LOCUS       NM_001382779            4490 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 19 (FBXL19),
            transcript variant 4, mRNA.
ACCESSION   NM_001382779
VERSION     NM_001382779.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4490)
  AUTHORS   Dong,H., Huang,C. and Huang,J.
  TITLE     FBXL19-AS1 promotes the progression of nasopharyngeal carcinoma by
            acting as a competing endogenous RNA to sponge miR-431 and
            upregulate PBOV1
  JOURNAL   Mol Med Rep 24 (3) (2021)
   PUBMED   34278444
  REMARK    GeneRIF: FBXL19AS1 promotes the progression of nasopharyngeal
            carcinoma by acting as a competing endogenous RNA to sponge miR431
            and upregulate PBOV1.
REFERENCE   2  (bases 1 to 4490)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4490)
  AUTHORS   Wang,L., Zhang,X., Liu,Y. and Xu,S.
  TITLE     Long noncoding RNA FBXL19-AS1 induces tumor growth and metastasis
            by sponging miR-203a-3p in lung adenocarcinoma
  JOURNAL   J Cell Physiol 235 (4), 3612-3625 (2020)
   PUBMED   31566718
  REMARK    GeneRIF: Long noncoding RNA FBXL19-AS1 induces tumor growth and
            metastasis by sponging miR-203a-3p in lung adenocarcinoma.
REFERENCE   4  (bases 1 to 4490)
  AUTHORS   Xu,C., Liu,K., Lei,M., Yang,A., Li,Y., Hughes,T.R. and Min,J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   5  (bases 1 to 4490)
  AUTHORS   Dong,S., Zhao,J., Wei,J., Bowser,R.K., Khoo,A., Liu,Z.,
            Luketich,J.D., Pennathur,A., Ma,H. and Zhao,Y.
  TITLE     F-box protein complex FBXL19 regulates TGFbeta1-induced E-cadherin
            down-regulation by mediating Rac3 ubiquitination and degradation
  JOURNAL   Mol Cancer 13, 76 (2014)
   PUBMED   24684802
  REMARK    GeneRIF: Collectively these data unveil that FBXL19 functions as an
            antagonist of Rac3 by regulating its stability and regulates the
            TGFbeta1-induced E-cadherin down-regulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4490)
  AUTHORS   Chandran,V.
  TITLE     The genetics of psoriasis and psoriatic arthritis
  JOURNAL   Clin Rev Allergy Immunol 44 (2), 149-156 (2013)
   PUBMED   22274791
  REMARK    Review article
REFERENCE   7  (bases 1 to 4490)
  AUTHORS   Stuart,P.E., Nair,R.P., Ellinghaus,E., Ding,J., Tejasvi,T.,
            Gudjonsson,J.E., Li,Y., Weidinger,S., Eberlein,B., Gieger,C.,
            Wichmann,H.E., Kunz,M., Ike,R., Krueger,G.G., Bowcock,A.M.,
            Mrowietz,U., Lim,H.W., Voorhees,J.J., Abecasis,G.R.,
            Weichenthal,M., Franke,A., Rahman,P., Gladman,D.D. and Elder,J.T.
  TITLE     Genome-wide association analysis identifies three psoriasis
            susceptibility loci
  JOURNAL   Nat Genet 42 (11), 1000-1004 (2010)
   PUBMED   20953189
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 4490)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   9  (bases 1 to 4490)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FBXL19 gene in silico
  JOURNAL   Int J Mol Med 14 (6), 1109-1114 (2004)
   PUBMED   15547684
REFERENCE   10 (bases 1 to 4490)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135048.2.
