LOCUS       NM_001163315            5198 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 17 (FBXL17),
            mRNA.
ACCESSION   NM_001163315
VERSION     NM_001163315.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5198)
  AUTHORS   Kang,H.M., Kim,D.H., Kim,M., Min,Y., Jeong,B., Noh,K.H., Lee,D.Y.,
            Cho,H.S., Kim,N.S., Jung,C.R. and Lim,J.H.
  TITLE     FBXL17/spastin axis as a novel therapeutic target of hereditary
            spastic paraplegia
  JOURNAL   Cell Biosci 12 (1), 110 (2022)
   PUBMED   35869491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5198)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5198)
  AUTHORS   Mena,E.L., Jevtic,P., Greber,B.J., Gee,C.L., Lew,B.G., Akopian,D.,
            Nogales,E., Kuriyan,J. and Rape,M.
  TITLE     Structural basis for dimerization quality control
  JOURNAL   Nature 586 (7829), 452-456 (2020)
   PUBMED   32814905
  REMARK    GeneRIF: Structural basis for dimerization quality control.
REFERENCE   4  (bases 1 to 5198)
  AUTHORS   Mason,B., Flach,S., Teixeira,F.R., Manzano Garcia,R., Rueda,O.M.,
            Abraham,J.E., Caldas,C., Edwards,P.A.W. and Laman,H.
  TITLE     Fbxl17 is rearranged in breast cancer and loss of its activity
            leads to increased global O-GlcNAcylation
  JOURNAL   Cell Mol Life Sci 77 (13), 2605-2620 (2020)
   PUBMED   31560077
  REMARK    GeneRIF: Rearrangements of Fbxl17 in breast cancer affect its
            ability to bind substrates and to assemble as part of a functional
            SCF ubiquitin ligase complex.
REFERENCE   5  (bases 1 to 5198)
  AUTHORS   Mena,E.L., Kjolby,R.A.S., Saxton,R.A., Werner,A., Lew,B.G.,
            Boyle,J.M., Harland,R. and Rape,M.
  TITLE     Dimerization quality control ensures neuronal development and
            survival
  JOURNAL   Science 362 (6411) (2018)
   PUBMED   30190310
REFERENCE   6  (bases 1 to 5198)
  AUTHORS   Candille,S.I., Absher,D.M., Beleza,S., Bauchet,M., McEvoy,B.,
            Garrison,N.A., Li,J.Z., Myers,R.M., Barsh,G.S., Tang,H. and
            Shriver,M.D.
  TITLE     Genome-wide association studies of quantitatively measured skin,
            hair, and eye pigmentation in four European populations
  JOURNAL   PLoS One 7 (10), e48294 (2012)
   PUBMED   23118974
REFERENCE   7  (bases 1 to 5198)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   8  (bases 1 to 5198)
  AUTHORS   Ichikawa,S., Koller,D.L., Padgett,L.R., Lai,D., Hui,S.L.,
            Peacock,M., Foroud,T. and Econs,M.J.
  TITLE     Replication of previous genome-wide association studies of bone
            mineral density in premenopausal American women
  JOURNAL   J Bone Miner Res 25 (8), 1821-1829 (2010)
   PUBMED   20200978
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5198)
  AUTHORS   Xiao,G.G., Zhou,B.S., Somlo,G., Portnow,J., Juhasz,A., Un,F.,
            Chew,H., Gandara,D. and Yen,Y.
  TITLE     Identification of F-box/LLR-repeated protein 17 as potential useful
            biomarker for breast cancer therapy
  JOURNAL   Cancer Genomics Proteomics 5 (3-4), 151-160 (2008)
   PUBMED   18820369
  REMARK    GeneRIF: F-box protein 17 (FBXL17) can serve as a therapeutic
            target and surrogate marker for breast cancer therapy.
            Erratum:[Cancer Genomics Proteomics. 2010 May-Jun;7(3):171]
REFERENCE   10 (bases 1 to 5198)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008462.6, AC092274.2, AC008513.7 and AC011419.7.
