LOCUS       NM_024963               8270 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 18 (FBXL18),
            transcript variant 2, mRNA.
ACCESSION   NM_024963
VERSION     NM_024963.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8270)
  AUTHORS   Ding X, Barodia SK, Ma L and Goldberg MS.
  TITLE     Fbxl18 targets LRRK2 for proteasomal degradation and attenuates
            cell toxicity
  JOURNAL   Neurobiol. Dis. 98, 122-136 (2017)
   PUBMED   27890708
  REMARK    GeneRIF: Study showed that LRRK2 phosphorylation is required for
            LRRK2 to bind to Fbxl18, and that this interaction is important for
            regulating the amount of LRRK2 via ubiquitination of LRRK2 by the
            SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation
            of LRRK2. We also show that LRRK2 can induce caspase 8 mediated
            cell death and that the degradation of LRRK2 mediated by Fbxl18 can
            prevent LRRK2-mediated toxicity.
REFERENCE   2  (bases 1 to 8270)
  AUTHORS   Zhang J, Yang Z, Ou J, Xia X, Zhi F and Cui J.
  TITLE     The F-box protein FBXL18 promotes glioma progression by promoting
            K63-linked ubiquitination of Akt
  JOURNAL   FEBS Lett. 591 (1), 145-154 (2017)
   PUBMED   27926990
  REMARK    GeneRIF: FBXL18 plays an oncogenic role through promoting lysine
            63-linked ubiquitination of Akt in glioma.
REFERENCE   3  (bases 1 to 8270)
  AUTHORS   Liu Y, Lear T, Zhao Y, Zhao J, Zou C, Chen BB and Mallampalli RK.
  TITLE     F-box protein Fbxl18 mediates polyubiquitylation and proteasomal
            degradation of the pro-apoptotic SCF subunit Fbxl7
  JOURNAL   Cell Death Dis 6, e1630 (2015)
   PUBMED   25654763
  REMARK    GeneRIF: Fbxl18 regulates apoptosis by mediating
            ubiquitin-dependent proteasomal degradation of the pro-apoptotic
            protein Fbxl7 that may impact cellular processes involved in cell
            cycle progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8270)
  AUTHORS   Ebstein F, Lange N, Urban S, Seifert U, Kruger E and Kloetzel PM.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int. J. Biochem. Cell Biol. 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   5  (bases 1 to 8270)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev. 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006483.3, DC307306.1,
            AK294949.1, AC092171.4, BC013435.1 and AA878073.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024963.5.
            
            Summary: The protein encoded by this gene is a member of a family
            of proteins that contain an approximately 40-amino acid F-box
            motif. This motif is important for interaction with SKP1 and for
            targeting some proteins for degradation. The encoded protein has
            been shown to control the cellular level of FBXL7, a protein that
            induces mitotic arrest, by targeting it for polyubiquitylation and
            proteasomal degradation. Members of the F-box protein family, such
            as FBXL18, are characterized by an approximately 40-amino acid
            F-box motif. F-box proteins interact with SKP1 through the F box,
            and they interact with ubiquitination targets through other protein
            interaction domains. [provided by RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1819318.1,
