LOCUS       NM_012166               4702 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box protein 10 (FBXO10), mRNA.
ACCESSION   NM_012166 XM_291314 XM_933940 XM_941902 XM_945524
VERSION     NM_012166.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4702)
  AUTHORS   Guo,F., Luo,Y., Jiang,X., Lu,X., Roberti,D., Lossos,C.,
            Kunkalla,K., Magistri,M., Rui,L., Verdun,R., Vega,F., Moy,V.T. and
            Lossos,I.S.
  TITLE     Recent BCR stimulation induces a negative autoregulatory loop via
            FBXO10 mediated degradation of HGAL
  JOURNAL   Leukemia 34 (2), 553-566 (2020)
   PUBMED   31570756
  REMARK    GeneRIF: Recent BCR stimulation induces a negative autoregulatory
            loop via FBXO10 mediated degradation of HGAL.
REFERENCE   2  (bases 1 to 4702)
  AUTHORS   Ju,U.I., Park,J.W., Park,H.S., Kim,S.J. and Chun,Y.S.
  TITLE     FBXO11 represses cellular response to hypoxia by destabilizing
            hypoxia-inducible factor-1alpha mRNA
  JOURNAL   Biochem Biophys Res Commun 464 (4), 1008-1015 (2015)
   PUBMED   26187670
  REMARK    GeneRIF: siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha
            expression in various cancer cells and HIF-1alpha-driven gene
            expressions, but the FBXO10 knockdown did not.
REFERENCE   3  (bases 1 to 4702)
  AUTHORS   Xu,X., Powell,D.W., Lambring,C.J., Puckett,A.H., Deschenes,L.,
            Prough,R.A., Poeschla,E.M. and Samuelson,D.J.
  TITLE     Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is
            induced by cellular stress and correlated with lens
            epithelium-derived growth factor (LEDGF)
  JOURNAL   Mol Carcinog 53 (4), 300-313 (2014)
   PUBMED   23138933
  REMARK    GeneRIF: Higher Fbxo10 expression in T cells is associated with
            Mcs5a increased susceptibility alleles
REFERENCE   4  (bases 1 to 4702)
  AUTHORS   Chiorazzi,M., Rui,L., Yang,Y., Ceribelli,M., Tishbi,N.,
            Maurer,C.W., Ranuncolo,S.M., Zhao,H., Xu,W., Chan,W.C., Jaffe,E.S.,
            Gascoyne,R.D., Campo,E., Rosenwald,A., Ott,G., Delabie,J.,
            Rimsza,L.M., Shaham,S. and Staudt,L.M.
  TITLE     Related F-box proteins control cell death in Caenorhabditis elegans
            and human lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 3943-3948 (2013)
   PUBMED   23431138
  REMARK    GeneRIF: FBXO10, a protein related to DRE-1, binds BCL2 and
            promotes its degradation, thereby initiating cell death. Moreover,
            some diffuse large B-cell lymphomas have inactivating mutations in
            FBXO10 or express FBXO10 at low levels.
REFERENCE   5  (bases 1 to 4702)
  AUTHORS   Barnholtz-Sloan,J.S., Shetty,P.B., Guan,X., Nyante,S.J., Luo,J.,
            Brennan,D.J. and Millikan,R.C.
  TITLE     FGFR2 and other loci identified in genome-wide association studies
            are associated with breast cancer in African-American and younger
            women
  JOURNAL   Carcinogenesis 31 (8), 1417-1423 (2010)
   PUBMED   20554749
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4702)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 4702)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (bases 1 to 4702)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 4702)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 4702)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513165.12, AI475671.1, AF174598.1, CN411883.1, AB209610.1 and
            BU623815.1.
            
            On Nov 30, 2018 this sequence version replaced NM_012166.2.
