LOCUS       NM_012158               3506 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 3 (FBXL3), mRNA.
ACCESSION   NM_012158
VERSION     NM_012158.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3506)
  AUTHORS   Luo,J., Tao,H., Wen,Z., Chen,L., Hu,H. and Guan,H.
  TITLE     [Tumor-associated fibroblasts promotes proliferation and migration
            of prostate cancer cells by suppressing FBXL3 via upregulating
            hsa-miR-18b-5p]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (7), 1284-1296 (2024)
   PUBMED   39051074
  REMARK    GeneRIF: [Tumor-associated fibroblasts promotes proliferation and
            migration of prostate cancer cells by suppressing FBXL3 via
            upregulating hsa-miR-18b-5p].
REFERENCE   2  (bases 1 to 3506)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3506)
  AUTHORS   Ansar,M., Paracha,S.A., Serretti,A., Sarwar,M.T., Khan,J.,
            Ranza,E., Falconnet,E., Iwaszkiewicz,J., Shah,S.F., Qaisar,A.A.,
            Santoni,F.A., Zoete,V., Megarbane,A., Ahmed,J., Colombo,R.,
            Makrythanasis,P. and Antonarakis,S.E.
  TITLE     Biallelic variants in FBXL3 cause intellectual disability, delayed
            motor development and short stature
  JOURNAL   Hum Mol Genet 28 (6), 972-979 (2019)
   PUBMED   30481285
  REMARK    GeneRIF: we conclude that homozygous FBXL3 LoF variants likely
            cause autosomal recessive ID, short stature, developmental delay
            and facial dysmorphism in humans, and that the Cys358Arg FBXL3
            variant likely adds the circadian phenotype because of abnormal
            interaction with CRY1 and CRY2
REFERENCE   4  (bases 1 to 3506)
  AUTHORS   Wang,D., Han,X., Li,C. and Bai,W.
  TITLE     FBXL3 is regulated by miRNA-4735-3p and suppresses cell
            proliferation and migration in non-small cell lung cancer
  JOURNAL   Pathol Res Pract 215 (2), 358-365 (2019)
   PUBMED   30594330
  REMARK    GeneRIF: FBXL3 was regulated by miR-4735-3p and suppressed cell
            proliferation and invasion in non-small cell lung cancer.
REFERENCE   5  (bases 1 to 3506)
  AUTHORS   Guo,X., Zhu,Y., Hong,X., Zhang,M., Qiu,X., Wang,Z., Qi,Z. and
            Hong,X.
  TITLE     miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms
            metabolism in colorectal cancer
  JOURNAL   Cell Death Dis 8 (7), e2958 (2017)
   PUBMED   28749470
  REMARK    GeneRIF: data indicate an oncogenic role of miR-181d in CRC by
            promoting glycolysis, and miR-181d/CRY2/FBXL3/c-myc feedback loop
            might be a therapeutic target for patients with CRC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3506)
  AUTHORS   Busino,L., Bassermann,F., Maiolica,A., Lee,C., Nolan,P.M.,
            Godinho,S.I., Draetta,G.F. and Pagano,M.
  TITLE     SCFFbxl3 controls the oscillation of the circadian clock by
            directing the degradation of cryptochrome proteins
  JOURNAL   Science 316 (5826), 900-904 (2007)
   PUBMED   17463251
  REMARK    GeneRIF: study demonstrates that the SCF(Fbxl3)ubiquitin ligase
            controls the oscillations of the circadian clock by mediating the
            degradation of Cry1 and Cry2 proteins
            Erratum:[Science. 2024 May 24;384(6698):eadq4777. doi:
            10.1126/science.adq4777.. PMID: 38781400]
REFERENCE   7  (bases 1 to 3506)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   8  (bases 1 to 3506)
  AUTHORS   Chiaur,D.S., Murthy,S., Cenciarelli,C., Parks,W., Loda,M.,
            Inghirami,G., Demetrick,D. and Pagano,M.
  TITLE     Five human genes encoding F-box proteins: chromosome mapping and
            analysis in human tumors
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 255-258 (2000)
   PUBMED   10828603
REFERENCE   9  (bases 1 to 3506)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 3506)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC001226.1.