                                           SRR1163655.434799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382368.8/ ENSP00000371805.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC006483.3         186750-186760
            12-17               DC307306.1         1-6
            18-377              AK294949.1         1-360
            378-378             AC092171.4         81016-81016         c
            379-517             AK294949.1         362-500
            518-518             AC092171.4         80876-80876         c
            519-1265            AK294949.1         502-1248
            1266-1266           AC092171.4         80128-80128         c
            1267-1614           AK294949.1         1250-1597
            1615-1615           AC092171.4         79779-79779         c
            1616-2135           AK294949.1         1599-2118
            2136-2478           BC013435.1         727-1069
            2479-8074           AC092171.4         54983-60578         c
            8075-8270           AA878073.1         25-220              c
FEATURES             Location/Qualifiers
     source          1..8270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..8270
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /note="F-box and leucine rich repeat protein 18"
                     /db_xref="GeneID:80028"
                     /db_xref="HGNC:HGNC:21874"
                     /db_xref="MIM:609084"
     exon            1..153
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2292
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /note="isoform 2 is encoded by transcript variant 2;
                     F-box/LRR-repeat protein 18"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 18 isoform 2"
                     /protein_id="NP_079239.3"
                     /db_xref="CCDS:CCDS43546.1"
                     /db_xref="GeneID:80028"
                     /db_xref="HGNC:HGNC:21874"
                     /db_xref="MIM:609084"
                     /translation="MASSGEDISNDDDDMHPAAAGMADGVHLLGFSDEILLHILSHVP
                     STDLILNVRRTCRKLAALCLDKSLIHTVLLQKDYQASEDKVRQLVKEIGREIQQLSMA
                     GCYWLPGSTVEHVARCRSLVKVNLSGCHLTSLRLSKMLSALQHLRSLAIDVSPGFDAS
                     QLSSECKATLSRVRELKQTLFTPSYGVVPCCTSLEKLLLYFEILDRTREGAILSGQLM
                     VGQSNVPHYQNLRVFYARLAPGYINQEVVRLYLAVLSDRTPQNLHAFLISVPGSFAES
                     GATKNLLDSMARNVVLDALQLPKSWLNGSSLLQHMKFNNPFYFSFSRCTLSGGHLIQQ
                     VINGGKDLRSLASLNLSGCVHCLSPDSLLRKAEDDIDSSILETLVASCCNLRHLNLSA
                     AHHHSSEGLGRHLCQLLARLRHLRSLSLPVCSVADSAPRADRAPAQPAMHAVPRGFGK
                     KVRVGVQSCPSPFSGQACPQPSSVFWSLLKNLPFLEHLELIGSNFSSAMPRNEPAIRN
                     SLPPCSRAQSVGDSEVAAIGQLAFLRHLTLAQLPSVLTGSGLVNIGLQCQQLRSLSLA
                     NLGMMGKVVYMPALSDMLKHCKRLRDLRLEQPYFSANAQFFQALSQCPSLQRLCLVSR
                     SGTLQPDAVLAFMARCLQVVMCHLFTGESLATCKSLQQSLLRSFQAERPALNVVIFPL
                     LHEGLTDVIRDVPLVHLDEITLFKSRVAEEPPNLWW"
     exon            154..372
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1916
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2135
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..8270
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8243..8248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /note="hexamer: AATAAA"
     polyA_site      8270
                     /gene="FBXL18"
                     /gene_synonym="Fbl18"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgacg agagcccgct ccttgccggg gtctcggttg agcggtggac gcgccggctt
