LOCUS       NM_183420              10356 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box protein 25 (FBXO25), transcript variant 2, mRNA.
ACCESSION   NM_183420
VERSION     NM_183420.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10356)
  AUTHORS   Quintero-Barceinas,R.S., Gehringer,F., Ducker,C., Saxton,J. and
            Shaw,P.E.
  TITLE     ELK-1 ubiquitination status and transcriptional activity are
            modulated independently of F-Box protein FBXO25
  JOURNAL   J Biol Chem 296, 100214 (2021)
   PUBMED   33428929
  REMARK    GeneRIF: ELK-1 ubiquitination status and transcriptional activity
            are modulated independently of F-Box protein FBXO25.
REFERENCE   2  (bases 1 to 10356)
  AUTHORS   Kuzmanov,A., Johansen,P. and Hofbauer,G.
  TITLE     FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth and
            Metastasis through Cyclin D1
  JOURNAL   J Invest Dermatol 140 (12), 2496-2504 (2020)
   PUBMED   32335130
  REMARK    GeneRIF: FBXO25 Promotes Cutaneous Squamous Cell Carcinoma Growth
            and Metastasis through Cyclin D1.
REFERENCE   3  (bases 1 to 10356)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 10356)
  AUTHORS   Harich,B., Klein,M., Ockeloen,C.W., van der Voet,M.,
            Schimmel-Naber,M., de Leeuw,N., Schenck,A. and Franke,B.
  TITLE     From man to fly - convergent evidence links FBXO25 to ADHD and
            comorbid psychiatric phenotypes
  JOURNAL   J Child Psychol Psychiatry 61 (5), 545-555 (2020)
   PUBMED   31849056
  REMARK    GeneRIF: From man to fly - convergent evidence links FBXO25 to ADHD
            and comorbid psychiatric phenotypes.
REFERENCE   5  (bases 1 to 10356)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 10356)
  AUTHORS   Manfiolli,A.O., Maragno,A.L., Baqui,M.M., Yokoo,S., Teixeira,F.R.,
            Oliveira,E.B. and Gomes,M.D.
  TITLE     FBXO25-associated nuclear domains: a novel subnuclear structure
  JOURNAL   Mol Biol Cell 19 (5), 1848-1861 (2008)
   PUBMED   18287534
  REMARK    GeneRIF: The cellular distribution of FBXO25 and its colocalization
            with some nuclear proteins is investigated by using immunochemical
            and biochemical approaches.
REFERENCE   7  (bases 1 to 10356)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 10356)
  AUTHORS   Hagens,O., Minina,E., Schweiger,S., Ropers,H.H. and Kalscheuer,V.
  TITLE     Characterization of FBX25, encoding a novel brain-expressed F-box
            protein
  JOURNAL   Biochim Biophys Acta 1760 (1), 110-118 (2006)
   PUBMED   16278047
  REMARK    GeneRIF: investigated hFBX25's genomic organization and established
            hFBX25 as an FBP by verifying its interaction with Skp1 and Cul1
REFERENCE   9  (bases 1 to 10356)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 10356)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF419858.1, BC050393.1,
            AA316216.1, AI223050.1 and AC083964.3.
