LOCUS       NM_012168               1287 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens F-box protein 2 (FBXO2), mRNA.
ACCESSION   NM_012168
VERSION     NM_012168.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1287)
  AUTHORS   Guo,W., Ren,Y. and Qiu,X.
  TITLE     FBXO2 promotes the progression of papillary thyroid carcinoma
            through the p53 pathway
  JOURNAL   Sci Rep 14 (1), 22574 (2024)
   PUBMED   39343799
  REMARK    GeneRIF: FBXO2 promotes the progression of papillary thyroid
            carcinoma through the p53 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1287)
  AUTHORS   Liu,Z., Chen,N.Y., Zhang,Z., Zhou,S. and Hu,S.Y.
  TITLE     F-box only protein 2 exacerbates non-alcoholic fatty liver disease
            by targeting the hydroxyl CoA dehydrogenase alpha subunit
  JOURNAL   World J Gastroenterol 29 (28), 4433-4450 (2023)
   PUBMED   37576703
  REMARK    GeneRIF: F-box only protein 2 exacerbates non-alcoholic fatty liver
            disease by targeting the hydroxyl CoA dehydrogenase alpha subunit.
REFERENCE   3  (bases 1 to 1287)
  AUTHORS   Ji,J., Shen,J., Xu,Y., Xie,M., Qian,Q., Qiu,T., Shi,W., Ren,D.,
            Ma,J., Liu,W. and Liu,B.
  TITLE     FBXO2 targets glycosylated SUN2 for ubiquitination and degradation
            to promote ovarian cancer development
  JOURNAL   Cell Death Dis 13 (5), 442 (2022)
   PUBMED   35525855
  REMARK    GeneRIF: FBXO2 targets glycosylated SUN2 for ubiquitination and
            degradation to promote ovarian cancer development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1287)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1287)
  AUTHORS   Liu,E.A., Schultz,M.L., Mochida,C., Chung,C., Paulson,H.L. and
            Lieberman,A.P.
  TITLE     Fbxo2 mediates clearance of damaged lysosomes and modifies
            neurodegeneration in the Niemann-Pick C brain
  JOURNAL   JCI Insight 5 (20), 136676 (2020)
   PUBMED   32931479
  REMARK    GeneRIF: Fbxo2 mediates clearance of damaged lysosomes and modifies
            neurodegeneration in the Niemann-Pick C brain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1287)
  AUTHORS   Yoshida,Y., Chiba,T., Tokunaga,F., Kawasaki,H., Iwai,K., Suzuki,T.,
            Ito,Y., Matsuoka,K., Yoshida,M., Tanaka,K. and Tai,T.
  TITLE     E3 ubiquitin ligase that recognizes sugar chains
  JOURNAL   Nature 418 (6896), 438-442 (2002)
   PUBMED   12140560
REFERENCE   7  (bases 1 to 1287)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   8  (bases 1 to 1287)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   9  (bases 1 to 1287)
  AUTHORS   Erhardt,J.A., Hynicka,W., DiBenedetto,A., Shen,N., Stone,N.,
            Paulson,H. and Pittman,R.N.
  TITLE     A novel F box protein, NFB42, is highly enriched in neurons and
            induces growth arrest
  JOURNAL   J Biol Chem 273 (52), 35222-35227 (1998)
   PUBMED   9857061
REFERENCE   10 (bases 1 to 1287)
  AUTHORS   Thalmann,I., Rosenthal,H.L., Moore,B.W. and Thalmann,R.