            
            On Aug 31, 2019 this sequence version replaced NM_012158.3.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbls class and, in addition to an F-box, contains several
            tandem leucine-rich repeats and is localized in the nucleus.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072448.1, AL833187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355619.10/ ENSP00000347834.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               AC001226.1         58236-58568         c
            334-682             AC001226.1         52922-53270         c
            683-805             AC001226.1         50009-50131         c
            806-977             AC001226.1         46818-46989         c
            978-3506            AC001226.1         36669-39197         c
FEATURES             Location/Qualifiers
     source          1..3506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.3"
     gene            1..3506
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /note="F-box and leucine rich repeat protein 3"
                     /db_xref="GeneID:26224"
                     /db_xref="HGNC:HGNC:13599"
                     /db_xref="MIM:605653"
     exon            1..333
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            334..682
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1621
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /note="F-box protein Fbl3a; F-box and leucine-rich repeat
                     protein 3A; F-box/LRR-repeat protein 3A"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 3"
                     /protein_id="NP_036290.1"
                     /db_xref="CCDS:CCDS9457.1"
                     /db_xref="GeneID:26224"
                     /db_xref="HGNC:HGNC:13599"
                     /db_xref="MIM:605653"
                     /translation="MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDII
                     LQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQI
                     IKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHF
                     ISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILC
                     VADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSS
                     WDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRL
                     VELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSI
                     MEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW"
     exon            683..805
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            806..977
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /inference="alignment:Splign:2.1.0"
     exon            978..3506
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3487..3492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /note="hexamer: AATAAA"
     polyA_site      3506
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /note="major polyA site"
ORIGIN      
        1 agactcgctg tttgtggccc aggtgcagga agcttacgcg gtggcagccg ctcgctgagg
       61 tagtctctcg cggcgccggg gatccctgaa cacagacagc gcgggactga gaaggaaagc
      121 ttctttctgg gcagccagag ccgcaaaggt ggagccgcgt tggcgccctc cgcgggacca
      181 gcgcctcgga tgcgggcgga gcgcgggggg ccgcggctgc gggagcgcga agcggggggc
      241 caggggcgcc tcatgtgaga gccgcgggac ctgcagccgc cgccgtcccc ggagcacggg
      301 gtggtgtgtg ggggaagccg cccccggcag caggatgaaa cgaggaggaa gagatagtga
      361 ccgtaattca tcagaagaag gaactgcaga gaaatccaag aaactgagga ctacaaatga
      421 gcattctcag acttgtgatt ggggtaatct ccttcaggac attattctcc aagtatttaa
      481 atatttgcct cttcttgacc gggctcatgc ttcacaagtt tgccgcaact ggaaccaggt
      541 atttcacatg cctgacttgt ggagatgttt tgaatttgaa ctgaatcagc cagctacatc