       61 cgagcatccc tagccgggca ggtgggaggc acggggttgc ggatcccgcg gccgcggttc
      121 ggacccgccg gcgacatggc cagctccgga gaggacatat ccaatgatga tgatgacatg
      181 caccctgcag cagccgggat ggcagacggg gtccacctcc tagggttctc tgatgagatc
      241 ctccttcaca tcctgagtca cgtccccagc acagatctga ttctgaacgt ccggcgtacc
      301 tgtcggaagc ttgcagccct gtgccttgac aagagcctca tccacaccgt gttgctgcaa
      361 aaggactatc aggcgagcga ggacaaagtg aggcagctgg tgaaggagat cggccgggag
      421 atccagcagc tgagcatggc tggctgctac tggctgcctg gctccaccgt ggaacacgtg
      481 gcccgctgcc gcagcctggt gaaggtgaac ctctcgggct gccacctcac ttccctgcgc
      541 ctctccaaga tgctctcggc cctgcagcac ctgcgctcgc tggccatcga cgtgagcccc
      601 ggcttcgacg ccagccagct gagcagcgag tgcaaggcca ccctgagccg cgtgcgggag
      661 ctcaagcaga cgctgttcac tccctcctac ggcgtggtgc cctgctgcac cagcctagag
      721 aagctgctgc tctacttcga gattctggac cgcacgcgcg agggcgccat cctctcgggc
      781 cagcttatgg tgggccagag caacgtgccg cactaccaga acctgcgggt cttctatgcg
      841 cgcctggccc ccggctacat caaccaggag gtggtgcggc tctacctggc tgtgcttagc
      901 gaccgcactc ctcagaacct ccacgccttc ctcatctccg tccctggcag cttcgcggag
      961 agcggcgcca ccaagaacct cctggactcc atggcgcgca atgtcgtgct ggatgccctg
     1021 cagctgccca agtcctggct gaacggctct tccctcctgc agcacatgaa attcaacaac
     1081 ccgttctact tcagtttcag ccgctgtacc ctgtcaggcg gccatctgat ccagcaggtc
     1141 atcaacggcg ggaaggacct gcggagcctg gccagcttga acctcagcgg ctgcgtccac
     1201 tgcctgtccc cagactcgct gctccgcaag gcggaggacg acatcgacag cagcatcctg
     1261 gagactctgg tggcgtcctg ctgcaacctg cgccacctga acctctcggc cgcccaccac
     1321 cacagctcgg agggcctggg ccgccacctc tgccagctcc tggcccggct gcgtcacctg
     1381 cgctccctct ccctgcctgt ctgctctgtc gctgactccg cgccgcgcgc cgaccgcgcg
     1441 cccgcccagc cggccatgca cgcagtgccg cgcggctttg gcaagaaagt gcgtgtgggc
     1501 gtgcagtcct gtcccagccc cttctcgggc caggcgtgcc cccagccctc ctccgtgttc
     1561 tggtctctgc tgaagaacct gcccttcctg gaacacctcg agctgattgg gtccaacttc
     1621 tcctccgcca tgccccgcaa cgagcccgcc atccgcaact cgctcccacc ctgcagccgc
     1681 gcacagagtg tcggggactc ggaggtggcc gccatcggcc agctggcctt cctgcggcac
     1741 ctgacgctcg cacagctgcc cagcgtcctt acgggctccg ggctggtcaa tatcggcctg
     1801 cagtgccagc agttgcggtc cctgtcgctg gccaacctgg gcatgatggg gaaggtggtg
     1861 tacatgcccg cgctctcaga catgttgaag cactgcaagc ggctgaggga cctcaggctg
     1921 gagcagccct acttcagcgc caacgcccag ttcttccagg cgctgagcca gtgcccctcg
     1981 ctgcagcgcc tgtgcctggt ctctcgcagc ggcaccctcc agcccgatgc cgtgctggcc
     2041 ttcatggctc gctgcctgca ggttgtcatg tgccacctgt tcaccgggga gtccctcgcc
     2101 acctgcaaga gcctgcagca gtcgcttctc cgcagcttcc aggccgagcg gcccgcgtta
     2161 aacgtcgtca tcttccctct gctccacgag ggcctgaccg acgtcatccg ggacgtcccc
     2221 ctggtgcacc tggatgagat caccttattt aagagcagag tggccgagga accgccgaac
     2281 ctgtggtggt gagaggcgga gccgccgccc atcggtctca gtcacctcga gaagctgcag
     2341 gagcctggga cgccagggac ccttggtttg tcacaagagg aagggggcct ctctcccggc
     2401 cagccacgcc ccacctggct cctggggctc ccggcgtctc cacggctctc tcatggggac
     2461 tgttgctctg tgaagtttag gtcgagggga tgcgttctgg gtgacatgag ggggctcggg
     2521 ggacggtcga tgtggggggc tggctgaacc aggctgaccc ttggggcctg gctggggggt
     2581 ttgtatactg agccgcaatc cctgggggcc ctgtccacgg gcctggaggg cccgaacccc
     2641 ctgccacttc cgaccgggaa gcgtgtccct tggctgttgt gtttgtggtc acctgccacc
     2701 ggggccccgt ggatgggcgg ccacatgctg tccccctgaa gtccagtcgg ccgggctggt
     2761 caccgtgtat ctgagtgtcc ccttgcatgg tcaagtgtga catggggaag ggcctgccag
