LOCUS       NM_025133               3859 bp    mRNA    linear   PRI 29-JUL-2024
DEFINITION  Homo sapiens F-box protein 11 (FBXO11), transcript variant 1, mRNA.
ACCESSION   NM_025133
VERSION     NM_025133.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3859)
  AUTHORS   Pan,X., Liu,L., Zhang,X., Tang,X., Qian,G., Qiu,H., Lin,S., Yao,H.,
            Dong,X. and Tan,B.
  TITLE     FBXO11 variants are associated with intellectual disability and
            variable clinical manifestation in Chinese affected individuals
  JOURNAL   J Hum Genet 69 (8), 391-400 (2024)
   PUBMED   38740982
  REMARK    GeneRIF: FBXO11 variants are associated with intellectual
            disability and variable clinical manifestation in Chinese affected
            individuals.
REFERENCE   2  (bases 1 to 3859)
  AUTHORS   Kasuga,Y., Ouda,R., Watanabe,M., Sun,X., Kimura,M., Hatakeyama,S.
            and Kobayashi,K.S.
  TITLE     FBXO11 constitutes a major negative regulator of MHC class II
            through ubiquitin-dependent proteasomal degradation of CIITA
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2218955120 (2023)
   PUBMED   37279268
  REMARK    GeneRIF: FBXO11 constitutes a major negative regulator of MHC class
            II through ubiquitin-dependent proteasomal degradation of CIITA.
REFERENCE   3  (bases 1 to 3859)
  AUTHORS   Jeon,Y., Chow,S.H., Stuart,I., Weir,A., Yeung,A.T., Hale,C.,
            Sridhar,S., Dougan,G., Vince,J.E. and Naderer,T.
  TITLE     FBXO11 governs macrophage cell death and inflammation in response
            to bacterial toxins
  JOURNAL   Life Sci Alliance 6 (6), e202201735 (2023)
   PUBMED   36977592
  REMARK    GeneRIF: FBXO11 governs macrophage cell death and inflammation in
            response to bacterial toxins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3859)
  AUTHORS   Abida,W.M., Nikolaev,A., Zhao,W., Zhang,W. and Gu,W.
  TITLE     FBXO11 promotes the Neddylation of p53 and inhibits its
            transcriptional activity
  JOURNAL   J Biol Chem 282 (3), 1797-1804 (2007)
   PUBMED   17098746
  REMARK    GeneRIF: FBXO11 promotes the Neddylation (NEDD8) of p53 and
            inhibits its transcriptional activity
REFERENCE   5  (bases 1 to 3859)
  AUTHORS   Segade,F., Daly,K.A., Allred,D., Hicks,P.J., Cox,M., Brown,M.,
            Hardisty-Hughes,R.E., Brown,S.D., Rich,S.S. and Bowden,D.W.
  TITLE     Association of the FBXO11 gene with chronic otitis media with
            effusion and recurrent otitis media: the Minnesota COME/ROM Family
            Study
  JOURNAL   Arch Otolaryngol Head Neck Surg 132 (7), 729-733 (2006)
   PUBMED   16847180
  REMARK    GeneRIF: The FBXO11 gene is the human homologue of the gene mutated
            in the novel deaf mouse mutant jeff (Jf), a single gene model of
            otitis media. FBXO11 gene for association with chronic otitis media
            with effusion.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3859)
  AUTHORS   Cook,J.R., Lee,J.H., Yang,Z.H., Krause,C.D., Herth,N., Hoffmann,R.
            and Pestka,S.
  TITLE     FBXO11/PRMT9, a new protein arginine methyltransferase,
            symmetrically dimethylates arginine residues
  JOURNAL   Biochem Biophys Res Commun 342 (2), 472-481 (2006)
   PUBMED   16487488
  REMARK    GeneRIF: A type II protein arginine methyltransferase that forms
            asymmetric dimethylarginine modifications in proteins.
REFERENCE   7  (bases 1 to 3859)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (bases 1 to 3859)
  AUTHORS   Le Poole,I.C., Sarangarajan,R., Zhao,Y., Stennett,L.S., Brown,T.L.,
            Sheth,P., Miki,T. and Boissy,R.E.
  TITLE     'VIT1', a novel gene associated with vitiligo
  JOURNAL   Pigment Cell Res 14 (6), 475-484 (2001)
   PUBMED   11775060
REFERENCE   9  (bases 1 to 3859)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 3859)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315108.1, AC079807.5,
            AC006509.15 and AI879484.1.
