LOCUS       NM_001367807             904 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 22 (FBXL22),
            transcript variant 2, mRNA.
ACCESSION   NM_001367807 XM_005254320
VERSION     NM_001367807.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 904)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 904)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 904)
  AUTHORS   Spaich,S., Will,R.D., Just,S., Spaich,S., Kuhn,C., Frank,D.,
            Berger,I.M., Wiemann,S., Korn,B., Koegl,M., Backs,J., Katus,H.A.,
            Rottbauer,W. and Frey,N.
  TITLE     F-box and leucine-rich repeat protein 22 is a cardiac-enriched
            F-box protein that regulates sarcomeric protein turnover and is
            essential for maintenance of contractile function in vivo
  JOURNAL   Circ Res 111 (12), 1504-1516 (2012)
   PUBMED   22972877
  REMARK    GeneRIF: Fbxl22 promotes the proteasome-dependent degradation of
            sarcomeric proteins and is essential for maintenance of normal
            contractile function.
REFERENCE   4  (bases 1 to 904)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC118274.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 19, 2018 this sequence version replaced XM_005254320.4.
            
            Summary: This gene encodes a member of the F-box protein family.
            This F-box protein interacts with S-phase kinase-associated protein
            1A and cullin in order to form SCF complexes which function as
            ubiquitin ligases.[provided by RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279836.9836.1, DN831295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638704.2/ ENSP00000492359.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC118274.9         109900-110258
            360-904             AC118274.9         113210-113754
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..904
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /note="F-box and leucine rich repeat protein 22"
                     /db_xref="GeneID:283807"
                     /db_xref="HGNC:HGNC:27537"
                     /db_xref="MIM:609088"
     exon            1..359
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..702
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /EC_number="3.4.19.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     F-box/LRR-repeat protein 22; F-box and leucine-rich
                     protein 22"
                     /codon_start=1
                     /product="F-box and leucine-rich protein 22 isoform 2"
                     /protein_id="NP_001354736.1"
                     /db_xref="CCDS:CCDS92016.1"
                     /db_xref="GeneID:283807"
                     /db_xref="HGNC:HGNC:27537"
                     /db_xref="MIM:609088"
                     /translation="MWPLLTMHITQLNRECLLHLFSFLDKDSRKSLARTCSQLHDVFE
                     DPALWSLLHFRSLTELQKDNFLLGPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICS
                     RHESLVNDFLLRVCDRCPNLASVTLSGCGHVTDDCLARLLRCCPRLRALRLENCARVT
                     NRTLAAVAADGRALQTLHVDFCRNVSAAGLRRLRAACPRLALRAEHSAAMLPDQPPRP
                     RAPAAALGKLLQR"
     exon            360..904
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /note="hexamer: ATTAAA"
     polyA_site      904
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /note="major polyA site"
ORIGIN      
        1 actcacatgt ggccactgct caccatgcac ataacccagc tcaaccggga gtgcctgctg
       61 cacctcttct ccttcctaga caaggacagc aggaagagcc ttgccaggac ctgctcccag
      121 ctccacgacg tgtttgagga ccccgcactc tggtccctgc tgcacttccg ttccctcact
      181 gaactccaga aggacaactt cctcctgggc ccggcactcc gcagcctctc catctgctgg
      241 cactccagcc gcgtgcaggt gtgcagcatt gaggactggc tcaagagtgc cttccagaga
      301 agcatctgca gccggcacga gagcctggtc aatgatttcc tcctccgggt gtgcgacagg
      361 tgccccaacc tggcgtccgt cacgctctcg ggctgcggcc acgttaccga cgactgcctg
      421 gcgcgcctgc tgcgctgctg cccacgcctg cgcgcactgc gcctggagaa ctgcgcgcgc
      481 gtcaccaacc gcacgttggc tgccgtggcg gcggacgggc gcgcgctgca gacattgcac
      541 gtggacttct gccgcaacgt gagcgcggcc ggcctgcgcc gcctgcgcgc cgcgtgcccg
      601 cgcctggccc tgcgggcaga gcacagcgcc gccatgctgc ccgaccagcc cccgcgcccg
      661 cgcgcgcccg ccgcggccct cggcaagctg ctgcagcgct agacgccgcc ccgccgctgc
      721 ccccggggaa ggagcgcagc cccagaccgt cctggcttcg aacccagctc ttccaccttc
      781 agaccaccac cgcatattct gagcctcatt ttccccgtct gcacagtggg gataagaaag
      841 cctacctcac gttacgattt tatacatagg ataaacgcaa gattaaatgg atatttggaa
      901 aaca
//