            
            On Jun 2, 2019 this sequence version replaced NM_183420.1.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class. Three alternatively spliced transcript variants
            encoding distinct isoforms have been found for this gene. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, as compared to variant 1. The encoded isoform (2)
            is missing an internal segment, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.122961.1,
                                           SRR1803614.87936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350302.8/ ENSP00000342077.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1444              AF419858.1         151-1594
            1445-1454           BC050393.1         1475-1484
            1455-1750           AA316216.1         180-475
            1751-1967           AI223050.1         2-218               c
            1968-2265           BC050393.1         1998-2295
            2266-10356          AC083964.3         105718-113808
FEATURES             Location/Qualifiers
     source          1..10356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.3"
     gene            1..10356
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /note="F-box protein 25"
                     /db_xref="GeneID:26260"
                     /db_xref="HGNC:HGNC:13596"
                     /db_xref="MIM:609098"
     exon            1..109
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            110..250
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1193
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     protein Fbx25; F-box only protein 25"
                     /codon_start=1
                     /product="F-box only protein 25 isoform 2"
                     /protein_id="NP_904356.1"
                     /db_xref="CCDS:CCDS5952.1"
                     /db_xref="GeneID:26260"
                     /db_xref="HGNC:HGNC:13596"
                     /db_xref="MIM:609098"
                     /translation="MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNRCNISHS
                     IILNSEDGEIFNNEEHEYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGYCT
                     LGEAFNRLDFSSAIQDIRRFNYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVL
                     DDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETILAWQQQLQDLQM
                     TKQVNNGLTLSDLPLHMLNNILYRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYH
                     FAEKQFCRHLILSEKGHIEWKLMYFALQKHYPAKEQYGDTLHFCRHCSILFWKDSGHP
                     CTAADPDSCFTPVSPQHFIDLFKF"
     exon            251..354
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            355..404
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            405..497
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            498..591
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            592..776
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            777..959
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1103
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..10356
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /note="hexamer: ATTAAA"
     polyA_site      1444
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /note="major polyA site"
