LOCUS       NM_024907               2218 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box protein 17 (FBXO17), transcript variant 2, mRNA.
ACCESSION   NM_024907
VERSION     NM_024907.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Shen,S., Jiang,M., Deng,W., Liu,X., Xiong,J., Zeng,Z., Zhao,H.,
            Zeng,X. and Fu,B.
  TITLE     Circ_0008717 promotes renal cell carcinoma progression by
            upregulating FBXO17 via targeting miR-217
  JOURNAL   J Gene Med 24 (11), e3418 (2022)
   PUBMED   35357059
  REMARK    GeneRIF: Circ_0008717 promotes renal cell carcinoma progression by
            upregulating FBXO17 via targeting miR-217.
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Zheng,Z.M., Wang,Y.Y., Chen,M., Yang,H.L., Lai,Z.Z., Li,M.Q. and
            Shao,J.
  TITLE     FBXO17 Inhibits the Wnt/beta-Catenin Pathway and Proliferation of
            Ishikawa Cells
  JOURNAL   Int J Med Sci 19 (9), 1430-1441 (2022)
   PUBMED   36035375
  REMARK    GeneRIF: FBXO17 Inhibits the Wnt/beta-Catenin Pathway and
            Proliferation of Ishikawa Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2218)
  AUTHORS   Deng,C., Li,H. and Li,Q.
  TITLE     F-box protein 17 promotes glioma progression by regulating
            glycolysis pathway
  JOURNAL   Biosci Biotechnol Biochem 86 (4), 455-463 (2022)
   PUBMED   35044455
  REMARK    GeneRIF: F-box protein 17 promotes glioma progression by regulating
            glycolysis pathway.
REFERENCE   4  (bases 1 to 2218)
  AUTHORS   Sun,D., Yang,K.S., Chen,J.L. and Wang,Z.B.
  TITLE     Identification and validation of an immune-associated RNA-binding
            proteins signature to predict clinical outcomes and therapeutic
            responses in colon cancer patients
  JOURNAL   World J Surg Oncol 19 (1), 314 (2021)
   PUBMED   34702278
  REMARK    GeneRIF: Identification and validation of an immune-associated
            RNA-binding proteins signature to predict clinical outcomes and
            therapeutic responses in colon cancer patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2218)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2218)
  AUTHORS   Glenn,K.A., Nelson,R.F., Wen,H.M., Mallinger,A.J. and Paulson,H.L.
  TITLE     Diversity in tissue expression, substrate binding, and SCF complex
            formation for a lectin family of ubiquitin ligases
  JOURNAL   J Biol Chem 283 (19), 12717-12729 (2008)
   PUBMED   18203720
REFERENCE   7  (bases 1 to 2218)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: the apparent occurrence of an unusual TG 3' splice site in
            intron 3 is discussed
REFERENCE   8  (bases 1 to 2218)
  AUTHORS   Ilyin,G.P., Serandour,A.L., Pigeon,C., Rialland,M., Glaise,D. and
            Guguen-Guillouzo,C.
  TITLE     A new subfamily of structurally related human F-box proteins
  JOURNAL   Gene 296 (1-2), 11-20 (2002)
   PUBMED   12383498
REFERENCE   9  (bases 1 to 2218)
  AUTHORS   Kipreos,E.T. and Pagano,M.
  TITLE     The F-box protein family
  JOURNAL   Genome Biol 1 (5), REVIEWS3002 (2000)
   PUBMED   11178263
  REMARK    Review article
REFERENCE   10 (bases 1 to 2218)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF594009.1, AF386743.1,
            BM711851.1, CA429117.1 and AI050825.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_024907.6.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by the F-box motif. The F-box proteins
            constitute one of the four subunits of the ubiquitin protein ligase
            complex called SCFs (SKP1-cullin-F-box), which function in
            phosphorylation-dependent ubiquitination. The F-box proteins are
            divided into 3 classes: Fbws containing WD-40 domains, Fbls
            containing leucine-rich repeats, and Fbxs containing either
            different protein-protein interaction modules or no recognizable
            motifs. The protein encoded by this gene belongs to the Fbxs class
            and it contains an F-box domain. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) encodes the shorter isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF386743.1, SRR1660805.194695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292852.9/ ENSP00000292852.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CF594009.1         198-199
            3-1358              AF386743.1         1-1356
            1359-1717           BM711851.1         15-373
            1718-2177           CA429117.1         59-518              c
            2178-2218           AI050825.1         8-48                c