            
            On Jun 13, 2010 this sequence version replaced NM_025133.3.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class. It can function as an arginine methyltransferase
            that symmetrically dimethylates arginine residues, and it acts as
            an adaptor protein to mediate the neddylation of p53, which leads
            to the suppression of p53 function. This gene is known to be
            down-regulated in melanocytes from patients with vitiligo, a skin
            disorder that results in depigmentation. Polymorphisms in this gene
            are associated with chronic otitis media with effusion and
            recurrent otitis media (COME/ROM), a hearing loss disorder, and the
            knockout of the homologous mouse gene results in the deaf mouse
            mutant Jeff (Jf), a single gene model of otitis media.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been identified for this gene. [provided by RefSeq,
            Jun 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315108.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               AK315108.1         1-557
            558-558             AC079807.5         20783-20783         c
            559-2646            AK315108.1         559-2646
            2647-3546           AC006509.15        8990-9889
            3547-3859           AI879484.1         1-313               c
FEATURES             Location/Qualifiers
     source          1..3859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..3859
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="F-box protein 11"
                     /db_xref="GeneID:80204"
                     /db_xref="HGNC:HGNC:13590"
                     /db_xref="MIM:607871"
     exon            1..94
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            95..222
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2646
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 11; ubiquitin protein ligase E3 component
                     n-recognin 6; vitiligo-associated protein VIT-1; protein
                     arginine N-methyltransferase 9; vitiligo-associated
                     protein 1"
                     /codon_start=1
                     /product="F-box only protein 11 isoform 1"
                     /protein_id="NP_079409.3"
                     /db_xref="CCDS:CCDS1837.1"
                     /db_xref="GeneID:80204"
                     /db_xref="HGNC:HGNC:13590"
                     /db_xref="MIM:607871"
                     /translation="MVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTE
                     NFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRF
                     SELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAH
                     VKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYI
                     ESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNA
                     HHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDH
                     AQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHR
                     NRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNS
                     DPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDG
                     QHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGH
                     GVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNA
                     MAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHP
                     ILRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQD
                     AIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIR
                     HDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN"
     exon            223..304
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..449
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..579
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..663
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..796
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..903
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1015
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1122
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1260
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1478
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1564
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1659
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1782
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1868
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1945
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2089
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2200
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2308
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2417
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2516
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..3844
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3823..3828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="hexamer: AATAAA"