     regulatory      10336..10341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
                     /note="hexamer: ATTAAA"
     polyA_site      10356
                     /gene="FBXO25"
                     /gene_synonym="FBX25"
ORIGIN      
        1 aataaccgcc tggtcgccgt caggtgcggg cccaggtggc cggcgcgccc gttgggcact
       61 gggggacgcg ggcgcgtcag gtgaagactg ggggccgcag gcgcgctagg agaactatgc
      121 catttttggg tcaggactgg agatctcctg gatggagttg gattaagaca gaagatggct
      181 ggaagagatg tgaatcttgt agtcagaaac ttgaaagaga gaataaccgt tgtaacatca
      241 gtcacagcat tatcttaaat agtgaagatg gagaaatatt caataatgaa gagcatgaat
      301 atgcatcgaa aaaaaggaaa aaggaccatt ttagaaatga cacaaatact caaagttttt
      361 atcgtgaaaa atggatctat gtccataaag aaagcacaaa ggaaaggcat ggctattgca
      421 ccttgggaga agcctttaat cggttagact tctcaagtgc aattcaagat atccgaaggt
      481 tcaattatgt ggtcaaactg ttgcagctaa ttgcaaaatc ccagttaact tcattgagtg
      541 gcgtggcaca gaagaattac ttcaacattt tggataaaat cgttcaaaag gttcttgatg
      601 accaccacaa tcctcgctta atcaaagatc ttctgcaaga cctaagctct accctctgca
      661 ttcttattag aggagtaggg aagtctgtat tagtgggaaa catcaatatt tggatttgcc
      721 gattagaaac tattctcgcc tggcaacaac agctacagga tcttcagatg actaagcaag
      781 tgaacaatgg cctcaccctc agtgaccttc ctctgcacat gctgaacaac atcctatacc
      841 ggttctcaga cggatgggac atcatcacct taggccaggt gacccccacg ttgtatatgc
      901 ttagtgaaga cagacagctg tggaagaagc tttgtcagta ccattttgct gaaaagcagt
      961 tttgtagaca tttgatcctt tcagaaaaag gtcatattga atggaagttg atgtactttg
     1021 cacttcagaa acattaccca gcgaaggagc agtacggaga cacactgcat ttctgtcggc
     1081 actgcagcat tctcttttgg aaggactcag gacacccctg cacggcggcc gaccctgaca
     1141 gctgcttcac gcctgtgtct ccgcagcact tcatcgacct cttcaagttt taagggctgc
     1201 ccctgccatc cctattggag attgtgaatc ctgctgtctg tgcagggctc atagtgagtg
     1261 ttctgtgagg tgggtggaga ctcctcggaa gcccctgctt ccagaaagcc tgggaagaac
     1321 tgcccttctg caaagggggg actgcatggt tgcattttca tcactgaaag tcagaggcca
     1381 aggaaatcat ttctacttct ttaaaaactc cttctaagca tattaaaatg tgaaattttg
     1441 cgtactctct ctctctatat atatagttca aaaatacttt aggtggtcag ctccacattc
     1501 tttgttgacg tgacactaac ggccaataat atgcttctta attatcaaat tatagtttcc
     1561 caattgggaa actaattggg ggtgggttac aaaacatttg atccttgtaa atacattgta
     1621 cagaatattt attttttctc aaaatgcatt ttaactacta cattggctgt gcccaaatga
     1681 gtcctctttg aatagaaagt gaacccaggg caatgacagc cattcttgtc ttagggatta
     1741 tggatcgggg tatgaagtgt gcacacgcag cccaacaacg ggcagtggtc tctgtgctcc
     1801 taggcatcca gcacaggttc tggcagggca cccctgctgg ggttgggggc tggtctgtgc
     1861 ataatcctgg actgtgatgg gaacagccca gtgcagtcta aacttcaatt gtgttgaaac
     1921 tactttaata gacaaagtaa taaatcatgt ttatctattg atttaaactt catcagtttt
     1981 gcatcctact gagaaatgtt agtgattttg atacttaaat ccttaaaaga ttgcttcgtt
     2041 tttaaaataa cgcatgtcca ttttagaaaa ttagaaaatc agtcccacca cccaaagatt
     2101 attgtgcatg ctgaaaagag tatgaaaaat cccctcagca ggcataggat agaaacgtat
     2161 tgttgtatat ttccattttt gaatagggtc aaggagccca agcaaatcat ttctactttt
     2221 tcctttaagc ataataataa aagtatactt ttatggcgtt ataaatagga ctaaaaaaag
     2281 attctggatt tttcagcccc acttctgtga actgacacaa atggccaaga atgcatttat
     2341 ttgtcaaatt atagtttctc ctgaggcgat gcaaatacct ggggcctctg cgaatatatg
     2401 ttagtttttc ataagaccat aaatgtcccg tataccactg ttacttcaca acgccccccg