     2821 tttagtggct gcagacttgg gactctccat cccattagga cacacttgag cccactcatg
     2881 tctctggggc ttttctagcc agatgatgcc tgtggcccca gagaggtccc ctgaggttgg
     2941 gactgctggt tggagcctct cctgtgactt ttcagcccaa ccagcagggc ccgtttctaa
     3001 cgagagaggc ctcctccccc tcccacccac cccacggcct tcagcttccc tgggaaggtc
     3061 catgcgcgtt cctggggaaa tcgatacaca ttcggctttg ttagaataac gcgaaacatt
     3121 aaaacccaga aaggattctt aaggctggag tagcaatcac atgaccccat ttcaaatgac
     3181 ttcatttaag actttaaaaa tactcagctg ggcgcgatgg ctcacgcctg taatcccggc
     3241 actttgggag gctgaggtgg gtggatcacg aggtcaggag ttcaagacca gcctggccaa
     3301 catggtgaaa ccccatctct actaaaaata caaaaattag ctgggcgtgg tggcgggcgc
     3361 ctgtaatcct agctactcag gaggctgagg caggagaatc gtttgaacct gggaggcgga
     3421 ggttgcagtg agccgagatc acaccattgc actccagcct ggacaacagg gtgagactcc
     3481 gcctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaata tatatatata tatatatatt
     3541 caacacactt tgggaggatc acttgagccc aggagtttga gatcagcctg ggcaacacag
     3601 ggatacccca tctctgaaaa agaaagagaa aaaaacaaag ttattccaaa aatgaggaca
     3661 tcctcctggc atctgagtcc tcaccccatg tgccacggtg gccgcttctg ccgtcctcca
     3721 cctccaggcg ctcctagagc tgtccctggg ccagtggctt ccaaaggggg ctgtagttgg
     3781 gccctgctag cctggaccgc cgccctggcc gctcttggtg aagggcccct tgtccagccc
     3841 gccttcctcc tcctgggttt ccgtgtgaca gatgccccgt cctgtggggt ggtgtctcac
     3901 atttgctttg ctgttaaaaa atggggtaca ccatccccag gcctccaatc accggccctg
     3961 cccctgagtg gggatggttt tcagcagctc cttgctctgg gggccaagct ccttgtccag
     4021 gaggcctttg gagaactggg gtcagagctg tggggaggta cagccctcct gtgcaggctg
     4081 cctcccagct ctccacctgg cagtcttgac cccaccctgg cgcctctgct cactggcaca
     4141 ggtggatctg gggtttgagg tctcctccca cttcaccctg actttcttgt atgtatgggg
     4201 tcatcgcctc ctctctgaag cccacgggtc ctctcccagc cccaggctgc acccagtgca
     4261 gaacctttgc ctcctggcca gagggaccct tctgcaggct gattccagca gtgcccgatg
     4321 gtgggaccca caccagacca agccttcgcc tcccagaggc ctcctggccc tcctgtcatg
     4381 gcctgtgaga gccacacccc taggccccgt ctcctagtct gcaggccgca ggaccagctg
     4441 cccacggccc cagggggcag gggctgtaga tgagggtctc agaggtggtg ggagcacccc
     4501 ccccacccac agttcctggg catttcttta gagctttaaa atggcacctg gagaccacca
     4561 ggcgcggcga tcagatcggg tggtgtggtg cctcctggga ctgaccactt cttgctctcc
     4621 gaccaggcag gggcgagtgg cctgggaggt tcccggaccc tcagggggcc tgtgtctctg
     4681 ggcaccgcag ctccgcccca ctccttcctc cagaacattc cccactcggg ctagagaatt
     4741 gcgtctgctc caggaatgca tcctagcgtg tgtacgatcg cgcctgggtg tcctgttctc
     4801 atgagcaagc ggttttaacc agcagcataa tttatactca tagacaggac tgggggaagg
     4861 gctgttcctg aggctggggt gcagtgcctt ggaaagcacc cctgaaacag tggaccttgt
     4921 atttttagtg tcccctgcaa ccatcctctg acttagagca agaatttccg ctgctgctac
     4981 ccccgagatg ggcttcacca gatgttaata acgtgcttat tttctctaag tgctattttg
     5041 gcaccagcgt tagttgcaat ttatattctg cagcatttga tgctgggaaa agaacccacc
     5101 ctaatggtcc ccaattggca gagctcggct gttaagcagc agaccatatg ctgcctgctg
     5161 gaggagcgtg gtcagcactt gtccccgtgc ctgcgtgcgt gtgcctgcgt gcacgtgtgc
     5221 ctgcgggtac ctgtgccctg tgtgtgcaca tgtgcctgca tgcgtgtgcc tgcgtgcacg
     5281 tgtgcctgtg tgtacatgtg cctgcgtgta cctgtgccct gtgtgtgcac gtgtgccttc
     5341 gtgtacctgt gccctgtgtg tgcatgtgtg tgtgagtcac gtcttccgtg tgtgtatgtg
     5401 agggagagac tgtggggttg gagggaggga ggaggggaaa gggtatgtat ccctttgttc
     5461 tttaaaaggg agagccccaa cctctctggc tgccccctcc tgcctgtgct cccagctcac
