in nasopharyngeal
            carcinoma. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.134945.1,
                                           SRR1660809.40145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237281.5/ ENSP00000237281.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL356599.19        19720-19729         c
            11-42               BG718454.1         14-45
            43-4359             BC024326.1         1-4317
            4360-4418           AF248640.2         3171-3229
            4419-7386           AL356599.19        101-3068            c
            7387-9051           AL023806.1         1-1665
FEATURES             Location/Qualifiers
     source          1..9051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.3"
     gene            1..9051
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /note="F-box protein 30"
                     /db_xref="GeneID:84085"
                     /db_xref="HGNC:HGNC:15600"
                     /db_xref="MIM:609101"
     exon            1..193
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /inference="alignment:Splign:2.1.0"
     exon            194..2243
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2447
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /note="F-box only protein, helicase, 18; F-box domain
                     protein"
                     /codon_start=1
                     /product="F-box only protein 30"
                     /protein_id="NP_115521.3"
                     /db_xref="CCDS:CCDS5208.1"
                     /db_xref="GeneID:84085"
                     /db_xref="HGNC:HGNC:15600"
                     /db_xref="MIM:609101"
                     /translation="MEEELQHSHCVNCVSRRCMTRPEPGISCDLIGCPLVCGAVFHSC
                     KADEHRLLCPFERVPCLNSDFGCPFTMARNKVAEHLEMCPASVVCCTMEWNRWPVSYA
                     DRKSYENLSRDVDEVAQLDMALALQDQRMLLESLKVATMMSKATDKVSKPREQISVKS
                     SVPEIPHANGLVSVDEESYGALYQATVETTRSLAAALDILNTATRDIGMLNTSVPNDM
                     DEQQNARESLEDQNLKDQDHLYEEEIGAVGGIDYNDTNQNAQSEQNGSSDLLCDLNTS
                     SYDTSALCNGFPLENICTQVIDQNQNLHGDSKQSNLTNGDCVASSDGTSKPSSSLAVA
                     AQLREIIPSSALPNGTVQHILMPDDEGEGELCWKKVDLGDVKNVDVLSFSHAPSFNFL
                     SNSCWSKPKEDKAVDTSDLEVAEDPMGLQGIDLITAALLFCLGDSPGGRGISDSRMAD
                     IYHIDVGTQTFSLPSAILATSTMVGEIASASACDHANPQLSNPSPFQTLGLDLVLECV
                     ARYQPKQRSMFTFVCGQLFRRKEFSSHFKNVHGDIHAGLNGWMEQRCPLAYYGCTYSQ
                     RRFCPSIQGAKIIHDRHLRSFGVQPCVSTVLVEPARNCVLGLHNDHLSSLPFEVLQHI
                     AGFLDGFSLCQLSCVSKLMRDVCGSLLQSRGMVILQWGKRKYPEGNSSWQIKEKVWRF
                     STAFCSVNEWKFADILSMADHLKKCSYNVVEKREEAIPLPCMCVTRELTKEGRSLRSV
                     LKPVL"
     exon            2244..9051
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4336..4341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /note="hexamer: AATAAA"
     polyA_site      4359
