LOCUS       NM_012161               3488 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5),
            transcript variant 1, mRNA.
ACCESSION   NM_012161
VERSION     NM_012161.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3488)
  AUTHORS   Zhang,S., Ji,B., Li,J., Ji,W., Yang,C. and Yang,L.
  TITLE     FBXL5 promotes lipid accumulation in alcoholic fatty liver disease
            by promoting the ubiquitination and degradation of TFEB
  JOURNAL   Cell Signal 112, 110905 (2023)
   PUBMED   37743009
  REMARK    GeneRIF: FBXL5 promotes lipid accumulation in alcoholic fatty liver
            disease by promoting the ubiquitination and degradation of TFEB.
REFERENCE   2  (bases 1 to 3488)
  AUTHORS   Cho,Y.A., Kim,S.E., Park,C.K., Koh,H.H., Park,C.K. and Ha,S.Y.
  TITLE     Loss of F-Box and Leucine Rich Repeat Protein 5 (FBXL5) Expression
            Is Associated With Poor Survival in Patients With Hepatocellular
            Carcinoma After Curative Resection: A Two-institute Study
  JOURNAL   Cancer Genomics Proteomics 20 (3), 298-307 (2023)
   PUBMED   37093682
  REMARK    GeneRIF: Loss of F-Box and Leucine Rich Repeat Protein 5 (FBXL5)
            Expression Is Associated With Poor Survival in Patients With
            Hepatocellular Carcinoma After Curative Resection: A Two-institute
            Study.
REFERENCE   3  (bases 1 to 3488)
  AUTHORS   Park,C.K., Heo,J., Ham,W.S., Choi,Y.D., Shin,S.J. and Cho,N.H.
  TITLE     Ferroportin and FBXL5 as Prognostic Markers in Advanced Stage Clear
            Cell Renal Cell Carcinoma
  JOURNAL   Cancer Res Treat 53 (4), 1174-1183 (2021)
   PUBMED   33735560
  REMARK    GeneRIF: Ferroportin and FBXL5 as Prognostic Markers in Advanced
            Stage Clear Cell Renal Cell Carcinoma.
REFERENCE   4  (bases 1 to 3488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3488)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3488)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 3488)
  AUTHORS   Zhang,N., Liu,J., Ding,X., Aikhionbare,F., Jin,C. and Yao,X.
  TITLE     FBXL5 interacts with p150Glued and regulates its ubiquitination
  JOURNAL   Biochem Biophys Res Commun 359 (1), 34-39 (2007)
   PUBMED   17532294
  REMARK    GeneRIF: Our findings provide a potential mechanism by which
            p150(Glued) protein function is regulated by SCFs.
REFERENCE   8  (bases 1 to 3488)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   9  (bases 1 to 3488)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 3488)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030656.1, AF142481.1,
            BF432189.1, AI858616.1 and AC116651.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_012161.3.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbls class and, in addition to an F-box, contains several
            tandem leucine-rich repeats. Alternatively spliced transcript
            variants have been described for this locus. [provided by RefSeq,
            Aug 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.10919.1,
                                           SRR1803613.212535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341285.8/ ENSP00000344866.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               BC030656.1         27-250
            225-2855            AF142481.1         202-2832
            2856-3330           BF432189.1         3-477               c
            3331-3338           AI858616.1         147-154             c
            3339-3339           AC116651.6         42381-42381         c
            3340-3485           AI858616.1         1-146               c
            3486-3488           AC116651.6         42232-42234         c
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..3488
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="F-box and leucine rich repeat protein 5"
                     /db_xref="GeneID:26234"
                     /db_xref="HGNC:HGNC:13602"
                     /db_xref="MIM:605655"
     exon            1..154
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2146
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 5; p45SKP2-like protein; F-box
                     protein FBL4/FBL5"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 5 isoform 1"
                     /protein_id="NP_036293.1"
                     /db_xref="CCDS:CCDS3415.1"
                     /db_xref="GeneID:26234"
                     /db_xref="HGNC:HGNC:13602"
                     /db_xref="MIM:605655"
                     /translation="MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALL
                     QSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNE
                     YEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCS
                     QKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFS
                     YLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVK
                     NRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKT
                     LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSG
                     CEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDL
                     TNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVME
                     TASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPES
                     SAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGG
                     LPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCG
                     FRACCRSGE"
     exon            155..370
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..466