      601 ttatttgaaa gctacccatc cagagctgat caaacagatt attaaaagac attcaaacca
      661 tctacaatat gtcagcttca aggtggacag cagcaaggaa tcagctgaag cagcttgtga
      721 tatactatcg caacttgtga attgctcttt aaaaacactt ggacttattt caactgctcg
      781 accaagcttt atggatttac caaagtctca ctttatctct gcactgacag ttgtgttcgt
      841 aaactccaaa tccctgtctt cgcttaagat agatgatact ccagtagatg atccatctct
      901 caaagtacta gtggccaaca atagtgatac actcaagctg ttgaaaatga gcagctgtcc
      961 tcatgtctct ccagcaggta tcctttgtgt ggctgatcag tgtcacggct taagagaact
     1021 agccctgaac taccacttat tgagtgatga gttgttactt gcattgtctt ctgaaaaaca
     1081 tgttcgatta gaacatttgc gcattgatgt agtcagtgag aatcctggac agacacactt
     1141 ccatactatt cagaagagta gctgggatgc tttcatcaga cattcaccca aagtgaactt
     1201 agtgatgtat ttttttttat atgaagaaga atttgacccc ttctttcgct atgaaatacc
     1261 tgccacccat ctgtactttg ggagatcagt aagcaaagat gtgcttggcc gtgtgggaat
     1321 gacatgccct agactggttg aactagtagt gtgtgcaaat ggattacggc cacttgatga
     1381 agagttaatt cgcattgcag aacgttgcaa aaatttgtca gctattggac taggggaatg
     1441 tgaagtctca tgtagtgcct ttgttgagtt tgtgaagatg tgtggtggcc gcctatctca
     1501 attatccatt atggaagaag tactaattcc tgaccaaaag tatagtttgg agcagattca
     1561 ctgggaagtg tccaagcatc ttggtagggt gtggtttccc gacatgatgc ccacttggta
     1621 aaaactgcat gatgaatagc accttaattt caagcaaatg tattataatt aaagttttat
     1681 ttgctgtagt tctgatataa ttctactatt ttgtggcaca gaaatttgat atcttcagtc
     1741 agtatatgta aagattgttt atcggaagac ccatgaatga gttttggtca gaaaattcca
     1801 cttgtttcct tagtgtaata gcagtcatat ctccgaattt tttttaatgt ggttcggatg
     1861 tgaaataacc agttatacgt attaaacagt ttacagtcta aaggaaacaa aacctatatg
     1921 ttataatatc caagaagtac taataggttt tctgaaatgt tatattctct atgcatttaa
     1981 aaaaaaatgt aaacttgaca ttttagggtc ttcagttaca catacacctg ttataaggtg
     2041 tttaatatag ctcaggaaag tgagcatttt gtgagaaaaa tgaatatatc atatctaatg
     2101 gaaaagattg gatgaatgtt ctcaaatgtt acaaagctgt ttaaagaaaa aggtatatat
     2161 aagtaatcag aacacttaga agactgatag atgtcacaca gtggtattat agaaggataa
     2221 tacagagcca agatcaaatt aaaagacaat aaatggaaca gaagggaggc agtgtttagc
     2281 tttgtataaa cttttaggtt tgctctgtaa tctgctaaac catatacatt cttttgtgat
     2341 atgttattat gtatgtggca cttgaggcac tgtatgtaaa gtaaggaatg ctttactagt
     2401 tctccttggt tttatctttg tttaaactag ctttaaagta ttaaacaata attgaaatga
     2461 aaagcttacc tattttaaaa agccaaattt aaataaatat agaactttaa aatgtttatc
     2521 agttgtttcc atgaaagaat attagtttcc agtaaatttt agtgatggct cactcacttt
     2581 tctattttgg aattacatag ttatgtaagt aaaattttta aaaatcataa agggagcacc
     2641 attgtacagt ctagcataaa cagcaaattt taaagaggac atatttaagt tcataatcat
     2701 atttttcagt aaatattgct cagtgaactg gaaaacttta atagaaaaat gtctgcagtt
     2761 ttgtgattgt taatttggtt aaaccgatat tttatattat ttaagttagg taacatttta
     2821 tattactttc atatgaataa aagtaatcca tgcattgtag agtctataaa atgttgagtt
     2881 ttaaaagatg atataaactt tgatgctggg cactagtgct agtagatatt actaccctcc
     2941 tgagggaaat cagaaatgat ttaaccccgg tggaatacat taattcttaa agcggctctt
     3001 ttcagtggtg tgacttttag attgtgtctc agtggttgag gaagctaaca gtcttagatc
     3061 tacttttaaa acggatggcc ttcttaagaa taaagcaaaa ggtgattttc tacataattt
     3121 ttgctttcca aaagtgatga tatgctctcc tacagcaaca tatgagaaga aaaaaggctt
     3181 atctagattc gaaaattaac agcaattata gtaatatatc ccctccttct aaatagtaaa
     3241 aagctctgat tgtacaagaa ttacctgtgc tagtcaagtt gttgtttttc cttgaacaac
     3301 tttggaaaaa tggatttgac agtacataat cagttctact aaccaaagct tgtatttgga
     3361 aatttacttt ttgtacaaat tgaattatat aatgcttaaa atactttgtc actttataag
     3421 caaaatgcat agtacttaat ttgtttatac tgtaaagtat atgttaaatg cttttatcac
     3481 tttgagaata aaaagttact aatgct
//