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /note="major polyA site"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /note="hexamer: AATAAA"
     polyA_site      4429
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
     regulatory      9031..9036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
                     /note="hexamer: AATAAA"
     polyA_site      9051
                     /gene="FBXO30"
                     /gene_synonym="Fbx30"
ORIGIN      
        1 gcgcgaggag ggtggctgcc tctggagcag gccgggagaa gagaaaaggc ggcggcccgg
       61 ctggggaaga ggggcggagg aggcggttcg gacggctgtg tggggtacgg agcgtcgccg
      121 ggacagagcg gagcagctgg gcacggcgtc cagggcagct agggcctggg ccgcggttcg
      181 gccgcgccgg ccgagctgga ctggccatta tggaggagga gctgcagcat tcccattgtg
      241 tgaattgtgt cagtagacgg tgcatgacca ggccagagcc agggatttcc tgtgatttga
      301 ttggttgtcc attggtttgt ggtgcagttt tccattcttg taaagctgat gagcatcgac
      361 ttttatgtcc atttgaacga gtgccttgct taaatagtga ctttggatgt ccatttacca
      421 tggcccgaaa taaagttgct gaacatctag aaatgtgtcc tgcaagtgtg gtgtgctgta
      481 ctatggaatg gaatcgatgg ccagttagtt atgcagaccg gaaatcatat gaaaatctaa
      541 gcagagatgt cgatgaagtg gcacaattgg atatggcctt ggctcttcaa gaccaaagga
      601 tgctcttaga atccctcaaa gtagccacca tgatgtcaaa agcaactgat aaagtatcca
      661 aacctagaga acaaatctca gttaaatcaa gtgtcccaga aataccacat gctaatggtt
      721 tagtgtctgt tgatgaagaa tcttatggtg cactttatca agctactgta gaaacaacca
      781 gaagtttggc tgctgctttg gatatcctga atactgctac aagagacatt ggcatgttaa
      841 atacaagtgt cccaaatgac atggatgaac agcaaaatgc gagagaaagc ttagaggatc
      901 aaaacttgaa agaccaagat catctttatg aggaggaaat aggagcagta ggtggaattg
      961 actacaatga cacaaatcag aatgcccagt ctgaacaaaa tggttcaagt gatttattat
     1021 gtgacttgaa tacaagttct tatgacactt ctgctctttg taatggcttt cctttggaaa
     1081 atatatgtac ccaggtcata gaccagaatc agaatttaca tggtgattca aaacaaagta
     1141 acttaacaaa tggagactgt gtggcatcat cagatggcac ttcaaaacct tccagctcac
     1201 ttgcggtggc agcacaactt agggaaataa taccatccag tgctttgcct aatggcacag
     1261 ttcagcatat cctcatgcca gatgatgaag gtgaaggtga attgtgttgg aaaaaagtag
     1321 acttagggga cgtgaagaat gtggatgtct tatctttcag tcatgctcct tcattcaatt
     1381 ttctttctaa ttcatgttgg tctaaaccaa aggaagataa agcagtagat acatcagatt
     1441 tggaagttgc agaagatcct atgggcctcc aaggaataga tctgatcaca gcagcattgc
     1501 ttttttgtct aggagattct ccaggaggga ggggtatatc tgatagccgc atggctgata
     1561 tttatcacat tgacgttggg actcagactt tttcacttcc atctgcaata ttagctacaa
     1621 gtacaatggt tggggagata gcttcagctt cagcttgtga tcatgccaat ccacagcttt
     1681 caaatccaag tccgtttcag acacttgggc tggatttagt attggaatgt gtcgctaggt
     1741 accaacccaa gcagcgttca atgtttacct ttgtgtgtgg acagttattt agaaggaaag
     1801 aattttcttc ccactttaag aatgtgcatg gtgacattca tgctggactc aatggctgga
     1861 tggaacagag gtgcccttta gcttactatg gttgtaccta ttctcagcgt agattttgtc
     1921 catcaataca aggagcaaag attatacatg accgccattt gaggtcattt ggagttcagc