            
            Summary: Members of the F-box protein family, such as FBXO10, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1870256.1,
                                           SRR11853560.28371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000432825.7/
                                                ENSP00000403802.2
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AL513165.12        71923-72049         c
            128-170             AI475671.1         1-43
            171-662             AF174598.1         43-534
            663-700             CN411883.1         536-573
            701-4692            AB209610.1         162-4153
            4693-4702           BU623815.1         18-27               c
FEATURES             Location/Qualifiers
     source          1..4702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..4702
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /note="F-box protein 10"
                     /db_xref="GeneID:26267"
                     /db_xref="HGNC:HGNC:13589"
                     /db_xref="MIM:609092"
     exon            1..170
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            171..761
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3047
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /note="F-box protein Fbx10"
                     /codon_start=1
                     /product="F-box only protein 10"
                     /protein_id="NP_036298.2"
                     /db_xref="CCDS:CCDS47966.1"
                     /db_xref="GeneID:26267"
                     /db_xref="HGNC:HGNC:13589"
                     /db_xref="MIM:609092"
                     /translation="MEAGGLPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTR
                     WRQLCLGCTECRHPNWPNQPDVEPESWREAFKQHYLASKTWTKNALDLESSICFSLFR
                     RRRERRTLSVGPGREFDSLGSALAMASLYDRIVLFPGVYEEQGEIILKVPVEIVGQGK
                     LGEVALLASIDQHCSTTRLCNLVFTPAWFSPIMYKTTSGHVQFDNCNFENGHIQVHGP
                     GTCQVKFCTFKNTHIFLHNVPLCVLENCEFVGSENNSVTVEGHPSADKNWAYKYLLGL
                     IKSSPTFLPTEDSDFLMSLDLESRDQAWSPKTCDIVIEGSQSPTSPASSSPKPGSKAG
                     SQEAEVGSDGERVAQTPDSSDGGLSPSGEDEDEDQLMYRLSYQVQGPRPVLGGSFLGP
                     PLPGASIQLPSCLVLNSLQQELQKDKEAMALANSVQGCLIRKCLFRDGKGGVFVCSHG
                     RAKMEGNIFRNLTYAVRCIHNSKIIMLRNDIYRCRASGIFLRLEGGGLIAGNNIYHNA
                     EAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGIIRNNQIFSNKEAGIYILYHGNP
                     VVSGNHIFKGRAAGIAVNENGKGLITENVIRENQWGGVDIRRGGIPVLRSNLICFGYS
                     DGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGVAVFSQKDGS
                     SELPRGHRAQENFSEDGDAILWETELEKEDDPLRRPITIALVESNSINHNGASGLYVQ
                     SSEALHVITNVIHANGDRGITVAQSSQPTRVANNSISCNRQSGVKVEAQCKVELRGNG
                     IYDNRGHGIITKGDSTIVIENDIIGNRGSGLQLLPRSDTKVIKNRIHSFRAYGIAVRG
                     RAKALVQENIIFQGKTSKTIFQQISNNRECIMQNNKFLVFKKKSDTWRLVNPPARPHL
                     ENSLRRPSAAHNGQKVTAMATRITARVEGGYHSNRSVFCTIL"
     exon            762..1595
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1745
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1882
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1953
