LOCUS       NM_015002               5976 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box protein 21 (FBXO21), transcript variant 2, mRNA.
ACCESSION   NM_015002
VERSION     NM_015002.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5976)
  AUTHORS   Dobish,K.K., Wittorf,K.J., Swenson,S.A., Bean,D.C., Gavile,C.M.,
            Woods,N.T., Ghosal,G., Hyde,R.K. and Buckley,S.M.
  TITLE     FBXO21 mediated degradation of p85alpha regulates proliferation and
            survival of acute myeloid leukemia
  JOURNAL   Leukemia 37 (11), 2197-2208 (2023)
   PUBMED   37689825
  REMARK    GeneRIF: FBXO21 mediated degradation of p85alpha regulates
            proliferation and survival of acute myeloid leukemia.
REFERENCE   2  (bases 1 to 5976)
  AUTHORS   Jia,Z., Liu,J. and Wang,J.
  TITLE     circRNA-MSR regulates the expression of FBXO21 to inhibit
            chondrocyte autophagy by targeting miR-761 in osteoarthritis
  JOURNAL   Kaohsiung J Med Sci 38 (12), 1168-1177 (2022)
   PUBMED   36278814
  REMARK    GeneRIF: circRNA-MSR regulates the expression of FBXO21 to inhibit
            chondrocyte autophagy by targeting miR-761 in osteoarthritis.
REFERENCE   3  (bases 1 to 5976)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5976)
  AUTHORS   Lin,Z., Miao,J., Zhang,T., He,M., Wang,Z., Feng,X. and Bai,L.
  TITLE     JUNB-FBXO21-ERK axis promotes cartilage degeneration in
            osteoarthritis by inhibiting autophagy
  JOURNAL   Aging Cell 20 (2), e13306 (2021)
   PUBMED   33450132
  REMARK    GeneRIF: JUNB-FBXO21-ERK axis promotes cartilage degeneration in
            osteoarthritis by inhibiting autophagy.
REFERENCE   5  (bases 1 to 5976)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 5976)
  AUTHORS   Ravindranath,A.K., Kaur,S., Wernyj,R.P., Kumaran,M.N.,
            Miletti-Gonzalez,K.E., Chan,R., Lim,E., Madura,K. and
            Rodriguez-Rodriguez,L.
  TITLE     CD44 promotes multi-drug resistance by protecting P-glycoprotein
            from FBXO21-mediated ubiquitination
  JOURNAL   Oncotarget 6 (28), 26308-26321 (2015)
   PUBMED   26299618
  REMARK    GeneRIF: Ser291-phosphorylated form of the multifunctional protein
            and stem cell marker, CD44, inhibits FBXO21-directed degradation of
            P-gp.
REFERENCE   7  (bases 1 to 5976)
  AUTHORS   Watanabe,K., Yumimoto,K. and Nakayama,K.I.
  TITLE     FBXO21 mediates the ubiquitylation and proteasomal degradation of
            EID1
  JOURNAL   Genes Cells 20 (8), 667-674 (2015)
   PUBMED   26085330
  REMARK    GeneRIF: The results suggest that EID1 is a bona fide substrate of
            FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21)
            might affect the transcriptional repression activity of EID1.
REFERENCE   8  (bases 1 to 5976)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   9  (bases 1 to 5976)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 5976)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI550121.1, AB020682.1,
            BC042333.1, BC034045.1 and AC026368.37.
