LOCUS       NM_012304               4580 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7),
            transcript variant 1, mRNA.
ACCESSION   NM_012304
VERSION     NM_012304.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Camuzi,D., Buexm,L.A., Lourenco,S.Q.C., Grazziotin,R., Guaraldi,S.,
            Valverde,P., Rapozo,D., Brooks,J.M., Mehanna,H., Ribeiro Pinto,L.F.
            and Soares-Lima,S.C.
  TITLE     FBXL7 Body Hypomethylation Is Frequent in Tumors from the Digestive
            and Respiratory Tracts and Is Associated with Risk-Factor Exposure
  JOURNAL   Int J Mol Sci 23 (14), 7801 (2022)
   PUBMED   35887149
  REMARK    GeneRIF: FBXL7 Body Hypomethylation Is Frequent in Tumors from the
            Digestive and Respiratory Tracts and Is Associated with Risk-Factor
            Exposure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Ni,J., Shen,L., Xu,L., Jin,Q. and Wang,G.
  TITLE     7-Ethoxyrosmanol alleviates hyperglycemia-induced vascular
            endothelial dysfunction by regulating FBXL7 expression
  JOURNAL   J Bioenerg Biomembr 53 (5), 553-560 (2021)
   PUBMED   34427826
  REMARK    GeneRIF: 7-Ethoxyrosmanol alleviates hyperglycemia-induced vascular
            endothelial dysfunction by regulating FBXL7 expression.
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Moro,L., Simoneschi,D., Kurz,E., Arbini,A.A., Jang,S.,
            Guaragnella,N., Giannattasio,S., Wang,W., Chen,Y.A., Pires,G.,
            Dang,A., Hernandez,E., Kapur,P., Mishra,A., Tsirigos,A., Miller,G.,
            Hsieh,J.T. and Pagano,M.
  TITLE     Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs
            c-SRC degradation and promotes epithelial-to-mesenchymal transition
            and metastasis
  JOURNAL   Nat Cell Biol 22 (9), 1130-1142 (2020)
   PUBMED   32839549
  REMARK    GeneRIF: Epigenetic silencing of the ubiquitin ligase subunit FBXL7
            impairs c-SRC degradation and promotes epithelial-to-mesenchymal
            transition and metastasis.
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Kong,S., Fang,Y., Wang,B., Cao,Y., He,R. and Zhao,Z.
  TITLE     miR-152-5p suppresses glioma progression and tumorigenesis and
            potentiates temozolomide sensitivity by targeting FBXL7
  JOURNAL   J Cell Mol Med 24 (8), 4569-4579 (2020)
   PUBMED   32150671
  REMARK    GeneRIF: miR-152-5p suppresses glioma progression and tumorigenesis
            and potentiates temozolomide sensitivity by targeting FBXL7.
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Venables,J.P., Bourgeois,C.F., Dalgliesh,C., Kister,L., Stevenin,J.
            and Elliott,D.J.
  TITLE     Up-regulation of the ubiquitous alternative splicing factor
            Tra2beta causes inclusion of a germ cell-specific exon
  JOURNAL   Hum Mol Genet 14 (16), 2289-2303 (2005)
   PUBMED   16000324
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Watanabe,N., Arai,H., Nishihara,Y., Taniguchi,M., Watanabe,N.,
            Hunter,T. and Osada,H.
  TITLE     M-phase kinases induce phospho-dependent ubiquitination of somatic
            Wee1 by SCFbeta-TrCP
  JOURNAL   Proc Natl Acad Sci U S A 101 (13), 4419-4424 (2004)
   PUBMED   15070733
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010477.8, AB020647.2 and
            BU633031.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012304.4.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by a 42-48 amino acid motif, the F-box,
            which binds to the S-phase kinase-associated protein 1 (Skp1)
            protein. The F-box proteins constitute one of the four subunits of
            E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which
            play a role in phosphorylation-dependent ubiquitination of
            proteins. The F-box proteins are divided into 3 subfamilies based
            on the other domain in the protein: F-box proteins that also have a
            WD-40 domain (Fbws subfamily), F-box proteins that also have
            leucine-rich repeats (Fbls subfamily) and F-box proteins that
            contain other motifs or lack known protein-interaction domains
