LOCUS       NP_001354736             231 aa            linear   PRI 28-APR-2025
DEFINITION  F-box and leucine-rich protein 22 isoform 2 [Homo sapiens].
ACCESSION   NP_001354736 XP_005254377
VERSION     NP_001354736.1
DBSOURCE    REFSEQ: accession NM_001367807.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 231)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 231)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 231)
  AUTHORS   Spaich,S., Will,R.D., Just,S., Spaich,S., Kuhn,C., Frank,D.,
            Berger,I.M., Wiemann,S., Korn,B., Koegl,M., Backs,J., Katus,H.A.,
            Rottbauer,W. and Frey,N.
  TITLE     F-box and leucine-rich repeat protein 22 is a cardiac-enriched
            F-box protein that regulates sarcomeric protein turnover and is
            essential for maintenance of contractile function in vivo
  JOURNAL   Circ Res 111 (12), 1504-1516 (2012)
   PUBMED   22972877
  REMARK    GeneRIF: Fbxl22 promotes the proteasome-dependent degradation of
            sarcomeric proteins and is essential for maintenance of normal
            contractile function.
REFERENCE   4  (residues 1 to 231)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC118274.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 19, 2018 this sequence version replaced XP_005254377.1.
            
            Summary: This gene encodes a member of the F-box protein family.
            This F-box protein interacts with S-phase kinase-associated protein
            1A and cullin in order to form SCF complexes which function as
            ubiquitin ligases.[provided by RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279836.9836.1, DN831295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638704.2/ ENSP00000492359.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     Protein         1..231
                     /product="F-box and leucine-rich protein 22 isoform 2"
                     /EC_number="3.4.19.12"
                     /note="F-box/LRR-repeat protein 22; F-box and leucine-rich
                     protein 22"
                     /calculated_mol_wt=25897
     Region          9..51
                     /region_name="F-box_FBXL22"
                     /note="F-box domain found in F-box/LRR-repeat protein 22
                     (FBXL22) and similar proteins; cd22129"
                     /db_xref="CDD:438901"
     Site            order(12,16,19..20,23..24,28,30..31,35..37,39)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438901"
     Region          113..>200
                     /region_name="AMN1"
                     /note="Antagonist of mitotic exit network protein 1;
                     cd09293"
                     /db_xref="CDD:187754"
     Region          122..147
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          148..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          174..199
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..231
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /coded_by="NM_001367807.1:7..702"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS92016.1"
                     /db_xref="GeneID:283807"
                     /db_xref="HGNC:HGNC:27537"
                     /db_xref="MIM:609088"
ORIGIN      
        1 mwplltmhit qlnrecllhl fsfldkdsrk slartcsqlh dvfedpalws llhfrsltel
       61 qkdnfllgpa lrslsicwhs srvqvcsied wlksafqrsi csrheslvnd fllrvcdrcp
      121 nlasvtlsgc ghvtddclar llrccprlra lrlencarvt nrtlaavaad gralqtlhvd
      181 fcrnvsaagl rrlraacprl alraehsaam lpdqpprpra paaalgkllq r
//