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..653
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..836
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..962
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1111
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1194
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1920
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2069
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3488
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2831..2836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="hexamer: AATAAA"
     polyA_site      2863
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="major polyA site"
     regulatory      3312..3317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="hexamer: AATAAA"
     polyA_site      3339
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
     regulatory      3382..3387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      3400
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
                     /note="hexamer: AATAAG"
     polyA_site      3488
                     /gene="FBXL5"
                     /gene_synonym="FBL4; FBL5; FLR1"
ORIGIN      
        1 gccccgcggc gagggtgtct atggagaggc ggcggccgcg gctgctgagg cggaggctga
       61 ggcagtggcg atggcgccct ttcctgaaga agtggacgtc ttcaccgccc cacactggcg
      121 gatgaagcag ctggtggggc tctactgcga caagctttct aaaaccaatt tttccaacaa
      181 caacgatttc cgtgctcttc tgcagtcttt gtatgctact ttcaaggagt tcaaaatgca
      241 tgagcagatt gaaaatgaat acattattgg tttgcttcaa caacgcagcc agaccattta
      301 taatgtacat tctgacaata aactctccga gatgcttagc ctctttgaaa agggactgaa
      361 gaatgttaag aatgaatatg aacagttaaa ttatgcaaaa caactgaaag agagattgga
      421 ggcttttaca agagattttc ttcctcacat gaaagaggaa gaggaggttt ttcagcccat
      481 gttaatggaa tattttacct atgaagagct taaggatatt aaaaagaaag tgattgcaca
      541 acactgctct cagaaggata ctgcagaact ccttagaggt cttagcctat ggaatcatgc
      601 tgaagagcga cagaagtttt ttaaatattc cgtggatgaa aagtcagata aagaagcaga
      661 agtgtcagaa cactccacag gtataaccca tcttcctcct gaggtaatgc tgtcaatttt
      721 cagctatctt aatcctcaag agttatgtcg atgcagtcaa gtaagcatga aatggtctca
      781 gctgacaaaa acgggatcgc tttggaaaca tctttaccct gttcattggg ccagaggtga
      841 ctggtatagt ggtcccgcaa ctgaacttga tactgaacct gatgatgaat gggtgaaaaa
      901 taggaaagat gaaagtcgtg cttttcatga gtgggatgaa gatgctgaca ttgatgaatc
      961 tgaagagtct gcggaggaat caattgctat cagcattgca caaatggaaa aacgtttact
     1021 ccatggctta attcataacg ttctaccata tgttggtact tctgtaaaaa ccttagtatt
     1081 agcatacagc tctgcagttt ccagcaaaat ggttaggcag attttagagc tttgtcctaa
     1141 cctggagcat ctggatctta cccagactga catttcagat tctgcatttg acagttggtc
     1201 ttggcttggt tgctgccaga gtcttcggca tcttgatctg tctggttgtg agaaaatcac
     1261 agatgtggcc ctagagaaga tttccagagc tcttggaatt ctgacatctc atcaaagtgg
     1321 ctttttgaaa acatctacaa gcaaaattac ttcaactgcg tggaaaaata aagacattac
     1381 catgcagtcc accaagcagt atgcctgttt gcacgattta actaacaagg gcattggaga
     1441 agaaatagat aatgaacacc cctggactaa gcctgtttct tctgagaatt tcacttctcc
     1501 ttatgtgtgg atgttagatg ctgaagattt ggctgatatt gaagatactg tggaatggag
     1561 acatagaaat gttgaaagtc tttgtgtaat ggaaacagca tccaacttta gttgttccac
     1621 ctctggttgt tttagtaagg acattgttgg actaaggact agtgtctgtt ggcagcagca
     1681 ttgtgcttct ccagcctttg cgtattgtgg tcactcattt tgttgtacag gaacagcttt
     1741 aagaactatg tcatcactcc cagaatcttc tgcaatgtgt agaaaagcag caaggactag
     1801 attgcctagg ggaaaagact taatttactt tgggagtgaa aaatctgatc aagagactgg
     1861 acgtgtactt ctgtttctca gtttatctgg atgttatcag atcacagacc atggtctcag
     1921 ggttttgact ctgggaggag ggctgcctta tttggagcac cttaatctct ctggttgtct
     1981 tactataact ggtgcaggcc tgcaggattt ggtttcagca tgtccttctc tgaatgatga
     2041 atacttttac tactgtgaca acattaacgg tcctcatgct gataccgcca gtggatgcca
     2101 gaatttgcag tgtggttttc gagcctgctg ccgctctggc gaatgaccct tgacttctga
     2161 tctttgtcta cttcatttag ctgagcaggc tttctttcat gcactttact catagcacat
     2221 ttcttgtgtt aaccatccct ttttgagcgt gacttgtttt ggccccattt cttacaactt
     2281 cagaaatctt aatttaccag tgaattgtaa tgttgtttct cttgcaaatt atacttttgg
     2341 tttagaaagg gattaggtct tttcaaaagg gtgagaacag tcttacattt ttcttttaaa
     2401 tgaaatgctt taaagaatgt tggtaatgcc atgtcattta aagtatttca tagataattt
     2461 tgagttttaa agtccatgga ggtgattggt tctctttaca cattaacact gtaccaagct
     2521 ttgcagatct tttccgacac acatgtctga agacttattt tcaaagacag cacatttttg
     2581 gaaactaatc tcttttccgt aatatttcct ttatttcaat gattctcaga aggccaattc
     2641 aaacaaaccc acatttaagg ttctttagga ttatagaata aattggcttc tgagtgttag
     2701 ctcagtgagc taggaaagca ccaatcgata tttgtttcct ttagggatac tttgttctca
     2761 ccactgtccc tatgtcatca aatttgggag agatttttta aaataccaca atcatttgaa
     2821 gaaatgtata aataaaatct actttgagga ctttaccaag taatactgtt gtgttgtgat
     2881 ttttattata aatctcaatc caggtttact ttagtataga ataggactac atactttgtc
     2941 tttggacctc ccatgaactt attaccctga caaatagttt tagacagata ctgaatttta
     3001 ttgagctgaa ttttcttttt gaaatgagtt attcagtagt caaaatttga atccgtaagt
     3061 atatctactt tgctttgtta aaacatcatg agagtggagg cctgccaccc agaaaggcac
     3121 atactagtgc cttttagtac aattttatgt catgtagaag aaaatggcaa tgttcctcct
     3181 attgatacag atacaggcat atgtcatctt attgcgtttt gctttattgc actttgcaaa
     3241 taatgcattt tttacaaatg gaaggtttat ggcaactctg cgttgagcca gtctattggt
     3301 gccatgtttc caataaaact tctcctttca tgtctcgtat attgtgataa ttcttggagt
     3361 atttcatagt ttttcactat tattaaatct gttgtggtga tctgtggcca gtgattgttg
     3421 ttactattgt aattgctttg gaatgccatg aactgtgccc taataagaca gagaacttaa
     3481 ttgataaa
//
