LOCUS       NM_001190274            4760 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens F-box protein 11 (FBXO11), transcript variant 4, mRNA.
ACCESSION   NM_001190274
VERSION     NM_001190274.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4760)
  AUTHORS   Pan,X., Liu,L., Zhang,X., Tang,X., Qian,G., Qiu,H., Lin,S., Yao,H.,
            Dong,X. and Tan,B.
  TITLE     FBXO11 variants are associated with intellectual disability and
            variable clinical manifestation in Chinese affected individuals
  JOURNAL   J Hum Genet 69 (8), 391-400 (2024)
   PUBMED   38740982
  REMARK    GeneRIF: FBXO11 variants are associated with intellectual
            disability and variable clinical manifestation in Chinese affected
            individuals.
REFERENCE   2  (bases 1 to 4760)
  AUTHORS   Kasuga,Y., Ouda,R., Watanabe,M., Sun,X., Kimura,M., Hatakeyama,S.
            and Kobayashi,K.S.
  TITLE     FBXO11 constitutes a major negative regulator of MHC class II
            through ubiquitin-dependent proteasomal degradation of CIITA
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2218955120 (2023)
   PUBMED   37279268
  REMARK    GeneRIF: FBXO11 constitutes a major negative regulator of MHC class
            II through ubiquitin-dependent proteasomal degradation of CIITA.
REFERENCE   3  (bases 1 to 4760)
  AUTHORS   Jeon,Y., Chow,S.H., Stuart,I., Weir,A., Yeung,A.T., Hale,C.,
            Sridhar,S., Dougan,G., Vince,J.E. and Naderer,T.
  TITLE     FBXO11 governs macrophage cell death and inflammation in response
            to bacterial toxins
  JOURNAL   Life Sci Alliance 6 (6), e202201735 (2023)
   PUBMED   36977592
  REMARK    GeneRIF: FBXO11 governs macrophage cell death and inflammation in
            response to bacterial toxins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4760)
  AUTHORS   Abida,W.M., Nikolaev,A., Zhao,W., Zhang,W. and Gu,W.
  TITLE     FBXO11 promotes the Neddylation of p53 and inhibits its
            transcriptional activity
  JOURNAL   J Biol Chem 282 (3), 1797-1804 (2007)
   PUBMED   17098746
  REMARK    GeneRIF: FBXO11 promotes the Neddylation (NEDD8) of p53 and
            inhibits its transcriptional activity
REFERENCE   5  (bases 1 to 4760)
  AUTHORS   Segade,F., Daly,K.A., Allred,D., Hicks,P.J., Cox,M., Brown,M.,
            Hardisty-Hughes,R.E., Brown,S.D., Rich,S.S. and Bowden,D.W.
  TITLE     Association of the FBXO11 gene with chronic otitis media with
            effusion and recurrent otitis media: the Minnesota COME/ROM Family
            Study
  JOURNAL   Arch Otolaryngol Head Neck Surg 132 (7), 729-733 (2006)
   PUBMED   16847180
  REMARK    GeneRIF: The FBXO11 gene is the human homologue of the gene mutated
            in the novel deaf mouse mutant jeff (Jf), a single gene model of
            otitis media. FBXO11 gene for association with chronic otitis media
            with effusion.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4760)
  AUTHORS   Cook,J.R., Lee,J.H., Yang,Z.H., Krause,C.D., Herth,N., Hoffmann,R.
            and Pestka,S.
  TITLE     FBXO11/PRMT9, a new protein arginine methyltransferase,
            symmetrically dimethylates arginine residues
  JOURNAL   Biochem Biophys Res Commun 342 (2), 472-481 (2006)
   PUBMED   16487488
  REMARK    GeneRIF: A type II protein arginine methyltransferase that forms
            asymmetric dimethylarginine modifications in proteins.
REFERENCE   7  (bases 1 to 4760)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (bases 1 to 4760)
  AUTHORS   Le Poole,I.C., Sarangarajan,R., Zhao,Y., Stennett,L.S., Brown,T.L.,
            Sheth,P., Miki,T. and Boissy,R.E.
