LOCUS       NM_012157               3827 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 2 (FBXL2),
            transcript variant 1, mRNA.
ACCESSION   NM_012157
VERSION     NM_012157.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Li,F., Niu,M., Qin,K., Guo,R., Yi,Y., Xu,J., Li,L., Xie,S., Fu,M.,
            Wen,N., Liao,W. and Xiao,Z.J.
  TITLE     FBXL2 promotes E47 protein instability to inhibit breast cancer
            stemness and paclitaxel resistance
  JOURNAL   Oncogene 42 (5), 339-350 (2023)
   PUBMED   36460773
  REMARK    GeneRIF: FBXL2 promotes E47 protein instability to inhibit breast
            cancer stemness and paclitaxel resistance.
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Niu,M., Xu,J., Liu,Y., Li,Y., He,T., Ding,L., He,Y., Yi,Y., Li,F.,
            Guo,R., Gao,Y., Li,R., Li,L., Fu,M., Hu,Q., Luo,Y., Zhang,C.,
            Qin,K., Yi,J., Yu,S., Yang,J., Chen,H., Wang,L., Li,Z., Dong,B.,
            Qi,S., Ouyang,L., Zhang,Y., Cao,Y. and Xiao,Z.J.
  TITLE     FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven
            NSCLC growth
  JOURNAL   Nat Commun 12 (1), 5919 (2021)
   PUBMED   34635651
  REMARK    GeneRIF: FBXL2 counteracts Grp94 to destabilize EGFR and inhibit
            EGFR-driven NSCLC growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Wang,C., Gale,M. Jr., Keller,B.C., Huang,H., Brown,M.S.,
            Goldstein,J.L. and Ye,J.
  TITLE     Identification of FBL2 as a geranylgeranylated cellular protein
            required for hepatitis C virus RNA replication
  JOURNAL   Mol Cell 18 (4), 425-434 (2005)
   PUBMED   15893726
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
REFERENCE   10 (bases 1 to 3827)
  AUTHORS   Ilyin,G.P., Rialland,M., Glaise,D. and Guguen-Guillouzo,C.
  TITLE     Identification of a novel Skp2-like mammalian protein containing
            F-box and leucine-rich repeats
  JOURNAL   FEBS Lett 459 (1), 75-79 (1999)
   PUBMED   10508920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001271.1 and AC122176.2.
            
            On May 17, 2019 this sequence version replaced NM_012157.4.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbls class and, in addition to an F-box, contains 12 tandem
            leucine-rich repeats. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.214718.1,
                                           SRR1803616.71448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000484457.6/ ENSP00000417601.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-633               AK001271.1         1-633
            634-634             AC122176.2         120071-120071
            635-2097            AK001271.1         635-2097
            2098-3827           AC122176.2         132749-134478
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..3827
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /note="F-box and leucine rich repeat protein 2"
                     /db_xref="GeneID:25827"
                     /db_xref="HGNC:HGNC:13598"
                     /db_xref="MIM:605652"
     exon            1..74
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1343
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein containing leucine-rich repeats; F-box/LRR-repeat
                     protein 2; F-box protein FBL2/FBL3"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 2 isoform 1"
                     /protein_id="NP_036289.3"
                     /db_xref="CCDS:CCDS2658.1"
                     /db_xref="GeneID:25827"
                     /db_xref="HGNC:HGNC:13598"
                     /db_xref="MIM:605652"
                     /translation="MVFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNI
                     LALDGSNWQRIDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQN
                     CRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEY
                     LNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSC
                     SRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDA
                     GFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLS
                     NSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLELYDCQQVTRAGIKRMRAQLP
                     HVKVHAYFAPVTPPTAVAGSGQRLCRCCVIL"
     exon            75..136
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            137..191
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..266
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            267..361
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            362..430
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            431..526
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..653
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..728
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            729..859
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..920
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            921..965
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1022
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1235
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..3827
