LOCUS       NM_148169               2176 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box protein 17 (FBXO17), transcript variant 1, mRNA.
ACCESSION   NM_148169
VERSION     NM_148169.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Shen,S., Jiang,M., Deng,W., Liu,X., Xiong,J., Zeng,Z., Zhao,H.,
            Zeng,X. and Fu,B.
  TITLE     Circ_0008717 promotes renal cell carcinoma progression by
            upregulating FBXO17 via targeting miR-217
  JOURNAL   J Gene Med 24 (11), e3418 (2022)
   PUBMED   35357059
  REMARK    GeneRIF: Circ_0008717 promotes renal cell carcinoma progression by
            upregulating FBXO17 via targeting miR-217.
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Zheng,Z.M., Wang,Y.Y., Chen,M., Yang,H.L., Lai,Z.Z., Li,M.Q. and
            Shao,J.
  TITLE     FBXO17 Inhibits the Wnt/beta-Catenin Pathway and Proliferation of
            Ishikawa Cells
  JOURNAL   Int J Med Sci 19 (9), 1430-1441 (2022)
   PUBMED   36035375
  REMARK    GeneRIF: FBXO17 Inhibits the Wnt/beta-Catenin Pathway and
            Proliferation of Ishikawa Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Deng,C., Li,H. and Li,Q.
  TITLE     F-box protein 17 promotes glioma progression by regulating
            glycolysis pathway
  JOURNAL   Biosci Biotechnol Biochem 86 (4), 455-463 (2022)
   PUBMED   35044455
  REMARK    GeneRIF: F-box protein 17 promotes glioma progression by regulating
            glycolysis pathway.
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Sun,D., Yang,K.S., Chen,J.L. and Wang,Z.B.
  TITLE     Identification and validation of an immune-associated RNA-binding
            proteins signature to predict clinical outcomes and therapeutic
            responses in colon cancer patients
  JOURNAL   World J Surg Oncol 19 (1), 314 (2021)
   PUBMED   34702278
  REMARK    GeneRIF: Identification and validation of an immune-associated
            RNA-binding proteins signature to predict clinical outcomes and
            therapeutic responses in colon cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Glenn,K.A., Nelson,R.F., Wen,H.M., Mallinger,A.J. and Paulson,H.L.
  TITLE     Diversity in tissue expression, substrate binding, and SCF complex
            formation for a lectin family of ubiquitin ligases
  JOURNAL   J Biol Chem 283 (19), 12717-12729 (2008)
   PUBMED   18203720
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: the apparent occurrence of an unusual TG 3' splice site in
            intron 3 is discussed
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Kipreos,E.T. and Pagano,M.
  TITLE     The F-box protein family
  JOURNAL   Genome Biol 1 (5), REVIEWS3002 (2000)
   PUBMED   11178263
  REMARK    Review article
REFERENCE   10 (bases 1 to 2176)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057934.1, AF386743.1,
            BM711851.1, CA429117.1 and AI050825.1.
            
            On Aug 13, 2020 this sequence version replaced NM_148169.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by the F-box motif. The F-box proteins
            constitute one of the four subunits of the ubiquitin protein ligase
            complex called SCFs (SKP1-cullin-F-box), which function in
            phosphorylation-dependent ubiquitination. The F-box proteins are
            divided into 3 classes: Fbws containing WD-40 domains, Fbls
            containing leucine-rich repeats, and Fbxs containing either
            different protein-protein interaction modules or no recognizable
            motifs. The protein encoded by this gene belongs to the Fbxs class
            and it contains an F-box domain. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) contains an alternate 5'
            terminal exon and initiates translation at an alternate start
            codon, compared to variant 2. It encodes isoform 1, which has a
            longer N-terminus, compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AK057934.1         1-125
            126-1316            AF386743.1         166-1356
            1317-1675           BM711851.1         15-373
            1676-2135           CA429117.1         59-518              c
            2136-2176           AI050825.1         8-48                c
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2176