            (Fbxs subfamily). The protein encoded by this gene belongs to the
            Fbls subfamily. Alternative splicing results in multiple transcript
            variants of this gene. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020647.2, BC136424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504595.2/ ENSP00000423630.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC010477.8         30321-30336         c
            17-4578             AB020647.2         1-4562
            4579-4580           BU633031.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.1"
     gene            1..4580
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /note="F-box and leucine rich repeat protein 7"
                     /db_xref="GeneID:23194"
                     /db_xref="HGNC:HGNC:13604"
                     /db_xref="MIM:605656"
     exon            1..534
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..1973
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein Fbl7; F-box/LRR-repeat protein 7"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 7 isoform 1"
                     /protein_id="NP_036436.1"
                     /db_xref="CCDS:CCDS54833.1"
                     /db_xref="GeneID:23194"
                     /db_xref="HGNC:HGNC:13604"
                     /db_xref="MIM:605656"
                     /translation="MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDS
                     DLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIR
                     LASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLT
                     GETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLE
                     VSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRY
                     LDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDC
                     RFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDH
                     GVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVA
                     ANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF"
     exon            535..624
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1236
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..4580
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4560..4565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /note="hexamer: AATAAA"
     polyA_site      4580
                     /gene="FBXL7"
                     /gene_synonym="FBL6; FBL7"
                     /note="major polyA site"
ORIGIN      
        1 gccgggtcgc tagtcttcac tcgctccggg gacccgcaac aagtggccgc cgcgccctcc
       61 ccggggaagc cgcgggcgcg caggggcagc cgaaggaggc ggtcgagccg cggagcccag
      121 gggcctgccc ggctcagcgc ccaccggagg ggatcggggc gggcggatgg ggacccggcg
      181 gcggcggcgc ggtgagcctc tgggcggccc cggggcgcgg gctgtgcgcg gcgctgcgcc
      241 cgccggcccc cagcgcggat tgtaagtgct gcagctgtgc ccggccccgc ctggagccac
      301 cgggggtgcc aggaggggac gcagcacccc ctcccactgg agtgcgggga cctctccagg
      361 ccggaggtcg gccccggagc ttggggggga tgtgcagcta acggtcccgt cgggcgggct
      421 ttcctcgggc cgagcgcgca ggacgtgcgc cgcagctatg gagtgtcccg ggagacggcg
      481 ggcatgacgg ctacaggatg ggcgcgaaca atggcaaaca gtacggcagt gagggcaaag
      541 gcagctcgag catctcatct gacgtgagtt caagtacaga tcacacgccc actaaagccc
      601 agaagaatgt ggctaccagc gaagactccg acctgagcat gcgcacactg agcacgccca
      661 gcccagccct gatatgtcca ccgaatctcc caggatttca gaatggaagg ggctcgtcca
      721 cctcctcgtc ctccatcacc ggggagacgg tggccatggt gcactccccg cccccgaccc
      781 gcctcacaca cccgctcatc cggctcgcct ccagacccca gaaggagcag gccagcatag
      841 accggctccc ggaccactcc atggtgcaga tcttctcctt cctgcccacc aaccagctgt
      901 gccgctgcgc gcgagtgtgc cgccgctggt acaacctggc ctgggacccg cggctctgga
      961 ggactatccg cctgacgggc gagaccatca acgtggaccg cgccctcaag gtgctgaccc
     1021 gcagactctg ccaggacacc cccaacgtgt gtctcatgct ggaaaccgta actgtcagtg
     1081 gctgcaggcg gctcacagac cgagggctgt acaccatcgc ccagtgctgc cccgaactga
     1141 ggcgactgga agtctcaggc tgttacaata tctccaacga ggccgtcttt gatgtggtgt
     1201 ccctctgccc taatctggag cacctggatg tgtcaggatg ctccaaagtg acctgcatca
     1261 gcttgacccg ggaggcctcc attaaactgt cacccttgca tggcaaacag atttccatcc
