LOCUS       NM_012162               1745 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 6 (FBXL6),
            transcript variant 1, mRNA.
ACCESSION   NM_012162
VERSION     NM_012162.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Lavie,J., Lalou,C., Mahfouf,W., Dupuy,J.W., Lacaule,A.,
            Cywinska,A.A., Lacombe,D., Duchene,A.M., Raymond,A.A.,
            Rezvani,H.R., Ngondo,R.P. and Benard,G.
  TITLE     The E3 ubiquitin ligase FBXL6 controls the quality of newly
            synthesized mitochondrial ribosomal proteins
  JOURNAL   Cell Rep 42 (6), 112579 (2023)
   PUBMED   37267103
  REMARK    GeneRIF: The E3 ubiquitin ligase FBXL6 controls the quality of
            newly synthesized mitochondrial ribosomal proteins.
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Feng,G., Sun,H. and Piao,M.
  TITLE     FBXL6 is dysregulated in keloids and promotes keloid fibroblast
            growth by inducing c-Myc expression
  JOURNAL   Int Wound J 20 (1), 131-139 (2023)
   PUBMED   35606330
  REMARK    GeneRIF: FBXL6 is dysregulated in keloids and promotes keloid
            fibroblast growth by inducing c-Myc expression.
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Li,Y., Cui,K., Zhang,Q., Li,X., Lin,X., Tang,Y., Prochownik,E.V.
            and Li,Y.
  TITLE     FBXL6 degrades phosphorylated p53 to promote tumor growth
  JOURNAL   Cell Death Differ 28 (7), 2112-2125 (2021)
   PUBMED   33568778
  REMARK    GeneRIF: FBXL6 degrades phosphorylated p53 to promote tumor growth.
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Shi,W., Feng,L., Dong,S., Ning,Z., Hua,Y., Liu,L., Chen,Z. and
            Meng,Z.
  TITLE     FBXL6 governs c-MYC to promote hepatocellular carcinoma through
            ubiquitination and stabilization of HSP90AA1
  JOURNAL   Cell Commun Signal 18 (1), 100 (2020)
   PUBMED   32576198
  REMARK    GeneRIF: FBXL6 governs c-MYC to promote hepatocellular carcinoma
            through ubiquitination and stabilization of HSP90AA1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1745)
  AUTHORS   Lievens,S., Vanderroost,N., Van der Heyden,J., Gesellchen,V.,
            Vidal,M. and Tavernier,J.
  TITLE     Array MAPPIT: high-throughput interactome analysis in mammalian
            cells
  JOURNAL   J Proteome Res 8 (2), 877-886 (2009)
   PUBMED   19159283
REFERENCE   7  (bases 1 to 1745)
  AUTHORS   Roukens,M.G., Alloul-Ramdhani,M., Moghadasi,S., Op den Brouw,M. and
            Baker,D.A.
  TITLE     Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is
            facilitated by an evolutionarily conserved mechanism of
            F-box-mediated ubiquitination
  JOURNAL   Mol Cell Biol 28 (13), 4394-4406 (2008)
   PUBMED   18426905
  REMARK    GeneRIF: Fbl6 regulates Tel/Yan protein stability and allows
            appropriate spatiotemporal control of gene expression by these
            repressors.
REFERENCE   8  (bases 1 to 1745)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   9  (bases 1 to 1745)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 1745)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM761056.1, BC033066.1 and
            AC233992.5.
            
            On Nov 22, 2018 this sequence version replaced NM_012162.3.