            
            Summary: This gene encodes a member of the Skp1-Cullin-F-box family
            of E3 ubiquitin ligases. The encoded protein is reported to bind to
            the transmembrane receptor interleukin 1 receptor-like 1 and
            regulate its ubiquitination and degradation. This protein has been
            linked to the regulation of pulmonary inflammation and psoriasis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352444.330220.1,
                                           ERR4352443.631166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338343.10/ ENSP00000339712.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               AC135048.2         82271-83158         c
            889-1089            AC135048.2         80799-80999         c
            1090-1233           AC135048.2         79279-79422         c
            1234-1320           AC135048.2         79071-79157         c
            1321-1539           AC135048.2         78767-78985         c
            1540-1701           AC135048.2         78102-78263         c
            1702-2213           AC135048.2         76146-76657         c
            2214-2377           AC135048.2         64451-64614         c
            2378-2539           AC135048.2         64194-64355         c
            2540-2758           AC135048.2         59782-60000         c
            2759-4490           AC135048.2         57947-59678         c
FEATURES             Location/Qualifiers
     source          1..4490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..4490
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /note="F-box and leucine rich repeat protein 19"
                     /db_xref="GeneID:54620"
                     /db_xref="HGNC:HGNC:25300"
                     /db_xref="MIM:609085"
     exon            1..888
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1089
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             913..2937
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /note="isoform 4 is encoded by transcript variant 4;
                     jumonji C domain-containing histone demethylase 1C;
                     F-box/LRR-repeat protein 19"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 19 isoform 4"
                     /protein_id="NP_001369708.1"
                     /db_xref="CCDS:CCDS92142.1"
                     /db_xref="GeneID:54620"
                     /db_xref="HGNC:HGNC:25300"
                     /db_xref="MIM:609085"
                     /translation="MSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGG
                     PGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVH
                     PGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGW
                     KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHL
                     KKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPA
                     VPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGR
                     RPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPD
                     TLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRK
                     SLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGS
                     APLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTD
                     ASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHC
                     LPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS"
     exon            1090..1233
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1320
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1539
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1701
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2213
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2377
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2539
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2758
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..4490
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /note="hexamer: TATAAA"
     polyA_site      4490
                     /gene="FBXL19"
                     /gene_synonym="CXXC11; Fbl19; JHDM1C"
                     /note="major polyA site"
ORIGIN      
        1 aagagaggag gaaggaggaa ggagctgagg agggatgaga gaggcggcca gggccccggg
       61 ccgtagcagc gcggggctgg gggaccaggg gggctgagac accccaactg cccccttccc
      121 ctttccctct ccccctctat cctttccttc caccctcccg cttgaggagg gggatttatt
      181 caaattttat ttaaatccct atctcccgag ggtcgcgcgc ttgggggagg gggagaggtc
      241 gggggtgcgc gcgggctggg gggggcgggg ccggagcagc ttccttcacc tccccctccg
      301 ctcgcctcgc agccgtaggg cagggggtcg cagtccaggg gcgggcccag gggagggggg
      361 caggttacag cgaccccccc ctccccggga accggcggtg ggcgggcttg aaccccggaa
      421 acggtggggg gggcccaggc ctggcactgg acccctgggc agtggggtcc gggaaggggc
      481 cagttaaagg gccaggggcg ctggggagag gcggggcggg gtggggggag gggagctggg
      541 actcggaccc gggactgagt gggccccggg cagaagctga gcaccctgcg cccaaggagc