     1981 catgtgtatc tacagtatta gtggagcctg ctagaaactg tgtgttggga ttacataatg
     2041 accatctaag tagtcttcct tttgaggtcc tgcagcatat tgcaggcttt ctcgatggct
     2101 tcagcttatg tcagctctca tgtgtatcca agttaatgag ggatgtgtgt ggcagcctgc
     2161 ttcagtctcg tggcatggtc atactgcagt gggggaaaag gaagtatcca gaaggaaatt
     2221 catcatggca gataaaagaa aaggtatggc gatttagtac tgcattttgt tctgttaatg
     2281 aatggaaatt tgctgacatc ctaagcatgg cagaccactt gaagaaatgc agttacaatg
     2341 ttgtcgagaa acgggaggaa gcaatccctt tgccatgtat gtgtgtgaca cgagaactca
     2401 ctaaagaagg acgttcacta cgctcagttt taaaacctgt actttaaaag ttgtaatatt
     2461 actagcacat atatgcaagc acctagtata atttctttgt aatatgtgaa actttattaa
     2521 tgtattaaat attacaacta gctaaattta ttgtcactgt gtatataatg ttttgaagtg
     2581 acatctattt ttataaagta ctgtttagtt ggaaaaagtt gccttaatgt ttgaaatgtg
     2641 tgaaattttt ggaacttgct ggacagggtg atttaatttt tagctacata attttaagaa
     2701 ttagtatttt cagtggtgtg catattttgg ttcttaaatt tttgcttctt aaactaaaaa
     2761 aatcctgacc aatttatttg ttgttttctg tgggttgcga cccatgcaat caaaaagcaa
     2821 aattttgatt gagatttttt acagcatagg tttttcatat aaaaatattc tgaatttgtt
     2881 aagcactgcc ataatatcat tataatgttt ttgtctttta gtgcttccct atacaattgt
     2941 taatgcacaa atgatctcta atatatactt acatacgtaa aatcataaag tttggtaatg
     3001 cagtttatcg ttttaaaaat aatccacaaa gatgttttta tctcacatac ttacaactca
     3061 acacacagag tgaccatgtg cagctttctt ttttgttaga tgccacatcc gaagactcat
     3121 cgcagtgtgt tatatgacag gacaaagcaa aaacaaacaa aaagcaagcc tgtgaatata
     3181 atttaatttg aaactgctcc tggtattata tatttgctag ttatctaatg ttttaaaaga
     3241 aaatatacct catttaggtt tgaattgggc gtattgtgta aatttcaaat attcagaatg
     3301 caaagggctt gactattaaa tgtttgcctt tgatgtttat aaacattaca actatgttgt
     3361 tttaagacat ttaaaaacgt gaaatttgtt atctttgtaa aatgacaatc atgtagaaac
     3421 ctgtcttggt tgacaatctc tttgaaacat ttccgagtta atttcccata ggcttcacca
     3481 ccaagaaagt aagaattgca tctttacata atgatcaagg tataatggaa aaatatacct
     3541 attcttgaag tagtttatta tagttttcaa attgatttat accattatta acctgatgtg
     3601 gtctgcttaa aaaatgaata tatcagtatt tagaaataaa ttgcaaaggt gggaatatat
     3661 acttaaataa tttgtcttaa gtaaattagc atttggtagt ctgaaatggt gacagattac
     3721 ttgttaaaat tgtgaaaact ctgttgtgtc ctctcttcct acatttgtcc ctgagagtac
     3781 tccacgatta ctaggttctt gattccctta tatggcaatc aggcagaggc gttccttaag
     3841 cattagagag ttctgaagct taagatttgt tttggttgga tgaagtcctt agtacagttg
     3901 aaaaacagag cattaaagac taatcaattg ttttgcctca ccagtcattt taaatagtag
     3961 aatacttatt tctcagtgct taaaatttct ttttcaactg tgagattgaa taaacagtct
     4021 ctatttctgt ggaaaaaaca acagaaaaga gatattaaat accataaaat gtaactctgc
     4081 cttttaaagt tttgctgaag aatgtgtctg tggttaggat agcacaagca ttaacttttg
     4141 ttttatagtt atgcttttta aaattcattg tttttaaatt tagacttctt atttccacac
     4201 tggattatga gatacttaac aatttttcca ccttatattt cttttacaca ttttgctgtt
     4261 ctcttttttg ttattgttat gccaccatac cattttgtta aaatgttttc tttgtgaaac
     4321 atttgttcaa gttctaataa aattaatgtt ttcccttaac atggctcaat aacttaaaaa