  TITLE     Organ of Corti-specific polypeptides: OCP-I and OCP-II
  JOURNAL   Arch Otorhinolaryngol 226 (3), 123-128 (1980)
   PUBMED   7458746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF187318.1, AL031731.44 and
            AW162121.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012168.5.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbxs class. This protein is highly similar to the
            rat NFB42 (neural F Box 42 kDa) protein which is enriched in the
            nervous system and may play a role in maintaining neurons in a
            postmitotic state. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096747.1, SRR3476690.299589.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354287.5/ ENSP00000346240.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AF187318.1         254-458
            206-208             AL031731.44        24898-24900         c
            209-868             AF187318.1         459-1118
            869-1287            AW162121.1         6-424               c
FEATURES             Location/Qualifiers
     source          1..1287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..1287
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /note="F-box protein 2"
                     /db_xref="GeneID:26232"
                     /db_xref="HGNC:HGNC:13581"
                     /db_xref="MIM:607112"
     exon            1..111
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..980
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /note="F-box gene 1; organ of Corti protein 1"
                     /codon_start=1
                     /product="F-box only protein 2"
                     /protein_id="NP_036300.2"
                     /db_xref="CCDS:CCDS130.1"
                     /db_xref="GeneID:26232"
                     /db_xref="HGNC:HGNC:13581"
                     /db_xref="MIM:607112"
                     /translation="MDGDGDPESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAA
                     AYLDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGG
                     VEEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFT
                     HDESVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRSDAGCLYE
                     LTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTFTDYGPGVRFVRFEHGGQDS
                     VYWKGWFGARVTNSSVWVEP"
     exon            112..480
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..610
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..706
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..845
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1287
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /note="hexamer: AATAAA"
     polyA_site      1287
                     /gene="FBXO2"
                     /gene_synonym="FBG1; Fbs1; FBX2; NFB42; OCP1"
                     /note="major polyA site"
ORIGIN      
        1 agacgcggac agcgccggga ctcgccgccc cgggactcgc gcagcccgca gcgctccggc
       61 tcctcctctc gcgaccgccc tccgcagcga tggacggaga cggtgaccca gagagcgtgg
      121 gccagcccga ggaggcaagc ccggaggagc agccagagga ggcgagtgct gaggaggagc
      181 ggccggagga ccagcaggag gaggaggcgg cggccgccgc cgcgtacctg gacgagctgc
      241 ccgagccgct gctgctgcgc gtgctggccg cactgccggc cgccgagctg gtgcaggcct
      301 gccgcctggt gtgcctgcgc tggaaggagc tggtggacgg cgccccgctg tggctgctca
      361 agtgccagca ggaggggctg gtgcccgagg gcggcgtgga ggaggagcgc gaccactggc
      421 agcagttcta cttcctgagc aagcggcgcc gcaaccttct gcgtaacccg tgtggggaag
      481 aggacttgga aggctggtgt gacgtggagc atggtgggga cggctggagg gtggaggagc
      541 tgcctggaga cagtggggtg gagttcaccc acgatgagag cgtcaagaag tacttcgcct
      601 cctcctttga gtggtgtcgc aaagcacagg tcattgacct gcaggctgag ggctactggg
      661 aggagctgct ggacacgact cagccggcca tcgtggtgaa ggactggtac tcgggccgca
      721 gcgacgctgg ttgcctctac gagctcaccg ttaagctact gtccgagcac gagaacgtgc
      781 tggctgagtt cagcagcggg caggtggcag tgccccaaga cagtgacggc gggggctgga
      841 tggagatctc ccacaccttc accgactacg ggccgggcgt ccgcttcgtc cgcttcgagc
      901 acggggggca ggactccgtc tactggaagg gctggttcgg ggcccgggtg accaacagca
      961 gcgtgtgggt agaaccctga gcgaccctgc ctccactctc ccccagctgc ctggaggggc
     1021 aaaggtcgag ggtagatagg ccttaactta gtccatagcg tcctcacctt ccccaagcca
     1081 cacatcctcc tcccatccct tgctccgatc ccagcccctg agcagggaga gagaagtttt
     1141 gttggcatag gtttgcttag gtagccggct tctagaatgt agatccgtga gggcgtgagc
     1201 ttggactgga cccactgctg attccctgca cctagcacag tgcttgccac aaagtgggct
     1261 ctcaataaat attatttgtc caaggaa
//
