LOCUS       NM_153350               3519 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 16 (FBXL16),
            mRNA.
ACCESSION   NM_153350
VERSION     NM_153350.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3519)
  AUTHORS   Yao,L.P., Wang,Z.K., Jiang,X.Q., Jiang,B., Chen,S.J., Hua,Z.D.,
            Gao,D.D., Zheng,Q., Zhu,S.M., Qian,M.X., Zhang,F., Xu,L.F.,
            Chen,C.S. and Lu,F.
  TITLE     MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate
            chronic obstructive pulmonary disease through regulating
            FBXL16/HIF1alpha axis
  JOURNAL   Respir Res 25 (1), 376 (2024)
   PUBMED   39420370
  REMARK    GeneRIF: MiR-1307-5p enhances fibroblast transdifferentiation to
            exacerbate chronic obstructive pulmonary disease through regulating
            FBXL16/HIF1alpha axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3519)
  AUTHORS   Liu,H., Han,L., Zhong,L., Zhuang,X. and Peng,Y.
  TITLE     FBXL16 Promotes Endometrial Progesterone Resistance via
            PP2AB55alpha /Cyclin D1 Axis in Ishikawa
  JOURNAL   J Immunol Res 2022, 7372202 (2022)
   PUBMED   36106050
  REMARK    GeneRIF: FBXL16 Promotes Endometrial Progesterone Resistance via
            PP2A(B55alpha) /Cyclin D1 Axis in Ishikawa.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3519)
  AUTHORS   Kim,Y.J., Zhao,Y., Myung,J.K., Yi,J.M., Kim,M.J. and Lee,S.J.
  TITLE     Suppression of breast cancer progression by FBXL16 via
            oxygen-independent regulation of HIF1alpha stability
  JOURNAL   Cell Rep 37 (8), 109996 (2021)
   PUBMED   34818544
  REMARK    GeneRIF: Suppression of breast cancer progression by FBXL16 via
            oxygen-independent regulation of HIF1alpha stability.
REFERENCE   4  (bases 1 to 3519)
  AUTHORS   Yang,M. and Jing,F.
  TITLE     FBXL16 modulates the proliferation and autophagy in breast cancer
            cells via activating SRC-3-AKT signaling pathway
  JOURNAL   Reprod Biol 21 (3), 100538 (2021)
   PUBMED   34333223
  REMARK    GeneRIF: FBXL16 modulates the proliferation and autophagy in breast
            cancer cells via activating SRC-3-AKT signaling pathway.
REFERENCE   5  (bases 1 to 3519)
  AUTHORS   Morel,M., Shah,K.N. and Long,W.
  TITLE     The F-box protein FBXL16 up-regulates the stability of C-MYC
            oncoprotein by antagonizing the activity of the F-box protein FBW7
  JOURNAL   J Biol Chem 295 (23), 7970-7980 (2020)
   PUBMED   32345600
  REMARK    GeneRIF: The F-box protein FBXL16 up-regulates the stability of
            C-MYC oncoprotein by antagonizing the activity of the F-box protein
            FBW7.
REFERENCE   6  (bases 1 to 3519)
  AUTHORS   Sato,K., Kusama,Y., Tategu,M. and Yoshida,K.
  TITLE     FBXL16 is a novel E2F1-regulated gene commonly upregulated in
            p16INK4A- and p14ARF-silenced HeLa cells
  JOURNAL   Int J Oncol 36 (2), 479-490 (2010)
   PUBMED   20043084
  REMARK    GeneRIF: the expression of FBXL16 reproducibly upregulated in
            p16INK4A and p14ARF knockdown HeLa cells
REFERENCE   7  (bases 1 to 3519)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 3519)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   9  (bases 1 to 3519)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 3519)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z97653.14 and Z92544.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153350.3.
