LOCUS       NM_024326               1340 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens F-box and leucine rich repeat protein 15 (FBXL15),
            transcript variant 1, mRNA.
ACCESSION   NM_024326 XM_370575
VERSION     NM_024326.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Simanski,S., Maloof,M.E., Sato,T.K., Cavett,V., Caldwell Busby,J.
            and Ayad,N.G.
  TITLE     A cell based screening approach for identifying protein degradation
            regulators
  JOURNAL   Cell Cycle 16 (10), 940-946 (2017)
   PUBMED   28296622
  REMARK    GeneRIF: We identified the known APC/C regulator Cdh1 and the F-box
            protein Fbxl15 as specific modulators of N-cyclin B1-luciferase
            steady-state levels and turnover. Collectively, our studies suggest
            that analyzing the steady-state levels of luciferase fusion
            proteins in parallel facilitates identification of specific
            regulators of protein turnover.
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Cui,Y., He,S., Xing,C., Lu,K., Wang,J., Xing,G., Meng,A., Jia,S.,
            He,F. and Zhang,L.
  TITLE     SCFFBXL(1) regulates BMP signalling by directing the degradation of
            HECT-type ubiquitin ligase Smurf1
  JOURNAL   EMBO J 30 (13), 2675-2689 (2011)
   PUBMED   21572392
  REMARK    Erratum:[EMBO J. 2011;30(13):2748]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121928.13.
            
            On Sep 30, 2020 this sequence version replaced NM_024326.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036120.1, SRR18074967.2758373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369956.8/ ENSP00000358972.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AL121928.13        66202-66548
            348-501             AL121928.13        66720-66873
            502-1007            AL121928.13        67153-67658
            1008-1340           AL121928.13        68170-68502
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..1340
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /note="F-box and leucine rich repeat protein 15"
                     /db_xref="GeneID:79176"
                     /db_xref="HGNC:HGNC:28155"
                     /db_xref="MIM:610287"
     exon            1..347
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1197
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /note="F-box only protein 37; pleckstrin and Sec7 domain
                     protein"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 15"
                     /protein_id="NP_077302.3"
                     /db_xref="CCDS:CCDS31273.1"
                     /db_xref="GeneID:79176"
                     /db_xref="HGNC:HGNC:28155"
                     /db_xref="MIM:610287"
                     /translation="MEPPMEPSGGEQEPGAVRFLDLPWEDVLLPHVLNRVPLRQLLRL
                     QRVSRAFRSLVQLHLAGLRRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLS
                     DEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRG
                     LADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNC
                     PELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRKRGVDIDVE
                     PPLHQALVLLQDMAGFAPFVNLQV"
     exon            348..501
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /inference="alignment:Splign:2.1.0"
     exon            502..1007
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1340
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1320..1325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /note="hexamer: AATAAA"
     polyA_site      1340
                     /gene="FBXL15"
                     /gene_synonym="Fbl15; FBXO37; JET; PSD"
                     /note="major polyA site"
ORIGIN      
        1 gctcagaggc ggctactggc tcaagaggac gacagaagcc agtctctgat gcccaccgca
       61 ttctccagct tcaggcctca agccctgtag ccgagaaggc gaggcctaat gttacaccac
      121 cggtctgttc cgcctccgtt tcggggtcca cccgaaaagc tttcagatcg gatcctcggt
      181 gagacggcac tcgattaaat aggtctgtct ctacaggcca aggaggcggg tttggtgcgg
      241 ccactccaag gccaaagcga gaaaatctta ctgcgcacgc gcaatagaca gccgatggag
      301 ccaccgatgg agccgtccgg aggggagcaa gagcccggag ccgtcaggtt cctggacctg
      361 ccctgggaag acgtgctgct cccacacgtc ctgaaccggg tcccgctgcg ccagctgctc
      421 cggctgcagc gcgttagccg ggccttccgg tcgctggtgc agcttcacct ggccgggctg
      481 cgtcgcttcg atgccgcgca ggtgggtccg cagatcccgc gggccgcatt ggcccggctg
      541 ctgcgggatg ccgaggggct gcaggagctg gcactggcgc cgtgtcacga atggctgtca
      601 gacgaggacc tggtgccggt gctggcgcgg aatccgcagc tgcggagtgt ggcgttgggc
      661 ggctgcgggc aactgagtcg ccgggcgctt ggggctttgg ccgagggctg cccacgcctg
      721 cagcgcctgt cgctcgcgca ctgtgactgg gtggacgggc tggcgctgcg cggcctcgct
      781 gatcgctgcc cggccctgga ggagctggat ctcaccgcct gccgccagct caaggacgag
      841 gccatcgtgt acctggcgca gaggcgcggc gctggtctcc gcagcctctc tctggccgtc
      901 aacgccaacg tgggggacgc cgcggttcaa gagttggctc ggaactgccc agaactccac
      961 caccttgacc tcaccggctg cctccgcgtc ggaagcgacg gtgtcaggac attggccgag
     1021 tactgccccg tgctgcgttc gctgcgggtg cggcactgcc accatgtggc ggagtccagc
     1081 ctgagccgct tgcggaagcg cggcgtggac atcgacgtgg agccgccgct gcaccaggcc
     1141 ctggtgctgc tgcaggatat ggcgggcttc gcaccttttg tcaacctgca ggtctgaccc
     1201 gcctgccaat cggagcacag ctggactgtg tggctggggc ctgacactga gctgtaggga
     1261 aactgaactg tgaggacctc tggtgagagg ccagtgccct gccccaccct ggagcttcaa
     1321 ataaagagct ttttaccccc
//
