LOCUS       NM_001278716            8058 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 4 (FBXL4),
            transcript variant 2, mRNA.
ACCESSION   NM_001278716
VERSION     NM_001278716.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8058)
  AUTHORS   Nguyen-Dien,G.T., Townsend,B., Kulkarni,P.G., Kozul,K.L., Ooi,S.S.,
            Eldershaw,D.N., Weeratunga,S., Liu,M., Jones,M.J., Millard,S.S.,
            Ng,D.C., Pagano,M., Bonfim-Melo,A., Schneider,T., Komander,D.,
            Lazarou,M., Collins,B.M. and Pagan,J.K.
  TITLE     PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation
            via SCFFBXL4
  JOURNAL   EMBO Rep 25 (8), 3324-3347 (2024)
   PUBMED   38992176
  REMARK    GeneRIF: PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX
            degradation via SCF[FBXL4].
REFERENCE   2  (bases 1 to 8058)
  AUTHORS   Kulkarni,P., Nguyen-Dien,G.T., Kozul,K.L. and Pagan,J.K.
  TITLE     FBXL4: safeguarding against mitochondrial depletion through
            suppression of mitophagy
  JOURNAL   Autophagy 20 (6), 1459-1461 (2024)
   PUBMED   38423516
  REMARK    GeneRIF: FBXL4: safeguarding against mitochondrial depletion
            through suppression of mitophagy.
REFERENCE   3  (bases 1 to 8058)
  AUTHORS   Gao,K., Chen,Y., Mo,R. and Wang,C.
  TITLE     Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the
            pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome
  JOURNAL   Autophagy 20 (2), 460-462 (2024)
   PUBMED   37876279
  REMARK    GeneRIF: Excessive BNIP3- and BNIP3L-dependent mitophagy underlies
            the pathogenesis of FBXL4-mutated mitochondrial DNA depletion
            syndrome.
REFERENCE   4  (bases 1 to 8058)
  AUTHORS   Nguyen-Dien,G.T., Kozul,K.L., Cui,Y., Townsend,B., Kulkarni,P.G.,
            Ooi,S.S., Marzio,A., Carrodus,N., Zuryn,S., Pagano,M., Parton,R.G.,
            Lazarou,M., Millard,S.S., Taylor,R.W., Collins,B.M., Jones,M.J. and
            Pagan,J.K.
  TITLE     FBXL4 suppresses mitophagy by restricting the accumulation of NIX
            and BNIP3 mitophagy receptors
  JOURNAL   EMBO J 42 (13), e112767 (2023)
   PUBMED   37161784
  REMARK    GeneRIF: FBXL4 suppresses mitophagy by restricting the accumulation
            of NIX and BNIP3 mitophagy receptors.
REFERENCE   5  (bases 1 to 8058)
  AUTHORS   Elcocks,H., Brazel,A.J., McCarron,K.R., Kaulich,M., Husnjak,K.,
            Mortiboys,H., Clague,M.J. and Urbe,S.
  TITLE     FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating
            NIX levels
  JOURNAL   EMBO J 42 (13), e112799 (2023)
   PUBMED   37102372
  REMARK    GeneRIF: FBXL4 ubiquitin ligase deficiency promotes mitophagy by
            elevating NIX levels.
REFERENCE   6  (bases 1 to 8058)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   7  (bases 1 to 8058)
  AUTHORS   Kipreos,E.T. and Pagano,M.
  TITLE     The F-box protein family
  JOURNAL   Genome Biol 1 (5), REVIEWS3002 (2000)
   PUBMED   11178263
  REMARK    Review article
REFERENCE   8  (bases 1 to 8058)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   9  (bases 1 to 8058)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 8058)
  AUTHORS   Almannai,M., Dai,H., El-Hattab,A.W. and Wong,L.J.C.
  TITLE     FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion
            Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28383868
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA782779.1, DA391493.1,
            BC091484.1 and AL022395.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001278716.1.
            
            Summary: This gene encodes a member of the F-box protein family,
            which are characterized by an approximately 40 amino acid motif,
            the F-box. F-box proteins constitute one subunit of modular E3
            ubiquitin ligase complexes, called SCF complexes, which function in
            phosphorylation-dependent ubiquitination. The F-box domain mediates
            protein-protein interactions and binds directly to S-phase
            kinase-associated protein 1. In addition to an F-box domain, the
            encoded protein contains at least 9 tandem leucine-rich repeats.