            
            On Jun 2, 2019 this sequence version replaced NM_015002.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class. Alternative splicing of this gene generates 2
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks a 21 nt fragment within
            the coding region, and thus encodes a 7 aa shorter isoform than
            variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.91233.1,
                                           SRR1660807.40256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622495.5/ ENSP00000483508.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BI550121.1         36-48
            14-2848             AB020682.1         1-2835
            2849-2899           BC042333.1         2595-2645
            2900-4181           AB020682.1         2887-4168
            4182-4187           BC034045.1         4137-4142
            4188-5976           AC026368.37        33180-34968
FEATURES             Location/Qualifiers
     source          1..5976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.22"
     gene            1..5976
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="F-box protein 21"
                     /db_xref="GeneID:23014"
                     /db_xref="HGNC:HGNC:13592"
                     /db_xref="MIM:609095"
     exon            1..253
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1880
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 21"
                     /codon_start=1
                     /product="F-box only protein 21 isoform 2"
                     /protein_id="NP_055817.1"
                     /db_xref="CCDS:CCDS44989.1"
                     /db_xref="GeneID:23014"
                     /db_xref="HGNC:HGNC:13592"
                     /db_xref="MIM:609095"
                     /translation="MAAAAVDSAMEVVPALAEEAAPEVAGLSCLVNLPGEVLEYILCC
                     GSLTAADIGRVSSTCRRLRELCQSSGKVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKV
                     RQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKAL
                     TWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISLKDIQ
                     AQIDSIVELVCKTLRGINSRHPSLAFKAGESSMIMEIELQSQVLDAMNYVLYDQLKFK
                     GNRMDYYNALNLYMHQVLIRRTGIPISMSLLYLTIARQLGVPLEPVNFPSHFLLRWCQ
                     GAEGATLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNL
                     LSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKVLDILQHI
                     QTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSDEKHRDVCYSIGLIMKHKRYG
                     YNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVE
                     PQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLEFVYETVQNIYSAKKENIDE"
     exon            254..389
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            390..484
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            485..606
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            607..753
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            754..890
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1027
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1207
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1340
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1531
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1689
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..5976
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4160..4165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="hexamer: AATAAA"
     polyA_site      4187
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="major polyA site"
     polyA_site      4480
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="major polyA site"
     regulatory      4616..4621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="hexamer: AACAAA"
     polyA_site      4621
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