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /note="hexamer: CATAAA"
     polyA_site      2354
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
     regulatory      2980..2985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="FBXL2"
                     /gene_synonym="FBL2; FBL3"
                     /note="major polyA site"
ORIGIN      
        1 gtcaccagga caacgggcgt cgccggcgcc gtgtgacttc gggctgtggg ctcgctcgcg
       61 gctcttcggc catggttttc tcaaacaatg atgaaggcct tattaacaaa aagttaccca
      121 aagaacttct gttaagaata ttttccttct tggatatagt aactttgtgc cgatgtgcac
      181 agatttccaa ggcttggaac atcttagccc tggatggaag caactggcaa agaatagatc
      241 tttttaactt tcaaacagat gtagagggtc gagtggtgga aaatatctcg aagcgatgcg
      301 gtggattcct gaggaagctc agcttgcgag gctgcattgg tgttggggat tcctccttga
      361 agacctttgc acagaactgc cgaaacattg aacatttgaa cctcaatgga tgcacaaaaa
      421 tcactgacag cacgtgttat agccttagca gattctgttc caagctgaaa catctggatc
      481 tgacctcctg tgtgtctatt acaaacagct ccttgaaggg gatcagtgag ggctgccgaa
      541 acctggagta cctgaacctc tcttggtgtg atcagatcac gaaggatggc atcgaggcac
      601 tggtgcgagg ttgtcgaggc ctgaaagccc tgctcctgag gggctgcaca cagttagaag
      661 atgaagctct gaaacacatt cagaattact gccatgagct tgtgagcctc aacttgcagt
      721 cctgctcacg tatcacggat gaaggtgtgg tgcagatatg caggggctgt caccggctac
      781 aggctctctg cctttcgggt tgcagcaacc tcacagatgc ctctcttaca gccctgggtt
      841 tgaactgtcc gcgactgcaa attttggagg ctgcccgatg ctcccatttg actgacgcag
      901 gttttacact tttagctcgg aattgccacg aattggagaa gatggatctt gaagaatgca
      961 tcctgataac cgacagcaca ctcatccagc tctccattca ctgtcctaaa ctgcaagccc
     1021 tgagcctgtc ccactgtgaa ctcatcacag atgatgggat cctgcacctg agcaacagta
     1081 cctgtggcca tgagaggctg cgggtactgg agttggacaa ctgcctcctc atcactgatg
     1141 tggccctgga acacctagag aactgccgag gcctggagcg cctcgagctg tacgactgcc
     1201 agcaggttac ccgtgcaggc atcaagcgga tgcgggctca gctccctcat gtcaaagtcc
     1261 acgcctactt tgctcccgtc accccaccga cagcagtggc aggaagtgga cagcgactgt
     1321 gcaggtgctg tgtcattctc tgacagcagc tgcctgggcc caaggggtga tgaggcatcc
     1381 tttcctctag aagacctgag tcttcctgac cgactccacc atcacccaat ctgttgattc
     1441 tccattggga aaggcattta caggtaaaag acttctgtat ggattgcagt tactctggtg
     1501 atagttttca cctttattct gctgtgaaac aatcaaatca aagccttgtg tcagttaaca
     1561 catgacaagt ggtctcaatg cagctaggac catgccagaa acctggatct cttaagagat
     1621 tggtacctac ctaggtacga aagttctacc cttggcatac tcagcattcc tcaaaaagac
     1681 catcagtgtt agcacaaact gagcagaaaa aataagctgt tgattttcta cctgatactt
     1741 aagccagtgg cctactttaa ttcacaattc cattttgatt agcaggactt ttccactttg
     1801 aagataaata gcaactttat caaagtgact gtactgcaaa ttaattcata atgcctgata
     1861 gttttatata tagagactta tgtggaaggc atgttaatag gtttccatga gacaccaaag
     1921 aaaagaggac tctatactgg gtggagcagg gtcttcacct ttttgtttct gtcaacttgt
     1981 catatacacc tccagggacc aaaaacaaaa gcagctcgga gtctgtgttg cctgattgga
     2041 aagtagaagc tctggtgtat gctacagcac ataacacatt tttactaaag gaaaaaagct
     2101 aattatgtcc atgcctctcg taaaactggg gggaacctta aagagaaaga actaaggctt
     2161 aagttatctg tagtataatc aattagaagt aatgaatgga tgcatgtaaa atggatgtga
     2221 ttttttttca agcttatttt gaaatcttaa aaatcaggtt acaccatagc tactcaaaag
     2281 ttttacacac ttaaaactca gatcagtaag tgttggtacc ttttagactc ataaaattga
     2341 ataaaccatt gcaatgcttt aaaaaaaatt aagtcagagg gttttattgc tatgatttta
     2401 tggcagacac atccaagcaa aaccattttc caaatgcaga ccttcctgat gttatctgaa
     2461 atctgataaa atgaccctac tctctgctgt ggttcattct tgctccatgc tgtccatatt
     2521 tatgatcttt attaagaacc tgtcaatcag tcatcaccac cttcattgta aacttaggtg
     2581 ttcatggtgg ctggcccttc caaacaacca ctcccccaaa ctgaagggcc agagctcatg
     2641 agaaacttaa aagtgaaacg gcaaaagcaa gatgtgttcc catgactacc aataccttta
     2701 ttaggcagtt ttagaagtgt ttttaaggat atattatgtc agctgcattc taggaagaga
     2761 agcagattat atatatatat aatctcccca taaacggact tagcacaatt atcatcagag
     2821 taagcattaa agtcatttta ttgccttatg atatattcca gtattccttg gtctaaaaat
     2881 tgtgtggata ccatagcagt tagttaaata tacatttata cccactgttt gttgtggaag
     2941 agatgatggg ggaggaggac tgatgcagga agcaacttca ataaatgagc atataacaga
     3001 cttgcttcag tgattatgaa ttagtttagt ttctattaaa aaaaattaac ttaaggctgg
     3061 ccacggtggt tcatgcctat aatcccagca cttggggagg ccaaggcggg tggatcacct
     3121 gaggtcagga gtttgagacc agcctggcca acacagtaaa accccatctc tactgaaaat
     3181 acaaaaatta gccgggcgtg gtgctgggca cctgtaatct cagctactcg ggaggctgaa
     3241 gcaggagaaa tgctggaacc caggaggcgg aggtggcagt gagccgagat tgtgccattg
     3301 cactccatcc agcccaggag acaacagtga gactccatca tcatctcaaa acaaaacaaa
     3361 caaacaaaca aaacaaacca ccagagcctt ctatacatga ttgatttctt ttgagccagg
     3421 atacaaccta tcatcagtca cagctattgg acttgatgct caatgatcca tggcctcatt
     3481 tacaaaacag gagaacctct tgtaagaaaa tcaggtttgc aggctgggca cggtggctca
     3541 cgcctgtaat cccagcactt tgggaggcag aggcgggcgg atcgtgagat caggagatca
     3601 agaccatcct ggctaacaca gtgaaacccc gtctctacta aaaatacaaa aaaaattagc
     3661 cgggcatagt ggcgggtgcc tgtagtccca gctactcagg agactgaggc agaagaatgg
     3721 cgtgaacccg ggaggcagag cttgcagtga gccgagattg cgccactgca ctccagcctg
     3781 ggtgacagag ccagactccg tctcaaaaaa aaaaaaaaaa aagaaaa
//