     4381 cgttcattta aataaaattt taatacttgt ttgacaaatt ccaacacaat catattgttt
     4441 ctgtaatgtg gattttctgc atgttatggt agttgttgat tatcatcatt actcacccat
     4501 gttttactag tgaaccttaa tttttttaaa atttgagaca cgcattagtt agctttctct
     4561 gatccttcag tgtctcgaaa gtaataccac ctaggtgcac tgaaaggcgg aagagtttct
     4621 agcatggtta tagctctaaa agttgtcatg gaaaccatct ctctctcctc ttaagtatga
     4681 aaaggttttt atgttggcct aatagattgt actttgagaa gtcatcattg attccttagt
     4741 ctttgctaaa tagcaaggta aaaggcaagc atcgggatgg agggaagtat ttgaattcac
     4801 ttttgtcctc tgcctccttc ctcaatactg cctgttagct taatctttct ccctctccct
     4861 ttcccttctc cctctctcac tcttttttct agattttgag actcacagat cttacagcag
     4921 tggttcctaa agtgtggtcc ttggaccagc aggaacatca acacctagga atttgttaga
     4981 aatgcagatt attaggcttc tctccagact tagtgaatca ggaactctgg ggtgggaccc
     5041 aacaatctgt tttaacaaga tctctaggtg attctaacgc acagtaaagt attagaactt
     5101 agagggaaga ctgggtcatg ccagctaccc tctggtgcat tactggagtg gatatatgtg
     5161 tgtacctgtg tgtgtttgta taaatatatg tgtaatccaa aagtcagtaa tggtaattta
     5221 ttaatggtta aactatatat gttgtctcaa ttttacagcc atatgacaaa atacactggg
     5281 tactgtagtt gttggacttg tattctttaa attagtattt actagtattt aaaattttac
     5341 taaaatttta ctagtgtttc ttctgttcaa ggtaaattgc agtgcaaatt ttagttcatt
     5401 agcagtaaca tttagcctag tcatctcatt ctcttgttta gtggttgtag agtcgtgaac
     5461 atattcaaat tgtagggtaa tcaaagagta gaagtagaca aatattggat taaatcctac
     5521 aaaaaatatt tttagggatc ttttcaaccc tatcaataag atgttatgaa agattggatc
     5581 tcttgtttac aagtagtata gaatcttttt tgatctttga ctctgtgctg cctatctcat
     5641 caatgttgtt gctattaata tctgtccttt aacactggat gttgggatct tagtaatgtt
     5701 gctgataata ggattttcag caaaacttcc atatcccttg aagatatggt agtttatatt
     5761 actatatcga taacagtttt gcctgtggag atttgactag ttttaggtgt ttggaagcaa
     5821 aacagatttc ttcatgtttt gcatcccaac ctgaaaagac atggggttta ttaattttaa
     5881 aatttcctaa ggaaaagtta ttcaaatatt ttaaaatgtg tttgtttcat gcatgacatg
     5941 ccacattggt gatgtgattg gagcttgcag agttggttgt ttagaagtgc agtagagaga
     6001 aagcaattgg ccctcattct ctggacagac ttttgatgga aagaatttct ctgataggtg
     6061 tttgactggt tatctaaacg ttgctgttaa gtagtcttac ttaagatgct cataaggtct
     6121 aggaagcaga gaatattagt tataccttta tcaactcatc agtgacttgt ttgatggtgt
     6181 ttaagataat ttaataatgg ggtttgacag gatttgtctg atttccaaaa aagcaaagtt
     6241 cgaattcaga aaagatcaac tctaatgaag tcctttctaa ataagggaaa aggaaagatg
     6301 gtttgctttt gaagtcatct tttacataat tatttccctt tatttaaaag attaaagtga
     6361 gatcaagaga taaaaccttt caaatttgaa ttttatggat gagaaaatag gtactcaaaa
     6421 tttaggcagt gattagtgta ctgggatatt tgagagagaa ttatgtcctt acatagatca
     6481 ctttttcact ttacgaatgc aggaagaaaa gagatgttta gatgtaagga aatttggaaa
     6541 atgttgccta ggatatttga ttcctactgc tttggaaagc attttggagc aataccaaaa
     6601 ggaaactaac taaccaagtg tgatatgttg ctctgaaaat ctttgcgaaa tgagggcctc
     6661 ttgctgaatt ttacaagtag gttattgcat ctatgattaa acttttttaa ataaattgct
