LOCUS       NM_001374325            3996 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens F-box protein 11 (FBXO11), transcript variant 5, mRNA.
ACCESSION   NM_001374325 XM_017005017
VERSION     NM_001374325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Pan,X., Liu,L., Zhang,X., Tang,X., Qian,G., Qiu,H., Lin,S., Yao,H.,
            Dong,X. and Tan,B.
  TITLE     FBXO11 variants are associated with intellectual disability and
            variable clinical manifestation in Chinese affected individuals
  JOURNAL   J Hum Genet 69 (8), 391-400 (2024)
   PUBMED   38740982
  REMARK    GeneRIF: FBXO11 variants are associated with intellectual
            disability and variable clinical manifestation in Chinese affected
            individuals.
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   Kasuga,Y., Ouda,R., Watanabe,M., Sun,X., Kimura,M., Hatakeyama,S.
            and Kobayashi,K.S.
  TITLE     FBXO11 constitutes a major negative regulator of MHC class II
            through ubiquitin-dependent proteasomal degradation of CIITA
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2218955120 (2023)
   PUBMED   37279268
  REMARK    GeneRIF: FBXO11 constitutes a major negative regulator of MHC class
            II through ubiquitin-dependent proteasomal degradation of CIITA.
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Jeon,Y., Chow,S.H., Stuart,I., Weir,A., Yeung,A.T., Hale,C.,
            Sridhar,S., Dougan,G., Vince,J.E. and Naderer,T.
  TITLE     FBXO11 governs macrophage cell death and inflammation in response
            to bacterial toxins
  JOURNAL   Life Sci Alliance 6 (6), e202201735 (2023)
   PUBMED   36977592
  REMARK    GeneRIF: FBXO11 governs macrophage cell death and inflammation in
            response to bacterial toxins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Abida,W.M., Nikolaev,A., Zhao,W., Zhang,W. and Gu,W.
  TITLE     FBXO11 promotes the Neddylation of p53 and inhibits its
            transcriptional activity
  JOURNAL   J Biol Chem 282 (3), 1797-1804 (2007)
   PUBMED   17098746
  REMARK    GeneRIF: FBXO11 promotes the Neddylation (NEDD8) of p53 and
            inhibits its transcriptional activity
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Segade,F., Daly,K.A., Allred,D., Hicks,P.J., Cox,M., Brown,M.,
            Hardisty-Hughes,R.E., Brown,S.D., Rich,S.S. and Bowden,D.W.
  TITLE     Association of the FBXO11 gene with chronic otitis media with
            effusion and recurrent otitis media: the Minnesota COME/ROM Family
            Study
  JOURNAL   Arch Otolaryngol Head Neck Surg 132 (7), 729-733 (2006)
   PUBMED   16847180
  REMARK    GeneRIF: The FBXO11 gene is the human homologue of the gene mutated
            in the novel deaf mouse mutant jeff (Jf), a single gene model of
            otitis media. FBXO11 gene for association with chronic otitis media
            with effusion.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Cook,J.R., Lee,J.H., Yang,Z.H., Krause,C.D., Herth,N., Hoffmann,R.
            and Pestka,S.
  TITLE     FBXO11/PRMT9, a new protein arginine methyltransferase,
            symmetrically dimethylates arginine residues
  JOURNAL   Biochem Biophys Res Commun 342 (2), 472-481 (2006)
   PUBMED   16487488
  REMARK    GeneRIF: A type II protein arginine methyltransferase that forms
            asymmetric dimethylarginine modifications in proteins.
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Le Poole,I.C., Sarangarajan,R., Zhao,Y., Stennett,L.S., Brown,T.L.,
            Sheth,P., Miki,T. and Boissy,R.E.
  TITLE     'VIT1', a novel gene associated with vitiligo
  JOURNAL   Pigment Cell Res 14 (6), 475-484 (2001)
   PUBMED   11775060
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079807.5 and AC006509.15.