            The ubiquitin ligase complex containing the encoded protein may
            function in cell-cycle control by regulating levels of
            lysine-specific demethylase 4A. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1050775.1,
                                           SRR1803616.61138.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369244.7/ ENSP00000358247.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               DA782779.1         61-379
            320-320             DA391493.1         368-368
            321-2516            BC091484.1         301-2496
            2517-8058           AL022395.2         84071-89612
FEATURES             Location/Qualifiers
     source          1..8058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.1-q16.2"
     gene            1..8058
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="F-box and leucine rich repeat protein 4"
                     /db_xref="GeneID:26235"
                     /db_xref="HGNC:HGNC:13601"
                     /db_xref="MIM:605654"
     exon            1..141
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            142..259
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            260..377
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            378..961
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..2315
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 4"
                     /protein_id="NP_001265645.1"
                     /db_xref="CCDS:CCDS5041.1"
                     /db_xref="GeneID:26235"
                     /db_xref="HGNC:HGNC:13601"
                     /db_xref="MIM:605654"
                     /translation="MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQT
                     SPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGT
                     WWDQCPSASLPFKRTPPNFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSAN
                     PYSPNPPAEVRWEILWSERPTKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYT
                     ELDAVVLHGVKDKPVLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPN
                     NGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDD
                     TSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETC
                     LEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFC
                     SELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLE
                     ELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDI
                     LGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSFTQ"
     exon            962..1307
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1552
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1766
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1838
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2151
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..8058
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2488..2493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="hexamer: CATAAA"
     polyA_site      2516
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="major polyA site"
     regulatory      6894..6899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="hexamer: AGTAAA"
     polyA_site      6917
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="major polyA site"
     regulatory      8032..8037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="hexamer: AATAAA"