     6721 tatacatgtt tatttgacat atataatctt cataattggc cagtacacct tgagatgtat
     6781 taatggcgat acatcttgag gtgctttgtt accttagcac atttcaaaac tggcattttg
     6841 tattcagatt gttttatatt tcaatgtatt atgtggagag tgacttttca ttaataaact
     6901 acaaagaaat gggttataag gaatattcat gaacatgctc tatagaaata taataaaaat
     6961 tcattgatgc aaagtccttt tttaaaaata attttcaatc tttttgataa gctggacgga
     7021 agcatctgtc ttttactatg aagaaaacat ttttgaagtg aactgacaac ataaggcaaa
     7081 tactgggtaa aaatttaagc atctccaaaa tcattttatt aacccatttg catgcaaata
     7141 ctagggaatg gttcttcaat atgtagctag ttcttgtggt ggttaatagt tcttcgtgta
     7201 tttgaaagta acaaaactgc atttgtgttg aactcttaag accaattaat caggtcaaat
     7261 tgctcttaag accaataaat taggtcagtt gctcctaaca aaggcaaatt catcagattt
     7321 aatttctacc cttttctaat ataaattttt agaaattttg tttctcagat gtgaggcaaa
     7381 taggttgatc tatttgttta ttctttgaca gagagactga ctagagttag acagcttttt
     7441 aatacccctt ccagtcaaaa agtaacattg ttatattagt atttagtagt tttaaagtct
     7501 gatgacataa gaacagtaac aatttgttaa tattcaaaag attgaaattg aaaaaaaggg
     7561 gtcctgcatt ctgctgtcct agaatttttt tttgtgttga aatcttcttt tccatattgt
     7621 cattattgct tctttatccc atgacattaa ttttctggtg aggtgaccct gaatttagtc
     7681 attttcgtca gtaattttag atttaagtaa cttatcatgc ttgttttaaa gtctctctca
     7741 gctcacccgt gaagaaacaa attttttttc atttttttct tcaaaaatca gcaagtattg
     7801 ctgaatctaa caagtatcag cattcaggtt taaccgtgtt atttgattga aataaatcaa
     7861 accatggaaa taatgggcac tgtgtctgct caagagtaaa attacccaat gaatgattat
     7921 gtcaactgga tgtcttttat atcaattgat gactttttaa aaaatctgta ttttaaataa
     7981 aatatggaga gaacagtatt ggtccctaca acattccaat agctttgtca tgacagccat
     8041 gtcatatgaa ataacttact ctgaatggct aataattcag tggagatgaa ttctaaagat
     8101 ttttatttgc acttaaaatg ttaaagtagt attgttcatt tgatcaatgt ttgaatacta
     8161 ctcagtattg aaaactttaa ctgcattctg aaaggtcatt gcgccgattg gcttacctaa
     8221 gatgtcattt agcttccttt tctcatgatt tacataaatg ttgttacctt aaatgcagaa
     8281 agatgtgata ttctttggag gataaaaaac ctaagtgaat gaagctagac acaaaaggct
     8341 acatattata tgatttcatt tatatgaaat atgcagaata ggtaaattca tagagataaa
     8401 tcagattcat ggttgctggg ggaatgggag tgactgcttc atgggtatgg ggttttcttt
     8461 tggattgatg aaaatattgt agaacaagat agtggggata gttgcacatt gtgaatgtgc
     8521 caaaatgcca gtgaattgta tactttaaaa tggtgtattt gatgtgtatt ttattacaat
     8581 taaaaagaaa agaatttgat atttgcaatc attaccaaag ccaaaaacta gtgttctcaa
     8641 cgtttgtgaa atgcccaaac cgtggtttag aattaattta tagcattagt aacatgacaa
     8701 atctattcag cttaaagttc tagtaaaatt tgtgaatccc atcatagaag tactcctgac
     8761 agcagcagaa ataaagctgt aattcatcaa aatttcctta tatttaaaac ttctgtgact
     8821 gagtgattga cttctgtgtc aatgtttatt ttttatcttt tgaaatttat tatgattcct
     8881 tgtggcacat cccaatcacg ctttttaaag atgtgttttt aaaaccatgc tttgaaaaaa
     8941 atttgtataa ttttcaaggt ttttttttat agttttatac tttgtttctt ttaaagaaca
     9001 aatgcaactt gttgtattag agtaagacta aataaattgt actgatgtgt a
//
