LOCUS       NM_178820               2315 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 27 (FBXO27), mRNA.
ACCESSION   NM_178820
VERSION     NM_178820.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2315)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2315)
  AUTHORS   Yoshida,Y., Yasuda,S., Fujita,T., Hamasaki,M., Murakami,A.,
            Kawawaki,J., Iwai,K., Saeki,Y., Yoshimori,T., Matsuda,N. and
            Tanaka,K.
  TITLE     Ubiquitination of exposed glycoproteins by SCFFBXO27 directs
            damaged lysosomes for autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (32), 8574-8579 (2017)
   PUBMED   28743755
  REMARK    GeneRIF: SCF(FBXO27) ubiquitinates glycoproteins exposed upon
            lysosomal damage to induce lysophagy.
REFERENCE   3  (bases 1 to 2315)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   4  (bases 1 to 2315)
  AUTHORS   Glenn,K.A., Nelson,R.F., Wen,H.M., Mallinger,A.J. and Paulson,H.L.
  TITLE     Diversity in tissue expression, substrate binding, and SCF complex
            formation for a lectin family of ubiquitin ligases
  JOURNAL   J Biol Chem 283 (19), 12717-12729 (2008)
   PUBMED   18203720
REFERENCE   5  (bases 1 to 2315)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   6  (bases 1 to 2315)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
REFERENCE   7  (bases 1 to 2315)
  AUTHORS   Bauters,F. and Goudemand,M.
  TITLE     [Clinical conference: Thrombocythemic introduction to chronic
            myeloid leukemia]
  JOURNAL   Nouv Rev Fr Hematol 15 (2), 241-244 (1975)
   PUBMED   126433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX377760.2, AF436061.1, AC010605.4 and BC014527.2.
            
            On Nov 23, 2018 this sequence version replaced NM_178820.4.
            
            Summary: Members of the F-box protein family, such as FBXO27, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014527.2, GQ901044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292853.9/ ENSP00000292853.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BX377760.2         49-58
            11-94               AF436061.1         1-84
            95-95               AC010605.4         36495-36495         c
            96-1036             AF436061.1         86-1026
            1037-1320           AC010605.4         29305-29588         c
            1321-2311           AF436061.1         1311-2301
            2312-2315           BC014527.2         2321-2324
FEATURES             Location/Qualifiers
     source          1..2315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2315
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /note="F-box protein 27"
                     /db_xref="GeneID:126433"
                     /db_xref="HGNC:HGNC:18753"
                     /db_xref="MIM:609099"
     exon            1..47
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /inference="alignment:Splign:2.1.0"
     exon            48..437
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..925
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /note="F-box protein FBG5; F-box/G-domain protein 5;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="F-box only protein 27"
                     /protein_id="NP_849142.1"
                     /db_xref="CCDS:CCDS12527.1"
                     /db_xref="GeneID:126433"
                     /db_xref="HGNC:HGNC:18753"
                     /db_xref="MIM:609099"
                     /translation="MGASVSRGRAARVPAPEPEPEEALDLSQLPPELLLVVLSHVPPR
                     TLLGRCRQVCRGWRALVDGQALWLLILARDHGATGRALLHLARSCQSPARNARPCPLG
                     RFCARRPIGRNLIRNPCGQEGLRKWMVQHGGDGWVVEENRTTVPGAPSQTCFVTSFSW
                     CCKKQVLDLEEEGLWPELLDSGRIEICVSDWWGARHDSGCMYRLLVQLLDANQTVLDK