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2106
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2376
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2690
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2872
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..4702
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4675..4680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /note="hexamer: AATAAA"
     polyA_site      4702
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /note="major polyA site"
ORIGIN      
        1 acatgacggc ggcggctccg cacgatcccc aggcagctgt ccgcccccgg gcggggctgg
       61 ccgcacgccg caatcctacc ggctgctgcg gctccagcgg gggcggcggg tggcttccag
      121 ggcaccggcg gccgcggccc ggactccgcg gtgggcgagc gccctgtgag gtgaccatgg
      181 aggctggtgg cctccccttg gagctgtggc gcatgatctt agcctacttg caccttcccg
      241 acctgggccg ctgcagcctg gtatgcaggg cctggtatga actgatcctc agtctcgaca
      301 gcacccgctg gcggcagctg tgtctgggtt gcaccgagtg ccgccatccc aattggccca
      361 accagccaga tgtggagcct gagtcttgga gagaagcctt caagcagcat taccttgcat
      421 ccaagacatg gaccaagaat gccttggact tggagtcttc catctgcttt tctctattcc
      481 gccggaggag ggaacgacgt accctgagtg ttgggccagg ccgtgagttt gacagcctgg
      541 gcagtgcctt ggccatggcc agcctgtatg accgaattgt gctcttccca ggtgtgtacg
      601 aagagcaagg tgaaatcatc ttgaaggtgc ctgtggagat tgtagggcag gggaagttgg
      661 gtgaagtggc cctgctggcc agcattgatc agcactgctc aaccacacgc ctgtgcaacc
      721 tcgtcttcac gccagcctgg ttctcaccca tcatgtataa gacaacatca ggtcacgtcc
      781 agtttgacaa ctgcaacttt gagaacgggc acatccaggt ccatggcccg ggtacttgcc
      841 aagtgaagtt ctgtaccttc aaaaacaccc atatcttcct gcacaacgtg cccctgtgtg
      901 tcctggaaaa ctgtgaattt gtgggcagtg aaaacaactc tgtgactgtt gagggtcacc
      961 catctgcaga taagaactgg gcctacaagt atctactagg gcttatcaag tcctcaccca
     1021 cttttctccc cacagaggac tctgactttt taatgtccct ggacctagag agccgggacc
     1081 aggcctggag cccaaagacc tgtgacattg ttatcgaggg cagccagagc cctaccagcc
     1141 cagcctctag ctccccaaag ccaggctcca aggctggctc acaggaggca gaggtgggta
     1201 gtgatggtga aagggtggcc cagaccccgg acagcagcga tggaggcctg agtcccagcg
     1261 gtgaggatga agatgaggac cagctgatgt acagactatc ctaccaagtg cagggcccac
     1321 gccctgtatt ggggggctca tttctgggcc cacctctacc aggagcatcc attcagctgc
     1381 ccagctgcct agtgctgaac tcactgcagc aggagctgca gaaggataag gaggccatgg
     1441 cactggccaa ctccgtgcag ggctgcctca tccgcaagtg cctcttccgg gacgggaagg
     1501 gaggcgtctt cgtctgctcc cacggcagag ccaagatgga aggaaacatc ttccggaacc
     1561 tgacttacgc agtgcggtgt atacataata gcaagatcat catgctcagg aacgacattt
     1621 accgctgccg agcgtcaggc atctttcttc gcttggaggg cggtggcttg attgccggca
     1681 acaacattta ccacaatgca gaggctggtg tagacatccg gaaaaagtcc aacccactca
     1741 tactgtgtaa ccagatccac catggccttc gctctggcat tgtcgtcctt ggcaatggga
     1801 aaggcatcat ccggaacaat caaatctttt ccaataagga ggctggcatt tacatcctgt
     1861 accacggaaa ccccgttgtg agcgggaacc acatcttcaa gggccgtgct gccggcatag
     1921 cagtgaatga gaacggcaaa ggcctcatca cagaaaatgt catccgtgag aatcagtggg
     1981 gaggtgtgga catccgccgt ggagggatcc ccgttctcag gagtaacctc atctgctttg
     2041 gctattcaga tggtgtggtt gtgggagacg aaggcaaagg cctcatagaa ggaaatacca
     2101 tctacgctaa caagggctgt ggtgtgtgga tgatgtcgtc cagcctcccc catgtcacca