     1321 gctacctgga catgacggac tgcttcgtgc tggaggacga aggcctgcac accatcgcgg
     1381 cgcactgcac gcagctcacc cacctctacc tgcgccgctg cgtccgcctg accgacgaag
     1441 gcctgcgcta cctggtgatc tactgcgcct ccatcaagga gctgagcgtc agcgactgcc
     1501 gcttcgtcag cgacttcggc ctgcgggaga tcgccaagct ggagtcccgc ctgcggtacc
     1561 tgagcatcgc gcactgcggc cgggtcaccg acgtgggcat ccgctacgtg gccaagtact
     1621 gcagcaagct gcgctacctc aacgcgaggg gctgcgaggg catcacggac cacggtgtgg
     1681 agtacctcgc caagaactgc accaaactca aatccctgga tatcggcaaa tgccctttgg
     1741 tatccgacac gggcctggag tgcctggccc tgaactgctt caacctcaag cggctcagcc
     1801 tcaagtcctg cgagagcatc accggccagg gcttgcagat cgtggccgcc aactgctttg
     1861 acctccagac gctgaatgtc caggactgcg aggtctccgt ggaggccctg cgctttgtca
     1921 aacgccactg caagcgctgc gtcatcgagc acaccaaccc ggctttcttc tgaagggaca
     1981 gagttcatcc ggcgttgtat tcacacaaac ctgaacaaag caaatttttt taaaagcagc
     2041 gtatgtaagc accgacaccc actcaaaaca gctctttctt ccgggaaggt tattaggaat
     2101 ctggccttta tttttcctca tttctcatgg gcaacagagg ccaaagaaac gaagcaagac
     2161 aaacagcaaa caggcatttt ggtcaggtca tttgtaggca gtttctcttc tcacaaaaga
     2221 tgtacttaag caggctgatc gctgttcctt gagcaaggcg cttactctcc tccgctcagg
     2281 cccccaaggc cgccctttcc ctcgcacaca ggccccaccc ccacagttcc acgccccccc
     2341 cccaaggcca caccctccct ccctagagca gcagcgagga tccatcatca gaatcacagt
     2401 gctctccaga cctcctctct aaactgcttc attgacctaa gtcactctct tcaatcccac
     2461 acccatggac attcttgtca actcaatacc atagcacttt gcataggcaa aatacttttc
     2521 aggccttttt aaaaaattca ttacagcaaa cagctgggga aggacatgca gtcctccccc
     2581 agctctgtca atgactatga ccttggccaa agcacttcac tgctctgggc tgcagcttcc
     2641 agcactgaat cagaggccac acagcccaaa gattagcttc atgtccatta tagcattgag
     2701 ggagcagaga tacccataca cagaagcacc ttggcataga gcacccaggc atcgacctct
     2761 tccaggagaa ctgattctgt ggatggatgt gatttcagga gattgtgcag tgccagcatc
     2821 agtgcataaa gggtcctgta tgtcctttgg ctgcaaatca cccacttccc tgtgtttcag
     2881 tgggagaatt tcctctccca cctcctcaca tcctcttttg ccaggctgga tgctgtcgtc
     2941 tctgtacaca aatactttct gcattccccc ctccacacca tcctagcgag gcaccagcac
     3001 acctaatcac agcaaagccc agatcccccc atcagttgct tttactcagt gttttcaaat
     3061 aggagtaaag gcccttgcaa tttttaatta acaagcaagg cccaagggaa cacatgtcct
     3121 caaaagtttt tctgatccct cgccttgcac acctggcatg catcaggcac atctgtccta
     3181 cagctggcag agacagatgc ctcggttctt tgtcattcag attgcatttg acctcttctc
     3241 atctatttat ttctttatac atccagactt catcacatga agcctattgg ggttaagttt
     3301 gtaagtgttt aattgtgcaa attgccaccc tgtgtacctc ctccatgtct gtctgcgtgt
     3361 tttccaccaa agaatgcaaa gcagacttcc aggtgtttaa attctgttca ctcaacaatg
     3421 ccagatgaat ggaagaggga acacactgag atgacttaga ctctggtcca ccaaccagac
     3481 ccttggaaag gaatactaaa atcattacaa ggtatggatt ttaaatggat gaaacttcaa
     3541 attatcttat ttggatagaa gtctatattc tagcctcatt tgcatgaagt cagatagcca
     3601 gaagaaattc cattgctggt tttcacgaaa ttcacttgtc ttttgctaat aaacacatgg
     3661 ccctttccca gattattctc tagccaagcc ccacctttgt tacgttgaaa tccctcattt
     3721 attttcttct caaaatgccc attatccaaa tgcagaacct ctgcatctcc aagccagtta
     3781 tgctgaattt gtcaaactta gacacccttg acaactgcac tcctactgta ggctcctgtg
     3841 catactgtcg tcttctgtgg gggatggaga ggttagtgtg atgaggtggt gtctgcccag
     3901 gaggtttctt tcaaacatca tggcctccca tccaatcaac atcatcaaat tacatgtgta
     3961 atcaaggctc tgtgccatgg gggaaatgaa tcatttagct aggccaggat ctagtgaaag
     4021 ccacagagtt taaaaccatg aaagaagttg aaggcagcat tcctcagctc tgtgacttgt
     4081 gaccctattt gaagtttcag gatttgggtg tcacaaagga ttgtccctaa tccttggccc
     4141 tggggtcttc cgagtgagct ggtttaatac tctgagaatg agcagggaga tccagagaat
     4201 gaatccctga ccgcatcacc taaactgtct tccaaacatg agacaaagct gactgttcac
     4261 actgattgcc cagcacatac cgtcttgcca gtttcttctt ttctcccagt ctcctgttca
     4321 tccattctgt tctcccttgg ggtgggaatc tatgatggag gttactgggg aaacagctca
     4381 gcagattttt ggagaccaaa ccaaaggtct cactaggaaa tttatctgtt ttaaaacatt
     4441 gcttccttcc tggctctgct aaattgaatg ctcattgttt gttgttgttg ttttttaatt
     4501 ctaatgttca aatcactgcg tgctgtatga atctagaaag ccttaattta ctaccaagaa
     4561 ataaagcaat atgttcgtaa
//