                     FSAVPDPIPQWNNNACLHVTHVFSNIKMGVRFVSFEHRGQDTQFWAGHYGARVTNSSV
                     IVRVRLS"
     exon            438..549
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /inference="alignment:Splign:2.1.0"
     exon            550..645
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /inference="alignment:Splign:2.1.0"
     exon            646..781
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /inference="alignment:Splign:2.1.0"
     exon            782..2315
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /note="hexamer: AATAAA"
     polyA_site      2315
                     /gene="FBXO27"
                     /gene_synonym="FBG5; Fbx27"
                     /note="major polyA site"
ORIGIN      
        1 gcggcacagc tagggcatcc cggcgaggag cgccgccagg ccccgggcca cagccgggcc
       61 tggcgggggg accatgggcg cctcggtctc caggggccgg gccgcccggg tccccgcgcc
      121 ggagccggaa cccgaagagg cgctggacct gagccaacta cccccagagc tgcttctggt
      181 ggtgctgagc cacgtccccc cgcgcacgct gctcgggcgc tgccgccaag tgtgccgggg
      241 ctggcgagcc ctggtggacg gccaggccct gtggctgctg atcctggccc gcgaccacgg
      301 cgccaccggc cgcgcgctgc tgcacctcgc ccgcagctgc cagtctcccg cccgtaacgc
      361 caggccttgc cccctgggcc gcttctgcgc gcgcagaccc atcggacgca accttattcg
      421 caacccctgc ggccaagaag gcctccgaaa gtggatggtg caacacggtg gggacggctg
      481 ggtggtggag gaaaacagga caaccgtgcc tggggcccct tctcagacgt gcttcgtgac
      541 ttcattcagc tggtgttgca agaagcaggt cttggaccta gaggaggagg gtctgtggcc
      601 agaactgctg gatagtggca ggattgagat ttgtgtctct gactggtggg gagcccgaca
      661 cgacagcggc tgtatgtaca gactcctcgt ccaacttcta gacgccaacc agactgttct
      721 agataaattc tctgctgtgc ctgatcccat cccgcagtgg aacaacaatg cctgccttca
      781 cgtcacccac gtgttctcca acatcaagat gggcgtccgc tttgtgtctt tcgaacaccg
      841 gggccaggac acacagttct gggctggcca ctatggagcc cgtgtgacca actccagtgt
      901 gatcgtgcga gtccgtctgt cctagtccag cactaccctt cttgcaagac agcctgactg
      961 tgccttccag ggcctgggac cattggctgg gacccctcat taaccaacca agcacttgta
     1021 cctccctggc atactgagaa ttcctgggtc caatcaaagg ccctgacggg ccctgtcttc
     1081 aggttctaga aactaccaga agaagcttct tccatcttat ctacctactg cagctgctgc
     1141 tttgcggggg ggccctactg tactgagggg aaacccacaa gtgagcatgg gggaatgccc
     1201 atcctggaga agaattcttg ccctcccctc tcttctcctc ccaaccaaaa ccctccgatc
     1261 cagccccagg cccctctgta ccatcccctc ccctccgcac cactgacctc ttgtctcctg
     1321 ttgtttctgc cacagggact tccttggtcc cttcagggaa gccctcaact catctctgaa
     1381 cttagaatct catccttagg gctcagagag tcccagccct aagggtgtga acctcacctc
     1441 ctggggcttc cgagctacag ggctgggacc aggtcatgca gctgaaagtc tacgttaaaa
     1501 aaaaaaagtt tgggccaggc acagtggctc atgcctgtaa tcccagcact ttgggaggct
     1561 gaggcaggcg gatcacctga ggtcaggagt tcaagaccag cctggccaac atggtgaaac
     1621 cccgtctcta ctaaaaatcc aaaaaattag ccgggcttgg tggtgtgcac ctgtaattcc
     1681 agctactcgg gaggctgagg caggagaatt gcttgagccc gggaggcaga ggctgcagtg
     1741 aaccaagatc atgccactgc actccagcct gggcaacaca gcgagactcc gtctcaaaaa
     1801 gaaaaagttt ggatcaggca gggtggctca cacctgtaat ccctgcactt tgggaggcca
     1861 aggtgggagg atcagttgag ccccagagtt caagaccagc ctgggcaatg tagtaagacc
     1921 cccatcgcta caaaaaatac aaaagttagc caggtacagt agtacacacc tgtagtccaa
     1981 gctacttggg aggctgaagt gggaggatca tttgtgccca ggttgaggct atagtgagcc
     2041 atgatcatac cactgcactc cagcctgggt gacagagcga gaccctgtct caaaaaaaaa
     2101 aaagaatttg gagatggttc tgcccactct ggtttctctg aaaaaacgag gtaattccct
     2161 gagcccaacc ctgatcctca aggacctgta attgtgtggt atttaaaatt aaaataacat
     2221 tatttttatt ttgacttttt ttcaaacagt aagaataata tatcagcagc atgtatctgc
     2281 caatcatatg taataaattt cttattttgc caaaa
//