     regulatory      5959..5964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
                     /note="hexamer: AATAGA"
     polyA_site      5976
                     /gene="FBXO21"
                     /gene_synonym="FBX21"
ORIGIN      
        1 ggtacgcgga caagatggcg gcggcagcag tcgacagcgc gatggaggtg gtgccggcgc
       61 tggcggagga ggccgcgccg gaggtagcgg gcctcagctg cctcgtcaac ctgccgggtg
      121 aggtgctgga gtacatcctg tgctgcggct cgctgacggc cgccgacatc ggccgtgtct
      181 ccagcacctg ccggcggctg cgcgagctgt gccagagcag cgggaaggtg tggaaggagc
      241 agttccgggt gaggtggcct tcccttatga aacactacag ccccaccgac tacgtcaatt
      301 ggttggaaga gtataaagtt cggcaaaaag ctgggttaga agcgcggaag attgtagcct
      361 cgttctcaaa gaggttcttt tcagagcacg ttccttgtaa tggcttcagt gacattgaga
      421 accttgaagg accagagatt ttttttgagg atgaactggt gtgtatccta aatatggaag
      481 gaagaaaagc tttgacctgg aaatactacg caaaaaaaat tctttactac ctgcggcaac
      541 agaagatctt aaataatctt aaggcctttc ttcagcagcc agatgactat gagtcgtatc
      601 ttgaaggtgc tgtatatatt gaccagtact gcaatcctct ctccgacatc agcctcaaag
      661 acatccaggc ccaaattgac agcatcgtgg agcttgtttg caaaaccctt cggggcataa
      721 acagtcgcca ccccagcttg gccttcaagg caggtgaatc atccatgata atggaaatag
      781 aactccagag ccaggtgctg gatgccatga actatgtcct ttacgaccaa ctgaagttca
      841 aggggaatcg aatggattac tataatgccc tcaacttata tatgcatcag gttttgattc
      901 gcagaacagg aatcccaatc agcatgtctc tgctctattt gacaattgct cggcagttgg
      961 gagtcccact ggagcctgtc aacttcccaa gtcacttctt attaaggtgg tgccaaggcg
     1021 cagaaggggc gaccctggac atctttgact acatctacat agatgctttt gggaaaggca
     1081 agcagctgac agtgaaagaa tgcgagtact tgatcggcca gcacgtgact gcagcactgt
     1141 atggggtggt caatgtcaag aaggtgttac agagaatggt gggaaacctg ttaagcctgg
     1201 ggaagcggga aggcatcgac cagtcatacc agctcctgag agactcgctg gatctctatc
     1261 tggcaatgta cccggaccag gtgcagcttc tcctcctcca agccaggctt tacttccacc
     1321 tgggaatctg gccagagaag gtgcttgaca tcctccagca catccaaacc ctagacccgg
     1381 ggcagcacgg ggcggtgggc tacctggtgc agcacactct agagcacatt gagcgcaaaa
     1441 aggaggaggt gggcgtagag gtgaagctgc gctccgatga gaagcacaga gatgtctgct
     1501 actccatcgg gctcattatg aagcataaga ggtatggcta taactgtgtg atctacggct
     1561 gggaccccac ctgcatgatg ggacacgagt ggatccggaa catgaacgtc cacagcctgc
     1621 cgcacggcca ccaccagcct ttctataacg tgctggtgga ggacggctcc tgtcgatacg
     1681 cagcccaaga aaacttggaa tataacgtgg agcctcaaga aatctcacac cctgacgtgg
     1741 gacgctattt ctcagagttt actggcactc actacatccc aaacgcagag ctggagatcc
     1801 ggtatccaga agatctggag tttgtctatg aaacggtgca gaatatttac agtgcaaaga
     1861 aagagaacat agatgagtaa agtctagaga ggacattgca cctttgctgc tgctgctatc
     1921 ttccaagaga acgggactcc ggaagaagac gtctccacgg agccctcggg acctgctgca
     1981 ccaggaaagc cactccacca gtagtgctgg ttgcctccta ctaagtttaa ataccgtgtg
     2041 ctcttcccca gctgcaaaga caatgttgct ctccgcctac actagtgaat taatctgaaa
     2101 ggcactgtgt cagtggcatg gcttgtatgc ttgtcctgtg gtgacagttt gtgacattct
     2161 gtcttcatga ggtctcacag tcgacgctcc tgtaatcatt ctttgtattc actccattcc
     2221 cctgtctgtc tgcatttgtc tcagaacatt tccttggctg gacagatggg gttatgcatt
     2281 tgcaataatt tccttctgat ttctctgtgg aacgtgttcg gtcccgagtg aggactgtgt
     2341 gtctttttac cctgaagtta gttgcatatt cagaggtaaa gttgtgtgct atcttggcag
     2401 catcttagag atggagacat taacaagcta atggtaatta gaatcatttg aatttatttt
     2461 tttctaatat gtgaaacaca gatttcaagt gttttatctt ttttttttaa atttaaatgg
     2521 gaatataaca cagttttccc ttccatattc ctctcttgag tttatgcaca tctctataaa
     2581 tcattagttt tctattttat tacataaaat tcttttagaa aatgcaaata gtgaactttg
     2641 tgaatggatt tttccatact catctacaat tcctccattt taaatgacta cttttatttt
     2701 ttaatttaaa aaatctactt cagtatcatg agtaggtctt acatcagtga tgggttcttt
     2761 ttgtagtgag acatacaaat ctgatgttaa tgtttgctct tagaagtcat actccatggt
     2821 cttcaaagac caaaaaatga ggttttgctt ttgtaatcag gaaaaaaaaa aattaatgaa