     2461 tcccgaccct gccttttttt agaaacgtag aaccatatcc taaatgttat ttggaaactt
     2521 ggcttttatt agctccacag aatcacccag atggaacagg ctttttcatc acaacatatt
     2581 ggggttcctg agtgtctcgc cgttagcatc aataactatg ataagcatcg tcacacaaca
     2641 atgtggccgt ctccttacaa ccactggtag tacagccaac atcatgagtc aaacatattt
     2701 taaggctttt aaatatattt ctagattgtt catgaaaaaa aatttttttg gagtttgttt
     2761 ttgagacagg gtcttgctct gtcacccagg ctggagtgca ggggtatgat gtcggcttac
     2821 tgcaacctct gtcccccagg ctcaagtgat cctcccacct caccctccag tgatcctccc
     2881 acctcagcct cccaagcagt caggaccaca ggcatatacc accatgctca gctgtttttt
     2941 tgtattttta gtagagatgg ggtttcacca tgttgcccag gctggtctca ggagtttgag
     3001 ctcaagcaat ccacctgcct cagcttccca aagtgctggg attacaggca tgagccacca
     3061 cgtccagctg agaaaagaaa ttgttctaat ctaggaaagg gagtaagtac attgagtttc
     3121 cattatccct gaagcacagg tatttctttt tctgttggtg ctgttttaat aagtgaagaa
     3181 tttgatgtat gataaattgt gagcttgaat atttccatat atttattatc catttgcttt
     3241 tcttgttttt ggtaaattac ttaatgtggt atttgcctgt tttttggggt ggatgtcagt
     3301 cttttttcat gttagtttct tcttaaaagg aaactatcct tttgaagttg tggttctttc
     3361 ccctaatttg tcatatactg ttactgtcat ttaattgtta gatgttataa cagttctcag
     3421 ctgtgctatc aaatcacaga tgtgcattta acttgtataa attgagcagt acttgcttgg
     3481 aaaacataac catattaata gtgtaggatt ccagctgttc tgctgggctg gcatatttcc
     3541 acaggccatg gacacagcta gccgcattgc cactgcatgg gtcacagcct cctgcaggtg
     3601 cgttcgaggg acaagctgtg ggagctgggc aggtaagcag ggatggctta cattgctggg
     3661 gagagattga aaggttaatg gagggtataa ggacagaata aagacaattt tgaggcactg
     3721 atcagttatt tacagaagat cggacaacac caaacagaga tgagaagaga aatcatagat
     3781 ctccactttg gaatggtatt tttgaataca gtttctatca gggggccttc caaaagtagg
     3841 gatgccactc ctgtgagatt aagttacatt ctgatgcctt cattacaatg aagtagataa
     3901 ttcaggaccc caggagccta aagccaggta gtaagtttca cttgcccatc gctcctgtga
     3961 aaggcaatgc cagacactct caagatagaa tctccagtca ttctcggacc tgttctcagt
     4021 ctgcgctgct cactcagggc tggtgtctct tgacacccag ttacaacttc cttttgccta
     4081 ttttgagtca aaaagtcaca ttcctcacct aatttatgaa tacacacaaa ttggaaagcc
     4141 atgcagtagc ctctcaggag cagaccgatt tgtagctgtc gtggtttact gcatgacgta
     4201 caggctctct gtatgcactg tgtgtgcgta ctgtacaggg ctgtacacag caaactgtgt
     4261 ctactttatg gaaaaaattt aaccatctgt gaacagtttt ttgccttaag tgctgctttt
     4321 agaaccaaac tgtcatataa gatttatcag ctcttttaac acctttgtag attcctgatg
     4381 ctgtgtacaa aatcatgtca tctatgaata gacagtttca cttcttcctc tcagtctaga
     4441 tgtcctttat tctttcttac cccgtttcgc tggctagaat ctctagtaca atgttgaata
     4501 gcagtgcgag agtgaacatc cttgtcttgt tcctcatctt aggggaaagc tttcagtctc
     4561 accattaact atgatgttaa ccctgggttt tccatacata ccctctatta ggttggggag
     4621 gttcccttct attcctagtt tgtttttatc gtgaaagggt gtggattttg tcaaatgctt
     4681 tttctgcatc tcttaagata atgtagtttt tggccttcat aagatcatgt gctgttatta
     4741 cattgactga tttctatatc ttgaaccaac cttgcattct tgggtcaaag cccactaagt
     4801 catggtttat gatacctttt atacatagct gttagatttg gtgtgctgga acagccagcc
     4861 ctctgtatcc acgggggatt ggttccaaga cccccacccc caccccacct gccacccacc
     4921 accttgtgat ctcttgggtt ttggtgtcca tctcatagga taagcttaga aagtgttccc
     4981 tcttctgtgt tttggaagtg tttgtggtgg tttcttgtta attcttcttt aaatgtttga
     5041 gagaactcca tataagattt gaagtcactg agaagcttca attatccttt aagaggataa
