LOCUS       NP_277041                580 aa            linear   PRI 28-APR-2025
DEFINITION  F-box only protein 24 isoform 1 [Homo sapiens].
ACCESSION   NP_277041
VERSION     NP_277041.1
DBSOURCE    REFSEQ: accession NM_033506.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 580)
  AUTHORS   El-Mergawy,R., Chafin,L., Ovando-Ricardez,J.A., Rosas,L., Tsai,M.,
            Rojas,M., Mora,A.L. and Mallampalli,R.K.
  TITLE     FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin
            mediated degradation modulates mitochondrial respiration
  JOURNAL   J Biol Chem 300 (6), 107359 (2024)
   PUBMED   38735474
  REMARK    GeneRIF: FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for
            ubiquitin mediated degradation modulates mitochondrial respiration.
REFERENCE   2  (residues 1 to 580)
  AUTHORS   Li,Z., Liu,X., Zhang,Y., Li,Y., Zhou,L. and Yuan,S.
  TITLE     FBXO24 modulates mRNA alternative splicing and MIWI degradation and
            is required for normal sperm formation and male fertility
  JOURNAL   Elife 12, 91666 (2024)
   PUBMED   38470475
  REMARK    GeneRIF: FBXO24 modulates mRNA alternative splicing and MIWI
            degradation and is required for normal sperm formation and male
            fertility.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 580)
  AUTHORS   Dong,B., Song,X., Wang,X., Dai,T., Wang,J., Yu,Z., Deng,J.,
            Evers,B.M. and Wu,Y.
  TITLE     FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting LSD1 for
            Ubiquitination
  JOURNAL   Mol Cancer Res 21 (12), 1303-1316 (2023)
   PUBMED   37540490
  REMARK    GeneRIF: FBXO24 Suppresses Breast Cancer Tumorigenesis by Targeting
            LSD1 for Ubiquitination.
REFERENCE   4  (residues 1 to 580)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 580)
  AUTHORS   Chen,W., Gao,D., Xie,L., Wang,A., Zhao,H., Guo,C., Sun,Y., Nie,Y.,
            Hong,A. and Xiong,S.
  TITLE     SCF-FBXO24 regulates cell proliferation by mediating ubiquitination
            and degradation of PRMT6
  JOURNAL   Biochem Biophys Res Commun 530 (1), 75-81 (2020)
   PUBMED   32828318
  REMARK    GeneRIF: SCF-FBXO24 regulates cell proliferation by mediating
            ubiquitination and degradation of PRMT6.
REFERENCE   6  (residues 1 to 580)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (residues 1 to 580)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   8  (residues 1 to 580)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   9  (residues 1 to 580)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069281.6, BU656991.1 and
            BC067293.1.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067293.1, AL136811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241071.11/ ENSP00000241071.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     Protein         1..580
                     /product="F-box only protein 24 isoform 1"
                     /note="F-box protein Fbx24; F-box only protein 24"
                     /calculated_mol_wt=64758
     Region          38..84
                     /region_name="F-box_FBXO24"
                     /note="F-box domain found in F-box only protein 24
                     (FBXO24) and similar proteins; cd22098"
                     /db_xref="CDD:438870"
     Site            order(42,46,49..50,53..54,58,60..61,65..67,69)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438870"
     Region          <363..>425
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          376..425
                     /region_name="RCC1"
                     /note="propagated from UniProtKB/Swiss-Prot (O75426.2)"
     CDS             1..580
                     /gene="FBXO24"
                     /gene_synonym="FBX24"
                     /coded_by="NM_033506.3:299..2041"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS5698.1"
                     /db_xref="GeneID:26261"
                     /db_xref="HGNC:HGNC:13595"
                     /db_xref="MIM:609097"
ORIGIN      
        1 mgekavpllr rrrvkrscps cgselgveek rgkgnpisiq lfppelvehi isflpvrdlv
       61 algqtcryfh evcdgegvwr ricrrlsprl qdqgsgvrpw kraailnytk glyfqafggr
      121 rrclsksvap llahgyrrfl ptkdhvfild yvgtlfflkn alvstlgqmq wkracryvvl
      181 crgakdfasd prcdtvyrky lyvlatrepq evvgttssra cdcvevylqs sgqrvfkmtf
      241 hhsmtfkqiv lvgqetqral lllteegkiy slvvnetqld qprsytvqla lrkvshylph
      301 lrvacmtsnq sstlyvtdqg gvyfevhtpg vyrdlfgtlq afdpldqqmp lalslpakil
      361 fcalgynhlg lvdefgrifm qgnnrygqlg tgdkmdrgep tqvcylqrpi tlwcglnhsl
      421 vlsqssefsk ellgcgcgag grlpgwpkgs asfvklqvkv plcacalcat reclyilssh
      481 dieqhapyrh lpasrvvgtp epslgarapq dpggmaqace eylsqihscq tlqdrtekmk
      541 eivgwmplma aqkdffweal dmlqraeggg ggvgppapet
//