     polyA_site      8058
                     /gene="FBXL4"
                     /gene_synonym="FBL4; FBL5; MTDPS13"
                     /note="major polyA site"
ORIGIN      
        1 ccttccgggt cgcgctaggc cgggcttgcg gcggttgtgc cgcatctaga gagtcgggga
       61 gccgcccccg cacccaggcc ttctcgcgct gcctggtcgc tggtgaagcc cgcggcgcgc
      121 gcctctcccg gaccctgcag gatttttctt cctggcctgg ttcccttgcc ttctccattt
      181 gcttcattcg cttggatttt caagaagctt tgaagctgga taggagtctc cagtcttcct
      241 cttgatccat atgtttcagg taaaagaatg tcacatgtca gcatttgtac ctgaagtcag
      301 catgcaaagt tcagggtacc tggatgaatg ccaacttttg catttcccat gtgtatcctg
      361 tgaccattct atctgggaac atccttcaaa gagttcatgc atcttactga ggacacctga
      421 ccttttgaag cttcataatt cacatctaga tgtcaccggt ctttcccatg ttaacagttc
      481 tgaccatgtt ttattatata tgccttcggc gccgagccag gacagctaca agaggagaaa
      541 tgatgaacac ccatagagct atagaatcaa acagccagac ttcccctctc aatgcagagg
      601 tagtccagta tgccaaagaa gtagtggatt tcagttccca ttatggaagt gagaatagta
      661 tgtcctatac tatgtggaat ttggctggtg taccaaatgt attcccaagt tctggtgact
      721 ttactcagac agctgtgttt cgaacttatg ggacatggtg ggatcagtgt cctagtgctt
      781 ccttgccatt caagaggacg ccacctaatt ttcagagcca ggactatgtg gaacttactt
      841 ttgaacaaca ggtgtatcct acagctgtac atgttctaga aacctatcat cccggagcag
      901 tcattagaat tctcgcttgt tctgcaaatc cttattcccc aaatccacca gctgaagtaa
      961 gatgggagat tctttggtca gagagaccta cgaaggtgaa tgcttcccaa gctcgccagt
     1021 ttaaaccttg tattaagcag ataaatttcc ccacaaatct tatacgactg gaagtaaata
     1081 gttctcttct ggaatattac actgaattag atgcagttgt gctacatggt gtgaaggaca
     1141 agccagtgct ttctctcaag acttcactta ttgacatgaa tgatatagaa gatgatgcct
     1201 atgcagaaaa ggatggttgt ggaatggaca gtcttaacaa aaagtttagc agtgctgtcc
     1261 tcggggaagg gccaaataat gggtattttg ataaactacc ttatgagctt attcagctga
     1321 ttctgaatca tcttacacta ccagacctgt gtagattagc acagacttgc aaactactga
     1381 gccagcattg ctgtgatcct ctgcaataca tccacctcaa tctgcaacca tactgggcaa
     1441 aactagatga cacttctctg gaatttctac agtctcgctg cactcttgtc cagtggctta
     1501 atttatcttg gactggcaat agaggcttca tctctgttgc aggatttagc aggtttctga
     1561 aggtttgtgg atccgaatta gtacgccttg aattgtcttg cagccacttt cttaatgaaa
     1621 cttgcttaga agttatttct gagatgtgtc caaatctaca ggccttaaat ctctcctcct
     1681 gtgataagct accacctcaa gctttcaacc acattgccaa gttatgcagc cttaaacgac
     1741 ttgttctcta tcgaacaaaa gtagagcaaa cagcactgct cagcattttg aacttctgtt
     1801 cagagcttca gcacctcagt ttaggcagtt gtgtcatgat tgaagactat gatgtgatag
     1861 ctagcatgat aggagccaag tgtaaaaaac tccggaccct ggatctgtgg agatgtaaga
     1921 atattactga gaatggaata gcagaactgg cttctgggtg tccactactg gaggagcttg
     1981 accttggctg gtgcccaact ctgcagagca gcaccgggtg cttcaccaga ctggcacacc
     2041 agctcccaaa cttgcaaaaa ctctttctta cagctaatag atctgtgtgt gacacagaca
     2101 ttgatgaatt ggcatgtaat tgtaccaggt tacagcagct ggacatatta ggaacaagaa
     2161 tggtaagtcc ggcatcctta agaaaactcc tggaatcttg taaagatctt tctttacttg
     2221 atgtgtcctt ctgttcgcag attgataaca gagctgtgct agaactgaat gcaagctttc
     2281 caaaagtgtt cataaaaaag agctttactc agtgacttaa tatatgttct gtattaaaat
     2341 taatgtgctt tgttggggtt taattttggg attggttttg ggttttgttt ttagttgttt
     2401 taatggtaag aattaagaca tttgtagatt ttaaagaaaa atatgaaatt gtccattaaa
     2461 tcaagtaaaa atgtgcacaa atgttttcat aaaatactgc aagcacttct cttcaagaat
     2521 atgagtggat attattttta ccttatgtta atcagtgata tgctttagtc aataatatga