  TITLE     'VIT1', a novel gene associated with vitiligo
  JOURNAL   Pigment Cell Res 14 (6), 475-484 (2001)
   PUBMED   11775060
REFERENCE   9  (bases 1 to 4760)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 4760)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079807.5, DN994547.1,
            AY827075.1, AC006509.15 and AI879484.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 19, 2019 this sequence version replaced NM_001190274.1.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class. It can function as an arginine methyltransferase
            that symmetrically dimethylates arginine residues, and it acts as
            an adaptor protein to mediate the neddylation of p53, which leads
            to the suppression of p53 function. This gene is known to be
            down-regulated in melanocytes from patients with vitiligo, a skin
            disorder that results in depigmentation. Polymorphisms in this gene
            are associated with chronic otitis media with effusion and
            recurrent otitis media (COME/ROM), a hearing loss disorder, and the
            knockout of the homologous mouse gene results in the deaf mouse
            mutant Jeff (Jf), a single gene model of otitis media.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been identified for this gene. [provided by RefSeq,
            Jun 2010].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region, and uses an alternate start codon, compared to
            variant 1. The resulting isoform (4) has a distinct and longer
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043258.1, SRR14038192.1435225.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403359.8/ ENSP00000384823.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-705               AC079807.5         90684-91388         c
            706-778             DN994547.1         9-81
            779-3484            AY827075.1         1-2706
            3485-4462           AC006509.15        8912-9889
            4463-4760           AI879484.1         16-313              c
FEATURES             Location/Qualifiers
     source          1..4760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.3"
     gene            1..4760
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="F-box protein 11"
                     /db_xref="GeneID:80204"
                     /db_xref="HGNC:HGNC:13590"
                     /db_xref="MIM:607871"
     exon            1..1010
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             779..3562
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="isoform 4 is encoded by transcript variant 4; F-box
                     only protein 11; ubiquitin protein ligase E3 component
                     n-recognin 6; vitiligo-associated protein VIT-1; protein
                     arginine N-methyltransferase 9; vitiligo-associated
                     protein 1"
                     /codon_start=1
                     /product="F-box only protein 11 isoform 4"
                     /protein_id="NP_001177203.1"
                     /db_xref="CCDS:CCDS54357.1"
                     /db_xref="GeneID:80204"
                     /db_xref="HGNC:HGNC:13590"
                     /db_xref="MIM:607871"
                     /translation="MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQ
                     PPPPPQQQQQQQPPPPPPPPPPLPQERNNVGERDDDVPADMVAEESGPGAQNSPYQLR
                     RKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLP
                     DEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKF
                     YQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDAL
                     GGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFME
                     GSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVS
                     GQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNH
                     IHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVH
                     EKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDI
