LOCUS       NM_033506               2259 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens F-box protein 24 (FBXO24), transcript variant 1, mRNA.
ACCESSION   NM_033506
VERSION     NM_033506.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2259)
  AUTHORS   El-Mergawy,R., Chafin,L., Ovando-Ricardez,J.A., Rosas,L., Tsai,M.,
            Rojas,M., Mora,A.L. and Mallampalli,R.K.
  TITLE     FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin
            mediated degradation modulates mitochondrial respiration
  JOURNAL   J Biol Chem 300 (6), 107359 (2024)
   PUBMED   38735474
  REMARK    GeneRIF: FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for
            ubiquitin mediated degradation modulates mitochondrial respiration.
REFERENCE   2  (bases 1 to 2259)
  AUTHORS   Li,Z., Liu,X., Zhang,Y., Li,Y., Zhou,L. and Yuan,S.
  TITLE     FBXO24 modulates mRNA alternative splicing and MIWI degradation and
            is required for normal sperm formation and male fertility
  JOURNAL   Elife 12, 91666 (2024)
   PUBMED   38470475
  REMARK    GeneRIF: FBXO24 modulates mRNA alternative splicing and MIWI
            degradation and is required for normal sperm formation and male
            fertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2259)
  AUTHORS   Dong,B., Song,X., Wang,X., Dai,T., Wang,J., Yu,Z., Deng,J.,
            Evers,B.M. and Wu,Y.
  TITLE     FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for
            Ubiquitination
  JOURNAL   Mol Cancer Res 21 (12), 1303-1316 (2023)
   PUBMED   37540490
  REMARK    GeneRIF: FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting
            LSD1 for Ubiquitination.
REFERENCE   4  (bases 1 to 2259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2259)
  AUTHORS   Chen,W., Gao,D., Xie,L., Wang,A., Zhao,H., Guo,C., Sun,Y., Nie,Y.,
            Hong,A. and Xiong,S.
  TITLE     SCF-FBXO24 regulates cell proliferation by mediating ubiquitination
            and degradation of PRMT6
  JOURNAL   Biochem Biophys Res Commun 530 (1), 75-81 (2020)
   PUBMED   32828318
  REMARK    GeneRIF: SCF-FBXO24 regulates cell proliferation by mediating
            ubiquitination and degradation of PRMT6.
REFERENCE   6  (bases 1 to 2259)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 2259)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   8  (bases 1 to 2259)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   9  (bases 1 to 2259)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069281.6, BU656991.1 and
            BC067293.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033506.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067293.1, AL136811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241071.11/ ENSP00000241071.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC069281.6         16835-16839         c
            6-65                BU656991.1         1-60
            66-2259             BC067293.1         1-2194
FEATURES             Location/Qualifiers
     source          1..2259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2259
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /note="F-box protein 24"
                     /db_xref="GeneID:26261"
                     /db_xref="HGNC:HGNC:13595"
                     /db_xref="MIM:609097"
     exon            1..337
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2041
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein Fbx24; F-box only protein 24"
                     /codon_start=1
                     /product="F-box only protein 24 isoform 1"
                     /protein_id="NP_277041.1"
                     /db_xref="CCDS:CCDS5698.1"
                     /db_xref="GeneID:26261"
                     /db_xref="HGNC:HGNC:13595"
                     /db_xref="MIM:609097"
                     /translation="MGEKAVPLLRRRRVKRSCPSCGSELGVEEKRGKGNPISIQLFPP
                     ELVEHIISFLPVRDLVALGQTCRYFHEVCDGEGVWRRICRRLSPRLQDQGSGVRPWKR
                     AAILNYTKGLYFQAFGGRRRCLSKSVAPLLAHGYRRFLPTKDHVFILDYVGTLFFLKN
                     ALVSTLGQMQWKRACRYVVLCRGAKDFASDPRCDTVYRKYLYVLATREPQEVVGTTSS