            
            On Sep 19, 2019 this sequence version replaced XM_017005017.1.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class. It can function as an arginine methyltransferase
            that symmetrically dimethylates arginine residues, and it acts as
            an adaptor protein to mediate the neddylation of p53, which leads
            to the suppression of p53 function. This gene is known to be
            down-regulated in melanocytes from patients with vitiligo, a skin
            disorder that results in depigmentation. Polymorphisms in this gene
            are associated with chronic otitis media with effusion and
            recurrent otitis media (COME/ROM), a hearing loss disorder, and the
            knockout of the homologous mouse gene results in the deaf mouse
            mutant Jeff (Jf), a single gene model of otitis media.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been identified for this gene. [provided by RefSeq,
            Jun 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.30749.1,
                                           SRR1660807.248443.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC079807.5         89983-90228         c
            247-374             AC079807.5         24532-24659         c
            375-456             AC079807.5         24309-24390         c
            457-601             AC079807.5         23749-23893         c
            602-731             AC079807.5         20762-20891         c
            732-815             AC079807.5         19678-19761         c
            816-948             AC079807.5         19469-19601         c
            949-1055            AC079807.5         17854-17960         c
            1056-1167           AC079807.5         17659-17770         c
            1168-1274           AC079807.5         17462-17568         c
            1275-1412           AC079807.5         17239-17376         c
            1413-1630           AC079807.5         8033-8250           c
            1631-1716           AC079807.5         7108-7193           c
            1717-1811           AC079807.5         5252-5346           c
            1812-1934           AC079807.5         3846-3968           c
            1935-2020           AC079807.5         3669-3754           c
            2021-2097           AC006509.15        3240-3316
            2098-2241           AC006509.15        3730-3873
            2242-2352           AC006509.15        6681-6791
            2353-2460           AC006509.15        7400-7507
            2461-2569           AC006509.15        7841-7949
            2570-2668           AC006509.15        8680-8778
            2669-3996           AC006509.15        8860-10187
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..3996
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="F-box protein 11"
                     /db_xref="GeneID:80204"
                     /db_xref="HGNC:HGNC:13590"
                     /db_xref="MIM:607871"
     exon            1..246
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..374
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2798
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="isoform 1 is encoded by transcript variant 5; F-box
                     only protein 11; ubiquitin protein ligase E3 component
                     n-recognin 6; vitiligo-associated protein VIT-1; protein
                     arginine N-methyltransferase 9; vitiligo-associated
                     protein 1"
                     /codon_start=1
                     /product="F-box only protein 11 isoform 1"
                     /protein_id="NP_001361254.1"
                     /db_xref="CCDS:CCDS1837.1"
                     /db_xref="GeneID:80204"
                     /db_xref="HGNC:HGNC:13590"
                     /db_xref="MIM:607871"
                     /translation="MVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTE
                     NFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRF
                     SELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAH
                     VKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYI
                     ESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNA
                     HHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDH
                     AQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHR
                     NRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNS
                     DPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDG
                     QHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGH
                     GVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNA
                     MAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHP
                     ILRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQD
                     AIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIR
                     HDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN"
     exon            375..456
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..601
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..731
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..815
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..948
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1055
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1167
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1274
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1412
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1630
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1716
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1811
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1934