     5101 gaccattttc tccagagatg ccttttaatg gtttttcttt tcattgcgaa ggcctaactt
     5161 agtagataag tggactgtga aacctagtct gttctgctta tcttcagaat tatcaaaagg
     5221 aaggggtgct gccctctgag aaaagtcaga agcaagcctg ccttatgaaa ctcgactttt
     5281 taatctccct ctcttcatta tgatgtgtgc acgtgatgga caccactcac ctccctttag
     5341 tccctatcaa atgctaccca atggcaaagc caagggatta gcaacaggta ggaggaaaaa
     5401 gaaggacctg catacatgac taaccagcac cagccattgg ggccctctat ggctgacacc
     5461 agcatccacc ctgcactcat atgtatctca acagaattgc tgcttctgtc ttcactcaag
     5521 ccccactcct tatcccttcc tgttgtttct gcatagagga ggcagaccct caactttgga
     5581 aagcagtgtc cccccgcgtc ccatgggcta aatgccactg agccggtagg agctgctcag
     5641 gtgtagcctc tgccttcaga atttcagcag gaactgcatc attgtgtgcc taaaaagccc
     5701 tggctcacag catgagacag tgtgttctag gtggtaacgt ggcacctgca catgcacccc
     5761 cagcagtcct ctctaaactc aggcagtgta tggctgctgc cattctcgcc ctcagcatct
     5821 gtgagatgaa ggagttgctc cccagggcac ctgccccaat acaggccacg tggatctgcc
     5881 attgcttttc acgtgaatgc ctaggagagg ctgttaaccc tcctagttgt cctttttgta
     5941 cttggtcctc ttccttccaa tcctcactgg ctcaaatcca cagagtgaca aagaacagag
     6001 atgcccagag caccagctgg aggggcaagc aggagaaggc actgctggtg ccacaggggt
     6061 cctgggctgg ctcttggacc ataaccagcg ttcactgagg atgcggtttc tttgaaatgc
     6121 tcttgttctt cctaagtaag ggagagcaaa aaaaatgagg acatctgtgt caaatagaag
     6181 agacacctca actgtctcgt ttttgcatgg aaatttcatt tttatttgat aatcatttga
     6241 gaaacttgca cagatgaagg caagttggtt tttattatct aacctatgta gtcaattcta
     6301 atgtcattta aaagaatttg acatgttaaa atacacgtga aatttaccat cttacctatt
     6361 ttaagtgtgc aatttagtgg cattaaatac attcatactg tgcaaccttc tctaccacgt
     6421 atccacaagt tcaactttac aagatgaact tttgtcatct tgtaaaactg aagctctgta
     6481 cccattaagc accaactccc tattccccat ccaccagccc ctggcagcct ctgttctcct
     6541 ttgtctcttt taatttgact tctgtaggga cctcgtatga gtggaaccag aagggatttg
     6601 tccttttgtg actggcttat ttcacttagc gtaatgtcct caaggtttat tcaagttgta
     6661 ggatatgtca agatttcttt ttaaggctga ttctatggat ggaccacatt ttgtttgtgt
     6721 actcatctgt tgaggacact tgagttgctt ccacctttta gctattgtga atattgctgc
     6781 cgtaaacatg ggtgtgcaaa tatctgagtc tctgctttca atcatatggc aatcctatgt
     6841 ttaatttctt agggcactgc cataagtgtt ttacacggtg gctgcaccat tttacattcc
     6901 cactgaaggt tccagttttg ccacatcctt gccaacacct gtttttaata attgccatcc
     6961 taatgagtgt gaagtggtat cctgctgaga ttttgatttg catttccgta atgactggtg
     7021 atgctgagta tctgtttgtt ggccgtttat atgtcgtctt tggagaaatg tctatttggg
     7081 ctctttgtcc atttttcaat caggtgtgtg tttttatatg ttctgggtat tcaccctttt
     7141 cagatatatc attttaaaat actttgtccc attccgtgga ttgcctttca ctctgttttg
     7201 ttctttgatg tacagaagtt gtttctttct tttagttacc tgtgtgtgcc tctggtgtca
     7261 tatctaagaa atcactgcct cacccttttc agatatatca ttttaaaata ctttgtccca
     7321 ttccgtggat tgcctttcac tctgttttgt tctttgatgt acagaagttg tttctttctt
     7381 ttagttacct gtgtgtgcct ctggtgtcat atctaagaaa tcactgccaa atccaatgtt
     7441 gttaaaagtt tcccttatgt ttctcctaaa tgttttagtt ttagctctta gtttaggcct
     7501 ttgatctatt ttaattttta tatatggtgt gaggtagatc tagcttcatg tggatgtcca
     7561 cttgtctagc accatttgtt gaaaagactg tcctttctcc cttgaatggt cttggcacca
     7621 tcaaaaatca tttgacccat atgtgcaagg gtttatttgg ggatttgcta ttctgttcca
     7681 ttggtctaca tgactgtctt tgtttcaata caacaccatt ttgattattg tagctttgtc