            
            Summary: Members of the F-box protein family, such as FBXL16, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC036680.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397621.6/ ENSP00000380746.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               Z97653.14          12120-12409         c
            291-937             Z97653.14          3381-4027           c
            938-1446            Z97653.14          2023-2531           c
            1447-1531           Z97653.14          1600-1684           c
            1532-1595           Z97653.14          1242-1305           c
            1596-2526           Z97653.14          101-1031            c
            2527-3519           Z92544.1           1-993
FEATURES             Location/Qualifiers
     source          1..3519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3519
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /note="F-box and leucine rich repeat protein 16"
                     /db_xref="GeneID:146330"
                     /db_xref="HGNC:HGNC:14150"
                     /db_xref="MIM:609082"
     exon            1..290
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /inference="alignment:Splign:2.1.0"
     exon            291..937
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1744
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 16"
                     /protein_id="NP_699181.2"
                     /db_xref="CCDS:CCDS10421.1"
                     /db_xref="GeneID:146330"
                     /db_xref="HGNC:HGNC:14150"
                     /db_xref="MIM:609082"
                     /translation="MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPATKN
                     RPCQPPPPPTLPPPSLAAPLSRAALAGGPCTPAGGPASALAPGHPAERPPLATDEKIL
                     NGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNL
                     QGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQ
                     GVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQ
                     AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVT
                     DDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSY
                     LSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRLLSLAGCPLLTTTGLSGLVQLQELE
                     ELELTNCPGATPELFKYFSQHLPRCLVIE"
     exon            938..1446
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1531
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1595
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..3519
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3493
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /note="major polyA site"
     regulatory      3499..3504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /note="hexamer: ATTAAA"
     polyA_site      3519
                     /gene="FBXL16"
                     /gene_synonym="C16orf22; c380A1.1; Fbl16"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggcgc ccgcctggtt ccctgcaaag cggccttatt tatctgggca cagcctcagc
       61 ctccccggtg ggaggcttgg ggcggccgat cctctcccac cggggagctc ctttccgtgc
      121 gctgccgagg gggcccggcc aggacgggac gcggggcgca gggcgcggcc gggccctgcc
      181 ggccagtcca gcaccccggc ggcccccgcg cgccgacgcc catgccgggc tccccatgac
      241 gggaggtcgc ccggcggaca gcgtggcatg agccaggagc ccgggccgag agcgtgccag
      301 gaagatgtcg agcccgggca tcgacggcga ccccaagcct ccatgcttgc ctcgaaacgg
      361 tctggtgaag ctgccgggcc agcccaacgg cctgggtgcg gccagcatca ccaagggcac
      421 gccagccacc aagaaccgcc cctgccagcc accaccccca cccaccctcc caccacccag
      481 cctggctgct ccactgtccc gggctgccct ggctgggggc ccgtgcaccc cggcaggtgg
      541 accagcctca gccttggcac ctgggcaccc agcggagcgg ccgccgctgg ccacggacga