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2218
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /note="F-box protein 17"
                     /db_xref="GeneID:115290"
                     /db_xref="HGNC:HGNC:18754"
                     /db_xref="MIM:609094"
     exon            1..157
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            158..523
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1011
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 26; F-box protein FBG4"
                     /codon_start=1
                     /product="F-box only protein 17 isoform 2"
                     /protein_id="NP_079183.4"
                     /db_xref="CCDS:CCDS12526.1"
                     /db_xref="GeneID:115290"
                     /db_xref="HGNC:HGNC:18754"
                     /db_xref="MIM:609094"
                     /translation="MGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRP
                     VCRAWRDIVDGPTVWLLQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLR
                     APFGRNLIFNSCGEQGFRGWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQ
                     LVDLVMEGVWQELLDSAQIEICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASP
                     DPVLQWTERGCRQVSHVFTNFGKGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIR
                     LS"
     exon            524..635
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            636..731
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            732..867
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     exon            868..2218
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2218
                     /gene="FBXO17"
                     /gene_synonym="FBG4; Fbx17; FBX26; FBXO26"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgcca cgccccggga gaggaccgac cgcccagacc gccggtcccg gggccccctg
       61 ggccacgccg atcacgggga gcccctcgac tgcctcccag aacaaagtgg gaaagggaag
      121 cttagcccgc cgctgccgcc tccgagcagc ccgccaggac tctggctact ggagatgggc
      181 gcccggctat cgcggcgacg gctgccggcg gacccatccc tggccctgga cgcgctgccc
      241 ccggagctgc tggtgcaggt gctgagccac gtgccgccac gctccttggt cacgcgatgc
      301 cgcccagtgt gccgcgcctg gcgcgacata gtggacgggc ccactgtgtg gctgctgcag
      361 ctggcccgcg accgcagcgc cgagggccgc gcactctacg cagtggctca acgctgcctg
      421 cccagcaacg aagacaagga ggagttcccg ctgtgcgccc tggcgcgcta ctgtctgcgc
      481 gcgcccttcg gccgcaatct catcttcaac tcctgcggag agcagggctt cagaggctgg
      541 gaggtggagc atggcgggaa cggctgggcc atagaaaaga acctaacacc ggtgcctggg
      601 gctccttcgc agacctgctt cgtgacctct ttcgaatggt gctccaagag gcagcttgtg
      661 gacctggtga tggaaggggt gtggcaggag ctgctggaca gcgcccagat tgagatctgt
      721 gtggctgact ggtggggcgc tcgagagaac tgcggctgcg tctaccagct ccgggtccgc
      781 cttctggatg tgtatgaaaa ggaagtggtc aagttctcag cctcacctga cccggtcctt
      841 cagtggactg agaggggctg ccgacaggtc tcccacgtct tcaccaactt tggcaagggc
      901 atccgctacg tatcttttga gcagtacggg agagacgtga gttcctgggt ggggcactat
      961 ggcgcccttg tgacccactc cagtgtgagg gtcaggatcc gtctgtccta gcgactggac
     1021 tactgcctga cgttgtcagt caagaccagc cttgcagcca ggtgcagtgg ctcacacctg
     1081 tggaatccca gcacttcagg aggccgaggt gggaggatca ctggagctcg ggagttcaag
     1141 accagcctgg gcaacatagt gaaaccgtct ccacaaataa tttttaaaaa attagccagg
     1201 catggtggtg ccgcctgtag tcccagctac tcaggaggct tgggtgggag gattgcctga
     1261 gaccaggagg ttgaggctgc agtgagccgt gatttcacca ccactccagc ctgggtgaga
     1321 aagcaagacc ctatatcaat gaaaaaaaaa aaaaaaaaga ccagctttgc agccagaagc
     1381 cagaggatac ccagggacag tagggctccc aggtggctgg ttctcagcac accttccatg
     1441 aatctgcttg ctgctgcttc agtgtggtgg ccatcatgct gtgtgacaaa ccaggctgtt
     1501 cacagcttcc tcagcccccc agaaggggag tgtcaggaag agacatttag ttcatttgcc
     1561 tgcaaatttt cttctcctgc aaggatctcg gtggactcag tcacaaaaca aaggctaaac
     1621 caggatttat aagagagggc ttataaatcc ctctgccgac gcagggagca gagacttgcc
     1681 ggcatgtttt gggggtaatg atcgtgggca gggagcagag gtccgctgag gcagtctgtc
     1741 cttgagacta acaaagtcat ctgctgtttg gggaaatctc tggtgttggg aacaggcccc
     1801 caaatctggc cataaactgg ccccaaaact ggccataaac aaaatatctg cagcactgtg
     1861 acatgtttgt gatggccatg acccccaccc tgaaggttgt gggtttactg gaacgagggc
     1921 gaggaacacc tggcccaccc agggcggaaa accgcttaaa ggggttcctg aaccacaaac
     1981 catagcataa gtgatctgtg ccttaacgac atgttcctgc tgcagataac tagccagacc
     2041 catcccttta tttcagccca tccctttatt tcctgtaaga aatgttttta gttaatctat
     2101 aatctataga aataatgctt atcactggct tgctgtcaat aaatatgtgg gtaaatctct
     2161 gttcaaggct ctcagctctg aaggccgtga gacccctgat ttcccactcc acacccta
//