     2581 ttgataaaag aataacatgg aatcatgcta acttattttc aaaggaacac tgagcaataa
     2641 agtatcgtgg catttatgca aaaaaaaaag ttaatttttt acaccttcat gtaaggatgt
     2701 cttattaagc ctgtgacctg gcaagtgttt tgtttggtat gtacaaaatg gtcagagcta
     2761 gttggagaat gagacatgct tttccagctg tttggttatt tctctggatt aactgttcaa
     2821 ctggaaaatt tttagttttt ctagccaggt gtggtggcac acacttgtag tcctagcgac
     2881 acaggaggtg gaggcaggag gattacttga gatgggattt tgagactcta gtgtacttat
     2941 gattgcacct gtgagcagcc actgcactcc aacctgggca atatagcaag tccctttctc
     3001 ttaaaaaaaa ttgtagtgtt tccacttttc ttctgatatt tttgtctatt tcactactgg
     3061 ataatgccaa tataaaaatt tgggtataat caagaataag aggtaaacta ctaaataaaa
     3121 aaagctttcc aactgttaga agcagatgcc ttaacatttt gtgaaaggta aagttttgag
     3181 gtttctgaat tatataaaaa aacataaatg tggagatata tattatatat acacattata
     3241 tatacatatt atagataata tatatccaca tttatgattt ttaatatata catgtatata
     3301 ttatatatta tataattata tattacattt atattatatg taatgtacat gtatatatta
     3361 tatacatata tataattata tatattatat agagagagat atatatcttg ctagggtgtg
     3421 tggatgctgg aatataacga ttttgcactt aacaggacaa tgaattttgt tatactacag
     3481 ttaatattag ttttgtgttc aaaacagctg tgccttttca tgccacaaaa tattttctgt
     3541 ctactttctg agtagcagaa ttaattcatt tttttaacaa aacgatgtat gtcaagtgtt
     3601 cagtagtcac atgaggagaa tgcttccttt gtgcctggca ctgtttcttg tgctttgcat
     3661 tgactaattc aattctcaca acaaccctgt aagataaatg ccattactta cccccattta
     3721 cagatgagga aactgaggca aagaaagatt gaagaattta tttatgatca tacagctgct
     3781 agtggcagag ccaacatata aacccaggcc atctggcttc tgaagcattg cattaaacct
     3841 gtgcttttag gtgttcaggg tagcttctgg ctctagggca gaggtcagga aactttttct
     3901 ataaagggcc agatagtaaa tattttaggc tttgtgggct aagaggtaaa actgagattg
     3961 ttatgtagat acttaaataa ctagagagaa ataaaatttg cacgaaaatt ttattgacaa
     4021 aattcaaaac aataatttag aacaattttt tttgtaatac gggtttacta atgaaaagaa
     4081 ttaaatattt acagggagga tcaaagttaa tgtttcgtgt cattaaagtt gattgtaagt
     4141 actcatttgt taatgctgat ctgtaataag attttatgta ttttacttct gaaaattcct
     4201 tgcagatagg tattgtcaaa tacttacatt aatccatgag aatatgattt ttgttgagca
     4261 tattcatcac ttgaaaggtt acttcttctc tggatatttt ccttttagca tgttattaca
     4321 ttgcagctta atcacttcca attgaagact aggcagaagc tcctcaattg cactgttaaa
     4381 ttgattttga aaaatggaaa tttcctttac atttgcaaac tccaaaaaat actgcaggca
     4441 ctatggtgtg agctacaaat ttgtgtgaga gtggagatct cgcttctttg tcttaccttt
     4501 tgatagcaca ggaaatgtgt aaagcagctt gttgttactt gtaattcaaa caatgttgtc
     4561 atcaaaatga cttatgtttt gcttgtaaac acgttttgcc ttgtaatttt ggcttgaatt
     4621 catttcaaaa ttttattaag tcttgagcaa aagctaaatt ccaaagccat tcagtgttcc
     4681 ataatagtga ttgaggacat gtcttctttt tcagaaaaat gtcaatatca gccctgaacg
     4741 caaaagctca caatagaact aacactatta tgccaatgtg gttgggcaaa tcagcatatt
     4801 catcttctgt atctgacaaa agataactga accattgatg tttaatctat cagaaactat
     4861 gagagcaaat gaagttcacc attgctacca gtagttcagt aatacaaaat tgaatcaaat
     4921 atatcccaca aagtacctgc tgatgaataa tacagtaaat aaccatagat tttaaatacc
     4981 ttcttacctt ttcacaggct ttataaattt gacaaacgta atcattttgc ttcacacatt
     5041 tttaacacca ccagttgtaa cacatcttag cagattctac ttcaggttgc atgaaatttg
     5101 tgttttcttc ttataaaata ttcatgcttg taattgtgcc acacagataa ttcatagaga
     5161 ctaatttcag tcacttcaac gttggcattg acttatcaaa taagcaataa ctaggcagtg
     5221 tcagtaacat ctgttgactc atcaagagcc aaggaaaacc actcagggtc atttgccttg
     5281 ttttttattg actgttgatg ttgttcccag tgttctcaat tctttaagca accattcttg
