LOCUS       NP_036298                956 aa            linear   PRI 28-APR-2025
DEFINITION  F-box only protein 10 [Homo sapiens].
ACCESSION   NP_036298 XP_291314 XP_939033 XP_946995 XP_950617
VERSION     NP_036298.2
DBSOURCE    REFSEQ: accession NM_012166.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 956)
  AUTHORS   Guo,F., Luo,Y., Jiang,X., Lu,X., Roberti,D., Lossos,C.,
            Kunkalla,K., Magistri,M., Rui,L., Verdun,R., Vega,F., Moy,V.T. and
            Lossos,I.S.
  TITLE     Recent BCR stimulation induces a negative autoregulatory loop via
            FBXO10 mediated degradation of HGAL
  JOURNAL   Leukemia 34 (2), 553-566 (2020)
   PUBMED   31570756
  REMARK    GeneRIF: Recent BCR stimulation induces a negative autoregulatory
            loop via FBXO10 mediated degradation of HGAL.
REFERENCE   2  (residues 1 to 956)
  AUTHORS   Ju,U.I., Park,J.W., Park,H.S., Kim,S.J. and Chun,Y.S.
  TITLE     FBXO11 represses cellular response to hypoxia by destabilizing
            hypoxia-inducible factor-1alpha mRNA
  JOURNAL   Biochem Biophys Res Commun 464 (4), 1008-1015 (2015)
   PUBMED   26187670
  REMARK    GeneRIF: siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha
            expression in various cancer cells and HIF-1alpha-driven gene
            expressions, but the FBXO10 knockdown did not.
REFERENCE   3  (residues 1 to 956)
  AUTHORS   Xu,X., Powell,D.W., Lambring,C.J., Puckett,A.H., Deschenes,L.,
            Prough,R.A., Poeschla,E.M. and Samuelson,D.J.
  TITLE     Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is
            induced by cellular stress and correlated with lens
            epithelium-derived growth factor (LEDGF)
  JOURNAL   Mol Carcinog 53 (4), 300-313 (2014)
   PUBMED   23138933
  REMARK    GeneRIF: Higher Fbxo10 expression in T cells is associated with
            Mcs5a increased susceptibility alleles
REFERENCE   4  (residues 1 to 956)
  AUTHORS   Chiorazzi,M., Rui,L., Yang,Y., Ceribelli,M., Tishbi,N.,
            Maurer,C.W., Ranuncolo,S.M., Zhao,H., Xu,W., Chan,W.C., Jaffe,E.S.,
            Gascoyne,R.D., Campo,E., Rosenwald,A., Ott,G., Delabie,J.,
            Rimsza,L.M., Shaham,S. and Staudt,L.M.
  TITLE     Related F-box proteins control cell death in Caenorhabditis elegans
            and human lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 3943-3948 (2013)
   PUBMED   23431138
  REMARK    GeneRIF: FBXO10, a protein related to DRE-1, binds BCL2 and
            promotes its degradation, thereby initiating cell death. Moreover,
            some diffuse large B-cell lymphomas have inactivating mutations in
            FBXO10 or express FBXO10 at low levels.
REFERENCE   5  (residues 1 to 956)
  AUTHORS   Barnholtz-Sloan,J.S., Shetty,P.B., Guan,X., Nyante,S.J., Luo,J.,
            Brennan,D.J. and Millikan,R.C.
  TITLE     FGFR2 and other loci identified in genome-wide association studies
            are associated with breast cancer in African-American and younger
            women
  JOURNAL   Carcinogenesis 31 (8), 1417-1423 (2010)
   PUBMED   20554749
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 956)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (residues 1 to 956)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (residues 1 to 956)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (residues 1 to 956)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (residues 1 to 956)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513165.12, AI475671.1, AF174598.1, CN411883.1, AB209610.1 and
            BU623815.1.
            
            On Jan 26, 2007 this sequence version replaced NP_036298.1.