            
            On Jul 18, 2019 this sequence version replaced NM_001163315.2.
            
            Summary: Members of the F-box protein family, such as FBXL17, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3929799.1,
                                           SRR14038191.2795187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542267.7/ ENSP00000437464.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1400              AC008462.6         57688-59087         c
            1401-1523           AC008462.6         44820-44942         c
            1524-1781           AC008462.6         41727-41984         c
            1782-1913           AC008462.6         25388-25519         c
            1914-2021           AC092274.2         113724-113831
            2022-2152           AC008513.7         11056-11186
            2153-2229           AC008513.7         176302-176378
            2230-2372           AC011419.7         91687-91829
            2373-5198           AC011419.7         111006-113831
FEATURES             Location/Qualifiers
     source          1..5198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.3"
     gene            1..5198
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /note="F-box and leucine rich repeat protein 17"
                     /db_xref="GeneID:64839"
                     /db_xref="HGNC:HGNC:13615"
                     /db_xref="MIM:609083"
     exon            1..1400
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..2513
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /note="F-box only protein 13"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 17"
                     /protein_id="NP_001156787.2"
                     /db_xref="CCDS:CCDS54886.1"
                     /db_xref="GeneID:64839"
                     /db_xref="HGNC:HGNC:13615"
                     /db_xref="MIM:609083"
                     /translation="MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQ
                     PAAPRSRDCFFRGPCMLCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLAR
                     RYAALAAEDCAAAARRFLLSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLF
                     LASLGPVRFLGPPAAVQLFRGPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGG
                     GCGGGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGG
                     DAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDINQLPPSILLKIFS
                     NLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEIN
                     ISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDK
                     LTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSV
                     KAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCK
                     NLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDV
                     GWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKR
                     TLERAYQMGWTPNMSAASS"
     exon            1401..1523
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1781
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1913
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2021
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2152
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2229
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2372
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..5198
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5057..5062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /note="hexamer: AATATA"