                     RACDCVEVYLQSSGQRVFKMTFHHSMTFKQIVLVGQETQRALLLLTEEGKIYSLVVNE
                     TQLDQPRSYTVQLALRKVSHYLPHLRVACMTSNQSSTLYVTDQGGVYFEVHTPGVYRD
                     LFGTLQAFDPLDQQMPLALSLPAKILFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTG
                     DKMDRGEPTQVCYLQRPITLWCGLNHSLVLSQSSEFSKELLGCGCGAGGRLPGWPKGS
                     ASFVKLQVKVPLCACALCATRECLYILSSHDIEQHAPYRHLPASRVVGTPEPSLGARA
                     PQDPGGMAQACEEYLSQIHSCQTLQDRTEKMKEIVGWMPLMAAQKDFFWEALDMLQRA
                     EGGGGGVGPPAPET"
     exon            338..436
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            437..620
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            621..856
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1091
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1250
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1372
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1504
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1675
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2259
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2241..2246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /note="hexamer: AATAAA"
     polyA_site      2259
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /note="major polyA site"
ORIGIN      
        1 agagcgctcg ccaacggccg acgctccagg ccgtcccgcc cagcgcagct gcacccaatc
       61 acaatgctca gatcgggagg tggagccaat caggtccaac caagaggagg ggacaccggc
      121 actccactag caggaaaacg ggccgaggga ccgcaagcag ggggtgccta gtcctcgtcc
      181 cccaaagacc aatcgtaagc cagatacagg cgagtgactg tcaagaaggc caattagagc
      241 ctccgaaggg aatctggacc tgcctcttct ctgagggacg gctctaccta ccaatagcat
      301 gggcgagaag gcggtccctt tgctaaggag gaggcgggtg aagagaagct gcccttcttg
      361 tggctcggag cttggggttg aagagaagag ggggaaagga aatccgattt ccatccagtt
      421 gttcccccca gagctggtgg agcatatcat ctcattcctc ccagtcagag accttgttgc
      481 cctcggccag acctgccgct acttccacga agtgtgcgat ggggaaggcg tgtggagacg
      541 catctgtcgc agactcagtc cgcgcctcca agatcagggt tctggagtcc ggccctggaa
      601 gagagctgcc attctgaact acacgaaggg cctgtatttc caggcatttg gaggccgccg
      661 ccgatgtctc agcaagagcg tggccccctt gctagcccac ggctaccgcc gcttcttgcc
      721 caccaaggat cacgtcttca ttcttgacta cgtggggacc ctcttcttcc tcaaaaatgc
      781 cctggtctcc accctcggcc agatgcagtg gaagcgggcc tgtcgctatg ttgtgttgtg
      841 tcgtggagcc aaggattttg cctcggaccc aaggtgtgac acagtttacc gtaaatacct
      901 ctacgtcttg gccactcggg agccgcagga agtggtgggt accaccagca gccgggcctg
      961 tgactgtgtt gaggtctatc tgcagtctag tgggcagcgg gtcttcaaga tgacattcca
     1021 ccactcaatg accttcaagc agatcgtgct ggttggtcag gagacccagc gggctctact
     1081 gctcctcaca gaggaaggaa agatctactc tttggtagtg aatgagaccc agcttgacca
     1141 gccacgctcc tacacggttc agctggccct gaggaaggtg tcccactacc tgcctcacct
     1201 gcgcgtggcc tgcatgactt ccaaccagag cagcaccctc tacgtcacag accagggggg
     1261 agtgtatttt gaggtgcata ccccaggggt gtatcgcgat ctctttggga cccttcaagc
     1321 ctttgacccc ctggaccagc agatgccgct tgctctctca ctgcctgcca agatcctatt
     1381 ctgtgctctt ggctacaacc accttggcct ggtggatgaa tttggccgaa tcttcatgca
     1441 aggaaataac agatacgggc agctaggaac aggggacaaa atggaccgag gggaacccac
     1501 acaggtttgt tacctgcagc ggcccatcac cctgtggtgc ggcctcaacc actccctggt
     1561 gctgagccag agctcagagt tcagcaagga gctgctgggc tgcggctgtg gggctggggg
     1621 ccgcctccca ggctggccca aggggagtgc ctccttcgtc aagctccaag tcaaggtccc
     1681 tctgtgtgcc tgtgccctct gtgccaccag ggagtgccta tacatcctgt ccagccacga
     1741 cattgagcag cacgccccct atcgccacct gccagccagc agggtggtgg ggactcctga
     1801 gcccagcctg ggggccagag caccccagga ccccgggggg atggcccagg cctgcgagga
     1861 gtacctcagc cagatccaca gttgccaaac gttgcaggac cgcacggaga agatgaagga
     1921 gatcgtaggg tggatgcccc tgatggccgc acagaaggac ttcttctggg aggccctgga
     1981 catgctgcag agggctgaag gaggcggggg tggtgtaggg cccccagccc ctgagaccta
     2041 atccccctca tgctagccta gtccctggag gagggagtcc ggccccaggc cagggactaa
     2101 ggagcaatga ccattgtgca catgcgtgtg ggaaggggtt gctagggggt ggggacggct
     2161 aaccagggta agaatgttca gggggctgcc caggaggggc ccccaacctg actatcatgg
     2221 acaagagatt tgatggatag aataaaaggc tgcagcgag
//