            
            Summary: Members of the F-box protein family, such as FBXO10, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1870256.1,
                                           SRR11853560.28371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000432825.7/
                                                ENSP00000403802.2
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     Protein         1..956
                     /product="F-box only protein 10"
                     /note="F-box protein Fbx10"
                     /calculated_mol_wt=105065
     Region          2..51
                     /region_name="F-box_FBXO10"
                     /note="F-box domain found in F-box only protein 10
                     (FBXO10) and similar proteins; cd22090"
                     /db_xref="CDD:438862"
     Site            order(6,10,13..14,17..18,22,24..25,29..31,33)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438862"
     Region          198..217
                     /region_name="PbH1 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          238..260
                     /region_name="PbH1 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          314..367
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TQF2; propagated from
                     UniProtKB/Swiss-Prot (Q9UK96.3)"
     Site            326
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7TQF2; propagated from
                     UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          427..448
                     /region_name="PbH1 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          449..470
                     /region_name="PbH1 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          464..610
                     /region_name="Beta_helix"
                     /note="Right handed beta helix region; pfam13229"
                     /db_xref="CDD:463811"
     Region          471..493
                     /region_name="PbH1 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          494..516
                     /region_name="PbH1 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          538..560
                     /region_name="PbH1 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          561..583
                     /region_name="PbH1 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          584..606
                     /region_name="PbH1 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          602..797
                     /region_name="Beta_helix"
                     /note="Right handed beta helix region; pfam13229"
                     /db_xref="CDD:463811"
     Region          607..629
                     /region_name="PbH1 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          630..652
                     /region_name="PbH1 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          653..675
                     /region_name="PbH1 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          717..739
                     /region_name="PbH1 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          735..893
                     /region_name="Beta_helix"
                     /note="Right handed beta helix region; pfam13229"
                     /db_xref="CDD:463811"
     Region          740..762
                     /region_name="PbH1 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          764..786
                     /region_name="PbH1 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          787..809
                     /region_name="PbH1 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     Region          832..854
                     /region_name="PbH1 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UK96.3)"
     CDS             1..956
                     /gene="FBXO10"
                     /gene_synonym="FBX10; PRMT11"
                     /coded_by="NM_012166.3:177..3047"
                     /db_xref="CCDS:CCDS47966.1"
                     /db_xref="GeneID:26267"
                     /db_xref="HGNC:HGNC:13589"
                     /db_xref="MIM:609092"
ORIGIN      
        1 meagglplel wrmilaylhl pdlgrcslvc rawyelilsl dstrwrqlcl gctecrhpnw
       61 pnqpdvepes wreafkqhyl asktwtknal dlessicfsl frrrrerrtl svgpgrefds
      121 lgsalamasl ydrivlfpgv yeeqgeiilk vpveivgqgk lgevallasi dqhcsttrlc
      181 nlvftpawfs pimykttsgh vqfdncnfen ghiqvhgpgt cqvkfctfkn thiflhnvpl
      241 cvlencefvg sennsvtveg hpsadknway kyllglikss ptflptedsd flmsldlesr
      301 dqawspktcd iviegsqspt spassspkpg skagsqeaev gsdgervaqt pdssdgglsp
      361 sgedededql myrlsyqvqg prpvlggsfl gpplpgasiq lpsclvlnsl qqelqkdkea
      421 malansvqgc lirkclfrdg kggvfvcshg rakmegnifr nltyavrcih nskiimlrnd
      481 iyrcrasgif lrleggglia gnniyhnaea gvdirkksnp lilcnqihhg lrsgivvlgn
      541 gkgiirnnqi fsnkeagiyi lyhgnpvvsg nhifkgraag iavnengkgl itenvirenq
      601 wggvdirrgg ipvlrsnlic fgysdgvvvg degkgliegn tiyankgcgv wmmssslphv
      661 tsnhvsyngl ygvavfsqkd gsselprghr aqenfsedgd ailwetelek eddplrrpit
      721 ialvesnsin hngasglyvq ssealhvitn vihangdrgi tvaqssqptr vannsiscnr
      781 qsgvkveaqc kvelrgngiy dnrghgiitk gdstiviend iignrgsglq llprsdtkvi
      841 knrihsfray giavrgraka lvqeniifqg ktsktifqqi snnrecimqn nkflvfkkks
      901 dtwrlvnppa rphlenslrr psaahngqkv tamatritar veggyhsnrs vfctil
//
