LOCUS       NM_001142958            1675 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 15 (FBXO15), transcript variant 2, mRNA.
ACCESSION   NM_001142958
VERSION     NM_001142958.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Zhao,Y., Shim,N., Cui,Y.H., Kang,J.H., Yoo,K.C., Kim,S., Yi,J.M.,
            Kim,M.J., Yoon,J.H. and Lee,S.J.
  TITLE     FBXO15 plays a critical suppressive functional role in regulation
            of breast cancer progression
  JOURNAL   Signal Transduct Target Ther 6 (1), 211 (2021)
   PUBMED   34083507
  REMARK    GeneRIF: FBXO15 plays a critical suppressive functional role in
            regulation of breast cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Simino,J., Sung,Y.J., Kume,R., Schwander,K. and Rao,D.C.
  TITLE     Gene-alcohol interactions identify several novel blood pressure
            loci including a promising locus near SLC16A9
  JOURNAL   Front Genet 4, 277 (2013)
   PUBMED   24376456
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1675)
  AUTHORS   Wojczynski,M.K., Li,M., Bielak,L.F., Kerr,K.F., Reiner,A.P.,
            Wong,N.D., Yanek,L.R., Qu,L., White,C.C., Lange,L.A.,
            Ferguson,J.F., He,J., Young,T., Mosley,T.H., Smith,J.A., Kral,B.G.,
            Guo,X., Wong,Q., Ganesh,S.K., Heckbert,S.R., Griswold,M.E.,
            O'Leary,D.H., Budoff,M., Carr,J.J., Taylor,H.A. Jr., Bluemke,D.A.,
            Demissie,S., Hwang,S.J., Paltoo,D.N., Polak,J.F., Psaty,B.M.,
            Becker,D.M., Province,M.A., Post,W.S., O'Donnell,C.J., Wilson,J.G.,
            Harris,T.B., Kavousi,M., Cupples,L.A., Rotter,J.I., Fornage,M.,
            Becker,L.C., Peyser,P.A., Borecki,I.B. and Reilly,M.P.
  TITLE     Genetics of coronary artery calcification among African Americans,
            a meta-analysis
  JOURNAL   BMC Med Genet 14, 75 (2013)
   PUBMED   23870195
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1675)
  AUTHORS   Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G.,
            Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M.,
            Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R.,
            Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M.,
            Bohringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de
            Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T.,
            Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T.,
            Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A.,
            Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S.,
            Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T.,
            Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K.,
            Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N.,
            Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C.,
            Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A.,
            Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E.,
            Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L.,
            Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P.,
            Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G.,
            Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I.,
            Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S.,
            Peeters,R.P. and Naitza,S.
  TITLE     A meta-analysis of thyroid-related traits reveals novel loci and
            gender-specific differences in the regulation of thyroid function
  JOURNAL   PLoS Genet 9 (2), e1003266 (2013)
   PUBMED   23408906
REFERENCE   7  (bases 1 to 1675)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 1675)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   9  (bases 1 to 1675)
  AUTHORS   Tokuzawa,Y., Kaiho,E., Maruyama,M., Takahashi,K., Mitsui,K.,
            Maeda,M., Niwa,H. and Yamanaka,S.
  TITLE     Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic
            stem cell self-renewal and mouse development
  JOURNAL   Mol Cell Biol 23 (8), 2699-2708 (2003)
   PUBMED   12665572
REFERENCE   10 (bases 1 to 1675)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB447209.1, AK094215.1 and
            BU729305.1.
            
            On May 17, 2019 this sequence version replaced NM_001142958.1.