     7741 gtaagttatg aaataaggaa gtgagagacc tcctacttgg ttccctttca agatgatttt
     7801 ggctgtgtga ggtctcttga gattccatat gagtttcagg atggaaaaaa aaaagccact
     7861 gggatattct gatagagatt gcatgaaatc tatagattgc tttggactat ggacatctta
     7921 aggtatccaa tccataaaca cgggattgct ttctatttat ttgtgttgac cttactttct
     7981 ttaagcagtg ttttatggtt ttcaagtaca agtcttttgc ttccttaagt ttattcctaa
     8041 atatttcagt ttttttgtta ctattataat ggaattttct taaatttcct tttgagattg
     8101 cttgttattg tatagaaata tcatggattt gttgtgttga ttttgtaaac tgcagtgtta
     8161 ctgaaatttt tttttgtata tgtatggaca ctaggatttt ctacatataa gatcatgtca
     8221 tctgcaaaca gataattttg cttcttcctt tccagtctgg atgcctttta tttctttttc
     8281 ttgcctaact gctctaagac tccagtactg tgttaaacag aagtggtgag acagggtatt
     8341 tctgtgttgt tcttgatctt aaagtccttt cagtcttatt gaatatgatg tttacagtgg
     8401 gatgttcata tggcctctat tttaggttgt ttccttctat tcccaattgt tgagttttta
     8461 tcatgaaagg gcatgacatt gtctcaaatg ctttttctcc atcaatggag atcacatttt
     8521 tttccttcat tctattaatg taatagacat tacatttatt gacttgagca tgttgaaaca
     8581 tctttgcata ccagctgtaa atcttacttg gccatgatgt gtaatccttt caatgtccca
     8641 ctgaatcctg ttggccagta ttttgttgaa tattgattta aaaaaatctt gatcaggaat
     8701 actgatgtgt ggtgtttttt tcttatagtg tctttgtctg gttttggtat cagaataatg
     8761 atggcctcat agaatgcatt tggaagtgtc ctttcctctt cagttttttg gaagagtttg
     8821 aggagaattg atttaattct tcagatgttt gccagaattc ccatatgacc ctgggctttt
     8881 ctttcttggg aggcttttct ttactacttc atgctcttga ctagcatagg tctgttcaga
     8941 ttttccattt cttcatgatt caatcttgat aggctgtgtg tttctaagaa tttgtccagt
     9001 tcatctaggt tatccaattc tttgatatgt aattgctcat agtactctta atccttttta
     9061 tttctgtaaa atcagttgta atgtctcctc ctggttttta gttgtttttc ttagtcactc
     9121 ttagctatca acaaactctt ggtttcattt atttttctct attgcttttc tgttctctat
     9181 tttgtctctg ctctaatctt tattattatt ataatcatct ccattctgct ggctttgggt
     9241 tgattgctct tctttttcta gttctttcag atgtaaattt agggttgact tgagatctta
     9301 atttgtttaa taggtgtatt tacagttaca aatttccctc ctaccactgc tttgactgta
     9361 cctgtttttt tgtatattac atttttcatt taccacaaga tattttctaa tttcccttgt
     9421 gagttcccca ttaatctgct ggttgagagc gttgtttaat tttcacataa ttgtgtactt
     9481 ttcagttttt tgtctgttac tgatttctag tttcatccca ctgtggccag aaaagatatt
     9541 ttatttcctc agtcttttga aatttgttga cttgtttagt catctaacat actgtctatc
     9601 ctagagaaag gtccatttgc acttgagaaa aacgtgtgta ctgctgttgt gtctgttagg
     9661 tccagctggt atgatgctgt tcaagttctg tcttgcgact gatcttctgt ctggttgtcc
     9721 tatccgttac tgaaagtggg ctactgcagt ctcctactct tactgtagaa ctatccattt
     9781 cttcctttga ttctgtcaat gtttgtttca tatattttgg gctctgatgt ttggtgcata
     9841 tatattacat cttggtgaat tttcaaactt tttaaatttc aacatgaaga tgaaattata
     9901 ggatgtctgg gatttccttt gaatccgtgg ggctgggagt aactataaat gaaacaagat
     9961 tggccgggaa tttgaggctg caaggatagg tacacacagg ggagtgaagc agggcttgga
    10021 gcagatggta aagattgttg gcttttccag ccatggggct ctcttgccac ttggcagtag
    10081 tggcatgaag ccgccaccag ggggccacgc accagtgcat gtggctgtgt tccaaacttt
    10141 ttggacaata aaatctgaat ttcacatact tttcttatgt cattagatat taccctttta
    10201 catcttttca ctatttaaaa atgtaaaaat cattcttaac atttgggctg tgcaaaaaca
    10261 gctggtgggc ccaattttgg cctgtatttc acttgccaac ctgatttata cttttgtatc
    10321 tatttgacat tttccattaa aagttatata acacta
//