     5521 cccacaccta gctgctattt attctcctga cccccttccc ggccctgcag ccccgtgtcc
     5581 cgcagcctcc gccccgcctc ctgctccacg tcaccaggca acactcggct ccaccaggct
     5641 tccgaaggtg gcccagagca ggcacttgag cctgatgacc cagagcaaag ctgcctttct
     5701 gggccttgag tactcctttc tgctatggaa ggcttttctt gttttcaacg gcccgtccag
     5761 cccagggggg ctgggtgagg gccgcttcct tctgcagcag agggggcggg ctctatcctt
     5821 gccatctgct gcccccagag gccctgccag gacatgggcc tgagcggttt cttctccaag
     5881 aggccctcct gggacctgtc tgtgcacagg gcgggaagac acttgctgct tcgacccagg
     5941 acggcagcca ggacgggctg agctcctctt gcgctgcaaa cacacaaggg ttgcctgcca
     6001 gctcagcagc gccctccctc aaccacaccc tgggtccgga cccagagcca caggccgttg
     6061 gacccagggg accggggctg ggctcaggcg tgggcctgga gggcttgtgg aggggccaga
     6121 cctagagccg tagggctcca acagctgagg gctgggcccc tgccggccaa tgaagctcca
     6181 gaccagtgct ccggccttgg cggtgccagc agtgctcctg cagggatgga gggtgctgga
     6241 ggcctggatg cggggacctt gatcccccag caggcagcgc tgtggcagcc tcccacctcc
     6301 tcttcccctg ttatctgctc cttttaggat ctgaaaatta cagagccttt tttttttttt
     6361 tgagagggag tcttgctttg tcccccaggc tggagtgcag tggcacgatc tcagctcact
     6421 cactacaacc tccacctcac aggttcaagc gattctccca catcagcctc ctgagtagct
     6481 gggattacag gcacctgcca tcatgaccgg ctaatttttg tatttttgca gagatggggt
     6541 tgcaccatgt tggtcaggct ggccttgaac tcctgacctc aagtgattct cctgcctcgg
     6601 cctcccaaag tgctaggata acaggtgtga gccaccgtgc ctggcgcatt acagagctct
     6661 tgtaagaaaa cgtgtgaaat tcatggacaa agtgaggtga tgaagtgtgg ggccactaaa
     6721 ccaaaggcag aggagacgtc ggccacttcc tgtggacgtg ggcagagcgc tgctgccagt
     6781 tcctggtagc cttgaccacg acgctggggg gtctttgtga tggtcatggg tctcatttgc
     6841 acttgggggt gtgggattca agttagaagt ttctagatct ggccgggcgc agtggctcac
     6901 gcctgtaatc ccagcacttt aggaggctga ggcaggcgga tcatgaggtc aggagatcga
     6961 gaccgtcctg gctaacacag tgaaaccccg tctctactaa aaatacaaaa aagtagtcgg
     7021 gtgtggtggc gggcgcctgt ggtcccagcc actcaggagg ctgaggcagg agaatggcat
     7081 gaacctggga ggcggagctt gcagtgagct gagatcgcac cactgcattc cagcctgggc
     7141 gacagagtga gactccgtct caaaaaaaaa aaaaacaaaa gaagtttcta gatctactgg
     7201 gcatgatgaa cacaaacccc acagacactg aggaacccag tggtggcagt gactcgggct
     7261 cctctgctct ctaaagctcc tttgagaaac atgggagggg ccgggcgtgg tggttcacgc
     7321 ctgtcatccc agcactttgg gaggctgggg caggaggatc gcttgagccc aggagttcga
     7381 gaccagcctg ggcaacatag tgagactgta tcgctacata aaataaaaaa aaaagttagc
     7441 tgggcattgt acatgtgcct gtggtcccag ctactcagga ggctgaggca ggaggattgc
     7501 ttgagcccag gagttggatg ttgcagtgag ccaagatcgc accattgccc tccactctgg
     7561 gccacggagc aataccctgt ctcagaaaac aaacaacaaa aagcagaaac gctgaagggg
     7621 tcggtttacg ggaaaaccgc ctgtcagaac acttggctac tcctacccca gatcagtgga
     7681 cctgggaatg agggttggtc ccgggaggct tttctccaag ctgttgccac cagacccgcc
     7741 atgggaaccc tggccacaga agcctcccgg ggagtgagcc agagcctgga ccgctgtgct
     7801 gatgtgtctg gggtggaggg agggtgggga gtgtgcaagg gtgtgtgtgt gcccgggggg
     7861 tgttcatggg caagcatgtg cgtgcctgtg tgtgtgcgtg cccctcccct gcagccgtcg
     7921 gtggtatctc cctccagccc cttcgccacc ttctgagcat tgtctgtcca cgtgagactg
     7981 cccagagaca gcagagctcc acgtggtttt aaggggagac ctttccctgg acctgggggt
     8041 ctcgccgtat ctcatgacca ggtgctaaat gacacgacat gcatcacctg cctttcgatg
     8101 accaacctcc ctgtccccgt cccgctgacc tgcccccgtg gcgtctcacg gtgatgcctg
     8161 ctcctgacat tggtgttcac tgtagcaaac tacattctgg atgggaattt tcatgtacat
     8221 gtgtggcatg tggaaaattt caaataaaat ggacttgatt tagaaagcca
//