            
            Summary: This gene encodes a member of a family of proteins that
            are characterized by an F-box motif. The encoded protein also
            contains leucine-rich repeats. F-box-containing proteins comprise
            one of the subunits of the SCF (SKP1-cullin-F-box) complex, which
            functions in phosphorylation-dependent ubiquitination. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033066.1, SRR1163658.178162.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331890.6/ ENSP00000330098.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               BM761056.1         52-499
            449-1510            BC033066.1         489-1550
            1511-1511           AC233992.5         117977-117977       c
            1512-1745           BC033066.1         1552-1785
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1745
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /note="F-box and leucine rich repeat protein 6"
                     /db_xref="GeneID:26233"
                     /db_xref="HGNC:HGNC:13603"
                     /db_xref="MIM:609076"
     exon            1..441
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1645
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein Fbl6; F-box/LRR-repeat protein 6"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 6 isoform 1"
                     /protein_id="NP_036294.2"
                     /db_xref="CCDS:CCDS6422.1"
                     /db_xref="GeneID:26233"
                     /db_xref="HGNC:HGNC:13603"
                     /db_xref="MIM:609076"
                     /translation="MAAPASRQVRRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDS
                     MLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAAKPKAGLRSEAAAAPAPAPAPTPT
                     PEEGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTV
                     TLSSPLVGRPAKGGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQVHPVLKLVGEC
                     CPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRK
                     LWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLR
                     LLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLR
                     GCARITPAGLQDLPCRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQ
                     GFSEKDLEQALAAFLSTPGGSHPALCSLNLRGTRVTPSTVSSVISGCPGLLYLNLESC
                     RCLPRGLKRAYRGLEEVQWCLEQLLTSPSPS"
     exon            442..600
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            601..664
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            665..796
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            797..904
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1018
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1250
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1497
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1745
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /note="hexamer: AATAAA"
     polyA_site      1745
                     /gene="FBXL6"
                     /gene_synonym="FBL6; FBL6A; PP14630"
                     /note="major polyA site"
ORIGIN      
        1 gcttccccga gcgccgtcgg tggtcatggc tgccccagcc tcccggcagg tccgacgcag
       61 agcccgggca gcgccgcggc cccgctcggc cgaggactgg tggtgggacc ggctggcgcc
      121 gaggggctcg gggtaccacc tgctgcagtc cgacagcatg ctgctggtgc tgtccgaacc
      181 cggccccgcc cggccccgcg cacagcggcg cgcttcccgc cgcactcccc ggcagccgcc
      241 ccggggcccc agcgccgcgg ccaagcccaa ggccgggctc aggtccgagg cggcggccgc
      301 gcccgcaccc gcaccggcac ccacgcccac gcccgaggaa gggcccgacg cgggctgggg
      361 agaccgcatt cccttggaaa tcctggtgca gattttcggg ttgttggtgg cggcggacgg
      421 ccccatgccc ttcctgggca gggctgcgcg cgtgtgccgc cgctggcagg aggccgcttc
      481 ccaacccgcg ctctggcaca ccgtgaccct gtcgtccccg ctggtcggcc ggcctgccaa
      541 gggcggggtc aaggcggaga agaagctcct tgcttccctg gagtggctta tgcccaatcg
      601 gttttcacag ctccagaggc tgaccctcat ccactggaag tctcaggtac accccgtgtt
      661 gaagctggta ggtgagtgct gtcctcggct cactttcctc aagctctccg gctgccacgg
      721 tgtgactgct gacgctctgg tcatgctagc caaagcctgc tgccagctcc atagcctgga
      781 cctacagcac tccatggtgg agtccacagc tgtggtgagc ttcttggagg aggcagggtc
      841 ccgaatgcgc aagttgtggc tgacctacag ctcccagacg acagccatcc tgggcgcact
      901 gctgggcagc tgctgccccc agctccaggt cctggaggtg agcaccggca tcaaccgtaa
      961 tagcattccc cttcagctgc ctgtcgaggc tctgcagaaa ggctgccctc agctccaggt
     1021 gctgcggctg ttgaacctga tgtggctgcc caagcctccg ggacgagggg tggctcccgg
     1081 accaggcttc cctagcctag aggagctctg cctggcgagc tcaacctgca actttgtgag
     1141 caacgaggtc ctgggccgcc tactccacgg ctctcccaac ctgcgcttac tggatcttcg
     1201 tggctgtgcg cgcatcacgc cggctggcct tcaggatctg ccatgtcggg agctggagca
     1261 gcttcatctg ggcctgtatg gcacgtcaga ccggctgact ctagccaagg agggcagccc
     1321 ctttttgacc cagaagtggt gccatacact gcgagaactg gacttgagtg gccaggggtt
     1381 cagtgagaag gacctggagc aggccctggc tgccttctta agcacccctg ggggctcaca
     1441 cccagccctg tgctctctta acctcagggg cacccgggtc acaccaagca ctgtcagctc
     1501 tgtgatcagc ggctgcccgg gcctgctcta cctcaacctg gagtcctgcc gctgccttcc
     1561 ccggggtctg aagcgggcct accggggcct ggaggaagtc cagtggtgtc tggagcagct
     1621 gctcaccagc ccctcaccca gctaggcagc cacagacctg ggacacctca gccagcttgc
     1681 ccaccctcca cctttgccca atttcagata tttgagcatt ttgttaaaat aaaacatttt
     1741 tagga
//