      601 gaagatcctc aatgggctct tctggtattt ctcggcctgc gagaagtgtg tgctggccca
      661 ggtgtgcaag gcctggcggc gcgtgctgta ccagcccaag ttctgggcag gcctcacgcc
      721 ggtgctgcat gccaaggagc tctacaacgt gctgcctggt ggcgagaagg agttcgtgaa
      781 cctgcagggt tttgccgcca gaggcttcga gggcttctgc ctggttggcg tctccgacct
      841 ggacatctgt gagttcattg acaactatgc gctctccaag aagggtgtca aagccatgag
      901 cctcaagcgc tccaccatca cggacgcagg cctcgaggtt atgcttgaac agatgcaggg
      961 cgtggtgcgt ctggagctgt cgggctgcaa cgacttcacc gaggccgggc tgtggtccag
     1021 cctgagcgcg cgcatcacct cgctgagcgt gagtgactgc atcaacgtgg ccgacgacgc
     1081 catcgcggcc atctcgcagc tgctgcccaa cctggcggag ctgagcctgc aggcctacca
     1141 cgtgacggac acggcgctgg cctacttcac ggcgcgccag ggccacagca cgcacacgct
     1201 gcgcctgctc tcctgctggg agatcaccaa ccacggcgtg gtcaacgtgg tgcacagcct
     1261 gcccaacctc accgcgctca gcctctcggg ctgctccaag gtcaccgacg acggcgtgga
     1321 gctcgtggcc gagaacctgc gcaagctgcg cagccttgac ctctcgtggt gcccacgcat
     1381 caccgacatg gcgctggagt acgtggcctg cgacctgcac cgcctagagg agctcgtgct
     1441 cgacaggtgt gtacgcatca cggacactgg cctcagctat ctgtccacca tgtcgtccct
     1501 ccgcagcctc tacctgcgat ggtgctgcca ggtgcaagac ttcgggctga agcacctcct
     1561 ggccctgggg agtttgcgcc tcctgtctct ggcaggctgc ccgctgctca ccaccaccgg
     1621 gctgtcgggc ctggtgcagc tgcaggagct ggaggagctg gagctgacca actgccccgg
     1681 ggccaccccc gagctcttca agtatttctc gcagcacctg ccccgctgcc tcgtcattga
     1741 gtagcgcgag gcccccgccc cggtcgcggg aacccggcca tgacctgggc gggggcgcgg
     1801 ggcgccgccg agccccctct tcccgccttg cgctcggggg agcccccgcg cccccggccc
     1861 agcgcgggag gcggggcgag ccgagggaaa gcccctcccc gaccttcggt ccctccgccc
     1921 tcccagcccc gccccgggca ggggggcggc gggtgggccc gccccacgca cgcacgcaca
     1981 ctcggggact ttgtgcatgc ccctcgtgcc cgcactgcac gccgccctcc gccacgccac
     2041 agccacagcc gccgccatca ctcgctcgcc ctcccgcttg gggggcgggg ctcggtcctt
     2101 gggggggctt tgagctctcc agactgtgcc cttaccgcct tccccgccac acccgctctg
     2161 tcttcccact gtccccccca tcccgggcag ggcccagtgg gattgagggg gctgggtccc
     2221 ccaggacacg ggcccagaag agccccacgg gcttcctgca tcttccaccg caccatacct
     2281 ggagccctcc gaggggtgtc aggggaaaca ggccaccgcc aaagccatgg cccgccgccg
     2341 agagcccagg ccccacccgc acctcctcac ccatccagcc tgacccacgc ggcctctcct
     2401 cctccttgcc gctgtgtggg gcagtcccct gtccgcccca aaacccggcc ttggtccctg
     2461 gccaggctga gagaattggg cagggagagg gcggaagggc tggcgatcgc ttggagtcat
     2521 taacgtgatc ccagctgact ccggtcggcc tcaacccagg ggtggcgcag gcaccttgca
     2581 agcctcgagc tgtagccacc ctcaggcctg ggaagaggcc tgggccgacc tcacacctca
     2641 gcccttgcac ccggccgggc tcagttcagg cctgggcacc gagcttcacc ctgggtgggt
     2701 ctcctcaggt ggagtctgca gagtggaccc agccaagggt cagggtcagc actgggtcag
     2761 cgactccaat cttccagtgg ccagcacacc ctagacaccc cgaggaggga gggctccttt
     2821 ctagcctgcc cccccacccc cacttcaccc ctccccagct tcccaaactt ctgtctgccc
     2881 aaatgggctc tgaccgtgct ctgtcggccc gagacatttg gaagtcctgg gggatgctgg
     2941 caaatctcag ctgttgctga ggagggggct gggacccctt cccatcccaa ccttgagccc
     3001 caggagatac cgcgcccaca cccaatcttg ggacactccc tatctggttg gaagagagta
     3061 accagtttcc agagagccag agagtgagag agagaaagag agtgagagag agagagaaag
     3121 agagagagag atgctgttga atcagaaaca gatcaacagc ccaaagattt tcctgtccct
     3181 ggagtgccag ccccaggaag ctccagggct gagtggtcag gagccagttt ctccagcccc
     3241 tcctccccac aacccctagt ggggaggggc agctgtccat ttgcccaaag tattaatgca
     3301 actgaagctg tgatatttcc aacgactgta ggaggaaaaa ttaaggggag agaggaaaac
     3361 aaaaccaacc aacccctaaa atcattttct tattgtacat aacgacctca ttctcctgta
     3421 tatgcggaag atataacctt atatttggta agtgtttctt gtgctatttt atcacgtgac
     3481 ctgtttataa aaatatatat taaaaaagtt gtaaaaaca
//
