LOCUS       NM_018378               1630 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 8 (FBXL8), mRNA.
ACCESSION   NM_018378
VERSION     NM_018378.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Yao,J., Wang,X.P., Yang,J., Yang,Z. and Zhang,Z.Y.
  TITLE     SCF-FBXL8 contributes to liver metastasis and stem-cell-like
            features in colorectal cancer cells by mediating ubiquitination and
            degradation of TP53
  JOURNAL   Clin Transl Med 13 (3), e1208 (2023)
   PUBMED   36855778
  REMARK    GeneRIF: SCF-FBXL8 contributes to liver metastasis and
            stem-cell-like features in colorectal cancer cells by mediating
            ubiquitination and degradation of TP53.
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Yoshida,A., Choi,J., Jin,H.R., Li,Y., Bajpai,S., Qie,S. and
            Diehl,J.A.
  TITLE     Fbxl8 suppresses lymphoma growth and hematopoietic transformation
            through degradation of cyclin D3
  JOURNAL   Oncogene 40 (2), 292-306 (2021)
   PUBMED   33122824
  REMARK    GeneRIF: Fbxl8 suppresses lymphoma growth and hematopoietic
            transformation through degradation of cyclin D3.
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Lievens,S., Vanderroost,N., Van der Heyden,J., Gesellchen,V.,
            Vidal,M. and Tavernier,J.
  TITLE     Array MAPPIT: high-throughput interactome analysis in mammalian
            cells
  JOURNAL   J Proteome Res 8 (2), 877-886 (2009)
   PUBMED   19159283
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074143.5.
            
            On Nov 26, 2018 this sequence version replaced NM_018378.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            the ubiquitin protein ligase complex called SCFs
            (SKP1-cullin-F-box), which function in phosphorylation-dependent
            ubiquitination. The F-box proteins are divided into 3 classes: Fbws
            containing WD-40 domains, Fbls containing leucine-rich repeats, and
            Fbxs containing either different protein-protein interaction
            modules or no recognizable motifs. The protein encoded by this gene
            belongs to the Fbls class. It shares 78% sequence identity with the
            mouse protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014414.1, SRR3476690.924531.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258200.8/ ENSP00000258200.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC074143.5         128593-128692
            101-303             AC074143.5         130371-130573
            304-1630            AC074143.5         131484-132810
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1630
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /note="F-box and leucine rich repeat protein 8"
                     /db_xref="GeneID:55336"
                     /db_xref="HGNC:HGNC:17875"
                     /db_xref="MIM:609077"
     exon            1..100
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /inference="alignment:Splign:2.1.0"
     exon            101..303
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1276
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /note="F-box protein FBL8"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 8"
                     /protein_id="NP_060848.2"
                     /db_xref="CCDS:CCDS10831.1"
                     /db_xref="GeneID:55336"
                     /db_xref="HGNC:HGNC:17875"
                     /db_xref="MIM:609077"
                     /translation="MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAV
                     WHDTKISCECELEGMLPPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPG
                     LRGLRLECRGEKPLFDAGRDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARS
                     CPELHSLFLDNSTLVGSVGPGSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAP
                     FALLALRCACPEDARASPLPNEAWVALRRRHPGLAVELELEPALPAESVTRVLQPAVP
                     VAALRLNLSGDTVGPVRFAAHHYAATLCALEVRAAASAELNAALEELAARCAALREVH
                     CFCVVSHSVLDAFRAHCPRLRTYTLKLTREPHPWRPTLVA"
     exon            304..1630
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /note="hexamer: AATAAA"
     polyA_site      1630
                     /gene="FBXL8"
                     /gene_synonym="FBL8"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtcccg ccccgcgggc tcccggtggc tgcttcccgt ccgctgtcct ctgctgccag
       61 tcccctgccc cgggcaaagc ccatctggtc cgccgagcag gccggagcta ttgggagtgg
      121 cggatcctcc caccccagcc ggatctgggc catggccgag cctggagagg gactgccaga
      181 ggaggtgctg gcactcatct tccgccacct gtccctgaga gaccgtgctg ccgccgccag
      241 ggtctgcagg gcctgggccg ccgctgctac ctgcagcgcc gtgtggcacg acacaaaaat
      301 cagttgcgaa tgtgagctgg aaggcatgct gccaccttat ctgtccgcct gcctcgacca
      361 cattcacaac ctacggctgg aatttgagcc atcgaggaag ccgagccgcc gggcggccat
      421 cgagctgctg atggttctgg cgggccgtgc cccggggctg cgaggcctgc gcctggagtg
      481 ccgcggagaa aaaccgctct tcgacgcggg ccgcgacgtc ctggaggctg tgcacgctgt
      541 atgcggggcg gccagccagc tacgccacct cgacctgcgg cgcttgtcct tcacactgga
      601 cgacgcgctg gtgctgcagg cggcgcgcag ctgtcccgag ctccacagcc tttttctgga
      661 caacagtacc ctagtgggca gcgtgggtcc cggctcagtg ctcgagctac tggaggcctg
      721 cccgcgcctg cgcgctctcg gcctgcacct agccagtttg tcgcacgcca tcctcgaagc
      781 actggcggcg ccagaccgag cgcctttcgc gctcttggct ctgcggtgcg cgtgccccga
      841 agatgcacgc gcgtccccgc tgcccaacga agcctgggtc gcgttgcgcc gccgccaccc
      901 tgggctggca gtggagctgg agctggagcc cgcgctgccc gctgagagcg tgacgcgcgt
      961 cctgcagcca gccgtccccg tggctgcgct gcgcctcaac ctctcaggcg acaccgtagg
     1021 cccagtgcgc ttcgcagcac accactacgc cgcaaccctg tgcgcgctcg aggtgcgcgc
     1081 agccgcttcg gccgagctga acgccgcgct ggaggagctg gcggcgcgct gcgcggccct
     1141 gcgcgaggtg cattgtttct gcgtggtgag ccactcggtg ctggacgcct tccgcgcgca
     1201 ctgcccgcgc ctgcgcacct ataccctcaa gctcacgcgc gagccgcatc cctggaggcc
     1261 tacgctcgtg gcgtgattgg gcgacttctc tcccccgtcc ccgtggacgt aagcgctctg
     1321 agagggaacg gggggggtgt ccaggcgcgc cccgagtgct agtgccttct tttgggattg
     1381 ttgccccccg ggtctttacc gagttgggaa ctgtgatggc atcgggacca gtcctgggcg
     1441 ccctgagacc actcgctgct ctcaccctct gcagacgccc cacccgctcg gtcctggaca
     1501 cactgccccc ctctcttgcc tccacccctc tgcggactct gcagctccgc ggccccggcg
     1561 cagggagagg gagggcacgg gcgcgggccg ggcctcaagg gtgagtgtga aataaacaaa
     1621 tcctgcagtg
//