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2020
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2097
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2241
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2352
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2460
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2569
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2668
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..3996
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3975..3980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="hexamer: AATAAA"
     polyA_site      3996
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcagcc cgggccgggc ccggccggca ggaaaagccg cggcttccct tctcgcctgg
       61 gctctcgctc aggccgcgct ttgtttggtt tcgggggctc agcaccctcc acccccaccc
      121 atccctttgg cttctccgct cgctcacaga ccccgcggga gtctgttggt ggccgggggg
      181 aaggcgagcg gcgtgatttc tcccttttct gccgccttcc atggtttagt ctgcctcttt
      241 ctagtgatga tgatgtgcct gcagatatgg ttgcagaaga atcaggtcct ggtgcacaaa
      301 atagtccata ccaacttcgt agaaaaactc ttttgccgaa aagaacagcg tgtcccacaa
      361 agaacagtat ggagggcgcc tcaacttcaa ctacagaaaa ctttggtcat cgtgcaaaac
      421 gtgcaagagt gtctggaaaa tcacaagatc tatcagcagc acctgctgaa cagtatcttc
      481 aggagaaact gccagatgaa gtggttctaa aaatcttctc ttacttgctg gaacaggatc
      541 tttgtagagc agcttgtgta tgtaaacgct tcagtgaact tgctaatgat ccaattttgt
      601 ggaaacgatt atatatggaa gtatttgaat atactcgccc tatgatgcat cctgaacctg
      661 gaaaattcta ccagattaat ccagaagagt atgaacatcc aaatccctgg aaagagagtt
      721 tccagcagtt gtataaaggt gcacatgtaa agccaggatt tgctgaacat ttctacagta
      781 accctgcaag atataaagga agagaaaata tgttgtatta tgatactatt gaagatgccc
      841 ttggtggggt acaagaggct cattttgatg gacttatctt tgttcattct ggaatatata
      901 ctgatgaatg gatatatatt gaatctccaa tcaccatgat tggtgcagca cctgggaaag
      961 tggcagacaa agttataatt gaaaacacta gagattcaac cttcgttttt atggaaggct
     1021 ctgaagatgc ttatgttgga tatatgacaa taaggtttaa ccctgatgac aaatctgcac
     1081 aacaccacaa tgcacaccac tgcttagaga ttacagtaaa ttgtagccct attattgatc
     1141 actgtatcat ccgaagtaca tgtacagttg gttctgcagt atgtgttagt ggtcaaggag
     1201 catgtcccac catcaagcac tgtaacatca gtgactgtga aaatgttgga ctatatataa
     1261 cagatcatgc acagggaata tatgaggata atgaaatttc caataatgcg ttagctggga
     1321 tttgggttaa aaatcatgga aacccaatta ttagacggaa tcatattcat catggacgtg
     1381 atgttggtgt gttcacattt gatcatggca tgggttactt tgaaagttgc aatatacaca
     1441 gaaataggat agcaggcttt gaagtaaaag cctatgctaa ccctacagtg gttcgatgtg
     1501 aaattcacca tgggcagact ggaggaatat atgtccatga aaaaggaaga ggacaattca
     1561 tagagaataa aatctatgca aacaactttg caggtgtatg gattacctca aatagtgacc
     1621 caacaataag gggaaattct atatttaatg gaaatcaagg aggagtttac atctttggtg
     1681 atggacgagg ccttattgaa ggaaatgaca tttatggcaa tgcattagca ggaattcaaa
     1741 ttaggacaaa cagttgtcca attgttcggc ataacaaaat tcatgatggc cagcatggtg
     1801 ggatttatgt gcatgaaaag ggacaaggag taatagaaga gaatgaagtt tatagtaaca
     1861 ctctagctgg agtctgggtg acaactggca gcactccagt actgagaaga aaccggatac
     1921 acagtggcaa gcaggttggt gtttattttt atgacaatgg acatggagtg ctagaagaca
     1981 atgatatcta taatcatatg tattcagggg ttcagataag gactggaagc aaccccaaaa
     2041 ttagacgcaa caaaatctgg ggaggacaga atggtggaat tctagtttat aattctggtc
     2101 taggctgtat agaagacaat gaaatatttg acaatgcaat ggctggagtc tggattaaga
     2161 cagatagtaa tcctacacta agaagaaata aaatccatga tggaagagat ggtggcatct
     2221 gtatatttaa tgggggtcga ggtctccttg aagaaaatga tattttcagg aatgctcaag
     2281 caggtgttct catcagcact aatagtcatc caatcttaag gaaaaacaga atatttgatg
     2341 gatttgccgc aggtattgaa attacaaatc acgcaactgc aacactagaa ggcaatcaga
     2401 tttttaacaa ccggtttgga ggcttatttt tagcatctgg tgttaatgtg acaatgaaag
     2461 ataacaaaat aatgaacaat caagatgcca tagaaaaggc tgttagtaga ggccaatgtt
     2521 tatataaaat atcaagttat accagctatc ccatgcatga tttctacaga tgtcatactt
     2581 gtaacaccac agatcgaaat gccatatgtg tgaactgcat taagaagtgc catcagggac
     2641 atgatgtaga gtttattaga catgataggt ttttctgtga ctgtggtgct ggaacactgt
     2701 ctaatccttg tacattagct ggtgagccta cacatgatac agatacacta tatgactctg
     2761 ctccacctat agaatctaat acattgcagc acaactgaat tccttcccta aagaaaaagt
     2821 cctgccattg taacatcata acttaaaaca cttttttgga agaagattta aaatatttgc
     2881 ccatgctaca ggaagagact gtattaaaaa tggatacaca aggtcagttg acactatgaa
     2941 gctcaagcta ccaaaaagaa agtggcaata tattgactca ggatctcaaa gctgggtgtt
     3001 ttagcattac tgtgtaaaga cttgaaggga cagaagtgaa gaaaataagc tgcaattttg
     3061 tacagatacc aacttctgaa aagctggtgt ttttacaact agcattgaat gcagtccaat
     3121 ttgcagtagt aatcttcaat agacaagcag ctttgttgct gcctttatgg acatgggtac
     3181 caattgcttt tgtaatatgg taaaaatgtg agctagcact tctgcgttcc ttttgatttt
     3241 ttttttttaa catgtattca gattgagaaa tatgatttta atgctttaat ctcatgtagt
     3301 ttgtttttaa tttcaagcaa aatcttactg tacttgaatg tgccctgttt tgttagcaca
     3361 cctagacttg ctgtaactgt actcatgtcc cagtatgtac gttctttcta tgaaagagaa
     3421 aacactaatc ttaaattata tccagcaatg tttctggtat cctttaagaa aagttaagac
     3481 tattatttcc ttcccttccc tgtgcagcat tcaaaatcac ccctagaaaa agtgagtgtt
     3541 ttaatgagac ttcctaggaa gggatgcact gtaaaacaaa agtattcttg taactcagtt
     3601 ttgtgaaagg taaaaaacta ctatgtttta agtacacttt agaaagtctc ttcaaaacaa
     3661 acagtcctgt atttgaactc tgttcatagt ttttttttga acagtttaga caaaactgct
     3721 ggaaattaaa ccaatttcct gcattaagct gagacaagta tatatacagc cctatacagt
     3781 ttcatagctt ttcctccccc atttatgtgt attggtgaca gtgggtataa aacagcctga
     3841 aagtgtatgc atgtaccata acatctagac ttaatatatt gtggagtatt caataaccat
     3901 tatgtagaag gtagataaga attaaaaggg tttaatttcc tagaaagaaa atggaaaaat
     3961 ggtcattttt aaaaaataaa gtttattaga tcataa
//