                     YGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTT
                     GSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIW
                     GGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNG
                     GRGLLEENDIFRNAQAGVLISTNSHPILRKNRIFDGFAAGIEITNHATATLEGNQIFN
                     NRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTC
                     NTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYD
                     SAPPIESNTLQHN"
     exon            1011..1138
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1220
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1365
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1495
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1579
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1712
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1819
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1931
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2038
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2176
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2394
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2480
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2575
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2698
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2784
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2861
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3005
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3116
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3224
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3333
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3432
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..4760
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="hexamer: AATAAA"
     polyA_site      4760
                     /gene="FBXO11"
                     /gene_synonym="FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1"
                     /note="major polyA site"
ORIGIN      
        1 gggcgagtgg aggctccggc ggtgtcaatg gctcctcctg ccacggagca gcagcagaag
       61 cagcggcgac agggctgacg aggaggagga ggaaaggttc ctttaaggag gaggaaggac
      121 gacgcctctt tttcccccta tctcctccct tcacactcat ttccccttcg ccgaggagag
      181 aaggggggga ggagagagaa gagaccgaag aaagagagaa aaattcctca cagaaatctc
      241 tttcaggggg tgtggggggg aggaagaggg aaaaaaaaga gccgggcgcc ccctgctccc
      301 tccctccctt ctctccctct ctttttctcc cttcctcacc cgcccgccca ctccccccgc
      361 tgccggagac gccgctcgcg agtcggcggg accgggatct gtctcttcag ccgccgccgc
      421 cgccgccgcc gcgcttcgcc tcgggatccc caagcggcgg acgccctttc tttctttctc
      481 tcggtctgcc cgtctttctg ccttcgtccc tcgcggccgc cccgcccggc ggcttcggcc
      541 ttccccgtgc gtcaggccct cccggccggc ctcgctcggt ctccgtctgt ctacccgggc
      601 ctttctccgg actcggggtc ccgctcgccc cctccgccct cagcgtctcc ccttcccctc
      661 gccccctctc cttcctcccc cctctcccac tctccccacc cctttctcct gccccgaagc
      721 tcgctgtgcg tgtgcgtgtg tgtgtccctc cgccaacgcc gccacctcag cccggcaaat
      781 gaactccgtc cgagccgcca accggagacc caggcgagtg tcgcggccgc gcccggtgca
      841 gcaacagcag cagcagcccc cgcagcagcc gccgccgcag ccgccccagc agcagccgcc
      901 ccagcagcag cctccgccgc cgccgcagca gcagcagcag cagcagcctc cgccgccgcc
      961 accgccgcct ccgccgctgc ctcaggagcg gaacaacgtc ggcgagcggg atgatgatgt
     1021 gcctgcagat atggttgcag aagaatcagg tcctggtgca caaaatagtc cataccaact
     1081 tcgtagaaaa actcttttgc cgaaaagaac agcgtgtccc acaaagaaca gtatggaggg
     1141 cgcctcaact tcaactacag aaaactttgg tcatcgtgca aaacgtgcaa gagtgtctgg
     1201 aaaatcacaa gatctatcag cagcacctgc tgaacagtat cttcaggaga aactgccaga
     1261 tgaagtggtt ctaaaaatct tctcttactt gctggaacag gatctttgta gagcagcttg
     1321 tgtatgtaaa cgcttcagtg aacttgctaa tgatccaatt ttgtggaaac gattatatat
     1381 ggaagtattt gaatatactc gccctatgat gcatcctgaa cctggaaaat tctaccagat
     1441 taatccagaa gagtatgaac atccaaatcc ctggaaagag agtttccagc agttgtataa
     1501 aggtgcacat gtaaagccag gatttgctga acatttctac agtaaccctg caagatataa