     5341 ccaaaaggct aatttaatag tcttaagttt actttggaca cagtccttca gccgatagaa
     5401 tcaaacacaa tttagttatc gttagtaaaa tgttttcctt gcttggttaa catctgagtc
     5461 actttggctg caactttatt ttcatttttg agtttgtttt tttttttttt tgagactgag
     5521 tctcattctt ttgcccaggc tggagtgcag tggcacaatc tcagttcact gcaacctcca
     5581 ccctgcaggt tcaagcgagt ctcctgcctc agcctcccaa gtagctgaga ttacaggcac
     5641 atgccaccac acctaactaa tttttatgtt tttagtagaa atggggtttt accatgttgt
     5701 ccaggctggt cttgaactcc tgacctcaag tgatccaccc acttcagcct cccaaaatgc
     5761 ttggattaca ggcatgaacc actgcatctg acctccctat agtattcttt aagaacagct
     5821 ataatgacat tgcatattaa acatcatact ctgacatcta atctgatttt taaaaattca
     5881 tatactaatg tgccttaaaa atgtcacttc aagtctactt ttcttttttt ctcttgtttt
     5941 gatgttatgg gtaagcacta gtaataaaaa atttaaaaat attgtggtat gacaacatat
     6001 gtggcactca aaatgctggt aactgcatta ctgcagtttt tagtgtgcca agtagcagtg
     6061 caaaatgatg acagcaccac ataagtctcc tttgcatttg ttcaactctg ccattctaat
     6121 gtgaaagcaa tcatagacag tacctaaacg aatgagtgtg gccatgttcc aataaaattt
     6181 catgagcact gaaagttgaa ttttacataa ttttgatgtg ttacaaaata ctactgtgtt
     6241 agccattaga ttttttcagc cattagaaaa tgtgaaactg ttcttatgag ctggctggat
     6301 ttggcttgtg gaccaaattt gtgaccccta ttccagagta ttttcgagtc agttaatcca
     6361 tgtttgccca ttcctaattt tataaaccac attcaaacct gttaattcgc tgttatcatt
     6421 ctcattttgc catttagatt ttaaaatgaa gagcagtgtt ttgttagaaa aaacaaaatg
     6481 tttaccataa caagaaagat gtgtagacaa gaaagatatt tatgtagact ctttgtttgt
     6541 taaattttga agccaggtga tgcattgtta gctttgacaa ctgacttaaa tttttgtata
     6601 attatttatc tttgcatttt gctcaggtaa attatcttcc cagagtctag aaataaagat
     6661 atccctgatc ctgtttaaga gcataaataa tactctcaat gtaaattgtt ttgaaataag
     6721 atcttaaaaa tacaaaatgt agacaattaa tattcaggtg cttacttttg agccaatatg
     6781 tagcagagaa aaactaattt ctctgtggca gtatttttat ttttggcatt tcccaggaat
     6841 taactgaaga ctaaaactca tatgtgaagt gtaatgatac taatcaaaga gtcagtaaaa
     6901 tttccatttg gctaccatgt atgtgtgtat atatttatgt atgtatgtgt gtgttacata
     6961 tttgagacag ggtctcactc tattgcccca ggctggagtg cagtggcatg atctcagctt
     7021 actgcagcct cagtctccca ggctcaagcg atcctcccac ctcggcctcc cgagtacctg
     7081 ggactacaga caccaccaca cctggctaat ttttttattt tttatagaga cacagtcttt
     7141 ccatgttgcc tatgttggtc ttgaactcct gggctcaaat aattttccca ccttggcctc
     7201 ctgtagtgct gggattacgg gcataagcca ctgtgtcagg ccccatgtat gttaatagtg
     7261 aatgtttggc ttttcatttg ttactttcag ctattaaagg atacctatta cagacacagg
     7321 aatttacatt ttcaaagtca tttttgacac atcagtgctg catctacttt tctcctttta
     7381 gcacatttga tattgatact tcagagaaac ttttttaact acccttaaaa tcttgtcaat
     7441 gaccattaac tgccaatcat cacctcattt gctttttttg acaacatact actagaaacc
     7501 taggctgtga gtgtaaaacc ataactgtta gaatcatttt tttggcaata gctcacattc
     7561 tgttaagagt catttgcttt aatcaaagat catgatttat tatatatttt ttataagtag
     7621 ggatggggcc aagattattc ctttggcaca gcagtaagtg tgctcaagat ctttgcctgt
     7681 aagcttgaat atttggctta aattttgtgc atatgaatac tgttaaaggt atatttgact
     7741 acattttgaa aggaaaaagg tagtcctgct aaaattgaca tttagggata ttttaatcta
     7801 tgtatttggt aaagtaatta gtgaagtatt agttataaaa attttaagga aaacatttaa
     7861 aagcaaaata gtcgtatcag ataaatagag tagaatacac taaagataaa acaagtctct
     7921 gttacaaatg aagttgtctg tacagacgac tgagatattt taattttatt tacataaaaa
     7981 tgctgttcaa tatctaatga tttctgttgt ttgtattctg tactttagag taataaaata
     8041 agtttgagta tctcatta
//