            
            Summary: Members of the F-box protein family, such as FBXO15, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region, and uses an upstream start codon, compared to
            variant 1. The resulting protein (isoform 2) is longer and has a
            distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094215.1, SRR5189667.252465.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419743.7/ ENSP00000393154.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DB447209.1         33-61
            30-1535             AK094215.1         1-1506
            1536-1675           BU729305.1         34-173              c
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..1675
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /note="F-box protein 15"
                     /db_xref="GeneID:201456"
                     /db_xref="HGNC:HGNC:13617"
                     /db_xref="MIM:609093"
     exon            1..165
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1582
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 15"
                     /codon_start=1
                     /product="F-box only protein 15 isoform 2"
                     /protein_id="NP_001136430.1"
                     /db_xref="CCDS:CCDS45884.1"
                     /db_xref="GeneID:201456"
                     /db_xref="HGNC:HGNC:13617"
                     /db_xref="MIM:609093"
                     /translation="MATGRGRILQQHWLGLQTLRGPSRGGGAARGRARAFGCRKGPGV
                     KLSAGSAALRCHAGGGQHWESSFSCCSGFLDGMPSEILLKIFSYLDAVSLLCTGCVSR
                     RFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYIT
                     KQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLS
                     INDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSH
                     LTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHHLVERSTLGSATIPY
                     ELPPHSPFLDDSPEYGLHGYQLHVDLHSGGVFYLCGTFRNLFTKRGNIENGHVKLIVI
                     HLKNNREHLPLIGKVGLSWKTDIFDGCIKSCSMMDVTLLDEHGKPFWCFSSPVCLRSP
                     ATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVNLVLYLSIAKINHWFGT
                     EY"
     exon            166..276
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            277..381
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            382..624
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            625..834
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            835..961
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1044
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1187
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1312
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1675
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /note="hexamer: AATAAA"
     polyA_site      1675
                     /gene="FBXO15"
                     /gene_synonym="FBX15"
                     /note="major polyA site"
ORIGIN      
        1 actcttcgtt tcagccctgg cgcggtcctg tggtgaactc cttgtctcta tggcgactgg
       61 acgcggtcgg atcttgcagc agcactggct cggcctccag acgctgcgcg ggcccagcag
      121 gggcggtggc gcggcccggg ggcgcgccag ggcctttggg tgcagaaagg ggccaggggt
      181 caagctttct gcaggctctg ctgccctgag gtgccatgcc ggaggtggac agcactggga
      241 gagctctttc tcctgctgtt ctgggttcct ggatggaatg ccttcagaaa tcttgctgaa
      301 gatattttcc tacttggatg ctgtgagcct tctgtgtact ggatgtgtga gcaggcgctt
      361 ttatcatcta gccaatgaca attttatttg gatcggaatc tactcaactg ctttttcacc
      421 tgcaagatca aattggaaat ttaattcagt agagaagata gctatgtcta tgagctttct
      481 gtcagttcag gataaagaag ctggttattg gaagaaagaa tatatcacaa aacaaatagc
      541 atctgtaaaa gccgcactag ctgacattct caaacctgtc aacccttaca caggccttcc
      601 agttaagacc aaagaggccc tcagaatatt tggtttaggt tgggcaatta tactgaaaga
      661 aaaaggtgga aaagaatata tcatggagca tgttgatctt tccataaatg acacatcagt
      721 tactgttata tggtatggca aaaaatggcc atgcctagca tcattgtcaa ccttagattt
      781 atgtggcatg acaccagttt ttaccgactg gtataaaact cccaccaaac atagactccg
      841 atggcattct ttaattgcaa agtacaatct gagtcatttg accatatcta ccatgattgg
      901 ctgtgacaga ctcattcgga tcttctgcct gcaccctggc ctcctggtgg gagtgtggaa
      961 gaaggaggaa gaactggctt ttgttatggc aaatcttcat tttcatcacc ttgtggagag
     1021 gagcacatta ggctcggcta ctatccccta tgaactgcct ccacatagcc cctttttgga
     1081 tgatagcccc gagtatggac tgcacggcta ccaactccat gttgatctgc acagcggtgg
     1141 ggttttctac ctatgtggta catttcgcaa tctcttcacc aagagaggaa atattgaaaa
     1201 tggacatgtg aagctcattg ttatacattt aaaaaataac agagaacacc tacctcttat
     1261 tggaaaagtt ggcctctcgt ggaaaactga tatttttgat ggctgtataa agagttgttc
     1321 catgatggac gtaactcttt tggatgaaca tgggaaaccc ttttggtgtt tcagttcccc
     1381 ggtgtgcctg agatcgcctg ccacaccctc tgacagctct agcttcttgg gacagacata
     1441 caacgtggac tacgttgatg cggaaggaag agtgcacgtg gagctggtgt ggatcagaga
     1501 gaccgaagaa taccttattg tcaacctggt cctttatctt agtatcgcaa aaatcaacca
     1561 ttggtttggg actgaatatt agcagtaggt ggcaaattat tgttgttatt tagttgttta
     1621 tttttgactg gctttgttct tggtgttgaa aattaaaata aagcaaatct gcaga
//