     2161 gcaaccacgt cagctacaat ggcctgtatg gagtggcagt atttagccag aaggatggct
     2221 ccagcgagtt acctcgaggc cacagggctc aagagaactt cagcgaggat ggggacgcca
     2281 tcctctggga gacagagctg gagaaggagg acgacccact gcgccggccc atcaccatag
     2341 ctcttgttga gtctaacagt attaatcaca atggagcctc aggactctat gtccagagca
     2401 gcgaggcact gcatgtcatc accaatgtga tccacgcgaa tggggacaga ggcattactg
     2461 tggcccagag cagccaaccc acccgagtgg ccaacaacag catctcctgc aaccggcaaa
     2521 gtggggtcaa ggttgaggcc cagtgcaaag tggagctccg gggcaatggt atctatgaca
     2581 acagaggcca cggcattatc accaagggcg acagcaccat cgtcattgaa aacgatatca
     2641 ttggcaaccg gggcagcggg ctgcagctgc tgcccaggtc cgacactaaa gtaataaaga
     2701 accggatcca ctcgttccgg gcctacggca tcgccgtgcg gggccgtgcc aaggccctgg
     2761 tgcaggaaaa catcatcttc cagggcaaaa ccagtaagac catctttcag cagatctcaa
     2821 acaaccgaga atgcatcatg caaaacaaca agttcctggt cttcaagaaa aagtctgata
     2881 cgtggcgcct ggtgaaccca ccagcacggc cccaccttga aaattctctc agacgtccct
     2941 cggcagccca caatgggcag aaggtgacag ccatggcaac gaggatcaca gcccgggtgg
     3001 aaggtggtta ccacagcaac cgcagtgtct tctgcaccat cctgtgagga cacagacctg
     3061 cttcagggcc aagcctggat gggtgctcag aggagctaag gtggaaatac tgcctgaaaa
     3121 gactccgccc ctccccctcc ccctcgaaca aatgggtccc gggcctccaa aacacggtac
     3181 ctccagaaca cttcagctcc acagcccata gcaagaagaa agtgggcaat gtttttcagg
     3241 gagaagggat agaagctggt gggtttccag tcactcgaag tctataaaga ttgtgaagag
     3301 cgggggaagc tcaaatgctg aagcttttgg tcaggatttt ctctgagttc taaggaactg
     3361 tgttttacac acaccaaacc cagactcttc tcaggaaaga gcagatttac ttctgatggc
     3421 gggaagtgat tctagtgagg tggagagaga caactgctcc agaattttcc cctttgctag
     3481 agctgtctcc ctctcaatcc ctccagggac cccaccacac cctcccagct gtctctggag
     3541 gctggaggag ttgagtttgg ttgacttgag gacttggaca tggacctggg aggaaggaag
     3601 gacctgggag caacaggaga ccccatggaa aggctgcccc agggatgaca agagggacat
     3661 gctgaaacag gtggggctgc agcgtgcagg cagatgctag gctgggtggg cagggatgca
     3721 caaggctcta ctccatcccc agagagctcc caaatgcaga aggattcaaa ccccatgtga
     3781 gcgtgcccac accagccgcc cctcctgagc atcagcctgt tcagatgagg gtacctgggc
     3841 ctctcgttcg catctgtgtt ctcatggatg agcgctggtc tttactgacc ctcccaagcc
     3901 tccccactct gtgccttggc tcatgctctt tcctcctccc ggcatgccct tctcccccat
     3961 ctccgtgtcc tcgttcctca aggtttagcc gagacactgc cacctccaca tagctctccc
     4021 tgccctcttt ccccctctgg gcctcagtgg cctttctctg ctccctctca gggtactgag
     4081 cactttctgc cttgtcctgg agctatctgg gtccattgcc tgacccccca ctcacctgtg
     4141 tgctccccgt aggtagggcc acttctgact gtgtgtcccc agatccagcc tggggttggg
     4201 gtaggattag tggcctgagt gaggagagga aggccagctc ccagaggact ttactgaacc
     4261 gtactgtgaa tatgtccaag tcccaaagcc aggtgaggtc agaccccact gcctgaggaa
     4321 gagggctgga tgcagggcca gctcaacctg aacaatcccc tcccactcgg cctttcctgt
     4381 ggggccttca ccagcctgct ggggtcactg tcgtgcactt ggctgcgtgg ctggttctat
     4441 tggccctagg tgctgctctg ttgggtggga tgggaggggg tagagggagc caggagcact
     4501 gggttctccc tgagaacact gggcacaaga gtactggcct cttctatccc tggcactgtc
     4561 ctttgcactt gtttggtggc cccaatgtga gtcgctgtaa aaaatgctgc cgttactatt
     4621 ttctaagaaa tgacttttct gtgaaccaac agtaacaaaa acctcagtaa ccaaaataaa
     4681 gttctatatt ttaaaaaagg ca
//