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /note="F-box protein 17"
                     /db_xref="GeneID:115290"
                     /db_xref="HGNC:HGNC:18754"
                     /db_xref="MIM:609094"
     exon            1..115
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..969
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 26; F-box protein FBG4"
                     /codon_start=1
                     /product="F-box only protein 17 isoform 1"
                     /protein_id="NP_680474.1"
                     /db_xref="GeneID:115290"
                     /db_xref="HGNC:HGNC:18754"
                     /db_xref="MIM:609094"
                     /translation="MKQGLWLLEMGARLSRRRLPADPSLALDALPPELLVQVLSHVPP
                     RSLVTRCRPVCRAWRDIVDGPTVWLLQLARDRSAEGRALYAVAQRCLPSNEDKEEFPL
                     CALARYCLRAPFGRNLIFNSCGEQGFRGWEVEHGGNGWAIEKNLTPVPGAPSQTCFVT
                     SFEWCSKRQLVDLVMEGVWQELLDSAQIEICVADWWGARENCGCVYQLRVRLLDVYEK
                     EVVKFSASPDPVLQWTERGCRQVSHVFTNFGKGIRYVSFEQYGRDVSSWVGHYGALVT
                     HSSVRVRIRLS"
     exon            116..481
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            482..593
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            594..689
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            690..825
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2176
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2176
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /note="major polyA site"
ORIGIN      
        1 atagaaatca ctgagaatga tgctaagagc agcgggagcg gccgtgagcc cagagctaaa
       61 attagggaga agagaggagt catgatctgg gtcagcagat gacgcatgaa gcaaggactc
      121 tggctactgg agatgggcgc ccggctatcg cggcgacggc tgccggcgga cccatccctg
      181 gccctggacg cgctgccccc ggagctgctg gtgcaggtgc tgagccacgt gccgccacgc
      241 tccttggtca cgcgatgccg cccagtgtgc cgcgcctggc gcgacatagt ggacgggccc
      301 actgtgtggc tgctgcagct ggcccgcgac cgcagcgccg agggccgcgc actctacgca
      361 gtggctcaac gctgcctgcc cagcaacgaa gacaaggagg agttcccgct gtgcgccctg
      421 gcgcgctact gtctgcgcgc gcccttcggc cgcaatctca tcttcaactc ctgcggagag
      481 cagggcttca gaggctggga ggtggagcat ggcgggaacg gctgggccat agaaaagaac
      541 ctaacaccgg tgcctggggc tccttcgcag acctgcttcg tgacctcttt cgaatggtgc
      601 tccaagaggc agcttgtgga cctggtgatg gaaggggtgt ggcaggagct gctggacagc
      661 gcccagattg agatctgtgt ggctgactgg tggggcgctc gagagaactg cggctgcgtc
      721 taccagctcc gggtccgcct tctggatgtg tatgaaaagg aagtggtcaa gttctcagcc
      781 tcacctgacc cggtccttca gtggactgag aggggctgcc gacaggtctc ccacgtcttc
      841 accaactttg gcaagggcat ccgctacgta tcttttgagc agtacgggag agacgtgagt
      901 tcctgggtgg ggcactatgg cgcccttgtg acccactcca gtgtgagggt caggatccgt
      961 ctgtcctagc gactggacta ctgcctgacg ttgtcagtca agaccagcct tgcagccagg
     1021 tgcagtggct cacacctgtg gaatcccagc acttcaggag gccgaggtgg gaggatcact
     1081 ggagctcggg agttcaagac cagcctgggc aacatagtga aaccgtctcc acaaataatt
     1141 tttaaaaaat tagccaggca tggtggtgcc gcctgtagtc ccagctactc aggaggcttg
     1201 ggtgggagga ttgcctgaga ccaggaggtt gaggctgcag tgagccgtga tttcaccacc
     1261 actccagcct gggtgagaaa gcaagaccct atatcaatga aaaaaaaaaa aaaaaagacc
     1321 agctttgcag ccagaagcca gaggataccc agggacagta gggctcccag gtggctggtt
     1381 ctcagcacac cttccatgaa tctgcttgct gctgcttcag tgtggtggcc atcatgctgt
     1441 gtgacaaacc aggctgttca cagcttcctc agccccccag aaggggagtg tcaggaagag
     1501 acatttagtt catttgcctg caaattttct tctcctgcaa ggatctcggt ggactcagtc
     1561 acaaaacaaa ggctaaacca ggatttataa gagagggctt ataaatccct ctgccgacgc
     1621 agggagcaga gacttgccgg catgttttgg gggtaatgat cgtgggcagg gagcagaggt
     1681 ccgctgaggc agtctgtcct tgagactaac aaagtcatct gctgtttggg gaaatctctg
     1741 gtgttgggaa caggccccca aatctggcca taaactggcc ccaaaactgg ccataaacaa
     1801 aatatctgca gcactgtgac atgtttgtga tggccatgac ccccaccctg aaggttgtgg
     1861 gtttactgga acgagggcga ggaacacctg gcccacccag ggcggaaaac cgcttaaagg
     1921 ggttcctgaa ccacaaacca tagcataagt gatctgtgcc ttaacgacat gttcctgctg
     1981 cagataacta gccagaccca tccctttatt tcagcccatc cctttatttc ctgtaagaaa
     2041 tgtttttagt taatctataa tctatagaaa taatgcttat cactggcttg ctgtcaataa
     2101 atatgtgggt aaatctctgt tcaaggctct cagctctgaa ggccgtgaga cccctgattt
     2161 cccactccac acccta
//