     polyA_site      3844
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="major polyA site"
ORIGIN      
        1 atcatagcaa taagatttgt aaaacattgc aatggctgaa aaactgtcta acaggaaatt
       61 ttaagtgtta ttccaaagaa gaacaagcct aaaaatgatg atgtgcctgc agatatggtt
      121 gcagaagaat caggtcctgg tgcacaaaat agtccatacc aacttcgtag aaaaactctt
      181 ttgccgaaaa gaacagcgtg tcccacaaag aacagtatgg agggcgcctc aacttcaact
      241 acagaaaact ttggtcatcg tgcaaaacgt gcaagagtgt ctggaaaatc acaagatcta
      301 tcagcagcac ctgctgaaca gtatcttcag gagaaactgc cagatgaagt ggttctaaaa
      361 atcttctctt acttgctgga acaggatctt tgtagagcag cttgtgtatg taaacgcttc
      421 agtgaacttg ctaatgatcc aattttgtgg aaacgattat atatggaagt atttgaatat
      481 actcgcccta tgatgcatcc tgaacctgga aaattctacc agattaatcc agaagagtat
      541 gaacatccaa atccctggaa agagagtttc cagcagttgt ataaaggtgc acatgtaaag
      601 ccaggatttg ctgaacattt ctacagtaac cctgcaagat ataaaggaag agaaaatatg
      661 ttgtattatg atactattga agatgccctt ggtggggtac aagaggctca ttttgatgga
      721 cttatctttg ttcattctgg aatatatact gatgaatgga tatatattga atctccaatc
      781 accatgattg gtgcagcacc tgggaaagtg gcagacaaag ttataattga aaacactaga
      841 gattcaacct tcgtttttat ggaaggctct gaagatgctt atgttggata tatgacaata
      901 aggtttaacc ctgatgacaa atctgcacaa caccacaatg cacaccactg cttagagatt
      961 acagtaaatt gtagccctat tattgatcac tgtatcatcc gaagtacatg tacagttggt
     1021 tctgcagtat gtgttagtgg tcaaggagca tgtcccacca tcaagcactg taacatcagt
     1081 gactgtgaaa atgttggact atatataaca gatcatgcac agggaatata tgaggataat
     1141 gaaatttcca ataatgcgtt agctgggatt tgggttaaaa atcatggaaa cccaattatt
     1201 agacggaatc atattcatca tggacgtgat gttggtgtgt tcacatttga tcatggcatg
     1261 ggttactttg aaagttgcaa tatacacaga aataggatag caggctttga agtaaaagcc
     1321 tatgctaacc ctacagtggt tcgatgtgaa attcaccatg ggcagactgg aggaatatat
     1381 gtccatgaaa aaggaagagg acaattcata gagaataaaa tctatgcaaa caactttgca
     1441 ggtgtatgga ttacctcaaa tagtgaccca acaataaggg gaaattctat atttaatgga
     1501 aatcaaggag gagtttacat ctttggtgat ggacgaggcc ttattgaagg aaatgacatt
     1561 tatggcaatg cattagcagg aattcaaatt aggacaaaca gttgtccaat tgttcggcat
     1621 aacaaaattc atgatggcca gcatggtggg atttatgtgc atgaaaaggg acaaggagta
     1681 atagaagaga atgaagttta tagtaacact ctagctggag tctgggtgac aactggcagc
     1741 actccagtac tgagaagaaa ccggatacac agtggcaagc aggttggtgt ttatttttat
     1801 gacaatggac atggagtgct agaagacaat gatatctata atcatatgta ttcaggggtt
     1861 cagataagga ctggaagcaa ccccaaaatt agacgcaaca aaatctgggg aggacagaat
     1921 ggtggaattc tagtttataa ttctggtcta ggctgtatag aagacaatga aatatttgac
     1981 aatgcaatgg ctggagtctg gattaagaca gatagtaatc ctacactaag aagaaataaa
     2041 atccatgatg gaagagatgg tggcatctgt atatttaatg ggggtcgagg tctccttgaa
     2101 gaaaatgata ttttcaggaa tgctcaagca ggtgttctca tcagcactaa tagtcatcca
     2161 atcttaagga aaaacagaat atttgatgga tttgccgcag gtattgaaat tacaaatcac
     2221 gcaactgcaa cactagaagg caatcagatt tttaacaacc ggtttggagg cttattttta
     2281 gcatctggtg ttaatgtgac aatgaaagat aacaaaataa tgaacaatca agatgccata
     2341 gaaaaggctg ttagtagagg ccaatgttta tataaaatat caagttatac cagctatccc
     2401 atgcatgatt tctacagatg tcatacttgt aacaccacag atcgaaatgc catatgtgtg
     2461 aactgcatta agaagtgcca tcagggacat gatgtagagt ttattagaca tgataggttt
     2521 ttctgtgact gtggtgctgg aacactgtct aatccttgta cattagctgg tgagcctaca
     2581 catgatacag atacactata tgactctgct ccacctatag aatctaatac attgcagcac
     2641 aactgaattc cttccctaaa gaaaaagtcc tgccattgta acatcataac ttaaaacact
     2701 tttttggaag aagatttaaa atatttgccc atgctacagg aagagactgt attaaaaatg
     2761 gatacacaag gtcagttgac actatgaagc tcaagctacc aaaaagaaag tggcaatata
     2821 ttgactcagg atctcaaagc tgggtgtttt agcattactg tgtaaagact tgaagggaca
     2881 gaagtgaaga aaataagctg caattttgta cagataccaa cttctgaaaa gctggtgttt
     2941 ttacaactag cattgaatgc agtccaattt gcagtagtaa tcttcaatag acaagcagct
     3001 ttgttgctgc ctttatggac atgggtacca attgcttttg taatatggta aaaatgtgag
     3061 ctagcacttc tgcgttcctt ttgatttttt ttttttaaca tgtattcaga ttgagaaata
     3121 tgattttaat gctttaatct catgtagttt gtttttaatt tcaagcaaaa tcttactgta
     3181 cttgaatgtg ccctgttttg ttagcacacc tagacttgct gtaactgtac tcatgtccca
     3241 gtatgtacgt tctttctatg aaagagaaaa cactaatctt aaattatatc cagcaatgtt
     3301 tctggtatcc tttaagaaaa gttaagacta ttatttcctt cccttccctg tgcagcattc
     3361 aaaatcaccc ctagaaaaag tgagtgtttt aatgagactt cctaggaagg gatgcactgt
     3421 aaaacaaaag tattcttgta actcagtttt gtgaaaggta aaaaactact atgttttaag
     3481 tacactttag aaagtctctt caaaacaaac agtcctgtat ttgaactctg ttcatagttt
     3541 ttttttgaac agtttagaca aaactgctgg aaattaaacc aatttcctgc attaagctga
     3601 gacaagtata tatacagccc tatacagttt catagctttt cctcccccat ttatgtgtat
     3661 tggtgacagt gggtataaaa cagcctgaaa gtgtatgcat gtaccataac atctagactt
     3721 aatatattgt ggagtattca ataaccatta tgtagaaggt agataagaat taaaagggtt
     3781 taatttccta gaaagaaaat ggaaaaatgg tcatttttaa aaaataaagt ttattagatc
     3841 ataaaaaaaa aaaaaaaaa
//