      601 ccccgttggc ctgggggggc tgagggactg agcctcccag agcaggacct ccccctggaa
      661 gggccgcgcc gcagcccgtg ggagggcctc gcccccggcg ccccccatct ccactcgccg
      721 ccgtcccggc ctccgccgga gggaggggcc gagcgccctc ggggggccgt ggaccccggc
      781 gttctgagcg ttccgcgccc cgcgccgccc ggcccccccg ccgccgatgg ccgccgaccc
      841 gccgggagct gccgagaagg gagagatggc tcccgggaca cgtgtgagcc ctcggcgttg
      901 ctgacgcccc caatgtcgtc gagcagccgg gggccggggg ccggagcgcg ccgacgccga
      961 acccgctgcc gccgctgccg ggcctgtgtg cgaactgagt gcggggattg ccacttctgc
     1021 cgagacatga agaagttcgg ggggcccggg cgcatgaagc agtcgtgcct gctccggcag
     1081 tgcactgccc ccgtgctccc acacacagct gtgtgcctct tgtgtgggga ggctgggaag
     1141 gaggacacgg tggagggaga ggaagagaaa tttggtttga gcctcatgga gtgtacaatc
     1201 tgcaacgaga tcgtccaccc cggctgcctg aagatgggga aggctgaggg tgtcatcaat
     1261 gcagagatcc ccaactgctg ggagtgccct cgctgcaccc aggaaggccg caccagcaag
     1321 gattcaggtg aggggcctgg ccgccgtagg gccgacaacg gcgaggaggg cgccagcttg
     1381 gggagcggat ggaagctgac agaggagcca ccgcttccac cgcccccgcc caggcgcaag
     1441 ggccccctgc ctgccgggcc ccccccggag gacgtgcctg ggccccccaa acgaaaggaa
     1501 agggaggcag ggaatgagcc tcccacccca aggaaaaagg tgaaaggagg ccgagagagg
     1561 cacctgaaga aggtgggtgg agacgcctgc ctcctccgag gatcggaccc aggcggcccg
     1621 ggcctgctgc cccccagggt tctgaatccg agccaggctt tctcatcctg ccaccctggg
     1681 ctccctcccg agaactggga gaaaccaaag ccgcctttgg cctctgcaga gggcccagcg
     1741 gtgccgtccc cgtccccgca gagggagaag ctagagcgtt tcaagcggat gtgccagctg
     1801 ctggaacggg tgcctgacac ctcctcttcc tcctcggact cagactccga ctccgactct
     1861 tcgggcacat cgctgagtga ggacgaagcc cccggcgagg cccggaatgg gcgacggcca
     1921 gcccggggca gctctggcga gaaggagaac cgtggggggc ggcgggctgt gcgccctggc
     1981 agtggggggc ccctactcag ctggcccctg ggcccagccc caccaccccg gcctccacag
     2041 ctggagcggc acgtggtgcg gcccccgcct cgaagccctg agcccgacac actccccttg
     2101 gctgctggat ccgaccaccc cctgccccgg gccgcctggc ttcgcgtctt ccagcacctc
     2161 gggccgcggg agctgtgtat ctgcatgcga gtctgccgaa cttggagccg ctggtgctat
     2221 gacaagcgtc tgtggcctcg aatggacctg agccggcgga agtcactgac cccgcccatg
     2281 ctcagtggtg tggttcgccg ccagccccgt gccctggacc tcagctggac aggtgtctcc
     2341 aagaagcagc tcatgtggct tctgaaccga ctacaaggcc tgcaggagct ggtgctctct
     2401 ggctgctcct ggctctctgt ctctgccctg ggctcagccc cactgccagc cctgcggctc
     2461 ctggacctcc gctggatcga ggatgttaaa gactcccagc tccgggagtt gctgctgcct
     2521 ccaccagaca ccaaaccagg gcaaacagag agccgtggtc ggctgcaggg ggtggcagaa
     2581 ctgcgtctgg caggtttgga gctgacagat gcctccctgc gtctcctgct gcgtcacgca
     2641 ccccagctga gcgccctgga cctgagccac tgcgcccacg tcggggaccc cagtgttcac
     2701 ctcctcacgg cccccacgtc cccactccgc gagaccctgg tgcacctcaa tcttgctggt
     2761 tgccaccgcc taacggacca ctgcctcccg ctgttccgcc gctgccctcg tctacgccgc
     2821 ctagacctgc gctcctgccg ccagctctca cccgaagctt gtgcccggct ggcagctgcc
     2881 gggccccctg gccccttccg ctgccctgag gagaagctgc ttctcaagga cagctagttg
     2941 ggcgcccccc accctccccc ggactcgaca ggagcctgga cctccggctt catttcaccc
     3001 ctgctgggag gccaggttcc cacctcacca ccctgggatt cctgagtgtc agtgacttgg
     3061 gattcccacc cagggactca agccagccac ccccttcttt cccccctgca ctgatatctc
     3121 tgggggtttc tccttcctat gtcctgcccc tgctacctgc ttcattgtcc atcccctggg
     3181 ggagtgggtc agaggtactg gagggtgctg agccgaaggg acggtgggag gggggttatg
     3241 gtgcaagtgt tgggggggag aatggggaaa ggacacacac aggatatggg agccaggggc
     3301 tgggggaggt ggaaggggcg gggggcgggg cagacagcag accaccaagg gttcagggaa
     3361 caaagaccag ttacttggag tggggggtgg gggtggggcc acaaaaggaa aaccggagga
     3421 gcaattgggg atccaggtgt cagaggtagg ggaaccaggg gcaagctggg gctgagctgg
     3481 aggtggggat gagagcaggt gtggggacag caataccccc ttgggggtca cctctctgct
     3541 tcccccctcc ccaggcttca gttccttccc cctgaccctg actccttgaa cgtcactgaa
     3601 aacggcagct attgcaagga gtgggggccg cgggcagccg ctcttcagct cgcggcccag
     3661 gggagtggcg aggggcgccc caaccccctg cccgcctctc cgcacaatac ttgaacattc
     3721 atctgtactg aagtgttact tgaaccgggg gaatctcgga cctgggggag ccggggtgtg
     3781 aggggactgg accagcttgg actgagacct gagaccgggc cggtgggcgc ccatttggga
     3841 ctgcgccacc cccaggcttg ttcttgtttt actgtattga gcggcggcac ccgccggacc
     3901 cgcattatgg ctgggggcgc cagcccaaga atggggacca tgggactcct ccagcctggc
     3961 tcttcccact ctttcatcgt catggaaact tgtatcccat ttgcccaggg aactgccact
     4021 cctggttgcc atggaaatag cagccaacgg acacctcccg atgccagtgc taaggctgga
     4081 aatggccccc tcttagttgc catgggaacc tagtaacaga ctctgctggc cctccttccc
     4141 tgccccttcc tcgagcgcgg ggtggggctt cgggaccccg gggatgagcc gggccaggtc
     4201 ccgcccctcc gcgcaggcct ccggggggcc ggggcttacc atgtagggga ggggagatct
     4261 atccacatac ctcaggtaac agggaggtgc gcgggtgggg ggagggctgg gcggaccaaa
     4321 ggccggaggg gtggggcctg gggatagcga gaggcttgag aatggggccg cttgggggag
     4381 ggaagaggca gcccggcgag gggcaagcgg gggacccagc cgggctgggc ccctgggccc
     4441 cgggtctgta caatacggtt tgctataaaa ctcaaaatct tccagccggg
//