     polyA_site      5078
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
     regulatory      5181..5186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /note="hexamer: AATAAA"
     polyA_site      5198
                     /gene="FBXL17"
                     /gene_synonym="Fbl17; Fbx13; FBXO13"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgcgg gtgcgcgcgc cggcggcgga tccgcagtta aaatggtccg agcgggaccc
       61 ggcctttccc cggccgctcc gctgactgac tgagccggct ggccgggccc ggactggtcg
      121 cctagccggc aggctcgctc gctccctccc tcgcgtcccc aaagctcgcg cccatcgttc
      181 tcccggcttc cctgggcaaa gcatgtagcc cccgtcgggc actccggcgg cccgcagctg
      241 acgcccaccc cccaccgtcg cgtgtgtgcc cgtgtgtgcg tgtgtgtgcg caggaagggc
      301 gacccctccg ggggccgagc cagcgagcgg cctgccccgc tgccgggagc ccgcctctct
      361 gggtctccct ccctcccgtc ccggtccccc tcctcggggc cttctatatg ggccaccttc
      421 tctcgaagga gccgcgtaac cgcccgagcc agaagaggcc tcgctgttgc agttggtgcc
      481 gccgccggcg ccctctcctc aggctgcccc gccggacccc agccaaggtg ccccctcagc
      541 cggcggcgcc ccggagccgg gactgcttct tccgcgggcc ctgcatgctc tgcttcatcg
      601 tgcacagtcc cggcgcgccc gcccccgccg gcccagagga ggagccgccg ctctcgccgc
      661 cgccgcggga cggggcctac gctgccgcct cctcctctca gcacctggcg cggcgctacg
      721 cggccctggc cgccgaggac tgcgccgctg ctgcccgccg cttcctgcta tcctcggccg
      781 ccgccgccgc cgccgctgcc gcctcggctt cgtcgcccgc ctcctgctgc aaagagttgg
      841 ggctggctgc ggccgccgcc tgggagcagc agggccgaag tctcttcctg gccagcttgg
      901 ggccggtgcg cttcctgggg ccgcccgccg ccgtgcagct cttccggggg ccgacaccgt
      961 caccggccga gctccctacg ccccccgaaa tggtgtgcaa gcggaagggg gccggggtcc
     1021 ccgcctgcac cccctgcaag cagccccgct gcggcggcgg gggctgcggc ggcggcggcg
     1081 gcggcggtgg cgggggaggg cctgcggggg gaggcgcttc gccgccccgg ccccccgacg
     1141 ccggctgctg ccaggccccg gagcagcccc cgcagccgct ctgccctccg ccctcttctc
     1201 ccacctccga aggtgccccc accgaagctg gcggggacgc tgtccgagcc gggggcaccg
     1261 cccccttgtc cgcccagcag cagcatgaat gtggcgacgc ggactgtcgg gagtcccccg
     1321 aaaacccctg cgactgtcac agggagccgc cccccgaaac cccagacatc aaccagctgc
     1381 cgccgtccat cctgctcaag atattttcca atttgtcact ggatgagcgt tgcctttccg
     1441 catcattggt ttgcaagtac tggcgtgacc tttgtttaga cttccagttt tggaagcagc
     1501 tggatcttag tagtcgtcag caggtcactg atgaattgtt ggaaaaaatt gcatcaagaa
     1561 gtcagaatat aattgaaatc aacatttctg attgtcgcag tatgtctgat aatggcgtat
     1621 gtgttttagc atttaaatgt cctggacttc ttaggtatac agcctacagg tgtaaacagc
     1681 tttctgacac ctctattatt gcggttgcct ctcactgtcc tttacttcag aaagtgcatg
     1741 taggcaacca ggacaaactc actgatgaag gactcaagca gctgggctca aaatgcagag
     1801 aactcaaaga tattcatttc ggccagtgtt acaagatctc agatgaaggc atgatcgtca
     1861 tagctaaggg ctgtctgaaa ttacaaagga tatacatgca ggaaaacaaa ttagtgacag
     1921 atcagtcagt gaaagcattt gctgaacact gtcctgagct tcaatatgta ggcttcatgg
     1981 gttgttcagt cacttctaaa ggagtcattc acctaaccaa gctaagaaac ctttccagct
     2041 tggacctacg tcatatcact gaactggata atgaaaccgt gatggaaatt gtcaagaggt
     2101 gcaaaaatct tagctctctc aatctctgtc tgaactggat cataaatgac aggtgtgtgg
     2161 aggtcattgc aaaggaagga caaaacctga aagagctata tttggtgtcc tgtaaaatca
     2221 cagattatgc actgatagcc attgggcgat acagcatgac aatagagact gtggatgtcg
     2281 gatggtgtaa agaaatcaca gaccaaggag ccaccctgat tgcacagagc agcaagtctc
     2341 tgagatattt ggggctgatg agatgtgata aagtcaacga agtgacggtg gaacagctgg
     2401 tgcagcagta cccccacatc accttcagca ccgtcctgca ggactgcaag aggaccttgg