     2881 ccttaaaaaa aaaaaaaaag gttttgaagg gaaaaaaagt ggtttcacac ctcttgttat
     2941 tccttagagt cacttcaagg cctgtttgaa tgtggcaggt tagaaagaga gagaatgtct
     3001 ttcatttgaa gagtgttgga cttgtgtgaa aggagatgtg cgtgttggaa tctgcttttc
     3061 caagccgcca gggtcctgac ggcagcagga cgaagcctgt tgtggcgtct tctgggaaag
     3121 cctgaccgtg tgttcggacg gcactggctc ctttccgaag ttctcagtaa ctgagcccag
     3181 agtaactgca cgcctttgtg cagctctgga gctccaccaa ctctcggcct gccagttctc
     3241 aagcgagcta atcttgtcat taatcgatag aagctaactt ccgaagttag gacctagtta
     3301 ctttgctctc aacatttaaa ataatgcagt tgctctagtg aatggggcgt taggggcctg
     3361 tctctgcacc tgtctgtcca tctgcatgca gtattctcac ccatgttgaa tgcctgctgc
     3421 ttgtttaccc tttggaaacc ctggggtgac caaggtttgg aaagccacct gagaccactt
     3481 catagcaagg gaaggcttta agcagttact agaaagagat ggggatttgg cccctggctc
     3541 ctccagcctg aatgagctat ttaatccact gtccatgttc ctcatcagtc aaatccaaag
     3601 tcaaaggatt tgaacctgca tctggaaacg taaccactca cagcacctgg cccgccaagg
     3661 ttgggaggat tgtacactac tttcatttaa aggggaaagt ttgataatac ggaattaatt
     3721 aatatgaatg agatgcatta ataagaacct gagcatgctg agagttgcaa ttgttggttt
     3781 tctggtttga ttgatttcct tttttcttag acacatcaaa gtcaagaaag atggttttac
     3841 ctttactgac ccagctgtac atatgtatct agactgtttt taaatgtctt tcttcatgaa
     3901 tgcttcatgg ggctccagga agcctgtatc acctgtgtaa gttggtattt gggcacttta
     3961 tatttttcta aaaacgtgtt ttggatcctg tactctaata aatcataagt ttctttttaa
     4021 aaattttcca aaacttttct ccattttaaa aagccctgtt ataaacgttg aactttcaca
     4081 atgttaaaat gttaaatatt tggatatagc aacttctttt ctcttcaaat gaatgccaag
     4141 atttttttgt acaatgatta ataaatggaa cttatccaga gaaaccacgc aaatggcctg
     4201 cccaatttcg tttgaggaca gaaagcccag ccatgacttg agtagaatgt ctctcacctc
     4261 tcttcggatc taaatatgaa aagtatgttc tgctgaattt ttctgagcat tggtgagcgg
     4321 acagcctacc tgtaaaccat gacctccttg ccaaacgtta attttatcag ctcactagta
     4381 acctttgaga attatctggt tgtcatgcaa agattgcact ttctgaatta tgttaaaaca
     4441 catgttgtaa aatgagaact gctcatgctt tgaaagaaaa ccaggttctt cgtgcgttct
     4501 gttgccgttg atttgaatgg ctgtgctgta tacgatgtgt ccagaatgtc ttcagagcac
     4561 tgtttccgtg tgatgttact acctactatg tgggaggaaa aaaggttata ggttaaacaa
     4621 agtcaattga ctctatggtg gtgtttctca atacctgtga cgcacagtac tgtgcgtcgt
     4681 gactttctaa gagaagtgtg cagcgggtgt gtcatcttga tatatgaaac cctggaattt
     4741 ccctccccta cacgcacgca ccgtccccgg gggtccggtg tttgcagaca tgctttgaaa
     4801 agctgtctca gtgagacatc agttatgtcc aaaatgagtt taccttagaa tcagaccggt
     4861 tttgccaggc gtcatgtttg caaacattat ccacctaatc agattttgaa aggccggctt
     4921 tcatgtcgcc tgcctgagac tcataacaga tccccattat aagcgcgttt acacagcaaa
     4981 atgattttat tgagaaaacc agcattaagt actgttgccg gctcagtttt ccattgcata
     5041 ctatctactt aaagtcccgt tctcatttgt aagtgttccg atctttcccc acggagaaaa
     5101 ctgagcagag ctgccgtgtc gcaggctttc tgctgctgat gtcgcatctc tttgctttcc
     5161 cctccttagt ccatactcca agtaagtgaa ctcagactac cagcaacttt ttaactgaaa
     5221 agtatctgtc catgatgatc aagatgcagc tcttcgtgtt tttattttgt cttttttttt
     5281 tttttttttt tttggaggga aggagagaca tcaactggac aaaatgcaaa atttggatgt
     5341 gggacaattg ctttttggag acgtgaatag ctgtactgta cgtattattt tgtgtggcat
     5401 gctaactttg agccgggcac tggcctaata aagtctttgt aatcctccca gcaatcctat
     5461 aaagcagacg cagatagtaa agattttagg ctttgcaggc cacgtacaga ctgtcacatg
     5521 ttctctgttt ttaaaagtgt caacaacatt cttagctcaa aaacaggctg caggtgggat
     5581 ggtgcccaca ggccatagtt ggctgacccc ggctagggtg taggcactta gcattccact
     5641 gtataaaggg gaaacccagg tcatactgcg tgtgcgtggg tgggaagccg gatgtggaat
     5701 acaggtggtc cctgagtctc caggaaccac tgagctccag ctgttcacac ccacactctg
     5761 cggcgcaagc aactacctcg ccacggttta gccttggtct agcagcgact ttaaccttga
     5821 atgttgcatt tctgaaaaat ttagaatctt gaaagtaaag gacgtccctc cggtgaataa
     5881 aattaggcgc aattatagaa tacatgtatt atggccacgt agcaatgact gtattagggc
     5941 tctgctagtt ctgtaataaa tagacccgaa aagcaa
//