     1561 aggaagagaa aatatgttgt attatgatac tattgaagat gcccttggtg gggtacaaga
     1621 ggctcatttt gatggactta tctttgttca ttctggaata tatactgatg aatggatata
     1681 tattgaatct ccaatcacca tgattggtgc agcacctggg aaagtggcag acaaagttat
     1741 aattgaaaac actagagatt caaccttcgt ttttatggaa ggctctgaag atgcttatgt
     1801 tggatatatg acaataaggt ttaaccctga tgacaaatct gcacaacacc acaatgcaca
     1861 ccactgctta gagattacag taaattgtag ccctattatt gatcactgta tcatccgaag
     1921 tacatgtaca gttggttctg cagtatgtgt tagtggtcaa ggagcatgtc ccaccatcaa
     1981 gcactgtaac atcagtgact gtgaaaatgt tggactatat ataacagatc atgcacaggg
     2041 aatatatgag gataatgaaa tttccaataa tgcgttagct gggatttggg ttaaaaatca
     2101 tggaaaccca attattagac ggaatcatat tcatcatgga cgtgatgttg gtgtgttcac
     2161 atttgatcat ggcatgggtt actttgaaag ttgcaatata cacagaaata ggatagcagg
     2221 ctttgaagta aaagcctatg ctaaccctac agtggttcga tgtgaaattc accatgggca
     2281 gactggagga atatatgtcc atgaaaaagg aagaggacaa ttcatagaga ataaaatcta
     2341 tgcaaacaac tttgcaggtg tatggattac ctcaaatagt gacccaacaa taaggggaaa
     2401 ttctatattt aatggaaatc aaggaggagt ttacatcttt ggtgatggac gaggccttat
     2461 tgaaggaaat gacatttatg gcaatgcatt agcaggaatt caaattagga caaacagttg
     2521 tccaattgtt cggcataaca aaattcatga tggccagcat ggtgggattt atgtgcatga
     2581 aaagggacaa ggagtaatag aagagaatga agtttatagt aacactctag ctggagtctg
     2641 ggtgacaact ggcagcactc cagtactgag aagaaaccgg atacacagtg gcaagcaggt
     2701 tggtgtttat ttttatgaca atggacatgg agtgctagaa gacaatgata tctataatca
     2761 tatgtattca ggggttcaga taaggactgg aagcaacccc aaaattagac gcaacaaaat
     2821 ctggggagga cagaatggtg gaattctagt ttataattct ggtctaggct gtatagaaga
     2881 caatgaaata tttgacaatg caatggctgg agtctggatt aagacagata gtaatcctac
     2941 actaagaaga aataaaatcc atgatggaag agatggtggc atctgtatat ttaatggggg
     3001 tcgaggtctc cttgaagaaa atgatatttt caggaatgct caagcaggtg ttctcatcag
     3061 cactaatagt catccaatct taaggaaaaa cagaatattt gatggatttg ccgcaggtat
     3121 tgaaattaca aatcacgcaa ctgcaacact agaaggcaat cagattttta acaaccggtt
     3181 tggaggctta tttttagcat ctggtgttaa tgtgacaatg aaagataaca aaataatgaa
     3241 caatcaagat gccatagaaa aggctgttag tagaggccaa tgtttatata aaatatcaag
     3301 ttataccagc tatcccatgc atgatttcta cagatgtcat acttgtaaca ccacagatcg
     3361 aaatgccata tgtgtgaact gcattaagaa gtgccatcag ggacatgatg tagagtttat
     3421 tagacatgat aggtttttct gtgactgtgg tgctggaaca ctgtctaatc cttgtacatt
     3481 agctggtgag cctacacatg atacagatac actatatgac tctgctccac ctatagaatc
     3541 taatacattg cagcacaact gaattccttc cctaaagaaa aagtcctgcc attgtaacat
     3601 cataacttaa aacacttttt tggaagaaga tttaaaatat ttgcccatgc tacaggaaga
     3661 gactgtatta aaaatggata cacaaggtca gttgacacta tgaagctcaa gctaccaaaa
     3721 agaaagtggc aatatattga ctcaggatct caaagctggg tgttttagca ttactgtgta
     3781 aagacttgaa gggacagaag tgaagaaaat aagctgcaat tttgtacaga taccaacttc
     3841 tgaaaagctg gtgtttttac aactagcatt gaatgcagtc caatttgcag tagtaatctt
     3901 caatagacaa gcagctttgt tgctgccttt atggacatgg gtaccaattg cttttgtaat
     3961 atggtaaaaa tgtgagctag cacttctgcg ttccttttga tttttttttt ttaacatgta
     4021 ttcagattga gaaatatgat tttaatgctt taatctcatg tagtttgttt ttaatttcaa
     4081 gcaaaatctt actgtacttg aatgtgccct gttttgttag cacacctaga cttgctgtaa
     4141 ctgtactcat gtcccagtat gtacgttctt tctatgaaag agaaaacact aatcttaaat
     4201 tatatccagc aatgtttctg gtatccttta agaaaagtta agactattat ttccttccct
     4261 tccctgtgca gcattcaaaa tcacccctag aaaaagtgag tgttttaatg agacttccta
     4321 ggaagggatg cactgtaaaa caaaagtatt cttgtaactc agttttgtga aaggtaaaaa
     4381 actactatgt tttaagtaca ctttagaaag tctcttcaaa acaaacagtc ctgtatttga
     4441 actctgttca tagttttttt ttgaacagtt tagacaaaac tgctggaaat taaaccaatt
     4501 tcctgcatta agctgagaca agtatatata cagccctata cagtttcata gcttttcctc
     4561 ccccatttat gtgtattggt gacagtgggt ataaaacagc ctgaaagtgt atgcatgtac
     4621 cataacatct agacttaata tattgtggag tattcaataa ccattatgta gaaggtagat
     4681 aagaattaaa agggtttaat ttcctagaaa gaaaatggaa aaatggtcat ttttaaaaaa
     4741 taaagtttat tagatcataa
//