     2461 agagagccta tcagatgggc tggaccccca acatgtctgc cgcctcctcc tagcgctcct
     2521 gcctcgccta gtccactggg atcattcagc agagcagagg agaattgtac atttggggag
     2581 ctgatctctc ggaagggttt taactgtcac ctgtctgtgt gtgttcaagt atgtgtattt
     2641 gtgtcttgtt tgcatactgc ataccaaaag tgcagttgtc atttgttccc aagtgagctg
     2701 gctttttttc ttagaaatta aagattatga aagccacaaa ctttttagtt tttaacttca
     2761 aaggcttctt tctctttaaa aaaaaattat ttttaatata gagtcaaaaa attggatgta
     2821 ttattttgag cttctaattg ctgccacttg gagatgtcca agtaagaagg ccttcttttt
     2881 acatgggatg aattgtgcac ttctactgat gatgactaca gcagaagtga tgttatacgt
     2941 acaggcactt acactctctc acatattcac acgtgtgcac atctacacca gggctctgat
     3001 ctactctaga tcgtttcctg acagagaagc cttcttccag gccactaagg tagcatgtta
     3061 tccactgtgg cactgcctaa ctccgtgtat cctcgggtgg ccaacttgct atctggtggg
     3121 tgacttgggg actagaaaga ataaagcctt ttctaaattt gttatataga ggcaacagtc
     3181 tgaactctcc tggccagctc acgaaagtta attatacatt attctacaaa tgcattctgt
     3241 tgagcactaa atattttagt tggttttatg ttaacattgt gttagctttt atttcctgga
     3301 tagtaactgg tcaggatata ttttaatgat atttgaaact aatcttagca ttgaagccac
     3361 caatgtaatt aatggtgtgc agttatttta aaaactacag atcatttcat tattttctta
     3421 attttggtaa ttattaaagt ctatttctga gatacgagag ggtagtcaca ttaatagaag
     3481 attcatgagt gagatataag tagacaatct ttctactgtt gttgctcttt ttgctttgct
     3541 ttgggttctt gaacaggttt tttggatata tgcatgttgt cattttggac tagttctcat
     3601 gctactgcaa agatctattg ctagctaata tatgagttaa gaaagaaaat tagaaaatct
     3661 gttcattgaa attctgttta cacttgtcag aaataagcat ttctttgttt aattaaggat
     3721 tgccagcttc agttaagaca agacctatca gtaaatgaat atatgttttg atttaacaca
     3781 tctttacaat taattcataa tagggactca ggctcaaata actgttcctg tgtctagatt
     3841 tataatgagg acatcaggga gcctttttaa gctaaagagt gattatcttt cacagtagaa
     3901 ctagaaacaa aaccctaact tgtgaagttg ctatttattt ttccctgagt gaatataact
     3961 gttatttggt ctttaacaga tatactgagg tttgagtttc actttcttta agtctcacat
     4021 tgctaacatg acattagctg taagaaacaa gatagcttta catttgaatg ccatttactg
     4081 atttctaatg attctctttt tttgtaaaca actgtttcct ttgattatgt caacatgttt
     4141 ctgatgtggc atttttgttt taatcccaat cggttaggaa aatctagtca gtaagcgcca
     4201 tgagtattct tcccataact aaatgggttt ctaatttaat ttgaagggaa taaaatttgt
     4261 gtaagaaaaa agctgtttaa cattaataaa ctatatttct tcttacacat tgaactgtat
     4321 cattttcata tccacttccc caccactgaa atatcttatt tcacaatatt ttaactgatt
     4381 tttaatccaa aactaattta taagacagta tgtatagtaa tagtagcttg agtgaatatg
     4441 caaaagttta atttttatat atgtcatact atattttaaa tagttaaaaa agacaaaaga
     4501 agggagagcc atctatgata tagatggtac catttcagtt caaagttgta ataacctttg
     4561 gagtgttaca gtttggttgt caaatggttt cagaatgtat aattgatttt tttaaatgtt
     4621 gcattgtttg aatctaaagt acagcactat aacatgcttt agcttggggg ggtgggggtg
     4681 gggtggggac ttgcacttat tctctaaaat gttgactaat ccagaaagcc tgatgcaaca
     4741 taatctggaa aactgctttg gtacatttgt agaaatccgt agaaatacca tatccagcct
     4801 caaagcatta atctcaaaaa aaaaaaaaaa aaaaaaaaaa aacagccaga aaaaagcatc
     4861 accttgagtg gtcctgtgat ggttgttgaa tgtgttctca ttagatgctt tgaaatgagg
     4921 cttaaaataa tttttctggg caatatagag tttctttttt ttgcttagaa tgtcataaat
     4981 acatgtgaac acgtttaatg cagggctttt tattctctcc aaaatgtcaa cagtattttc
     5041 agaataaaga ctatgaaata tattgctgta gtggaaaatt ctggtccttt gtctttaatg
     5101 tctttttgag tggataaaga aaattcaccc ggtttgtagt ttctatattt ccgtgaatct
     5161 ttgaccttgc agtgggttgc aataaaagag aaacaaaa
//
